Long-term effects of toluene inhalation on rat behavior.

Abstract:

:The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were made 11 to 35 days after the end of the exposure. The results indicate that toluene exposure causes a long-lasting impairment on the extinction process and reduction in the variability of the baseline response in the operant behavior situation. Toluene also had an effect on the water regulation.

journal_name

Neurotoxicol Teratol

authors

Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U

doi

10.1016/0892-0362(91)90052-x

subject

Has Abstract

pub_date

1991-09-01 00:00:00

pages

475-81

issue

5

eissn

0892-0362

issn

1872-9738

pii

0892-0362(91)90052-X

journal_volume

13

pub_type

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