Abstract：
:The effects of acute and chronic exposure to either ethylene dibromide (EDB) or mercuric chloride (MC) were studied in laboratory-reared Octopus joubini, O. maya and O. bimaculoides. The advantages of using octopuses were that the responses were immediate, highly visible and sensitive. All species demonstrated signs of toxicity to acute and chronic exposure to EDB and to MC. A dosage-sensitive relationship for the loss and subsequent recovery of locomotor response and of chromatophore expansion was found for each species after acute exposure. For each species the LC50 for chronic exposure occurred within 12 hr at 100 mg/l for EDB and within 3 hr at 1,000 mg/l for MC. This study demonstrated the potential usefulness of laboratory-reared octopuses in evaluating the toxicity of marine environmental pollutants.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Adams PM,Hanlon RT,Forsythe JWdoi
10.1016/0892-0362(88)90087-6subject
Has Abstractpub_date
1988-11-01 00:00:00pages
519-23issue
6eissn
0892-0362issn
1872-9738pii
0892-0362(88)90087-6journal_volume
10pub_type
杂志文章abstract：:Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2014.10.001
更新日期：2014-11-01 00:00:00
abstract：:Computer competition analysis of 3H-DHA (3H-dihydroalprenolol, a nonselective beta-adrenergic radioligand) binding in the presence of unlabeled metoprolol (a beta 1-selective antagonist) indicates the existence of both beta 1- and beta 2-adrenergic receptor subtypes in the rat placenta and confirms previous reports th...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90026-s
更新日期：1991-01-01 00:00:00
abstract：:Behavioral and neurochemical analyses were conducted on preweanling CD rats prenatally exposed to either 0, 0.375 or 0.750 mg/kg/day reserpine SC on gestation days 12-15. Offspring body weights were taken on test days, and pups were tested for negative geotaxis responding on postnatal day 8, developmental activity on ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90028-7
更新日期：1989-09-01 00:00:00
abstract：BACKGROUND:Ciguatoxins are extremely potent neurotoxins, produced by tropical marine dinoflagellates, that persistently enter into our food web. Over 100,000 people annually experience acute ciguatera poisoning from consuming toxic fish. Roughly 5% of these victims will develop chronic ciguatera (CC), a widespread, mul...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.05.007
更新日期：2010-11-01 00:00:00
abstract：:Following the passage of the Food Quality Protection Act, which mandated an increased focus on evaluating the potential toxicity of pesticides to children, the number of guideline developmental neurotoxicity (DNT) studies (OPPTS 870.6300) submitted to the U.S. Environmental Protection Agency (EPA) Office of Pesticide ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.04.053
更新日期：2010-09-01 00:00:00
abstract：:Hazard information essential to guide developmental neurotoxicity risk assessments is limited for many chemicals. As developmental neurotoxicity testing using rodents is laborious and expensive, alternative species such as zebrafish are being adapted for rapid toxicity screening. Assessing the developmental neurotoxic...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2009.04.065
更新日期：2010-01-01 00:00:00
abstract：:The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (n=8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas natu...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2005.04.003
更新日期：2005-07-01 00:00:00
abstract：:The effects of prenatal cocaine exposure on the levels of carotid body dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were investigated in 5-day-old rat pups exposed to normoxic and hypoxic conditions. Timed-pregnant Sprague-Dawley rats were injected b.i.d. with ei...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(96)90027-6
更新日期：1996-05-01 00:00:00
abstract：BACKGROUND:General anesthetics (GAs) may exert harmful effects on the developing brain by disrupting neuronal circuit formation. Anesthetics that act on γ-aminobutyric acid (GABA) receptors can interfere with axonal growth cone guidance, a critical process in the assembly of neuronal circuitry. Here we investigate the ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2019.106812
更新日期：2019-01-01 00:00:00
abstract：:Cortical thickness abnormalities have been identified in youth using both alcohol and marijuana. However, limited studies have followed individuals pre- and post initiation of alcohol and marijuana use to help identify to what extent discrepancies in structural brain integrity are pre-existing or substance-related. Ad...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/j.ntt.2016.09.005
更新日期：2016-01-01 00:00:00
abstract：:Consumption of the nutrients omega-3 fatty acids (omega-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. It may also reduce the incidence and severity of preterm births by prolonging gestational length. However several recent human and animal studies have reported that ove...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2006.10.009
更新日期：2007-03-01 00:00:00
abstract：:Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90064-4
更新日期：1991-09-01 00:00:00
abstract：:Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90027-2
更新日期：1994-07-01 00:00:00
abstract：:The present study was designed to investigate the in vivo effects of monosodium glutamate (MSG) and aspartame (ASM) individually and in combination on the cognitive behavior and biochemical parameters like neurotransmitters and oxidative stress indices in the brain tissue of mice. Forty male Swiss albino mice were ran...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2014.02.001
更新日期：2014-03-01 00:00:00
abstract：:The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2017.07.001
更新日期：2017-09-01 00:00:00
abstract：:The use of the club drugs 3,4-methylenedioxymethamphetamine (MDMA) and 5-methoxy-n,n-diisopropyltryptamine (Foxy) is of growing concern, especially as many of the effects, particularly during development, are unknown. The effects of these drugs upon homeostasis may be important since both are known to stimulate the hy...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2009.08.012
更新日期：2010-03-01 00:00:00
abstract：:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2014.03.006
更新日期：2014-05-01 00:00:00
abstract：:The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90040-x
更新日期：1994-11-01 00:00:00
abstract：:Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(02)00197-6
更新日期：2002-05-01 00:00:00
abstract：:The effect of prenatal ethanol exposure on the kainate-sensitive subtype of glutamate receptor binding sites was studied using in vitro 3H-vinylidene kainic acid (VKA) autoradiography. Pregnant Sprague-Dawley rats were fed a liquid diet containing either 3.35% or 6.7% ethanol throughout gestation. Pair-fed dams receiv...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(88)90093-1
更新日期：1988-11-01 00:00:00
abstract：:Ethanol alters the homeostasis between excitatory and inhibitory neurotransmitters and its intoxication reveals adenosine as responsible to modify several responses including signal transduction. Zebrafish has been recently investigated for knowledge the prolonged effect of ethanol on behavioral and biochemical parame...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2017.11.001
更新日期：2018-01-01 00:00:00
abstract：:The effects of repeated SC administration of soman on schedule-controlled performance and brain pathology were studied in the rat. Soman suppressed response rates in both components of a multiple fixed interval 50-sec fixed-ratio 25 (mult. FI 50-sec FR 25) schedule of reinforcement, although all animals revealed marke...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(90)90112-p
更新日期：1990-01-01 00:00:00
abstract：:The effects of a 14-day (gestation days 7-20) chronic methadone (6.3-9.0 mg/kg/day) infusion via osmotic minipumps were studied on the induction of physical dependence in both pregnant and nonpregnant female rats. Following continued methadone exposure, an acute injection of naloxone (2.0 mg/kg, SC) produced the follo...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90046-y
更新日期：1991-11-01 00:00:00
abstract：:The present study was aimed at investigating the long-term effects of prenatal exposure to lamivudine (3TC), an antiretroviral drug used in clinical practice alone or in combination with zidovudine (AZT) to prevent mother-to-child transmission of the HIV virus. Pregnant CD-1 mice were given per os twice daily either 3...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(00)00063-5
更新日期：2000-05-01 00:00:00
abstract：:Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(99)00046-x
更新日期：2000-01-01 00:00:00
abstract：:This longitudinal study evaluated whether the level of intrauterine cocaine exposure (IUCE) or the interaction between IUCE and contextual variables was related during middle childhood to executive functioning, as assessed with the Stroop Color-Word and Rey Osterrieth Complex Figure tests. The Stroop Interference scor...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2008.12.002
更新日期：2009-05-01 00:00:00
abstract：:Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brai...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2015.05.011
更新日期：2015-07-01 00:00:00
abstract：:Autism is a heterogeneous developmental disorder characterized by impaired social interaction, impaired communication skills, and restricted and repetitive behavior. The abnormal behaviors of these patients can make their anesthetic and perioperative management difficult. Evidence in the literature suggests that some ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2016.11.002
更新日期：2017-01-01 00:00:00
abstract：:Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic proj...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2012.07.003
更新日期：2013-03-01 00:00:00
abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2004.10.002
更新日期：2005-01-01 00:00:00
