Does chronic prenatal methadone exposure affect beta-receptor subtypes in placental, fetal and maternal brain homogenates?

abstract：:Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

journal_title：Neurotoxicology and teratology

authors： Oshiro WM,Krantz QT,Bushnell PJ

更新日期：2001-11-01 00:00:00

abstract：:While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

journal_title：Neurotoxicology and teratology

authors： Dribben WH,Creeley CE,Farber N

更新日期：2011-07-01 00:00:00

abstract：:Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of various types of cancer. Patients undergoing cisplatin treatment often suffer from a condition known as "chemobrain", ototoxicity, peripheral neuropathy, weight loss, nausea, vomiting, nephrotoxicity, seizures, hearing loss and tinni...

journal_title：Neurotoxicology and teratology

authors： Gopal KV,Wu C,Shrestha B,Campbell KC,Moore EJ,Gross GW

更新日期：2012-09-01 00:00:00

abstract：:In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedron...

journal_title：Neurotoxicology and teratology

authors： Naseri G,Fazel A,Golalipour MJ,Haghir H,Sadeghian H,Mojarrad M,Hosseini M,Shahrokhi Sabzevar S,Beheshti F,Ghorbani A

更新日期：2018-01-01 00:00:00

abstract：:The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Th...

journal_title：Neurotoxicology and teratology

authors： Warren DA,Reigle TG,Muralidhara S,Dallas CE

更新日期：1998-03-01 00:00:00

abstract：:Cigarette smoking in pregnant women has been shown to lead to intrauterine growth retardation and fetal death, and possibly also to neural dysmorphology and long-term learning deficits in the offspring. Because the teratogenic agent in cigarette smoke remains controversial, the present study on rat embryos in culture ...

journal_title：Neurotoxicology and teratology

authors： Joschko MA,Dreosti IE,Tulsi RS

更新日期：1991-05-01 00:00:00

abstract：:Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...

journal_title：Neurotoxicology and teratology

authors： Fulginiti S,Minetti SA,Virgolini MB

更新日期：1994-07-01 00:00:00

abstract：:Methylmercury (MeHg), an environmental contaminant primarily found in fish and seafood, may pose long-term health risks to pregnant women and their developing children. The objective of this study was to determine whether co-consumption of nutritional supplements would alter the effects of MeHg on reproductive and dev...

journal_title：Neurotoxicology and teratology

authors： Beyrouty P,Chan HM

更新日期：2006-01-01 00:00:00

abstract：:The ability of a neurobehavioral screening battery to differentiate the effects of two pyrethroids, permethrin and cypermethrin, was assessed in this experiment. Although the structures of these pesticides differ only in the alpha-cyano group, the behavioral syndromes associated with the Type I and II pyrethroids are ...

journal_title：Neurotoxicology and teratology

authors： McDaniel KL,Moser VC

更新日期：1993-03-01 00:00:00

abstract：:The identification of mechanisms and outcomes for neurobehavioral teratogenesis is critical to our ability to develop therapies to ameliorate or reverse the deleterious effects of exposure to developmental neurotoxicants. We established mechanistically-based complementary models for the study of cholinergic systems in...

journal_title：Neurotoxicology and teratology

authors： Yanai J,Brick-Turin Y,Dotan S,Langford R,Pinkas A,Slotkin TA

更新日期：2010-01-01 00:00:00

abstract：:Because of the important role of glial cells in brain maturation and reports on their delayed proliferation following ethanol exposure, it was considered of interest to investigate the mechanism of ethanol action on these cells. Biochemical parameters related to the apoptotic and necrotic processes in astroglial cells...

journal_title：Neurotoxicology and teratology

authors： Holownia A,Ledig M,Ménez JF

更新日期：1997-03-01 00:00:00

abstract：:The effects of preweaning experience in rats and mice on neuroendocrine and behavioral end points and their implications for prenatal drug effects are reviewed. The hypothalamo-pituitary-adrenal axis and the dopaminergic system were shown to be affected. Behavior related to hippocampal, adrenocortical functions and to...

journal_title：Neurotoxicology and teratology

authors： Clausing P,Mothes HK,Opitz B

更新日期：2000-01-01 00:00:00

abstract：:The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency ...

journal_title：Neurotoxicology and teratology

authors： Nagymajtényi L,Dési I,Lorencz R

更新日期：1988-09-01 00:00:00

abstract：:Disruptive Behavior Disorders (DBD) exhibit a sex-biased prevalence rate favoring boys, and prenatal testosterone exposure appears to be part of the complex etiology of these disorders. The current study examines whether high prenatal testosterone exposure may heighten the risk for DBD symptoms in males by increasing ...

journal_title：Neurotoxicology and teratology

authors： Martel MM,Roberts BA

更新日期：2014-07-01 00:00:00

abstract：BACKGROUND:Epidemiological studies examining the effects of prenatal toxic heavy metals exposure on neonatal development at the population-based level are limited. OBJECTIVE:To explore prenatal exposure levels to toxic heavy metals and examine whether exposure is associated with neonatal development. METHODS:A strati...

journal_title：Neurotoxicology and teratology

authors： Yu XD,Yan CH,Shen XM,Tian Y,Cao LL,Yu XG,Zhao L,Liu JX

更新日期：2011-07-01 00:00:00

abstract：:The purpose of this study was to determine the relationship between ornithine decarboxylase activity (ODC; a marker for perturbed cell development), the blood alcohol level, and alcohol-induced microencephaly in the developing rat brain after binge treatment with ethanol vapour. By manipulating ethanol flow we were ab...

journal_title：Neurotoxicology and teratology

authors： Davidson M,Bedi K,Wilce P

更新日期：1998-09-01 00:00:00

abstract：:We have utilized a mouse model of transplacental cocaine exposure to investigate the effects of cocaine dose and gestational timing in altering brain and body growth and postnatal behavior in exposed offspring. Pregnant dams were injected with cocaine HCl at 40 mg/kg/day (COC 40) or 20 mg/kg/day (COC 20), or 10 mg/kg/...

journal_title：Neurotoxicology and teratology

authors： Wilkins AS,Jones K,Kosofsky BE

更新日期：1998-05-01 00:00:00

abstract：:Prenatal cocaine or nicotine exposure is associated with a variety of teratogenic effects. The current study was conducted to determine their effects alone and in combination on cognitive function and sexual differentiation. Pregnant Long-Evans rats (N = 19) were exposed to either cocaine (15 mg/kg/dose b.i.d. SC on G...

journal_title：Neurotoxicology and teratology

authors： Cutler AR,Wilkerson AE,Gingras JL,Levin ED

更新日期：1996-11-01 00:00:00

abstract：:While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, ...

journal_title：Neurotoxicology and teratology

authors： MacPhail RC,Jarema KA

更新日期：2005-09-01 00:00:00

abstract：:The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post...

journal_title：Neurotoxicology and teratology

authors： Goffeng LO,Heier MS,Kjuus H,Sjöholm H,Sørensen KA,Skaug V

更新日期：2008-05-01 00:00:00

abstract：:Using a timed-breeding protocol, one group of female rhesus monkeys was implanted subcutaneously with osmotic minipumps containing 0.3 mg/kg/h cocaine (N=18) or saline (N=18) from day 24 postconception through gestation. Another group received cocaine (N=12) or saline (N=8) from conception through day 42 of gestation....

journal_title：Neurotoxicology and teratology

authors： Howell LL,Schama KF,Ellis JE,Grimley PJ,Kitchens AJ,Byrd LD

更新日期：2001-03-01 00:00:00

abstract：:Two hundred thirty-six children from two established cohorts at risk for exposure to polychlorinated biphenyls (PCBs) and related contaminants were evaluated at age 4 years. Prenatal exposure (assessed by cord serum PCB level) was associated with lower weight, an effect consistent with reports of growth retardation in...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW,Humphrey HE

更新日期：1990-07-01 00:00:00

abstract：:The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric ...

journal_title：Neurotoxicology and teratology

authors： Li AA,Sheets LP,Raffaele K,Moser V,Hofstra A,Hoberman A,Makris SL,Garman R,Bolon B,Kaufmann W,Auer R,Lau E,Vidmar T,Bowers WJ

更新日期：2017-09-01 00:00:00

abstract：:Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental ...

journal_title：Neurotoxicology and teratology

authors： Silva L,Zhao N,Popp S,Dow-Edwards D

更新日期：2012-01-01 00:00:00

abstract：:Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...

journal_title：Neurotoxicology and teratology

authors： Fried PA,Watkinson B

更新日期：2000-01-01 00:00:00

abstract：:In the present work, in vivo ROS formation and the activity of antioxidant enzymes in the hippocampus and the cerebellum of sodium metavanadate (NaVO₃) treated rats were studied. Rats were i.p. injected with 3 mg/kg bw/day (V₁ group) or with 7.2 mg/kg bw/day of NaVO₃ (V₂ group) for 5 consecutive days. Results show tha...

journal_title：Neurotoxicology and teratology

authors： Cuesta S,Francés D,García GB

更新日期：2011-03-01 00:00:00

abstract：:Visual thresholds for luminance increments were obtained behaviorally and electrophysiologically from rats exposed to a polychlorinated biphenyl (PCB) during development. Male Long-Evans rats exposed to 0, 0.25, or 1.0 microg/kg/day of 3,3',4,4', 5-pentachlorobiphenyl (PCB 126) through gestation and weaning were train...

journal_title：Neurotoxicology and teratology

authors： Geller AM,Bushnell PJ,Rice DC

更新日期：2000-07-01 00:00:00

abstract：:Pregnant rats received saline once daily (Control QD) or twice daily (Control BID), cocaine 2 mg/kg IV daily (COC QD) or twice daily (COC BID) throughout gestation beginning on gestational day 4. The treatment was continued in nursing mothers until postnatal day 7. All studies were performed in their offsprings on pos...

journal_title：Neurotoxicology and teratology

authors： Hseu SS,Yien HW,Du F,Sun LS

更新日期：1998-11-01 00:00:00

abstract：:Previous studies have indicated that prenatal ethanol (EtOH) exposure alters developing catecholamine (CA) systems and acute sensitivity to the locomotor stimulant effects of EtOH. The purpose of this study was to examine whether prenatal EtOH exposure influences the effects of the direct dopamine (DA) agonist apomorp...

journal_title：Neurotoxicology and teratology

authors： Becker HC,Weathersby RT,Hale RL

更新日期：1995-01-01 00:00:00

abstract：:Estrogen modulates baseline and amphetamine-stimulated dopamine (DA) release in the adult female rat striatum. The isoflavone found in soybeans, genistein, is a phytoestrogen and may have comparable effects on striatal DA levels. Similarly, the industrial intermediate and potential endocrine disrupter, para-nonylpheno...

journal_title：Neurotoxicology and teratology

authors： Ferguson SA,Flynn KM,Delclos KB,Newbold RR,Gough BJ

更新日期：2002-01-01 00:00:00