Neurobehavioral effects of prenatal exposure to AZT: a preliminary investigation with the D1 receptor agonist SKF 38393 in mice.

abstract：:Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...

journal_title：Neurotoxicology and teratology

authors： Wolansky MJ,Azcurra JM

更新日期：2005-03-01 00:00:00

abstract：:Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethano...

journal_title：Neurotoxicology and teratology

authors： Campo P,Lataye R,Cossec B,Villette V,Roure M,Barthelemy C

更新日期：1998-05-01 00:00:00

abstract：:Because of the important role of glial cells in brain maturation and reports on their delayed proliferation following ethanol exposure, it was considered of interest to investigate the mechanism of ethanol action on these cells. Biochemical parameters related to the apoptotic and necrotic processes in astroglial cells...

journal_title：Neurotoxicology and teratology

authors： Holownia A,Ledig M,Ménez JF

更新日期：1997-03-01 00:00:00

abstract：:Caffeine, added to the drinking water of males used for impregnation and gestant BALB/c mice such that their daily caffeine intake was 60 mg/kg, modified the passive avoidance behavior of the offspring when tested as adults. Caffeine-treated and control mice of the F1 generation were then cross-mated. The F2 generatio...

journal_title：Neurotoxicology and teratology

authors： Sinton CM

更新日期：1989-07-01 00:00:00

abstract：:Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term effects of this drug on the central nervous system (CNS) are not well understood, we conducted microPET/CT scans on young adult male rhesus monkeys (n=4/group) to gather in...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Newport GD,Callicott R,Liu S,Thompson J,Berridge MS,Apana SM,Slikker W Jr,Wang C,Paule MG

更新日期：2016-07-01 00:00:00

abstract：:Ionizing radiation is a precise tool for altering formation of the developing cerebral cortex of the fetal rat. Whole body exposure of the pregnant rat on gestational day 13, 15 or 17 to 1.0 Gy of gamma radiation resulted in maximum thinning of the cortex on days 15 and 17. In the preweaning period, functional tests (...

journal_title：Neurotoxicology and teratology

authors： Norton S,Kimler BF

更新日期：1988-07-01 00:00:00

abstract：:Two hundred thirty-six children from two established cohorts at risk for exposure to polychlorinated biphenyls (PCBs) and related contaminants were evaluated at age 4 years. Prenatal exposure (assessed by cord serum PCB level) was associated with lower weight, an effect consistent with reports of growth retardation in...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW,Humphrey HE

更新日期：1990-07-01 00:00:00

abstract：:This nonconcurrent, cohort study of consecutive admissions to one of three hospital units: labor and delivery (n = 474), well-born nursery (n = 100), and the neonatal intensive care unit (n = 100), was designed to determine the prevalence of cocaine exposure in a rural obstetrical sample and to determine the relations...

journal_title：Neurotoxicology and teratology

authors： Behnke M,Eyler FD,Conlon M,Woods NS,Casanova OQ

更新日期：1994-09-01 00:00:00

abstract：:Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and...

journal_title：Neurotoxicology and teratology

authors： Mattsson JL,Albee RR,Eisenbrandt DL,Chang LW

更新日期：1988-03-01 00:00:00

abstract：:Behavioral and neurochemical analyses were conducted on preweanling CD rats prenatally exposed to either 0, 0.375 or 0.750 mg/kg/day reserpine SC on gestation days 12-15. Offspring body weights were taken on test days, and pups were tested for negative geotaxis responding on postnatal day 8, developmental activity on ...

journal_title：Neurotoxicology and teratology

authors： Buelke-Sam J,Ali SF,Kimmel GL,Slikker W Jr,Newport GD,Harmon JR

更新日期：1989-09-01 00:00:00

abstract：:Early-life exposures to brominated diphenyl ethers (BDEs) lead to neurobehavioral abnormalities later in life. Although these agents are thyroid disruptors, it is not clear whether this mechanism alone accounts for the adverse effects. We evaluated the impact of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) on PC12 cel...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Card J,Infante A,Seidler FJ

更新日期：2013-05-01 00:00:00

abstract：BACKGROUND:Ciguatoxins are extremely potent neurotoxins, produced by tropical marine dinoflagellates, that persistently enter into our food web. Over 100,000 people annually experience acute ciguatera poisoning from consuming toxic fish. Roughly 5% of these victims will develop chronic ciguatera (CC), a widespread, mul...

journal_title：Neurotoxicology and teratology

authors： Shoemaker RC,House D,Ryan JC

更新日期：2010-11-01 00:00:00

abstract：:Memory problems lasting 8 months have previously been described for a small group of female solvent workers following an accidental workplace solvent intoxication. Three years after the intoxication the presence of longer-term residual impairment of cognitive functions was evaluated. The major residual difficulty unco...

journal_title：Neurotoxicology and teratology

authors： Stollery BT

更新日期：1996-07-01 00:00:00

abstract：:Cigarette smoking in pregnant women has been shown to lead to intrauterine growth retardation and fetal death, and possibly also to neural dysmorphology and long-term learning deficits in the offspring. Because the teratogenic agent in cigarette smoke remains controversial, the present study on rat embryos in culture ...

journal_title：Neurotoxicology and teratology

authors： Joschko MA,Dreosti IE,Tulsi RS

更新日期：1991-05-01 00:00:00

abstract：:A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...

journal_title：Neurotoxicology and teratology

authors： Samsam TE,Gadrinab LG,Bushnell PJ

更新日期：2004-01-01 00:00:00

abstract：:Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ,Spindel ER

更新日期：2011-05-01 00:00:00

abstract：:While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, ...

journal_title：Neurotoxicology and teratology

authors： MacPhail RC,Jarema KA

更新日期：2005-09-01 00:00:00

abstract：:Pregnant Sprague-Dawley rats were fed a liquid diet containing either 0% (group C), 18% (group L), or 36% (group H) ethanol-derived calories (EDC) from gestational day 1 to 20. Male offspring were assessed under a conditioned taste aversion paradigm (PND 35-45), in a complex maze (PND 68-80), and for operant behavior ...

journal_title：Neurotoxicology and teratology

authors： Clausing P,Ferguson SA,Holson RR,Allen RR,Paule MG

更新日期：1995-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Neurotoxicology and teratology

authors： Cross NC,Chelonis JJ,Finch MN,Edwards MC,Baldwin RL

更新日期：2009-02-05 00:00:00

abstract：:Pyrethroid insecticides have been divided into Types I and II based on behavioral profiles of toxicity produced by life-threatening dosages. In order to assess potential alterations in acquired (operant) behavior, acute dosage-effect and time-course determinations for permethrin (Type I) and cypermethrin (Type II) wer...

journal_title：Neurotoxicology and teratology

authors： Peele DB,Crofton KM

更新日期：1987-09-01 00:00:00

abstract：:We have utilized a mouse model of transplacental cocaine exposure to investigate the effects of cocaine dose and gestational timing in altering brain and body growth and postnatal behavior in exposed offspring. Pregnant dams were injected with cocaine HCl at 40 mg/kg/day (COC 40) or 20 mg/kg/day (COC 20), or 10 mg/kg/...

journal_title：Neurotoxicology and teratology

authors： Wilkins AS,Jones K,Kosofsky BE

更新日期：1998-05-01 00:00:00

abstract：:Employees of a factory producing antiknock additives for gasoline were examined psychologically after an exposure of an average of 14 years. A neurobehavioral symptom questionnaire, tests of single and choice reaction time, a cancellation task and a digit symbol test were the neurobehavioral variables. Total lead in u...

journal_title：Neurotoxicology and teratology

authors： Seeber A,Kiesswetter E,Neidhart B,Blaszkewicz M

更新日期：1990-11-01 00:00:00

abstract：:A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...

journal_title：Neurotoxicology and teratology

authors： Dick RB,Krieg EF Jr,Sim MA,Bernard BP,Taylor BT

更新日期：1997-11-01 00:00:00

abstract：:Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...

journal_title：Neurotoxicology and teratology

authors： Minck DR,Erway LC,Vorhees CV

更新日期：1989-05-01 00:00:00

abstract：:To identify the frequency range most sensitive to toluene-induced auditory damage, the auditory function of adult Long-Evans rats exposed to 1750 ppm of toluene (6 h/day, 5 days/week, 4 weeks), was tested by recording auditory-evoked potentials directly from the round window of the cochlea. The present electrocochleog...

journal_title：Neurotoxicology and teratology

authors： Lataye R,Campo P,Loquet G

更新日期：1999-05-01 00:00:00

abstract：:This paper discusses issues pertaining to the validity, precision, and interpretation of epidemiologic studies of neurotoxicity. With regard to validity, the critical issues pertain to the appropriate strategy for confounder adjustment, particularly when confounders are complex, multi-faceted constructs, and to the ne...

journal_title：Neurotoxicology and teratology

authors： Bellinger DC

更新日期：2009-09-01 00:00:00

abstract：:Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ab...

journal_title：Neurotoxicology and teratology

authors： Mitchell JA,Long SF,Wilson MC,Kallman MJ

更新日期：1989-01-01 00:00:00

abstract：:The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post...

journal_title：Neurotoxicology and teratology

authors： Goffeng LO,Heier MS,Kjuus H,Sjöholm H,Sørensen KA,Skaug V

更新日期：2008-05-01 00:00:00

abstract：:The effects of lindane on behavior and central monoaminergic systems were studied in rat pups at 15 days of postnatal age. Pups were previously given nonconvulsant lindane PO doses, either a single 20 mg/kg or 7-day repeated 10 mg/kg doses. Both treatment schedules improved the passive avoidance acquisition but only t...

journal_title：Neurotoxicology and teratology

authors： Rivera S,Rosa R,Martínez E,Suñol C,Serrano MT,Vendrell M,Rodríguez-Farré E,Sanfeliu C

更新日期：1998-03-01 00:00:00

abstract：:Exposing rats to the anticholinesterase (anti-ChE) diisopropyl fluorophosphate (DFP) causes a transient period of hypothermia followed by a period of hyperthermia lasting approximately 48 h. Because a fever is a predominant thermoregulatory response in humans exposed to anti-ChE pesticides, the hyperthermic response i...

journal_title：Neurotoxicology and teratology

authors： Gordon CJ

更新日期：1995-11-01 00:00:00