Abstract：
:Disruptive Behavior Disorders (DBD) exhibit a sex-biased prevalence rate favoring boys, and prenatal testosterone exposure appears to be part of the complex etiology of these disorders. The current study examines whether high prenatal testosterone exposure may heighten the risk for DBD symptoms in males by increasing susceptibility to negative environmental conditions such as maternal nicotine and alcohol use during pregnancy. Participants were 109 three- to six-year-olds (64% male; 72% with DBD) and their 109 primary caregivers and 55 daycare providers/teachers who completed a multi-informant diagnostic procedure. A proxy of prenatal testosterone exposure, finger-length ratios, interacted with maternal report of prenatal nicotine use to predict teacher-rated hyperactivity-impulsivity during preschool, for boys, but not girls, although the three-way interaction was not significant. Prenatal testosterone interacted with prenatal alcohol exposure to predict teacher-rated hyperactivity-impulsivity and ODD symptoms differentially based on child sex (significant three-way interaction). Boys with higher levels of prenatal testosterone who were also exposed to higher levels of nicotine and alcohol during pregnancy exhibited increased hyperactivity-impulsivity during early childhood, but girls did not exhibit this same pattern. Thus, high prenatal testosterone exposure seems to increase risk for DBD symptoms particularly in males by increasing susceptibility to prenatal environmental stressors.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Martel MM,Roberts BAdoi
10.1016/j.ntt.2014.05.001subject
Has Abstractpub_date
2014-07-01 00:00:00pages
11-7eissn
0892-0362issn
1872-9738pii
S0892-0362(14)00109-3journal_volume
44pub_type
杂志文章abstract：:Exposing rats to the anticholinesterase (anti-ChE) diisopropyl fluorophosphate (DFP) causes a transient period of hypothermia followed by a period of hyperthermia lasting approximately 48 h. Because a fever is a predominant thermoregulatory response in humans exposed to anti-ChE pesticides, the hyperthermic response i...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(95)02001-2
更新日期：1995-11-01 00:00:00
abstract：OBJECTIVE:To examine the association between prenatal exposure to nicotine from tobacco smoke and infant neurobehavior using tobacco biomarkers and a sensitive and comprehensive measure of infant neurobehavior. STUDY DESIGN:Participants were 318 infants (206 White, 95 Black, 17 Other) and their mothers. Prenatal tobac...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2009.07.004
更新日期：2009-11-01 00:00:00
abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2004.10.002
更新日期：2005-01-01 00:00:00
abstract：:The effects of administration by inhalation of metallic mercury vapour (Hg0) to pregnant rats, approximately corresponding to doses of 0.2 mg Hg0/kg/day (high dose) or 0.07 mg Hg0/kg/day (low dose), on the developmental and behavioural repertoire of the offspring were studied. Exposure occurred during days 11-14 plus ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(93)90056-t
更新日期：1993-11-01 00:00:00
abstract：:The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameter...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2005.10.007
更新日期：2006-01-01 00:00:00
abstract：BACKGROUND:General anesthetics (GAs) may exert harmful effects on the developing brain by disrupting neuronal circuit formation. Anesthetics that act on γ-aminobutyric acid (GABA) receptors can interfere with axonal growth cone guidance, a critical process in the assembly of neuronal circuitry. Here we investigate the ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2019.106812
更新日期：2019-01-01 00:00:00
abstract：:A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....
journal_title：Neurotoxicology and teratology
pub_type：
doi：10.1016/j.ntt.2012.01.008
更新日期：2012-03-01 00:00:00
abstract：:Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(99)00046-x
更新日期：2000-01-01 00:00:00
abstract：:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2006.10.001
更新日期：2007-03-01 00:00:00
abstract：:Pregnant Swiss mice were exposed to 0.3-1.5 Gy of gamma radiation on day 17 of gestation and allowed to deliver the offspring. When the F1 mice were 6 months old, they were subjected to a number of behavioral tests. Open-field and dark-bright arena tests were conducted to study locomotor and exploratory activities. Le...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(98)00039-7
更新日期：1999-03-01 00:00:00
abstract：:The purpose of this study was to determine the relationship between ornithine decarboxylase activity (ODC; a marker for perturbed cell development), the blood alcohol level, and alcohol-induced microencephaly in the developing rat brain after binge treatment with ethanol vapour. By manipulating ethanol flow we were ab...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(97)00135-9
更新日期：1998-09-01 00:00:00
abstract：:Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(97)00094-9
更新日期：1998-07-01 00:00:00
abstract：:Maneb, an organomanganese fungicide, is largely used in agricultural regions for control of field crop pathologies. Despite its apparent low toxicity, there are reports showing that maneb has harmful effects on peripheral and central nervous systems. In this work the effects of acute administration of maneb were studi...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90018-4
更新日期：1989-09-01 00:00:00
abstract：:Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90073-1
更新日期：1989-05-01 00:00:00
abstract：:A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/S0892-0362(03)00093-X
更新日期：2004-01-01 00:00:00
abstract：:Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...
journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章,随机对照试验
doi：10.1016/0892-0362(94)00057-k
更新日期：1995-03-01 00:00:00
abstract：:Measures of visual contrast sensitivity (VCS), rather than traditional measures of visual acuity using high-contrast stimuli, have been presented as better appraisals of visual dysfunction resulting from chemical exposures. The present study sought to determine if differences exist between two available measures of co...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2003.10.007
更新日期：2004-03-01 00:00:00
abstract：:In this study we used a rat model of graded perinatal asphyxia to study the long-term consequences of this manipulation on rat maternal behavior at adulthood. Rats were delivered by cesarean (C) section and the pups, still in the uterus horns, were placed into a water bath at 37 degrees C for periods of 0 (controls) o...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(03)00035-7
更新日期：2003-09-01 00:00:00
abstract：:The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(96)00227-9
更新日期：1997-05-01 00:00:00
abstract：:During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90009-4
更新日期：1994-01-01 00:00:00
abstract：:This population-based retrospective cohort study examined Structural Magnetic Resonance Imaging (MRI) of the brain in relation to prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water on Cape Cod, Massachusetts. Subjects were identified through birth records from 1969 through 1...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2013.03.060
更新日期：2013-07-01 00:00:00
abstract：:Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term effects of this drug on the central nervous system (CNS) are not well understood, we conducted microPET/CT scans on young adult male rhesus monkeys (n=4/group) to gather in...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2016.06.005
更新日期：2016-07-01 00:00:00
abstract：:The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acut...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.03.004
更新日期：2010-07-01 00:00:00
abstract：:The effects of preweaning experience in rats and mice on neuroendocrine and behavioral end points and their implications for prenatal drug effects are reviewed. The hypothalamo-pituitary-adrenal axis and the dopaminergic system were shown to be affected. Behavior related to hippocampal, adrenocortical functions and to...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/s0892-0362(99)00051-3
更新日期：2000-01-01 00:00:00
abstract：:This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzin...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(90)90005-w
更新日期：1990-09-01 00:00:00
abstract：:Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ab...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90084-6
更新日期：1989-01-01 00:00:00
abstract：:The effects of acute prenatal exposure to ethanol on the postnatal optic nerve have been examined in a C57B1/6J mouse model. Pregnant mice were exposed by intraperitoneal injection to ethanol (25% ethanol, each dose at 0.015 ml/g separated by 4 h), or to saline on the 8th gestational day and the optic nerve examined a...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90113-9
更新日期：1994-03-01 00:00:00
abstract：:In the United States, the regulation and testing of chemicals that may impact on human health is mandated by a number of different laws and regulated by several government agencies. Toxicologic screening in laboratory animals has created a major database for predicting adverse health effects of drugs, food and cosmeti...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/0892-0362(87)90052-3
更新日期：1987-11-01 00:00:00
abstract：:Rapid euthanasia of laboratory rodents without the use of anesthesia is a necessary research technique whenever there is the likelihood of anesthesia or stress interfering with the chemistry of the tissues under investigation. Decapitation has long been the procedure of choice under such circumstances. Recently, howev...
journal_title：Neurotoxicology and teratology
pub_type： 指南,杂志文章
doi：10.1016/0892-0362(92)90004-t
更新日期：1992-07-01 00:00:00
abstract：:Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90064-4
更新日期：1991-09-01 00:00:00
