Characterizing tolerance to trichloroethylene (TCE): effects of repeated inhalation of TCE on performance of a signal detection task in rats.

abstract：:The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency ...

journal_title：Neurotoxicology and teratology

authors： Nagymajtényi L,Dési I,Lorencz R

更新日期：1988-09-01 00:00:00

abstract：:One hundred and ten, 6- to 11-year-old children from a low-risk, predominantly middle class sample who are participants in an ongoing longitudinal drug study were assessed using a central auditory processing task (SCAN) that made perceptual rather than linguistic demands. Maternal smoking during pregnancy was linearly...

journal_title：Neurotoxicology and teratology

authors： McCartney JS,Fried PA,Watkinson B

更新日期：1994-05-01 00:00:00

abstract：:Although cocaine administration reduces blood flow to the fetus in the pregnant ewe, the effects of cocaine on uterine and placental blood flow in the pregnant rat have not been adequately documented. The current study tested the hypothesis that cocaine decreased uterine and placental blood flow in awake and freely mo...

journal_title：Neurotoxicology and teratology

authors： Patel TG,Laungani RG,Grose EA,Dow-Edwards DL

更新日期：1999-09-01 00:00:00

abstract：:Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brai...

journal_title：Neurotoxicology and teratology

authors： Oliveira-Pinto J,Paes-Branco D,Cristina-Rodrigues F,Krahe TE,Manhães AC,Abreu-Villaça Y,Filgueiras CC

更新日期：2015-07-01 00:00:00

abstract：:A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....

journal_title：Neurotoxicology and teratology

authors： Paule MG,Green L,Myerson J,Alvarado M,Bachevalier J,Schneider JS,Schantz SL

更新日期：2012-03-01 00:00:00

abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...

journal_title：Neurotoxicology and teratology

authors： Morris P,Binienda Z,Gillam MP,Klein J,McMartin K,Koren G,Duhart HM,Slikker W Jr,Paule MG

更新日期：1997-01-01 00:00:00

abstract：:The postnatal behavioral effects of 0.20, 0.62 and 2.0 mg/kg cadmium chloride administered to pregnant CFY rats on gestational days 7 through 15 were evaluated. Offspring were tested starting on postnatal day 23 on a rotorod for motor coordination, in an open field device for motor activity and emotionality, in a wate...

journal_title：Neurotoxicology and teratology

authors： Lehotzky K,Ungváry G,Polinák D,Kiss A

更新日期：1990-03-01 00:00:00

abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

journal_title：Neurotoxicology and teratology

authors： Vorhees CV

更新日期：1989-03-01 00:00:00

abstract：:The effects of a 14-day (gestation days 7-20) chronic methadone (6.3-9.0 mg/kg/day) infusion via osmotic minipumps were studied on the induction of physical dependence in both pregnant and nonpregnant female rats. Following continued methadone exposure, an acute injection of naloxone (2.0 mg/kg, SC) produced the follo...

journal_title：Neurotoxicology and teratology

authors： Darmani NA,Saady JJ,Schnoll SH,Martin BR

更新日期：1991-11-01 00:00:00

abstract：:Rats were fed a liquid diet containing ethanol from days 6-19 of gestation. Controls were pair-fed the same diet with sucrose substituted for ethanol, or received ad lib chow and water. The activity of the offspring was observed at 10, 16, 22 or 28 days-of-age. Overall, offspring exposed to alcohol prenatally were hyp...

journal_title：Neurotoxicology and teratology

authors： Bond NW

更新日期：1988-01-01 00:00:00

abstract：:Adolescence is a period of dramatic neural reorganization creating a period of vulnerability and the possibility for the development of psychopathology. The maturation of various neural circuits during adolescence depends, to a large degree, on one's experiences both physical and psychosocial. This occurs through a pr...

journal_title：Neurotoxicology and teratology

authors： Dow-Edwards D,MacMaster FP,Peterson BS,Niesink R,Andersen S,Braams BR

更新日期：2019-01-01 00:00:00

abstract：:Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...

journal_title：Neurotoxicology and teratology

authors： Kilburn KH,Warshaw RH

更新日期：1995-03-01 00:00:00

abstract：:Following the passage of the Food Quality Protection Act, which mandated an increased focus on evaluating the potential toxicity of pesticides to children, the number of guideline developmental neurotoxicity (DNT) studies (OPPTS 870.6300) submitted to the U.S. Environmental Protection Agency (EPA) Office of Pesticide ...

journal_title：Neurotoxicology and teratology

authors： Raffaele KC,Rowland J,May B,Makris SL,Schumacher K,Scarano LJ

更新日期：2010-09-01 00:00:00

abstract：:To determine whether there is an association between moderate alcohol consumption in the first trimester of pregnancy and increased risk of fetal malformations, we conducted a literature search using Medline (1966-present), PsycLit (1974-1995), and EMBASE (1988-1995). The following inclusion criteria were used to sele...

journal_title：Neurotoxicology and teratology

authors： Polygenis D,Wharton S,Malmberg C,Sherman N,Kennedy D,Koren G,Einarson TR

更新日期：1998-01-01 00:00:00

abstract：:Ethanol alters the homeostasis between excitatory and inhibitory neurotransmitters and its intoxication reveals adenosine as responsible to modify several responses including signal transduction. Zebrafish has been recently investigated for knowledge the prolonged effect of ethanol on behavioral and biochemical parame...

journal_title：Neurotoxicology and teratology

authors： Rico EP,Rosemberg DB,Berteli JFA,da Silveira Langoni A,Souto AA,Bogo MR,Bonan CD,Souza DO

更新日期：2018-01-01 00:00:00

abstract：:Early-life exposures to brominated diphenyl ethers (BDEs) lead to neurobehavioral abnormalities later in life. Although these agents are thyroid disruptors, it is not clear whether this mechanism alone accounts for the adverse effects. We evaluated the impact of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) on PC12 cel...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Card J,Infante A,Seidler FJ

更新日期：2013-05-01 00:00:00

abstract：:Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...

journal_title：Neurotoxicology and teratology

authors： Foss JA,Riley EP

更新日期：1991-09-01 00:00:00

abstract：:While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

journal_title：Neurotoxicology and teratology

authors： Dribben WH,Creeley CE,Farber N

更新日期：2011-07-01 00:00:00

abstract：:Sensory-evoked potentials (EPs) were studied in male Long-Evans and Fischer-344 rats in order to characterize the electrophysiological consequences of chronic inhalation exposure to trichloroethylene (TCE). Groups of ten Long-Evans rats were exposed to air or 1600 ppm or 3200 ppm TCE for twelve weeks and evaluated per...

journal_title：Neurotoxicology and teratology

authors： Rebert CS,Day VL,Matteucci MJ,Pryor GT

更新日期：1991-01-01 00:00:00

abstract：:High exposure to toluene may cause optic neuropathy and retinopathy, both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue-yellow dyschromatopsia. This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined befor...

journal_title：Neurotoxicology and teratology

authors： Muttray A,Wolters V,Jung D,Konietzko J

更新日期：1999-01-01 00:00:00

abstract：:The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acut...

journal_title：Neurotoxicology and teratology

authors： Mackenzie Ross SJ,Brewin CR,Curran HV,Furlong CE,Abraham-Smith KM,Harrison V

更新日期：2010-07-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are hypothesized to play a pathogenic role in aging and age-related neurodegenerative diseases such as Parkinson's disease (PD). In support of this, high levels of somatic mtDNA mutations in “POLG mutator” mice carrying a proofreading-deficient form of mtDNA polymerase ã (Polg(D257A...

journal_title：Neurotoxicology and teratology

authors： Dai Y,Clark J,Zheng K,Kujoth GC,Prolla TA,Simon DK

更新日期：2014-11-01 00:00:00

abstract：:A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...

journal_title：Neurotoxicology and teratology

authors： Samsam TE,Gadrinab LG,Bushnell PJ

更新日期：2004-01-01 00:00:00

abstract：:A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...

journal_title：Neurotoxicology and teratology

authors： McMichael AJ,Baghurst PA,Vimpani GV,Robertson EF,Wigg NR,Tong SL

更新日期：1992-09-01 00:00:00

abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...

journal_title：Neurotoxicology and teratology

authors： Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar A

更新日期：2005-01-01 00:00:00

abstract：:Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...

journal_title：Neurotoxicology and teratology

authors： Morris-Schaffer K,Sobolewski M,Welle K,Conrad K,Yee M,O'Reilly MA,Cory-Slechta DA

更新日期：2018-01-01 00:00:00

abstract：:The effects of acute and chronic exposure to either ethylene dibromide (EDB) or mercuric chloride (MC) were studied in laboratory-reared Octopus joubini, O. maya and O. bimaculoides. The advantages of using octopuses were that the responses were immediate, highly visible and sensitive. All species demonstrated signs o...

journal_title：Neurotoxicology and teratology

authors： Adams PM,Hanlon RT,Forsythe JW

更新日期：1988-11-01 00:00:00

abstract：:The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were m...

journal_title：Neurotoxicology and teratology

authors： Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U

更新日期：1991-09-01 00:00:00

abstract：:Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder, bent spine and yolk-sac...

journal_title：Neurotoxicology and teratology

authors： Chen J,Chen Y,Liu W,Bai C,Liu X,Liu K,Li R,Zhu JH,Huang C

更新日期：2012-11-01 00:00:00

abstract：:This is the first in a series of studies investigating the developmental stage-specific neurobehavioral effects of all-trans retinoic acid (RA) exposure. Because high doses of this compound are known to be lethal to the developing organism, we first conducted a dose-response study to identify RA doses that produce low...

journal_title：Neurotoxicology and teratology

authors： Holson RR,Gazzara RA,Ferguson SA,Ali SF,Laborde JB,Adams J

更新日期：1997-09-01 00:00:00