Visual discrimination by rats with transplacentally induced micrencephaly.

abstract：:Methylmercury (MeHg), an environmental contaminant primarily found in fish and seafood, may pose long-term health risks to pregnant women and their developing children. The objective of this study was to determine whether co-consumption of nutritional supplements would alter the effects of MeHg on reproductive and dev...

journal_title：Neurotoxicology and teratology

authors： Beyrouty P,Chan HM

更新日期：2006-01-01 00:00:00

abstract：:Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...

journal_title：Neurotoxicology and teratology

authors： Morris-Schaffer K,Sobolewski M,Welle K,Conrad K,Yee M,O'Reilly MA,Cory-Slechta DA

更新日期：2018-01-01 00:00:00

abstract：:A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...

journal_title：Neurotoxicology and teratology

authors： McMichael AJ,Baghurst PA,Vimpani GV,Robertson EF,Wigg NR,Tong SL

更新日期：1992-09-01 00:00:00

abstract：:This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

journal_title：Neurotoxicology and teratology

authors： Al Deeb S,Al Moutaery K,Khan HA,Tariq M

更新日期：2000-03-01 00:00:00

abstract：:Understanding the potentially harmful long term consequences of prenatal marijuana exposure is important given the increase in number of pregnant women smoking marijuana to relieve morning sickness. Altered executive functioning is one area of research that has suggested negative consequences of prenatal marijuana exp...

journal_title：Neurotoxicology and teratology

authors： Smith AM,Mioduszewski O,Hatchard T,Byron-Alhassan A,Fall C,Fried PA

更新日期：2016-01-01 00:00:00

abstract：UNLABELLED:This research examines the effects of different degrees of pesticide exposure on neuropsychological performance. Exposures varied from acute poisoning coupled with chronic exposure to low or high levels of chronic exposure (defined by years of exposure). A cross-sectional neuropsychological and biochemical s...

journal_title：Neurotoxicology and teratology

authors： Roldan-Tapia L,Nieto-Escamez FA,del Aguila EM,Laynez F,Parron T,Sanchez-Santed F

更新日期：2006-11-01 00:00:00

abstract：:Fifty nondrug-exposed infants and 74 cocaine/polydrug-exposed infants were evaluated on the Movement Assessment of Infants (MAI). The test provides an assessment of risk for motor dysfunction at age 4 months. There was a significant difference in total risk scores between the two groups of infants with cocaine-exposed...

journal_title：Neurotoxicology and teratology

authors： Schneider JW,Chasnoff IJ

更新日期：1992-03-01 00:00:00

abstract：:Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder, bent spine and yolk-sac...

journal_title：Neurotoxicology and teratology

authors： Chen J,Chen Y,Liu W,Bai C,Liu X,Liu K,Li R,Zhu JH,Huang C

更新日期：2012-11-01 00:00:00

abstract：:In this study we used a rat model of graded perinatal asphyxia to study the long-term consequences of this manipulation on rat maternal behavior at adulthood. Rats were delivered by cesarean (C) section and the pups, still in the uterus horns, were placed into a water bath at 37 degrees C for periods of 0 (controls) o...

journal_title：Neurotoxicology and teratology

authors： Cirulli F,Bonsignore LT,Venerosi A,Valanzano A,Chiarotti F,Alleva E

更新日期：2003-09-01 00:00:00

abstract：:Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ,Spindel ER

更新日期：2011-05-01 00:00:00

abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...

journal_title：Neurotoxicology and teratology

authors： Morris P,Binienda Z,Gillam MP,Klein J,McMartin K,Koren G,Duhart HM,Slikker W Jr,Paule MG

更新日期：1997-01-01 00:00:00

abstract：:The potential of emamectin benzoate (EB) to cause developmental neurotoxicity in Sprague-Dawley rats was assessed using a study design by the US EPA. Dosages of 0 (deionized water), 0.1, 0.6, or 3.6 mg/kg/day were administered at 5 ml/kg by oral gavage from gestational day (GD) 6 to lactational day (LD) 20 to groups o...

journal_title：Neurotoxicology and teratology

authors： Wise LD,Allen HL,Hoe CM,Verbeke DR,Gerson RJ

更新日期：1997-07-01 00:00:00

abstract：:Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...

journal_title：Neurotoxicology and teratology

authors： Kwan LY,Eaton DL,Andersen SL,Dow-Edwards D,Levin ED,Talpos J,Vorhees CV,Li AA

更新日期：2020-01-01 00:00:00

abstract：:Research suggests that use and abuse of marijuana can be especially harmful if it occurs during adolescence, a period of vast developmental changes throughout the brain. We examined the effects of 2mg/kg (9)-tetrahydrocannabinol (THC) administered daily via intra-peritoneal injections during juvenile/early adolescence...

journal_title：Neurotoxicology and teratology

authors： Harte LC,Dow-Edwards D

更新日期：2010-09-01 00:00:00

abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...

journal_title：Neurotoxicology and teratology

authors： Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar A

更新日期：2005-01-01 00:00:00

abstract：:Previous studies have shown that maternal doses of 1 microg/kg or less of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in late gestation can demasculinize and feminize reproductive behavior in male rats. However, it was not known whether coplanar polychlorinated biphenyls (PCBs) had similar effects, or whether non-repro...

journal_title：Neurotoxicology and teratology

authors： Amin S,Moore RW,Peterson RE,Schantz SL

更新日期：2000-09-01 00:00:00

abstract：:We examined the distribution of cocaine and its metabolites benzoylecgonine (BE) and norcocaine (NOR) in pregnant Sprague-Dawley rats and fetuses following twice-daily subcutaneous (s.c.) injections of 20 mg/kg cocaine HCl from gestational day (GD) 8 through GD 20. On GD 21, the animals received a single injection and...

journal_title：Neurotoxicology and teratology

authors： Collins LM,Pahl JA,Meyer JS

更新日期：1999-11-01 00:00:00

abstract：RATIONALE:In rats, neurotoxic doses of methamphetamine (MA) induce astrogliosis, long lasting monoamine reductions, reuptake transporter down-regulation, and learning impairments. OBJECTIVE:We tested whether comparable effects occur in C57BL/6 mice. METHOD:C57BL/6 mice were treated with 10mg/kgs.c.x4 MA on a single d...

journal_title：Neurotoxicology and teratology

authors： Grace CE,Schaefer TL,Herring NR,Graham DL,Skelton MR,Gudelsky GA,Williams MT,Vorhees CV

更新日期：2010-05-01 00:00:00

abstract：:Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...

journal_title：Neurotoxicology and teratology

authors： Fulginiti S,Minetti SA,Virgolini MB

更新日期：1994-07-01 00:00:00

abstract：:The effects of administration by inhalation of metallic mercury vapour (Hg0) to pregnant rats, approximately corresponding to doses of 0.2 mg Hg0/kg/day (high dose) or 0.07 mg Hg0/kg/day (low dose), on the developmental and behavioural repertoire of the offspring were studied. Exposure occurred during days 11-14 plus ...

journal_title：Neurotoxicology and teratology

authors： Danielsson BR,Fredriksson A,Dahlgren L,Gårdlund AT,Olsson L,Dencker L,Archer T

更新日期：1993-11-01 00:00:00

abstract：BACKGROUND:General anesthetics (GAs) may exert harmful effects on the developing brain by disrupting neuronal circuit formation. Anesthetics that act on γ-aminobutyric acid (GABA) receptors can interfere with axonal growth cone guidance, a critical process in the assembly of neuronal circuitry. Here we investigate the ...

journal_title：Neurotoxicology and teratology

authors： Xu J,Xu M,Wang Y,Mathena RP,Wen J,Zhang P,Furmanski O,Mintz CD

更新日期：2019-01-01 00:00:00

abstract：OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...

journal_title：Neurotoxicology and teratology

authors： Salisbury AL,Lester BM,Seifer R,Lagasse L,Bauer CR,Shankaran S,Bada H,Wright L,Liu J,Poole K

更新日期：2007-05-01 00:00:00

abstract：:The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency ...

journal_title：Neurotoxicology and teratology

authors： Nagymajtényi L,Dési I,Lorencz R

更新日期：1988-09-01 00:00:00

abstract：:Using a timed-breeding protocol, one group of female rhesus monkeys was implanted subcutaneously with osmotic minipumps containing 0.3 mg/kg/h cocaine (N=18) or saline (N=18) from day 24 postconception through gestation. Another group received cocaine (N=12) or saline (N=8) from conception through day 42 of gestation....

journal_title：Neurotoxicology and teratology

authors： Howell LL,Schama KF,Ellis JE,Grimley PJ,Kitchens AJ,Byrd LD

更新日期：2001-03-01 00:00:00

abstract：:In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM pCPA for 24h and subsequently rescued...

journal_title：Neurotoxicology and teratology

authors： Airhart MJ,Lee DH,Wilson TD,Miller BE,Miller MN,Skalko RG,Monaco PJ

更新日期：2012-01-01 00:00:00

abstract：:Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...

journal_title：Neurotoxicology and teratology

authors： Foss JA,Riley EP

更新日期：1991-09-01 00:00:00

abstract：:AZT (azidothymidine, zidovudine, ZDV) has become the standard medication to prevent the transmission of the human immunodeficiency virus from mother to fetus. The present study was designed to assess the acoustic startle response (ASR) in adult rats that had been perinatally exposed to AZT. Each litter was randomly as...

journal_title：Neurotoxicology and teratology

authors： Melnick SM,Weedon J,Dow-Edwards DL

更新日期：2002-11-01 00:00:00

abstract：:Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ab...

journal_title：Neurotoxicology and teratology

authors： Mitchell JA,Long SF,Wilson MC,Kallman MJ

更新日期：1989-01-01 00:00:00

abstract：:The effects of lindane on behavior and central monoaminergic systems were studied in rat pups at 15 days of postnatal age. Pups were previously given nonconvulsant lindane PO doses, either a single 20 mg/kg or 7-day repeated 10 mg/kg doses. Both treatment schedules improved the passive avoidance acquisition but only t...

journal_title：Neurotoxicology and teratology

authors： Rivera S,Rosa R,Martínez E,Suñol C,Serrano MT,Vendrell M,Rodríguez-Farré E,Sanfeliu C

更新日期：1998-03-01 00:00:00

abstract：:Cocaine-induced conditioned place preference (CPP) was tested in adult offspring of Sprague-Dawley dams that had been injected subcutaneously with 40 mg/kg/3cc cocaine HCl (C40) daily from gestational days 8-20, pair-fed (PF) dams injected with saline, and nontreated control (LC) dams. C40 and PF dams gained significa...

journal_title：Neurotoxicology and teratology

authors： Heyser CJ,Miller JS,Spear NE,Spear LP

更新日期：1992-01-01 00:00:00