Environmental enrichment and the behavioral effects of prenatal exposure to alcohol in rats.

abstract：:To identify the frequency range most sensitive to toluene-induced auditory damage, the auditory function of adult Long-Evans rats exposed to 1750 ppm of toluene (6 h/day, 5 days/week, 4 weeks), was tested by recording auditory-evoked potentials directly from the round window of the cochlea. The present electrocochleog...

journal_title：Neurotoxicology and teratology

authors： Lataye R,Campo P,Loquet G

更新日期：1999-05-01 00:00:00

abstract：:The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex o...

journal_title：Neurotoxicology and teratology

authors： Fu Y,He F,Zhang S,Huang J,Zhang J,Jiao X

更新日期：1995-05-01 00:00:00

abstract：:This study examined the effects of chronic postweaning lead (Pb) exposure in Long-Evans rats on a series of spatial alternation tasks. All tasks were administered in automated testing chambers, with a nosepoke as the critical response. While neither Pb-exposed group (median blood lead levels: 19 and 39 micrograms/dl, ...

journal_title：Neurotoxicology and teratology

authors： Alber SA,Strupp BJ

更新日期：1996-01-01 00:00:00

abstract：OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...

journal_title：Neurotoxicology and teratology

authors： Salisbury AL,Lester BM,Seifer R,Lagasse L,Bauer CR,Shankaran S,Bada H,Wright L,Liu J,Poole K

更新日期：2007-05-01 00:00:00

abstract：:Most behavioral teratology studies have focused on pharmaceutical agents. Investigations of developmental toxicity are lacking for the majority of the nearly 100,000 industrial chemicals currently in use. Only some three dozen chemicals have been examined for behavioral/neurochemical deviations in offspring following ...

journal_title：Neurotoxicology and teratology

authors： Nelson BK

更新日期：1990-07-01 00:00:00

abstract：:Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...

journal_title：Neurotoxicology and teratology

authors： Jacobson JL,Jacobson SW

更新日期：2002-05-01 00:00:00

abstract：:The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) leads to the hypothesis that Parkinson's disease (PD) is maybe initiated or precipitated by environmental or endogenous toxins by the mechanism similar to that of MPTP in genetically-predisposed individuals. Endogenous analogs of MPTP, such as beta-c...

journal_title：Neurotoxicology and teratology

authors： Matsubara K,Aoyama K,Suno M,Awaya T

更新日期：2002-09-01 00:00:00

abstract：:A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...

journal_title：Neurotoxicology and teratology

authors： McMichael AJ,Baghurst PA,Vimpani GV,Robertson EF,Wigg NR,Tong SL

更新日期：1992-09-01 00:00:00

abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...

journal_title：Neurotoxicology and teratology

authors： Morris P,Binienda Z,Gillam MP,Klein J,McMartin K,Koren G,Duhart HM,Slikker W Jr,Paule MG

更新日期：1997-01-01 00:00:00

abstract：:Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...

journal_title：Neurotoxicology and teratology

authors： Wolansky MJ,Azcurra JM

更新日期：2005-03-01 00:00:00

abstract：:Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

journal_title：Neurotoxicology and teratology

authors： Oshiro WM,Krantz QT,Bushnell PJ

更新日期：2001-11-01 00:00:00

abstract：:Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...

journal_title：Neurotoxicology and teratology

authors： Minck DR,Erway LC,Vorhees CV

更新日期：1989-05-01 00:00:00

abstract：:Pregnant rats received daily injections of saline, cocaine (20 mg/kg), morphine (2 mg/kg), or the combination of both drugs, on days 13-20 of gestation. Cyclin-dependent kinase 5 (Cdk5) activity was then measured in the resulting pups on postnatal days 1, 7, 14 and 28. Cocaine resulted in a time dependent increase in ...

journal_title：Neurotoxicology and teratology

authors： Bhat R,Chari G,Rao R,Wirtshafter D

更新日期：2006-09-01 00:00:00

abstract：:Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...

journal_title：Neurotoxicology and teratology

authors： Kilburn KH,Warshaw RH

更新日期：1995-03-01 00:00:00

abstract：:To assess teratogenic effects of cocaine exposure and maternal psychological distress on birth outcomes, we conducted a longitudinal prospective study of 415 infants (218 cocaine-exposed--CE, 197 nonexposed--NE). Drug exposure was determined through a combination of maternal self-report, urine, and meconium screens. M...

journal_title：Neurotoxicology and teratology

authors： Singer LT,Salvator A,Arendt R,Minnes S,Farkas K,Kliegman R

更新日期：2002-03-01 00:00:00

abstract：:A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...

journal_title：Neurotoxicology and teratology

authors： Mesbah-Oskui L,Penna A,Orser BA,Horner RL

更新日期：2017-05-01 00:00:00

abstract：:Pregnant Sprague-Dawley rats were fed a liquid diet containing either 0% (group C), 18% (group L), or 36% (group H) ethanol-derived calories (EDC) from gestational day 1 to 20. Male offspring were assessed under a conditioned taste aversion paradigm (PND 35-45), in a complex maze (PND 68-80), and for operant behavior ...

journal_title：Neurotoxicology and teratology

authors： Clausing P,Ferguson SA,Holson RR,Allen RR,Paule MG

更新日期：1995-09-01 00:00:00

abstract：:Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental ...

journal_title：Neurotoxicology and teratology

authors： Silva L,Zhao N,Popp S,Dow-Edwards D

更新日期：2012-01-01 00:00:00

abstract：:The effects of repeated SC administration of soman on schedule-controlled performance and brain pathology were studied in the rat. Soman suppressed response rates in both components of a multiple fixed interval 50-sec fixed-ratio 25 (mult. FI 50-sec FR 25) schedule of reinforcement, although all animals revealed marke...

journal_title：Neurotoxicology and teratology

authors： Hymowitz N,Ploshnick A,Laemle L,Brezenoff H

更新日期：1990-01-01 00:00:00

abstract：:This population-based retrospective cohort study examined Structural Magnetic Resonance Imaging (MRI) of the brain in relation to prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water on Cape Cod, Massachusetts. Subjects were identified through birth records from 1969 through 1...

journal_title：Neurotoxicology and teratology

authors： Janulewicz PA,Killiany RJ,White RF,Martin BM,Winter MR,Weinberg JM,Aschengrau A

更新日期：2013-07-01 00:00:00

abstract：:Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...

journal_title：Neurotoxicology and teratology

authors： Morris-Schaffer K,Sobolewski M,Welle K,Conrad K,Yee M,O'Reilly MA,Cory-Slechta DA

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:We have previously reported the inverse associations between in utero levels of lead (Pb), arsenic (As) (i.e., toxic elements), and neurodevelopmental indicators (i.e., motor and state regulation cluster score) measured by the Brazelton Neonatal Behavioral Assessment Scale, third edition (NBAS III) in this c...

journal_title：Neurotoxicology and teratology

authors： Parajuli RP,Fujiwara T,Umezaki M,Furusawa H,Watanabe C

更新日期：2014-01-01 00:00:00

abstract：:The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...

journal_title：Neurotoxicology and teratology

authors： Minnema DJ,Hammond PB

更新日期：1994-11-01 00:00:00

abstract：:The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were m...

journal_title：Neurotoxicology and teratology

authors： Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U

更新日期：1991-09-01 00:00:00

abstract：:Exposure to ethanol during development can lead to a constellation of congenital anomalies, resulting in prenatal and postnatal failure to thrive, central nervous system (CNS) deficits, and a number of patterning defects that lead to defects in the cardiovascular system, facial structures, and limbs. The cellular, bio...

journal_title：Neurotoxicology and teratology

authors： Carvan MJ 3rd,Loucks E,Weber DN,Williams FE

更新日期：2004-11-01 00:00:00

abstract：:The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (n=8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas natu...

journal_title：Neurotoxicology and teratology

authors： Golub MS,Hogrefe CE,Germann SL,Tran TT,Beard JL,Crinella FM,Lonnerdal B

更新日期：2005-07-01 00:00:00

abstract：:Memory problems lasting 8 months have previously been described for a small group of female solvent workers following an accidental workplace solvent intoxication. Three years after the intoxication the presence of longer-term residual impairment of cognitive functions was evaluated. The major residual difficulty unco...

journal_title：Neurotoxicology and teratology

authors： Stollery BT

更新日期：1996-07-01 00:00:00

abstract：:High exposure to toluene may cause optic neuropathy and retinopathy, both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue-yellow dyschromatopsia. This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined befor...

journal_title：Neurotoxicology and teratology

authors： Muttray A,Wolters V,Jung D,Konietzko J

更新日期：1999-01-01 00:00:00

abstract：:The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested have been shown to cause abnormal brain cell death in animals...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Liu F,Slikker W Jr,Wang C,Paule MG

更新日期：2017-01-01 00:00:00

abstract：:Rapid euthanasia of laboratory rodents without the use of anesthesia is a necessary research technique whenever there is the likelihood of anesthesia or stress interfering with the chemistry of the tissues under investigation. Decapitation has long been the procedure of choice under such circumstances. Recently, howev...

journal_title：Neurotoxicology and teratology

authors： Holson RR

更新日期：1992-07-01 00:00:00