This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence.

Abstract:

:Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, that brought together experts in research on drug dependence and toxicity related to nicotine, cannabis, cocaine, and other illicit drugs during adolescence. The goal of the workshop was to address the following issues: (1) Do the effects of adolescent exposure differ from the same exposure in adults? (2) Are there unique biological markers of adolescent brain development? If so, what are they and how reliable are they? (3) Since multiple factors influence substance use disorder, can we disentangle risk factors for abuse and/or toxicity? What are the underlying biological susceptibilities that lead to dependence and neurotoxicity? What are the social, psychosocial and environmental factors that contribute to abuse susceptibilities? This paper reviews drug policy and national trends in adolescent substance use; the public health consequences of e-cigarettes; rat models of adolescent-onset nicotine self-administration and persisting effects of gestational nicotine; sex-dependent effects of delta-9-tetrahydrocannabinol on adolescent brain-behavior relationships; and translational approaches for identifying adolescent risk factors for transition to drug dependence. There is strong evidence that drug exposure prior to adulthood has longer lasting effects on behavior and the underlying neural circuitry. These effects, which are sex-dependent and influenced by stress, may be candidates as predictors of adolescent vulnerability. A major challenge to determining if adolescents have a unique susceptibility to dependence is whether and to what extent the human data allow distinction between the increased risk due to biological immaturity, an underlying biological susceptibility to dependence, or psychosocial and environmental factors for substance dependence. Factors important to consider for development of animal models include the timing and pattern of exposure as it relates to adolescence; age of assessment, and direct comparison with similar effects following exposures to adults to demonstrate that these effects are unique to adolescence. Here we provide a roadmap for further research into what makes adolescent brain development unique.

journal_name

Neurotoxicol Teratol

authors

Kwan LY,Eaton DL,Andersen SL,Dow-Edwards D,Levin ED,Talpos J,Vorhees CV,Li AA

doi

10.1016/j.ntt.2020.106916

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

106916

eissn

0892-0362

issn

1872-9738

pii

S0892-0362(20)30059-3

journal_volume

81

pub_type

杂志文章,评审
  • Terbutaline impairs the development of peripheral noradrenergic projections: potential implications for autism spectrum disorders and pharmacotherapy of preterm labor.

    abstract::Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic proj...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2012.07.003

    authors: Slotkin TA,Seidler FJ

    更新日期:2013-03-01 00:00:00

  • 3-Nitropropionic acid produces indirect excitotoxic damage to rat striatum.

    abstract::The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex o...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(94)00076-p

    authors: Fu Y,He F,Zhang S,Huang J,Zhang J,Jiao X

    更新日期:1995-05-01 00:00:00

  • A new look at quantifying tobacco exposure during pregnancy using fuzzy clustering.

    abstract:BACKGROUND:Prenatal tobacco exposure is a risk factor for the development of externalizing behaviors and is associated with several adverse health outcomes. Because pregnancy smoking is a complex behavior with both daily fluctuations and changes over the course of pregnancy, quantifying tobacco exposure is a significan...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2010.08.003

    authors: Fang H,Johnson C,Stopp C,Espy KA

    更新日期:2011-01-01 00:00:00

  • Factors influencing diisopropyl fluorophosphate-induced hypothermia and hyperthermia in the rat.

    abstract::Exposing rats to the anticholinesterase (anti-ChE) diisopropyl fluorophosphate (DFP) causes a transient period of hypothermia followed by a period of hyperthermia lasting approximately 48 h. Because a fever is a predominant thermoregulatory response in humans exposed to anti-ChE pesticides, the hyperthermic response i...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(95)02001-2

    authors: Gordon CJ

    更新日期:1995-11-01 00:00:00

  • Behavioral evaluations in developmental toxicity testing: MARTA survey results.

    abstract::During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(94)90009-4

    authors: Lochry EA,Johnson C,Wier PJ

    更新日期:1994-01-01 00:00:00

  • Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced rat fetal brain lesions.

    abstract::1-beta-D-Arabinofuranosylcytosine (Ara-C), a cytidine analogue cytotoxic to proliferating cells, has a teratogenic effect in the brain of experimental animals and causes neural cell apoptosis in vitro and in vivo. In the present study, pregnant rats were injected with Ara-C on Day 13 of gestation and the fetal brain w...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2004.03.010

    authors: Yamauchi H,Katayama K,Ueno M,Uetsuka K,Nakayama H,Doi K

    更新日期:2004-07-01 00:00:00

  • Nerve conduction, visual evoked responses and electroretinography in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents.

    abstract::The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2008.01.006

    authors: Goffeng LO,Heier MS,Kjuus H,Sjöholm H,Sørensen KA,Skaug V

    更新日期:2008-05-01 00:00:00

  • Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin.

    abstract::Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2014.10.001

    authors: Habr SF,Macrini DJ,Florio JC,Bernardi MM

    更新日期:2014-11-01 00:00:00

  • Sensitivity to isoflurane anesthesia increases in autism spectrum disorder Shank3+/∆c mutant mouse model.

    abstract::Autism is a heterogeneous developmental disorder characterized by impaired social interaction, impaired communication skills, and restricted and repetitive behavior. The abnormal behaviors of these patients can make their anesthetic and perioperative management difficult. Evidence in the literature suggests that some ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2016.11.002

    authors: Li C,Schaefer M,Gray C,Yang Y,Furmanski O,Liu S,Worley P,Mintz CD,Tao F,Johns RA

    更新日期:2017-01-01 00:00:00

  • Neurobehavioral teratogenicity of perfluorinated alkyls in an avian model.

    abstract::Perfluorinated alkyls are widely-used agents that accumulate in ecosystems and organisms because of their slow rate of degradation. There is increasing concern that these agents may be developmental neurotoxicants and the present study was designed to develop an avian model for the neurobehavioral teratogenicity of pe...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2009.11.004

    authors: Pinkas A,Slotkin TA,Brick-Turin Y,Van der Zee EA,Yanai J

    更新日期:2010-03-01 00:00:00

  • Evaluation of tremor in aluminum production workers.

    abstract::A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0892-0362(97)00061-5

    authors: Dick RB,Krieg EF Jr,Sim MA,Bernard BP,Taylor BT

    更新日期:1997-11-01 00:00:00

  • Failure of acute cocaine administration to differentially affect acoustic startle and activity in rats prenatally exposed to cocaine.

    abstract::Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(91)90064-4

    authors: Foss JA,Riley EP

    更新日期:1991-09-01 00:00:00

  • Modulation of lead-induced performance deficit in children by varying signal rate in a serial choice reaction task.

    abstract::Evidence is presented showing that serial choice reaction performance is disrupted at low blood lead levels (PbB), and that parametric variation of task characteristics modulates the degree of disruption. This evidence is based on two independent studies in 6- to 9-year-old children living in two lead smelter areas in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(89)90043-3

    authors: Winneke G,Brockhaus A,Collet W,Krämer U

    更新日期:1989-11-01 00:00:00

  • Correlation of behavior with brain damage after in utero exposure to toxic agents.

    abstract::Early postnatal behaviors involving sensorimotor integration were measured along with thickness of the sensorimotor cortex in rats irradiated with 1.0 Gy on gestational day 11 or 17. Body weight and morphology of anterior pituitary cells were recorded. Irradiation on day 17 was more effective in reducing cortical thic...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(87)90091-2

    authors: Norton S,Kimler BF

    更新日期:1987-03-01 00:00:00

  • Effects of acute treatment with dopaminergic drugs on open field behavior of adult monkeys treated with lead during the first year postpartum.

    abstract::A pharmacological challenge of nonhuman primate open field behavior, similar to that which previously assessed the cholinergic system (10), was used here to measure potential lead-induced alterations in the dopaminergic system. Monkeys that had been treated with lead during the first year postpartum were assessed at 7...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(95)02050-0

    authors: Ferguson SA,Felipa HN,Bowman RE

    更新日期:1996-03-01 00:00:00

  • The effects of perinatal AZT exposure on the acoustic startle response in adult rats.

    abstract::AZT (azidothymidine, zidovudine, ZDV) has become the standard medication to prevent the transmission of the human immunodeficiency virus from mother to fetus. The present study was designed to assess the acoustic startle response (ASR) in adult rats that had been perinatally exposed to AZT. Each litter was randomly as...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(02)00317-3

    authors: Melnick SM,Weedon J,Dow-Edwards DL

    更新日期:2002-11-01 00:00:00

  • N-methylation underlying Parkinson's disease.

    abstract::The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) leads to the hypothesis that Parkinson's disease (PD) is maybe initiated or precipitated by environmental or endogenous toxins by the mechanism similar to that of MPTP in genetically-predisposed individuals. Endogenous analogs of MPTP, such as beta-c...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审

    doi:10.1016/s0892-0362(02)00212-x

    authors: Matsubara K,Aoyama K,Suno M,Awaya T

    更新日期:2002-09-01 00:00:00

  • Neurobehavioral deficits in neonatal rhesus monkeys exposed to cocaine in utero.

    abstract::In spite of significant efforts, the neurobehavioral deficits in infants born from cocaine-abusing mothers have not been clearly defined. In the present study, we examined the presence of these abnormalities in a rhesus monkey model of prenatal cocaine exposure using a nonhuman primate adaptation of the Neonatal Behav...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2003.08.003

    authors: He N,Bai J,Champoux M,Suomi SJ,Lidow MS

    更新日期:2004-01-01 00:00:00

  • Effect of early lead exposure on the maturation of children's postural balance: a longitudinal study.

    abstract::This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2006.02.003

    authors: Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

    更新日期:2006-05-01 00:00:00

  • Developmental exposure to an organophosphate flame retardant alters later behavioral responses to dopamine antagonism in zebrafish larvae.

    abstract::Human exposure to organophosphate flame retardants (OPFRs) is widespread, including pregnant women and young children with whom developmental neurotoxic risk is a concern. Given similarities of OPFRs to organophosphate (OP) pesticides, research into the possible neurotoxic impacts of developmental OPFR exposure has be...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2018.03.002

    authors: Oliveri AN,Ortiz E,Levin ED

    更新日期:2018-01-01 00:00:00

  • Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats.

    abstract::Previous studies have shown that maternal doses of 1 microg/kg or less of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in late gestation can demasculinize and feminize reproductive behavior in male rats. However, it was not known whether coplanar polychlorinated biphenyls (PCBs) had similar effects, or whether non-repro...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(00)00094-5

    authors: Amin S,Moore RW,Peterson RE,Schantz SL

    更新日期:2000-09-01 00:00:00

  • Ethanol effects on the developing zebrafish: neurobehavior and skeletal morphogenesis.

    abstract::Exposure to ethanol during development can lead to a constellation of congenital anomalies, resulting in prenatal and postnatal failure to thrive, central nervous system (CNS) deficits, and a number of patterning defects that lead to defects in the cardiovascular system, facial structures, and limbs. The cellular, bio...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2004.06.016

    authors: Carvan MJ 3rd,Loucks E,Weber DN,Williams FE

    更新日期:2004-11-01 00:00:00

  • Heart rate variability in neonatal rats after perinatal cocaine exposure.

    abstract::Pregnant rats received saline once daily (Control QD) or twice daily (Control BID), cocaine 2 mg/kg IV daily (COC QD) or twice daily (COC BID) throughout gestation beginning on gestational day 4. The treatment was continued in nursing mothers until postnatal day 7. All studies were performed in their offsprings on pos...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(98)00026-9

    authors: Hseu SS,Yien HW,Du F,Sun LS

    更新日期:1998-11-01 00:00:00

  • Postnatal function following prenatal reserpine exposure in rats: neurobehavioral toxicity.

    abstract::Behavioral and neurochemical analyses were conducted on preweanling CD rats prenatally exposed to either 0, 0.375 or 0.750 mg/kg/day reserpine SC on gestation days 12-15. Offspring body weights were taken on test days, and pups were tested for negative geotaxis responding on postnatal day 8, developmental activity on ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(89)90028-7

    authors: Buelke-Sam J,Ali SF,Kimmel GL,Slikker W Jr,Newport GD,Harmon JR

    更新日期:1989-09-01 00:00:00

  • Determining normal variability in a developmental neurotoxicity test: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints.

    abstract::With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审

    doi:10.1016/j.ntt.2007.12.009

    authors: Raffaele KC,Fisher JE Jr,Hancock S,Hazelden K,Sobrian SK

    更新日期:2008-07-01 00:00:00

  • Characterizing tolerance to trichloroethylene (TCE): effects of repeated inhalation of TCE on performance of a signal detection task in rats.

    abstract::Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(01)00182-9

    authors: Oshiro WM,Krantz QT,Bushnell PJ

    更新日期:2001-11-01 00:00:00

  • Effects of lifelong dietary exposure to genistein or nonylphenol on amphetamine-stimulated striatal dopamine release in male and female rats.

    abstract::Estrogen modulates baseline and amphetamine-stimulated dopamine (DA) release in the adult female rat striatum. The isoflavone found in soybeans, genistein, is a phytoestrogen and may have comparable effects on striatal DA levels. Similarly, the industrial intermediate and potential endocrine disrupter, para-nonylpheno...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(01)00193-3

    authors: Ferguson SA,Flynn KM,Delclos KB,Newbold RR,Gough BJ

    更新日期:2002-01-01 00:00:00

  • Thermoregulatory effects of chlorpyrifos in the rat: long-term changes in cholinergic and noradrenergic sensitivity.

    abstract::Subcutaneous injection of a sublethal dose of chlorpyrifos (CHLP), an organophosphate (OP) pesticide, causes long-term inhibition in cholinesterase activity (ChE) of brain, blood, and other tissues. Such prolonged inhibition in ChE should lead to marked behavioral and autonomic thermoregulatory patterns, especially in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(94)90002-7

    authors: Gordon CJ

    更新日期:1994-01-01 00:00:00

  • Effects of prenatal propofol exposure on postnatal development in rats.

    abstract::Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2014.03.006

    authors: Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A

    更新日期:2014-05-01 00:00:00

  • Visual contrast sensitivity testing: a comparison of two F.A.C.T. test types.

    abstract::Measures of visual contrast sensitivity (VCS), rather than traditional measures of visual acuity using high-contrast stimuli, have been presented as better appraisals of visual dysfunction resulting from chemical exposures. The present study sought to determine if differences exist between two available measures of co...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2003.10.007

    authors: Hitchcock EM,Dick RB,Krieg EF

    更新日期:2004-03-01 00:00:00