Optic nerve hypoplasia in an acute exposure model of the fetal alcohol syndrome.

abstract：BACKGROUND:Prenatal tobacco exposure is a risk factor for the development of externalizing behaviors and is associated with several adverse health outcomes. Because pregnancy smoking is a complex behavior with both daily fluctuations and changes over the course of pregnancy, quantifying tobacco exposure is a significan...

journal_title：Neurotoxicology and teratology

authors： Fang H,Johnson C,Stopp C,Espy KA

更新日期：2011-01-01 00:00:00

abstract：:Most behavioral teratology studies have focused on pharmaceutical agents. Investigations of developmental toxicity are lacking for the majority of the nearly 100,000 industrial chemicals currently in use. Only some three dozen chemicals have been examined for behavioral/neurochemical deviations in offspring following ...

journal_title：Neurotoxicology and teratology

authors： Nelson BK

更新日期：1990-07-01 00:00:00

abstract：:The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Th...

journal_title：Neurotoxicology and teratology

authors： Warren DA,Reigle TG,Muralidhara S,Dallas CE

更新日期：1998-03-01 00:00:00

abstract：:In the United States, the regulation and testing of chemicals that may impact on human health is mandated by a number of different laws and regulated by several government agencies. Toxicologic screening in laboratory animals has created a major database for predicting adverse health effects of drugs, food and cosmeti...

journal_title：Neurotoxicology and teratology

authors： Steinberg M

更新日期：1987-11-01 00:00:00

abstract：:Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l(-1) in drinking water, for 90 days) on electroencephalographic ...

journal_title：Neurotoxicology and teratology

authors： Lestaevel P,Bussy C,Paquet F,Dhieux B,Clarençon D,Houpert P,Gourmelon P

更新日期：2005-11-01 00:00:00

abstract：:The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex o...

journal_title：Neurotoxicology and teratology

authors： Fu Y,He F,Zhang S,Huang J,Zhang J,Jiao X

更新日期：1995-05-01 00:00:00

abstract：:Methylphenidate (MPD) is a dopamine uptake inhibitor and the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder in children. Several studies have shown that such stimulants as cocaine and amphetamine that are administered during gestation and lactation may disrupt maternal beha...

journal_title：Neurotoxicology and teratology

authors： Ponchio RA,Teodorov E,Kirsten TB,Coelho CP,Oshiro A,Florio JC,Bernardi MM

更新日期：2015-07-01 00:00:00

abstract：:Sodium valproate is an anticonvulsant widely prescribed because of its broad spectrum of activity. While acute toxicity from high doses is well recognized, there have been few animal studies of its chronic toxicity at therapeutic dose levels. Sodium valproate given continuously in drinking fluid (600 mg/l) throughout ...

journal_title：Neurotoxicology and teratology

authors： Chapman JB,Cutler MG

更新日期：1989-03-01 00:00:00

abstract：:Consumption of the nutrients omega-3 fatty acids (omega-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. It may also reduce the incidence and severity of preterm births by prolonging gestational length. However several recent human and animal studies have reported that ove...

journal_title：Neurotoxicology and teratology

authors： Church MW,Jen KL,Stafferton T,Hotra JW,Adams BR

更新日期：2007-03-01 00:00:00

abstract：:The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...

journal_title：Neurotoxicology and teratology

authors： Méndez-Armenta M,Barroso-Moguel R,Villeda-Hernández J,Romero-Díaz V,Ríos C

更新日期：1997-05-01 00:00:00

abstract：:With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...

journal_title：Neurotoxicology and teratology

authors： Raffaele KC,Fisher JE Jr,Hancock S,Hazelden K,Sobrian SK

更新日期：2008-07-01 00:00:00

abstract：:The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested have been shown to cause abnormal brain cell death in animals...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Liu F,Slikker W Jr,Wang C,Paule MG

更新日期：2017-01-01 00:00:00

abstract：:Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic proj...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ

更新日期：2013-03-01 00:00:00

abstract：:Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

journal_title：Neurotoxicology and teratology

authors： Oshiro WM,Krantz QT,Bushnell PJ

更新日期：2001-11-01 00:00:00

abstract：:Neurobehavioral studies often employ test batteries and confront issues of multiple testing and comparability between batteries. We have organized our battery of 12 tests into areas of neurobehavioral function to reduce the number of reported results, provide greater statistical power, and improve interpretability of ...

journal_title：Neurotoxicology and teratology

authors： Heyer NJ,Bittner AC Jr,Echeverria D

更新日期：1996-07-01 00:00:00

abstract：:AZT (azidothymidine, zidovudine, ZDV) has become the standard medication to prevent the transmission of the human immunodeficiency virus from mother to fetus. The present study was designed to assess the acoustic startle response (ASR) in adult rats that had been perinatally exposed to AZT. Each litter was randomly as...

journal_title：Neurotoxicology and teratology

authors： Melnick SM,Weedon J,Dow-Edwards DL

更新日期：2002-11-01 00:00:00

abstract：:We examined the distribution of cocaine and its metabolites benzoylecgonine (BE) and norcocaine (NOR) in pregnant Sprague-Dawley rats and fetuses following twice-daily subcutaneous (s.c.) injections of 20 mg/kg cocaine HCl from gestational day (GD) 8 through GD 20. On GD 21, the animals received a single injection and...

journal_title：Neurotoxicology and teratology

authors： Collins LM,Pahl JA,Meyer JS

更新日期：1999-11-01 00:00:00

abstract：:Human exposure to organophosphate flame retardants (OPFRs) is widespread, including pregnant women and young children with whom developmental neurotoxic risk is a concern. Given similarities of OPFRs to organophosphate (OP) pesticides, research into the possible neurotoxic impacts of developmental OPFR exposure has be...

journal_title：Neurotoxicology and teratology

authors： Oliveri AN,Ortiz E,Levin ED

更新日期：2018-01-01 00:00:00

abstract：:In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedron...

journal_title：Neurotoxicology and teratology

authors： Naseri G,Fazel A,Golalipour MJ,Haghir H,Sadeghian H,Mojarrad M,Hosseini M,Shahrokhi Sabzevar S,Beheshti F,Ghorbani A

更新日期：2018-01-01 00:00:00

abstract：:This paper discusses issues pertaining to the validity, precision, and interpretation of epidemiologic studies of neurotoxicity. With regard to validity, the critical issues pertain to the appropriate strategy for confounder adjustment, particularly when confounders are complex, multi-faceted constructs, and to the ne...

journal_title：Neurotoxicology and teratology

authors： Bellinger DC

更新日期：2009-09-01 00:00:00

abstract：:Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...

journal_title：Neurotoxicology and teratology

authors： Fried PA,Watkinson B

更新日期：2000-01-01 00:00:00

abstract：:Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder, bent spine and yolk-sac...

journal_title：Neurotoxicology and teratology

authors： Chen J,Chen Y,Liu W,Bai C,Liu X,Liu K,Li R,Zhu JH,Huang C

更新日期：2012-11-01 00:00:00

abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

journal_title：Neurotoxicology and teratology

authors： Vorhees CV

更新日期：1989-03-01 00:00:00

abstract：:Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to aut...

journal_title：Neurotoxicology and teratology

authors： Dzwilewski KLC,Merced-Nieves FM,Aguiar A,Korrick SA,Schantz SL

更新日期：2020-01-01 00:00:00

abstract：:The present study was designed to investigate the in vivo effects of monosodium glutamate (MSG) and aspartame (ASM) individually and in combination on the cognitive behavior and biochemical parameters like neurotransmitters and oxidative stress indices in the brain tissue of mice. Forty male Swiss albino mice were ran...

journal_title：Neurotoxicology and teratology

authors： Abu-Taweel GM,A ZM,Ajarem JS,Ahmad M

更新日期：2014-03-01 00:00:00

abstract：:In the literature on the effects of early exposure to neurotoxic agents on infant and child development, considerable attention has been devoted to two important issues--ascertainment of exposure and spurious correlation. In this paper, we review these research challenges and focus on three additional issues that, in ...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW

更新日期：2005-05-01 00:00:00

abstract：:The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric ...

journal_title：Neurotoxicology and teratology

authors： Li AA,Sheets LP,Raffaele K,Moser V,Hofstra A,Hoberman A,Makris SL,Garman R,Bolon B,Kaufmann W,Auer R,Lau E,Vidmar T,Bowers WJ

更新日期：2017-09-01 00:00:00

abstract：:This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

journal_title：Neurotoxicology and teratology

authors： Al Deeb S,Al Moutaery K,Khan HA,Tariq M

更新日期：2000-03-01 00:00:00

abstract：:In this study we used a rat model of graded perinatal asphyxia to study the long-term consequences of this manipulation on rat maternal behavior at adulthood. Rats were delivered by cesarean (C) section and the pups, still in the uterus horns, were placed into a water bath at 37 degrees C for periods of 0 (controls) o...

journal_title：Neurotoxicology and teratology

authors： Cirulli F,Bonsignore LT,Venerosi A,Valanzano A,Chiarotti F,Alleva E

更新日期：2003-09-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is a neurotrophin critical for many developmental and physiological aspects of CNS function. Severe hypothyroidism in the early neonatal period results in developmental and cognitive impairments and reductions in mRNA and protein expression of BDNF in a number of brain regions....

journal_title：Neurotoxicology and teratology

authors： Lasley SM,Gilbert ME

更新日期：2011-07-01 00:00:00