Abstract:
:This longitudinal study evaluated whether the level of intrauterine cocaine exposure (IUCE) or the interaction between IUCE and contextual variables was related during middle childhood to executive functioning, as assessed with the Stroop Color-Word and Rey Osterrieth Complex Figure tests. The Stroop Interference score measures verbal inhibitory control while the Rey Osterrieth Organizational score evaluates skills such as planning, organization and perception. Masked examiners assessed 143 children at 9.5 and 11 years of age (74 with IUCE and 69 demographically similar children without IUCE). Level of IUCE (Unexposed; Lighter, and Heavier) was documented by positive postpartum maternal reports and infant meconium assays. In covariate-controlled regressions, level of IUCE was not significantly associated with Stroop Interference or Rey Osterrieth Organization scores. However, in covariate controlled post-hoc tests comparing the Heavier exposed group to the combined Lighter/Unexposed group, children in the Heavier group had significantly poorer Stroop Interference scores, but there was no significant group difference for Rey Osterrieth Organizational scores. Children's average Organization scores in Unexposed, Lighter, and Heavier exposed groups were well below the test norm means. Results of this study indicate that heavier IUCE may be associated with mild compromise on school-aged children's ability to inhibit prepotent verbal responses.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Rose-Jacobs R,Waber D,Beeghly M,Cabral H,Appugleise D,Heeren T,Marani J,Frank DAdoi
10.1016/j.ntt.2008.12.002subject
Has Abstractpub_date
2009-05-01 00:00:00pages
159-68issue
3eissn
0892-0362issn
1872-9738pii
S0892-0362(08)00199-2journal_volume
31pub_type
杂志文章abstract::Exposure to ethanol during development can lead to a constellation of congenital anomalies, resulting in prenatal and postnatal failure to thrive, central nervous system (CNS) deficits, and a number of patterning defects that lead to defects in the cardiovascular system, facial structures, and limbs. The cellular, bio...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(87)90035-3
更新日期:1987-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
doi:10.1016/j.ntt.2005.06.007
更新日期:2005-09-01 00:00:00
abstract::A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...
journal_title:Neurotoxicology and teratology
pub_type: 临床试验,杂志文章
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2004.09.008
更新日期:2005-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 指南,杂志文章
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更新日期:1992-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2006.10.009
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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更新日期:1993-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2013.12.006
更新日期:2014-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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更新日期:2011-03-01 00:00:00
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pub_type: 杂志文章
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