Long-term effects of toluene inhalation on rat behavior.


:The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were made 11 to 35 days after the end of the exposure. The results indicate that toluene exposure causes a long-lasting impairment on the extinction process and reduction in the variability of the baseline response in the operant behavior situation. Toluene also had an effect on the water regulation.


Neurotoxicol Teratol


Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U




Has Abstract


1991-09-01 00:00:00














  • The development of a neurobehavioral test battery for use in hazard evaluations in occupational settings.

    abstract::The interest in, and number of, neurobehavioral test batteries for use in occupational settings has increased markedly over the last decade. While this is a welcome development in furthering the cause for greater acceptance of these methods in hazard evaluation and toxicity testing, there are a number of issues that a...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Williamson AM

    更新日期:1990-09-01 00:00:00

  • Effects of 2,5-hexanedione alone and in combination with acetone on radial arm maze behavior, the "brain-swelling" reaction and synaptosomal functions.

    abstract::A multidisciplinary study to investigate 2,5-hexanedione (2,5-HD)-induced CNS-neurotoxicity and its proposed potentiation by acetone (AC) was conducted. Neurobehavioral testing, estimation of the brain-swelling reaction, neuropathological and morphometric measurements as well as synaptosomal 5-hydroxytryptamine (5-HT)...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Lam HR,Larsen JJ,Ladefoged O,Møller A,Strange P,Arlien-Søborg P

    更新日期:1991-07-01 00:00:00

  • Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin.

    abstract::Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Habr SF,Macrini DJ,Florio JC,Bernardi MM

    更新日期:2014-11-01 00:00:00

  • Prenatal tetrahydrocannabinol (THC) alters cognitive function and amphetamine response from weaning to adulthood in the rat.

    abstract::Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Silva L,Zhao N,Popp S,Dow-Edwards D

    更新日期:2012-01-01 00:00:00

  • Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish.

    abstract::4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

    更新日期:2011-11-01 00:00:00

  • Terbutaline impairs the development of peripheral noradrenergic projections: potential implications for autism spectrum disorders and pharmacotherapy of preterm labor.

    abstract::Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic proj...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Slotkin TA,Seidler FJ

    更新日期:2013-03-01 00:00:00

  • Developmental neurotoxicity of anticonvulsants: human and animal evidence on phenytoin.

    abstract::Most epileptic women delivering children each year take anticonvulsants throughout pregnancy. The teratogenic potential of anticonvulsants is most notable for phenytoin, trimethadione, valproic acid, and carbamazepine. This review focuses on the human and animal evidence for the teratogenicity of phenytoin, with empha...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Adams J,Vorhees CV,Middaugh LD

    更新日期:1990-05-01 00:00:00

  • Central auditory processing in school-age children prenatally exposed to cigarette smoke.

    abstract::One hundred and ten, 6- to 11-year-old children from a low-risk, predominantly middle class sample who are participants in an ongoing longitudinal drug study were assessed using a central auditory processing task (SCAN) that made perceptual rather than linguistic demands. Maternal smoking during pregnancy was linearly...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章


    authors: McCartney JS,Fried PA,Watkinson B

    更新日期:1994-05-01 00:00:00

  • Correlation of behavior with brain damage after in utero exposure to toxic agents.

    abstract::Early postnatal behaviors involving sensorimotor integration were measured along with thickness of the sensorimotor cortex in rats irradiated with 1.0 Gy on gestational day 11 or 17. Body weight and morphology of anterior pituitary cells were recorded. Irradiation on day 17 was more effective in reducing cortical thic...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Norton S,Kimler BF

    更新日期:1987-03-01 00:00:00

  • Motor assessment of cocaine/polydrug exposed infants at age 4 months.

    abstract::Fifty nondrug-exposed infants and 74 cocaine/polydrug-exposed infants were evaluated on the Movement Assessment of Infants (MAI). The test provides an assessment of risk for motor dysfunction at age 4 months. There was a significant difference in total risk scores between the two groups of infants with cocaine-exposed...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Schneider JW,Chasnoff IJ

    更新日期:1992-03-01 00:00:00

  • Repeated methylphenidate administration during lactation reduces maternal behavior, induces maternal tolerance, and increases anxiety-like behavior in pups in adulthood.

    abstract::Methylphenidate (MPD) is a dopamine uptake inhibitor and the most commonly prescribed drug for the treatment of attention-deficit/hyperactivity disorder in children. Several studies have shown that such stimulants as cocaine and amphetamine that are administered during gestation and lactation may disrupt maternal beha...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Ponchio RA,Teodorov E,Kirsten TB,Coelho CP,Oshiro A,Florio JC,Bernardi MM

    更新日期:2015-07-01 00:00:00

  • Home environment and prenatal exposure to lead, arsenic and zinc on the neurodevelopment of six-month-old infants living in Chitwan Valley, Nepal.

    abstract:BACKGROUND:We have previously reported the inverse associations between in utero levels of lead (Pb), arsenic (As) (i.e., toxic elements), and neurodevelopmental indicators (i.e., motor and state regulation cluster score) measured by the Brazelton Neonatal Behavioral Assessment Scale, third edition (NBAS III) in this c...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Parajuli RP,Fujiwara T,Umezaki M,Furusawa H,Watanabe C

    更新日期:2014-01-01 00:00:00

  • Behavioral toxicology of cognition: extrapolation from experimental animal models to humans: behavioral toxicology symposium overview.

    abstract::A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....

    journal_title:Neurotoxicology and teratology



    authors: Paule MG,Green L,Myerson J,Alvarado M,Bachevalier J,Schneider JS,Schantz SL

    更新日期:2012-03-01 00:00:00

  • Adverse effects of serotonin depletion in developing zebrafish.

    abstract::In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM pCPA for 24h and subsequently rescued...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Airhart MJ,Lee DH,Wilson TD,Miller BE,Miller MN,Skalko RG,Monaco PJ

    更新日期:2012-01-01 00:00:00

  • Co-consumption of selenium and vitamin E altered the reproductive and developmental toxicity of methylmercury in rats.

    abstract::Methylmercury (MeHg), an environmental contaminant primarily found in fish and seafood, may pose long-term health risks to pregnant women and their developing children. The objective of this study was to determine whether co-consumption of nutritional supplements would alter the effects of MeHg on reproductive and dev...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Beyrouty P,Chan HM

    更新日期:2006-01-01 00:00:00

  • Minimally invasive biomarkers of general anesthetic-induced developmental neurotoxicity.

    abstract::The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested have been shown to cause abnormal brain cell death in animals...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Zhang X,Liu F,Slikker W Jr,Wang C,Paule MG

    更新日期:2017-01-01 00:00:00

  • Diabetic neuropathies in brain are induced by deficiency of BDNF.

    abstract::Diabetes is known to be one of the risk factors for dementia; however, neuropathic changes in the brain of patients with the disease have not been completely revealed. So in the present study, we investigated the brain function of rats with diabetes induced by streptozotocin (STZ), one of the most commonly used animal...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Nitta A,Murai R,Suzuki N,Ito H,Nomoto H,Katoh G,Furukawa Y,Furukawa S

    更新日期:2002-09-01 00:00:00

  • Influence of 5-azacytidine on differentiation and growth in rat nervous system tumor cell lines.

    abstract::In vitro studies with permanent cell lines derived from ENU-induced rat CNS and PNS tumors have shown that substances acting on second messenger systems as well as glucocorticoids have a cytostatic effect at high cell densities, but enhance proliferation at low densities. The nontoxic cytostatic effects are partially ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Stark M,Bilzer T,Inoue N,Wechsler W

    更新日期:1989-11-01 00:00:00

  • An update on incidence of FAS: FAS is not an equal opportunity birth defect.

    abstract::The incidence of Fetal Alcohol Syndrome is now estimated at 0.97 cases per 1,000 live births in the general obstetric population and 4.3% among "heavy" drinkers. The general incidence is more than 20 times higher in the United States (1.95 per 1,000) compared to Europe and other countries (0.08 per 1,000). Within the ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Abel EL

    更新日期:1995-07-01 00:00:00

  • Neuropsychological sequelae from acute poisoning and long-term exposure to carbamate and organophosphate pesticides.

    abstract:UNLABELLED:This research examines the effects of different degrees of pesticide exposure on neuropsychological performance. Exposures varied from acute poisoning coupled with chronic exposure to low or high levels of chronic exposure (defined by years of exposure). A cross-sectional neuropsychological and biochemical s...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Roldan-Tapia L,Nieto-Escamez FA,del Aguila EM,Laynez F,Parron T,Sanchez-Santed F

    更新日期:2006-11-01 00:00:00

  • Determining normal variability in a developmental neurotoxicity test: a report from the ILSI Research Foundation/Risk Science Institute expert working group on neurodevelopmental endpoints.

    abstract::With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Raffaele KC,Fisher JE Jr,Hancock S,Hazelden K,Sobrian SK

    更新日期:2008-07-01 00:00:00

  • Zebrafish as potential model for developmental neurotoxicity testing: a mini review.

    abstract::The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: de Esch C,Slieker R,Wolterbeek A,Woutersen R,de Groot D

    更新日期:2012-11-01 00:00:00

  • Schedule-controlled operant behavior of rats during 1,1,1-trichloroethane inhalation: relationship to blood and brain solvent concentrations.

    abstract::The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Th...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Warren DA,Reigle TG,Muralidhara S,Dallas CE

    更新日期:1998-03-01 00:00:00

  • WITHDRAWN: Use of Interval Schedules to Examine Motivation and Sustained Attention.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Cross NC,Chelonis JJ,Finch MN,Edwards MC,Baldwin RL

    更新日期:2009-02-05 00:00:00

  • Combined effects of simultaneous exposure to toluene and ethanol on auditory function in rats.

    abstract::Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethano...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Campo P,Lataye R,Cossec B,Villette V,Roure M,Barthelemy C

    更新日期:1998-05-01 00:00:00

  • Breast-feeding and gender as moderators of teratogenic effects on cognitive development.

    abstract::Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Jacobson JL,Jacobson SW

    更新日期:2002-05-01 00:00:00

  • Toxicological evaluation of the staircase test for assessing fine motor movements.

    abstract::A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Samsam TE,Gadrinab LG,Bushnell PJ

    更新日期:2004-01-01 00:00:00

  • Very low level environmental exposure to lead and prolactin levels during pregnancy.

    abstract::Lead (Pb) is a well-known poison interfering with calcium homeostasis and dopaminergic pathway. We hypothesized that environmental Pb exposure can interact with prolactin (PRL) secretion, regulated by calcium and dopamine, during pregnancy and in fetus. The objective of this longitudinal study was to determine the rel...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Takser L,Mergler D,Lafond J

    更新日期:2005-05-01 00:00:00

  • Chronic ambient hydrogen sulfide exposure and cognitive function.

    abstract:BACKGROUND:Exposures to hydrogen sulfide gas (H2S) have been inconclusively linked to a variety of negative cognitive outcomes. We investigated possible effects on cognitive function in an urban population with chronic, low-level exposure to H2S. METHODS:Participants were 1637 adults, aged 18-65 years from Rotorua cit...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Reed BR,Crane J,Garrett N,Woods DL,Bates MN

    更新日期:2014-03-01 00:00:00

  • Exacerbation of iminodipropionitrile-induced behavioral toxicity, oxidative stress, and vestibular hair cell degeneration by gentamicin in rats.

    abstract::This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Al Deeb S,Al Moutaery K,Khan HA,Tariq M

    更新日期:2000-03-01 00:00:00