Abstract:
:The purpose of this study was to determine the relationship between ornithine decarboxylase activity (ODC; a marker for perturbed cell development), the blood alcohol level, and alcohol-induced microencephaly in the developing rat brain after binge treatment with ethanol vapour. By manipulating ethanol flow we were able to adjust vapour concentrations (24-65 mg ethanol/l air) such that an acute exposure of ethanol vapour for 3 h resulted in a range of blood alcohol levels (2.3-5.5 mg/ml). Acute studies showed that ethanol dose-dependently inhibited rat hippocampal and cerebellar ODC activity at PND4-PND10. There was a significant correlation between the blood alcohol level and degree of inhibition at all ages tested. Chronic treatment from PND4 to PND9 caused a significant decrease in both brain to body weight ratio and in hippocampal and cerebellar ODC activities at PND10. These results indicate that ethanol-induced disruption in ODC could play a significant role in ethanol's teratogenic effects during early postnatal development.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Davidson M,Bedi K,Wilce Pdoi
10.1016/s0892-0362(97)00135-9subject
Has Abstractpub_date
1998-09-01 00:00:00pages
523-30issue
5eissn
0892-0362issn
1872-9738pii
S0892-0362(97)00135-9journal_volume
20pub_type
杂志文章abstract::A study of possible undue neurobehavioral effects of low-level lead exposure was performed in Danish school children who entered first grade in 1982. Lead absorption was found to relate to impaired psychological test performance and difficulties at school. However, this relationship was confounded by medical risk fact...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(88)90089-x
更新日期:1988-11-01 00:00:00
abstract::Zebrafish provide a powerful model of the impacts of embryonic toxicant exposure on neural development that may result in long-term behavioral dysfunction. In this study, zebrafish embryos were treated with 1.5mM strychnine for short embryonic time windows to induce transient changes in inhibitory neural signaling, an...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2012.08.001
更新日期:2012-11-01 00:00:00
abstract::Subcutaneous injection of a sublethal dose of chlorpyrifos (CHLP), an organophosphate (OP) pesticide, causes long-term inhibition in cholinesterase activity (ChE) of brain, blood, and other tissues. Such prolonged inhibition in ChE should lead to marked behavioral and autonomic thermoregulatory patterns, especially in...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(94)90002-7
更新日期:1994-01-01 00:00:00
abstract::The effects of acute prenatal exposure to ethanol on the postnatal optic nerve have been examined in a C57B1/6J mouse model. Pregnant mice were exposed by intraperitoneal injection to ethanol (25% ethanol, each dose at 0.015 ml/g separated by 4 h), or to saline on the 8th gestational day and the optic nerve examined a...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(94)90113-9
更新日期:1994-03-01 00:00:00
abstract::Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...
journal_title:Neurotoxicology and teratology
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1016/0892-0362(94)00057-k
更新日期:1995-03-01 00:00:00
abstract::A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2016.10.009
更新日期:2017-05-01 00:00:00
abstract::Zebrafish behavioral model is a powerful tool for neuroscience research. Behavioral changes in the zebrafish are studied by administering drugs. With the aid of automated and open-source MATLAB program, high-accuracy tracking of zebrafish can be achieved, and the important behavioral parameters can be calculated. Alth...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2018.01.007
更新日期:2018-01-01 00:00:00
abstract::Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
doi:10.1016/j.ntt.2020.106916
更新日期:2020-01-01 00:00:00
abstract::The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(94)90040-x
更新日期:1994-11-01 00:00:00
abstract::This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzin...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(90)90005-w
更新日期:1990-09-01 00:00:00
abstract::A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....
journal_title:Neurotoxicology and teratology
pub_type:
doi:10.1016/j.ntt.2012.01.008
更新日期:2012-03-01 00:00:00
abstract::Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2018.10.003
更新日期:2018-01-01 00:00:00
abstract::Rats were fed a liquid diet containing ethanol from days 6-19 of gestation. Controls were pair-fed the same diet with sucrose substituted for ethanol, or received ad lib chow and water. The activity of the offspring was observed at 10, 16, 22 or 28 days-of-age. Overall, offspring exposed to alcohol prenatally were hyp...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(88)90067-0
更新日期:1988-01-01 00:00:00
abstract::Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(99)00046-x
更新日期:2000-01-01 00:00:00
abstract::With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
doi:10.1016/j.ntt.2007.12.009
更新日期:2008-07-01 00:00:00
abstract::The effect of subdiaphragmatic vagotomy on the acquisition of a radiation-induced taste aversion was examined to assess the importance of the vagus nerve in transmitting information on the peripheral toxicity of radiation to the brain. Vagotomy had no effect on taste aversion learning, consistent with reports using ot...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(87)90073-0
更新日期:1987-01-01 00:00:00
abstract::In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedron...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2018.03.001
更新日期:2018-01-01 00:00:00
abstract:OBJECTIVE:The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses str...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2004.10.005
更新日期:2005-03-01 00:00:00
abstract::Exposure to general anesthetic agents during development has been associated with neurotoxicity and long-term behavioral impairments in rodents and non-human primates. The phenotype of anesthetic-induced cognitive impairment has a robust learning and memory component, however less is known about other psychological do...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2016.11.010
更新日期:2017-01-01 00:00:00
abstract::The interest in, and number of, neurobehavioral test batteries for use in occupational settings has increased markedly over the last decade. While this is a welcome development in furthering the cause for greater acceptance of these methods in hazard evaluation and toxicity testing, there are a number of issues that a...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(90)90015-5
更新日期:1990-09-01 00:00:00
abstract::Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and t...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(99)00012-4
更新日期:1999-07-01 00:00:00
abstract::In vitro studies with permanent cell lines derived from ENU-induced rat CNS and PNS tumors have shown that substances acting on second messenger systems as well as glucocorticoids have a cytostatic effect at high cell densities, but enhance proliferation at low densities. The nontoxic cytostatic effects are partially ...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(89)90037-8
更新日期:1989-11-01 00:00:00
abstract::Reversible protein phosphorylation is a central mechanism regulating many biological functions, and abnormal protein phosphorylation can have a devastating impact on cellular control mechanisms, including a contributing role in neurodegenerative processes. Hence, many promising novel drug development strategies involv...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2003.12.007
更新日期:2004-05-01 00:00:00
abstract::Gestational Toluene Exposure Effects on Spontaneous and Amphetamine-Induced Locomotor Behavior in Rats. Bowen, S.E., Mohammadi, M.H., Batis, J.C., and Hannigan, J.H. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) continues to be a major health concern throughout the world....
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2006.09.027
更新日期:2007-03-01 00:00:00
abstract::Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(89)90049-4
更新日期:1989-03-01 00:00:00
abstract::Using a timed-breeding protocol, one group of female rhesus monkeys was implanted subcutaneously with osmotic minipumps containing 0.3 mg/kg/h cocaine (N=18) or saline (N=18) from day 24 postconception through gestation. Another group received cocaine (N=12) or saline (N=8) from conception through day 42 of gestation....
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(01)00121-0
更新日期:2001-03-01 00:00:00
abstract::The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (n=8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas natu...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2005.04.003
更新日期:2005-07-01 00:00:00
abstract::A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(92)90038-c
更新日期:1992-09-01 00:00:00
abstract::A multidisciplinary study to investigate 2,5-hexanedione (2,5-HD)-induced CNS-neurotoxicity and its proposed potentiation by acetone (AC) was conducted. Neurobehavioral testing, estimation of the brain-swelling reaction, neuropathological and morphometric measurements as well as synaptosomal 5-hydroxytryptamine (5-HT)...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(91)90089-f
更新日期:1991-07-01 00:00:00
abstract::The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameter...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2005.10.007
更新日期:2006-01-01 00:00:00