Abstract:
:Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and somatosensory evoked potentials, mild nasal and pulmonary inflammation, mild kidney effects, and mild vacuolation in the brain. Auditory brainstem responses (ABRs) and brain histology were evaluated two months postexposure in 2 male and 2 female rats. Both the ABRs and brain histology were within normal limits at this time, indicating that these treatment effects were, to at least a great extent, reversible. Exposure to 100 ppm resulted in dental fluorosis and very minor slowing of some evoked responses; all other measures, including brain histology, were normal. No treatment effects were noted at 30 ppm.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Mattsson JL,Albee RR,Eisenbrandt DL,Chang LWdoi
10.1016/0892-0362(88)90076-1subject
Has Abstractpub_date
1988-03-01 00:00:00pages
127-33issue
2eissn
0892-0362issn
1872-9738pii
0892-0362(88)90076-1journal_volume
10pub_type
杂志文章abstract::Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...
journal_title:Neurotoxicology and teratology
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更新日期:2018-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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更新日期:2006-11-01 00:00:00
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abstract::Caffeine, added to the drinking water of males used for impregnation and gestant BALB/c mice such that their daily caffeine intake was 60 mg/kg, modified the passive avoidance behavior of the offspring when tested as adults. Caffeine-treated and control mice of the F1 generation were then cross-mated. The F2 generatio...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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更新日期:2014-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2008.02.006
更新日期:2008-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2010.10.006
更新日期:2011-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2015.06.007
更新日期:2015-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2005.07.005
更新日期:2005-11-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2011.07.005
更新日期:2011-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2016.11.002
更新日期:2017-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(87)90035-3
更新日期:1987-09-01 00:00:00
abstract::The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(96)00227-9
更新日期:1997-05-01 00:00:00
abstract::The indirubins long have been used in Chinese medicine for treatment of myelocytic leukemia. Among the many more recently described biological activities of the indirubins, attention has been directed toward the ability of these compounds to inhibit GSK-3 and CDKs, kinases implicated in neurodegenerative conditions. L...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2009.12.005
更新日期:2010-03-01 00:00:00
abstract::Most behavioral teratology studies have focused on pharmaceutical agents. Investigations of developmental toxicity are lacking for the majority of the nearly 100,000 industrial chemicals currently in use. Only some three dozen chemicals have been examined for behavioral/neurochemical deviations in offspring following ...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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更新日期:1990-07-01 00:00:00
abstract::The effect of prenatal ethanol exposure on the kainate-sensitive subtype of glutamate receptor binding sites was studied using in vitro 3H-vinylidene kainic acid (VKA) autoradiography. Pregnant Sprague-Dawley rats were fed a liquid diet containing either 3.35% or 6.7% ethanol throughout gestation. Pair-fed dams receiv...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(88)90093-1
更新日期:1988-11-01 00:00:00
abstract:BACKGROUND:Ciguatoxins are extremely potent neurotoxins, produced by tropical marine dinoflagellates, that persistently enter into our food web. Over 100,000 people annually experience acute ciguatera poisoning from consuming toxic fish. Roughly 5% of these victims will develop chronic ciguatera (CC), a widespread, mul...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2010.05.007
更新日期:2010-11-01 00:00:00
abstract::Measures of visual contrast sensitivity (VCS), rather than traditional measures of visual acuity using high-contrast stimuli, have been presented as better appraisals of visual dysfunction resulting from chemical exposures. The present study sought to determine if differences exist between two available measures of co...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2003.10.007
更新日期:2004-03-01 00:00:00