Abstract：
:The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Therefore, Sprague-Dawley rats trained to lever-press for evaporated milk on a variable interval 30-s reinforcement schedule were placed in an operant test cage and exposed to clean air for 20 min, followed by a single concentration of TRI vapor (500-5000 ppm) for 100 min. Additional rats were exposed to equivalent TRI concentrations for 10, 20, 40, 60, 80, or 100 min to determine blood and brain concentration vs. time profiles. Inhalation of 1000 ppm slightly increased operant response rates, whereas 2000, 3500, and 5000 ppm decreased operant response rates in a concentration- and time-dependent manner. Accumulation of TRI in blood and brain was rapid and concentration dependent, with the brain concentration roughly twice that of blood. Plots of blood and brain TRI concentrations against operant performance showed responding in excess of control rates at low concentrations, and decreasing response rates as concentrations increased. Linear regression analyses indicated that blood and brain concentrations, as well as measures of time integrals of internal dose, were strongly correlated with operant performance. Neurobehavioral toxicity in laboratory animals, as measured by changes in operant performance, can therefore be quantitatively related to internal measures of TRI exposure to enhance its predictive value for human risk assessment.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Warren DA,Reigle TG,Muralidhara S,Dallas CEdoi
10.1016/s0892-0362(97)00096-2subject
Has Abstractpub_date
1998-03-01 00:00:00pages
143-53issue
2eissn
0892-0362issn
1872-9738pii
S0892036297000962journal_volume
20pub_type
杂志文章abstract：:Dysmorphologic and anthropometric assessments were performed on 154 6-year-old children prenatally exposed to cocaine (PCE) and 131 high-risk controls (NCE) of similar race and social class. Adjusted mean height z scores demonstrated a dose-response with metahydroxybenzoylecgonine above a threshold of 100 ng/g of meco...
journal_title：Neurotoxicology and teratology
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更新日期：2006-01-01 00:00:00
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90126-0
更新日期：1994-09-01 00:00:00
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journal_title：Neurotoxicology and teratology
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更新日期：1991-09-01 00:00:00
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journal_title：Neurotoxicology and teratology
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更新日期：2012-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
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更新日期：1996-07-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
doi：10.1016/0892-0362(96)00026-8
更新日期：1996-07-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
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更新日期：1997-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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更新日期：1996-09-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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更新日期：2002-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
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更新日期：2017-01-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2011.10.006
更新日期：2012-01-01 00:00:00
abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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更新日期：2000-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
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