Visual discrimination by rats with transplacentally induced micrencephaly.

abstract：:Ionizing radiation is a precise tool for altering formation of the developing cerebral cortex of the fetal rat. Whole body exposure of the pregnant rat on gestational day 13, 15 or 17 to 1.0 Gy of gamma radiation resulted in maximum thinning of the cortex on days 15 and 17. In the preweaning period, functional tests (...

journal_title：Neurotoxicology and teratology

authors： Norton S,Kimler BF

更新日期：1988-07-01 00:00:00

abstract：:Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

journal_title：Neurotoxicology and teratology

authors： Oshiro WM,Krantz QT,Bushnell PJ

更新日期：2001-11-01 00:00:00

abstract：:The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms...

journal_title：Neurotoxicology and teratology

authors： de Esch C,Slieker R,Wolterbeek A,Woutersen R,de Groot D

更新日期：2012-11-01 00:00:00

abstract：:We examined the distribution of cocaine and its metabolites benzoylecgonine (BE) and norcocaine (NOR) in pregnant Sprague-Dawley rats and fetuses following twice-daily subcutaneous (s.c.) injections of 20 mg/kg cocaine HCl from gestational day (GD) 8 through GD 20. On GD 21, the animals received a single injection and...

journal_title：Neurotoxicology and teratology

authors： Collins LM,Pahl JA,Meyer JS

更新日期：1999-11-01 00:00:00

abstract：:The effects of administration by inhalation of metallic mercury vapour (Hg0) to pregnant rats, approximately corresponding to doses of 0.2 mg Hg0/kg/day (high dose) or 0.07 mg Hg0/kg/day (low dose), on the developmental and behavioural repertoire of the offspring were studied. Exposure occurred during days 11-14 plus ...

journal_title：Neurotoxicology and teratology

authors： Danielsson BR,Fredriksson A,Dahlgren L,Gårdlund AT,Olsson L,Dencker L,Archer T

更新日期：1993-11-01 00:00:00

abstract：:While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

journal_title：Neurotoxicology and teratology

authors： Dribben WH,Creeley CE,Farber N

更新日期：2011-07-01 00:00:00

abstract：:Cigarette smoking in pregnant women has been shown to lead to intrauterine growth retardation and fetal death, and possibly also to neural dysmorphology and long-term learning deficits in the offspring. Because the teratogenic agent in cigarette smoke remains controversial, the present study on rat embryos in culture ...

journal_title：Neurotoxicology and teratology

authors： Joschko MA,Dreosti IE,Tulsi RS

更新日期：1991-05-01 00:00:00

abstract：:The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...

journal_title：Neurotoxicology and teratology

authors： Minnema DJ,Hammond PB

更新日期：1994-11-01 00:00:00

abstract：:Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term effects of this drug on the central nervous system (CNS) are not well understood, we conducted microPET/CT scans on young adult male rhesus monkeys (n=4/group) to gather in...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Newport GD,Callicott R,Liu S,Thompson J,Berridge MS,Apana SM,Slikker W Jr,Wang C,Paule MG

更新日期：2016-07-01 00:00:00

abstract：:Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...

journal_title：Neurotoxicology and teratology

authors： Fulginiti S,Minetti SA,Virgolini MB

更新日期：1994-07-01 00:00:00

abstract：:4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

journal_title：Neurotoxicology and teratology

authors： Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

更新日期：2011-11-01 00:00:00

abstract：:The present study was aimed at investigating the long-term effects of prenatal exposure to lamivudine (3TC), an antiretroviral drug used in clinical practice alone or in combination with zidovudine (AZT) to prevent mother-to-child transmission of the HIV virus. Pregnant CD-1 mice were given per os twice daily either 3...

journal_title：Neurotoxicology and teratology

authors： Calamandrei G,Venerosi A,Branchi I,Valanzano A,Alleva E

更新日期：2000-05-01 00:00:00

abstract：:Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...

journal_title：Neurotoxicology and teratology

authors： Habr SF,Macrini DJ,Florio JC,Bernardi MM

更新日期：2014-11-01 00:00:00

abstract：:Cocaine-induced conditioned place preference (CPP) was tested in adult offspring of Sprague-Dawley dams that had been injected subcutaneously with 40 mg/kg/3cc cocaine HCl (C40) daily from gestational days 8-20, pair-fed (PF) dams injected with saline, and nontreated control (LC) dams. C40 and PF dams gained significa...

journal_title：Neurotoxicology and teratology

authors： Heyser CJ,Miller JS,Spear NE,Spear LP

更新日期：1992-01-01 00:00:00

abstract：:Behavioral and neurochemical analyses were conducted on preweanling CD rats prenatally exposed to either 0, 0.375 or 0.750 mg/kg/day reserpine SC on gestation days 12-15. Offspring body weights were taken on test days, and pups were tested for negative geotaxis responding on postnatal day 8, developmental activity on ...

journal_title：Neurotoxicology and teratology

authors： Buelke-Sam J,Ali SF,Kimmel GL,Slikker W Jr,Newport GD,Harmon JR

更新日期：1989-09-01 00:00:00

abstract：:A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...

journal_title：Neurotoxicology and teratology

authors： Mesbah-Oskui L,Penna A,Orser BA,Horner RL

更新日期：2017-05-01 00:00:00

abstract：:Prenatal cocaine or nicotine exposure is associated with a variety of teratogenic effects. The current study was conducted to determine their effects alone and in combination on cognitive function and sexual differentiation. Pregnant Long-Evans rats (N = 19) were exposed to either cocaine (15 mg/kg/dose b.i.d. SC on G...

journal_title：Neurotoxicology and teratology

authors： Cutler AR,Wilkerson AE,Gingras JL,Levin ED

更新日期：1996-11-01 00:00:00

abstract：:Estrogen modulates baseline and amphetamine-stimulated dopamine (DA) release in the adult female rat striatum. The isoflavone found in soybeans, genistein, is a phytoestrogen and may have comparable effects on striatal DA levels. Similarly, the industrial intermediate and potential endocrine disrupter, para-nonylpheno...

journal_title：Neurotoxicology and teratology

authors： Ferguson SA,Flynn KM,Delclos KB,Newbold RR,Gough BJ

更新日期：2002-01-01 00:00:00

abstract：:Electrical kindling of the amygdala and hippocampus was used to evaluate the effects of two formamidines, chlordimeform (CDF) and amitraz (AMZ), upon seizures susceptibility in the rat. Male Long-Evans rats were implanted with electrodes in the amygdala or dorsal dentate gyrus, and injected IP daily with 40 mg/kg CDF,...

journal_title：Neurotoxicology and teratology

authors： Gilbert ME

更新日期：1988-05-01 00:00:00

abstract：:This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzin...

journal_title：Neurotoxicology and teratology

authors： Allen RR,Slikker W Jr,Paule MG

更新日期：1990-09-01 00:00:00

abstract：:Because of the important role of glial cells in brain maturation and reports on their delayed proliferation following ethanol exposure, it was considered of interest to investigate the mechanism of ethanol action on these cells. Biochemical parameters related to the apoptotic and necrotic processes in astroglial cells...

journal_title：Neurotoxicology and teratology

authors： Holownia A,Ledig M,Ménez JF

更新日期：1997-03-01 00:00:00

abstract：:The present study provides a characterization of the behavioral changes induced in preweaning mice by prenatal exposure to lamivudine (3TC), an antiviral drug recently entered in the clinical practice to treat HIV patients. Pregnant CD1 mice were given per os bidaily either 3TC at different doses (125, 250, or 500 mg/...

journal_title：Neurotoxicology and teratology

authors： Calamandrei G,Venerosi A,Branchi I,Valanzano A,Puopolo M,Alleva E

更新日期：1999-07-01 00:00:00

abstract：:Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...

journal_title：Neurotoxicology and teratology

authors： Kilburn KH,Warshaw RH

更新日期：1995-03-01 00:00:00

abstract：:The present study was designed to investigate the in vivo effects of monosodium glutamate (MSG) and aspartame (ASM) individually and in combination on the cognitive behavior and biochemical parameters like neurotransmitters and oxidative stress indices in the brain tissue of mice. Forty male Swiss albino mice were ran...

journal_title：Neurotoxicology and teratology

authors： Abu-Taweel GM,A ZM,Ajarem JS,Ahmad M

更新日期：2014-03-01 00:00:00

abstract：:The purpose of this study was to determine the relationship between ornithine decarboxylase activity (ODC; a marker for perturbed cell development), the blood alcohol level, and alcohol-induced microencephaly in the developing rat brain after binge treatment with ethanol vapour. By manipulating ethanol flow we were ab...

journal_title：Neurotoxicology and teratology

authors： Davidson M,Bedi K,Wilce P

更新日期：1998-09-01 00:00:00

abstract：:Ethanol alters the homeostasis between excitatory and inhibitory neurotransmitters and its intoxication reveals adenosine as responsible to modify several responses including signal transduction. Zebrafish has been recently investigated for knowledge the prolonged effect of ethanol on behavioral and biochemical parame...

journal_title：Neurotoxicology and teratology

authors： Rico EP,Rosemberg DB,Berteli JFA,da Silveira Langoni A,Souto AA,Bogo MR,Bonan CD,Souza DO

更新日期：2018-01-01 00:00:00

abstract：:Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...

journal_title：Neurotoxicology and teratology

authors： Kwan LY,Eaton DL,Andersen SL,Dow-Edwards D,Levin ED,Talpos J,Vorhees CV,Li AA

更新日期：2020-01-01 00:00:00

abstract：:Ultrasonic calls are emitted by many species of rodents in a variety of situations. In particular, infants commonly emit such calls when removed from the nest; the rate and intensity of calling are related to the degree of development of homoiothermy. The relevant biological significance of these signals is documented...

journal_title：Neurotoxicology and teratology

authors： Cuomo V,De Salvia MA,Maselli MA,Santo L,Cagiano R

更新日期：1987-03-01 00:00:00

abstract：:Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and t...

journal_title：Neurotoxicology and teratology

authors： de Souza Spinosa H,Nicolau A,Maruo VM,Bernardi MM

更新日期：1999-07-01 00:00:00

abstract：:Pregnant C57BL/6 mice were chronically treated with 0, 4, 6, or 8 ppm of methylmercury chloride (MeHg) in drinking water during fetal and early postnatal development. Four behavioral functions were analyzed in female and male offspring between the age of 6 and 12 weeks: motor coordination learning on the rotarod; trai...

journal_title：Neurotoxicology and teratology

authors： Goulet S,Doré FY,Mirault ME

更新日期：2003-05-01 00:00:00