Postnatal function following prenatal reserpine exposure in rats: neurobehavioral toxicity.

abstract：:Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...

journal_title：Neurotoxicology and teratology

authors： Habr SF,Macrini DJ,Florio JC,Bernardi MM

更新日期：2014-11-01 00:00:00

abstract：:Long-Evans rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate and normal controls were trained in a two-choice box to discriminate between stimuli of different brightness (black vs. white) or pattern (horizontal vs. vertical alternating black-and-white stripes). Mild footshock was used...

journal_title：Neurotoxicology and teratology

authors： Rabe A,Lee MH

更新日期：1990-07-01 00:00:00

abstract：BACKGROUND:Ciguatoxins are extremely potent neurotoxins, produced by tropical marine dinoflagellates, that persistently enter into our food web. Over 100,000 people annually experience acute ciguatera poisoning from consuming toxic fish. Roughly 5% of these victims will develop chronic ciguatera (CC), a widespread, mul...

journal_title：Neurotoxicology and teratology

authors： Shoemaker RC,House D,Ryan JC

更新日期：2010-11-01 00:00:00

abstract：:This nonconcurrent, cohort study of consecutive admissions to one of three hospital units: labor and delivery (n = 474), well-born nursery (n = 100), and the neonatal intensive care unit (n = 100), was designed to determine the prevalence of cocaine exposure in a rural obstetrical sample and to determine the relations...

journal_title：Neurotoxicology and teratology

authors： Behnke M,Eyler FD,Conlon M,Woods NS,Casanova OQ

更新日期：1994-09-01 00:00:00

abstract：:Pregnant rats received daily injections of saline, cocaine (20 mg/kg), morphine (2 mg/kg), or the combination of both drugs, on days 13-20 of gestation. Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dependent increase in ...

journal_title：Neurotoxicology and teratology

authors： Bhat R,Chari G,Rao R,Wirtshafter D

更新日期：2006-09-01 00:00:00

abstract：:The potential of emamectin benzoate (EB) to cause developmental neurotoxicity in Sprague-Dawley rats was assessed using a study design by the US EPA. Dosages of 0 (deionized water), 0.1, 0.6, or 3.6 mg/kg/day were administered at 5 ml/kg by oral gavage from gestational day (GD) 6 to lactational day (LD) 20 to groups o...

journal_title：Neurotoxicology and teratology

authors： Wise LD,Allen HL,Hoe CM,Verbeke DR,Gerson RJ

更新日期：1997-07-01 00:00:00

abstract：:This study examined the effects of chronic postweaning lead (Pb) exposure in Long-Evans rats on a series of spatial alternation tasks. All tasks were administered in automated testing chambers, with a nosepoke as the critical response. While neither Pb-exposed group (median blood lead levels: 19 and 39 micrograms/dl, ...

journal_title：Neurotoxicology and teratology

authors： Alber SA,Strupp BJ

更新日期：1996-01-01 00:00:00

abstract：:Environmental silver exposures are increasing due to the use of silver nanoparticles, which exert antimicrobial actions by releasing Ag+, a suspected developmental neurotoxicant. We evaluated the long-term neurochemical and behavioral effects of embryonic Ag+ exposure in zebrafish at concentrations that had no overt e...

journal_title：Neurotoxicology and teratology

authors： Powers CM,Levin ED,Seidler FJ,Slotkin TA

更新日期：2011-03-01 00:00:00

abstract：:Sodium valproate is an anticonvulsant widely prescribed because of its broad spectrum of activity. While acute toxicity from high doses is well recognized, there have been few animal studies of its chronic toxicity at therapeutic dose levels. Sodium valproate given continuously in drinking fluid (600 mg/l) throughout ...

journal_title：Neurotoxicology and teratology

authors： Chapman JB,Cutler MG

更新日期：1989-03-01 00:00:00

abstract：:The present study was aimed at investigating the long-term effects of prenatal exposure to lamivudine (3TC), an antiretroviral drug used in clinical practice alone or in combination with zidovudine (AZT) to prevent mother-to-child transmission of the HIV virus. Pregnant CD-1 mice were given per os twice daily either 3...

journal_title：Neurotoxicology and teratology

authors： Calamandrei G,Venerosi A,Branchi I,Valanzano A,Alleva E

更新日期：2000-05-01 00:00:00

abstract：:Dysmorphologic and anthropometric assessments were performed on 154 6-year-old children prenatally exposed to cocaine (PCE) and 131 high-risk controls (NCE) of similar race and social class. Adjusted mean height z scores demonstrated a dose-response with metahydroxybenzoylecgonine above a threshold of 100 ng/g of meco...

journal_title：Neurotoxicology and teratology

authors： Minnes S,Robin NH,Alt AA,Kirchner HL,Satayathum S,Salbert BA,Ellison L,Singer LT

更新日期：2006-01-01 00:00:00

abstract：:In the United States, the regulation and testing of chemicals that may impact on human health is mandated by a number of different laws and regulated by several government agencies. Toxicologic screening in laboratory animals has created a major database for predicting adverse health effects of drugs, food and cosmeti...

journal_title：Neurotoxicology and teratology

authors： Steinberg M

更新日期：1987-11-01 00:00:00

abstract：:The effects of administration by inhalation of metallic mercury vapour (Hg0) to pregnant rats, approximately corresponding to doses of 0.2 mg Hg0/kg/day (high dose) or 0.07 mg Hg0/kg/day (low dose), on the developmental and behavioural repertoire of the offspring were studied. Exposure occurred during days 11-14 plus ...

journal_title：Neurotoxicology and teratology

authors： Danielsson BR,Fredriksson A,Dahlgren L,Gårdlund AT,Olsson L,Dencker L,Archer T

更新日期：1993-11-01 00:00:00

abstract：:Cocaine-induced conditioned place preference (CPP) was tested in adult offspring of Sprague-Dawley dams that had been injected subcutaneously with 40 mg/kg/3cc cocaine HCl (C40) daily from gestational days 8-20, pair-fed (PF) dams injected with saline, and nontreated control (LC) dams. C40 and PF dams gained significa...

journal_title：Neurotoxicology and teratology

authors： Heyser CJ,Miller JS,Spear NE,Spear LP

更新日期：1992-01-01 00:00:00

abstract：:Fifty nondrug-exposed infants and 74 cocaine/polydrug-exposed infants were evaluated on the Movement Assessment of Infants (MAI). The test provides an assessment of risk for motor dysfunction at age 4 months. There was a significant difference in total risk scores between the two groups of infants with cocaine-exposed...

journal_title：Neurotoxicology and teratology

authors： Schneider JW,Chasnoff IJ

更新日期：1992-03-01 00:00:00

abstract：:Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and t...

journal_title：Neurotoxicology and teratology

authors： de Souza Spinosa H,Nicolau A,Maruo VM,Bernardi MM

更新日期：1999-07-01 00:00:00

abstract：:Ethanol alters the homeostasis between excitatory and inhibitory neurotransmitters and its intoxication reveals adenosine as responsible to modify several responses including signal transduction. Zebrafish has been recently investigated for knowledge the prolonged effect of ethanol on behavioral and biochemical parame...

journal_title：Neurotoxicology and teratology

authors： Rico EP,Rosemberg DB,Berteli JFA,da Silveira Langoni A,Souto AA,Bogo MR,Bonan CD,Souza DO

更新日期：2018-01-01 00:00:00

abstract：:Numerous experiments have shown that the aromatic solvents can affect the auditory system in the rat, the cochlea being targeted first. Solvents differ in cochleotoxic potency: for example, styrene is more ototoxic than toluene or xylenes. The goal of this study was to determine the relative ototoxicity of the three i...

journal_title：Neurotoxicology and teratology

authors： Maguin K,Lataye R,Campo P,Cossec B,Burgart M,Waniusiow D

更新日期：2006-11-01 00:00:00

abstract：:Lead (Pb) is a well-known poison interfering with calcium homeostasis and dopaminergic pathway. We hypothesized that environmental Pb exposure can interact with prolactin (PRL) secretion, regulated by calcium and dopamine, during pregnancy and in fetus. The objective of this longitudinal study was to determine the rel...

journal_title：Neurotoxicology and teratology

authors： Takser L,Mergler D,Lafond J

更新日期：2005-05-01 00:00:00

abstract：:The effects of maternal urinary tract infection (UTI) or endotoxin exposure on fetal outcome in rats were investigated. Prior to conception, dams of the UTI group were water-deprived and anesthetized. The urinary tract was then catheterized and injected with 0.2 of 1 x 10(9) Escherichia coli. The endotoxin group was i...

journal_title：Neurotoxicology and teratology

authors： Cronise K,Kelly SJ

更新日期：2001-07-01 00:00:00

abstract：:The ability of a neurobehavioral screening battery to differentiate the effects of two pyrethroids, permethrin and cypermethrin, was assessed in this experiment. Although the structures of these pesticides differ only in the alpha-cyano group, the behavioral syndromes associated with the Type I and II pyrethroids are ...

journal_title：Neurotoxicology and teratology

authors： McDaniel KL,Moser VC

更新日期：1993-03-01 00:00:00

abstract：OBJECTIVE:The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses str...

journal_title：Neurotoxicology and teratology

authors： Sood BG,Nordstrom Bailey B,Covington C,Sokol RJ,Ager J,Janisse J,Hannigan JH,Delaney-Black V

更新日期：2005-03-01 00:00:00

abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

journal_title：Neurotoxicology and teratology

authors： Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

更新日期：2000-11-01 00:00:00

abstract：:Human exposure to organophosphate flame retardants (OPFRs) is widespread, including pregnant women and young children with whom developmental neurotoxic risk is a concern. Given similarities of OPFRs to organophosphate (OP) pesticides, research into the possible neurotoxic impacts of developmental OPFR exposure has be...

journal_title：Neurotoxicology and teratology

authors： Oliveri AN,Ortiz E,Levin ED

更新日期：2018-01-01 00:00:00

abstract：:Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...

journal_title：Neurotoxicology and teratology

authors： Kilburn KH,Warshaw RH

更新日期：1995-03-01 00:00:00

abstract：:A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...

journal_title：Neurotoxicology and teratology

authors： McMichael AJ,Baghurst PA,Vimpani GV,Robertson EF,Wigg NR,Tong SL

更新日期：1992-09-01 00:00:00

abstract：OBJECTIVE:To examine the association between prenatal exposure to nicotine from tobacco smoke and infant neurobehavior using tobacco biomarkers and a sensitive and comprehensive measure of infant neurobehavior. STUDY DESIGN:Participants were 318 infants (206 White, 95 Black, 17 Other) and their mothers. Prenatal tobac...

journal_title：Neurotoxicology and teratology

authors： Yolton K,Khoury J,Xu Y,Succop P,Lanphear B,Bernert JT,Lester B

更新日期：2009-11-01 00:00:00

abstract：:Memory problems lasting 8 months have previously been described for a small group of female solvent workers following an accidental workplace solvent intoxication. Three years after the intoxication the presence of longer-term residual impairment of cognitive functions was evaluated. The major residual difficulty unco...

journal_title：Neurotoxicology and teratology

authors： Stollery BT

更新日期：1996-07-01 00:00:00

abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

journal_title：Neurotoxicology and teratology

authors： Vorhees CV

更新日期：1989-03-01 00:00:00

abstract：:Understanding the potentially harmful long term consequences of prenatal marijuana exposure is important given the increase in number of pregnant women smoking marijuana to relieve morning sickness. Altered executive functioning is one area of research that has suggested negative consequences of prenatal marijuana exp...

journal_title：Neurotoxicology and teratology

authors： Smith AM,Mioduszewski O,Hatchard T,Byron-Alhassan A,Fall C,Fried PA

更新日期：2016-01-01 00:00:00