Abstract：
:Exposure to ethanol during development can lead to a constellation of congenital anomalies, resulting in prenatal and postnatal failure to thrive, central nervous system (CNS) deficits, and a number of patterning defects that lead to defects in the cardiovascular system, facial structures, and limbs. The cellular, biochemical, and molecular mechanisms by which ethanol exerts its developmental toxicity and the genes that influence sensitivity to developmental ethanol exposure have yet to be discovered, despite being one of the more common nongenetic causes of birth defects. The zebrafish undergoes much the same patterning and morphogenesis as other vertebrate embryos do--including humans--that are distinct and cannot be studied in invertebrates. Developmental processes in zebrafish are affected by ethanol exposure in a dose-dependent manner, resulting in learning and memory deficits, cell death in the CNS, skeletal dysmorphogenesis, and alterations in startle reflex responses. Interestingly, significant ethanol effects on learning and behavioral endpoints occurred at concentrations well below those that induced cell death in the CNS. This work provides the foundation for identifying genes and pathways involved in developmental alcohol toxicity in vertebrates, leading to a more complete mechanistic understanding of fetal alcohol disorders in humans.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Carvan MJ 3rd,Loucks E,Weber DN,Williams FEdoi
10.1016/j.ntt.2004.06.016subject
Has Abstractpub_date
2004-11-01 00:00:00pages
757-68issue
6eissn
0892-0362issn
1872-9738pii
S0892-0362(04)00097-2journal_volume
26pub_type
杂志文章abstract：:The central and peripheral nervous system effects of acute and subchronic exposure to three organic phosphoro-acid esters (dimethoate, dichlorvos, parathion-methyl) were studied. CNS-dependent variables included mean EEG amplitude, mean frequency of the EEG, and the activity (power density) of six component frequency ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(88)90004-9
更新日期：1988-09-01 00:00:00
abstract：:One hundred and ten, 6- to 11-year-old children from a low-risk, predominantly middle class sample who are participants in an ongoing longitudinal drug study were assessed using a central auditory processing task (SCAN) that made perceptual rather than linguistic demands. Maternal smoking during pregnancy was linearly...
journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
doi：10.1016/0892-0362(94)90048-5
更新日期：1994-05-01 00:00:00
abstract：:Cigarette smoking in pregnant women has been shown to lead to intrauterine growth retardation and fetal death, and possibly also to neural dysmorphology and long-term learning deficits in the offspring. Because the teratogenic agent in cigarette smoke remains controversial, the present study on rat embryos in culture ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90076-9
更新日期：1991-05-01 00:00:00
abstract：:Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of various types of cancer. Patients undergoing cisplatin treatment often suffer from a condition known as "chemobrain", ototoxicity, peripheral neuropathy, weight loss, nausea, vomiting, nephrotoxicity, seizures, hearing loss and tinni...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2012.06.002
更新日期：2012-09-01 00:00:00
abstract：:This is the first in a series of studies investigating the developmental stage-specific neurobehavioral effects of all-trans retinoic acid (RA) exposure. Because high doses of this compound are known to be lethal to the developing organism, we first conducted a dose-response study to identify RA doses that produce low...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(97)00039-1
更新日期：1997-09-01 00:00:00
abstract：BACKGROUND:Exposures to hydrogen sulfide gas (H2S) have been inconclusively linked to a variety of negative cognitive outcomes. We investigated possible effects on cognitive function in an urban population with chronic, low-level exposure to H2S. METHODS:Participants were 1637 adults, aged 18-65 years from Rotorua cit...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2014.02.002
更新日期：2014-03-01 00:00:00
abstract：:AZT (azidothymidine, zidovudine, ZDV) has become the standard medication to prevent the transmission of the human immunodeficiency virus from mother to fetus. The present study was designed to assess the acoustic startle response (ASR) in adult rats that had been perinatally exposed to AZT. Each litter was randomly as...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(02)00317-3
更新日期：2002-11-01 00:00:00
abstract：BACKGROUND:Prenatal tobacco exposure is a risk factor for the development of externalizing behaviors and is associated with several adverse health outcomes. Because pregnancy smoking is a complex behavior with both daily fluctuations and changes over the course of pregnancy, quantifying tobacco exposure is a significan...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.08.003
更新日期：2011-01-01 00:00:00
abstract：:The ability of a neurobehavioral screening battery to differentiate the effects of two pyrethroids, permethrin and cypermethrin, was assessed in this experiment. Although the structures of these pesticides differ only in the alpha-cyano group, the behavioral syndromes associated with the Type I and II pyrethroids are ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(93)90065-v
更新日期：1993-03-01 00:00:00
abstract：:With the implementation of the Food Quality Protection Act in 1996, more detailed evaluations of possible health effects of pesticides on developing organisms have been required. As a result, considerable developmental neurotoxicity (DNT) data have been generated on a variety of endpoints, including developmental chan...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/j.ntt.2007.12.009
更新日期：2008-07-01 00:00:00
abstract：BACKGROUND:General anesthetics (GAs) may exert harmful effects on the developing brain by disrupting neuronal circuit formation. Anesthetics that act on γ-aminobutyric acid (GABA) receptors can interfere with axonal growth cone guidance, a critical process in the assembly of neuronal circuitry. Here we investigate the ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2019.106812
更新日期：2019-01-01 00:00:00
abstract：:Hazard information essential to guide developmental neurotoxicity risk assessments is limited for many chemicals. As developmental neurotoxicity testing using rodents is laborious and expensive, alternative species such as zebrafish are being adapted for rapid toxicity screening. Assessing the developmental neurotoxic...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2009.04.065
更新日期：2010-01-01 00:00:00
abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(96)00187-0
更新日期：1997-01-01 00:00:00
abstract：:Lead (Pb) is a well-known poison interfering with calcium homeostasis and dopaminergic pathway. We hypothesized that environmental Pb exposure can interact with prolactin (PRL) secretion, regulated by calcium and dopamine, during pregnancy and in fetus. The objective of this longitudinal study was to determine the rel...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2005.03.009
更新日期：2005-05-01 00:00:00
abstract：:The effect of subdiaphragmatic vagotomy on the acquisition of a radiation-induced taste aversion was examined to assess the importance of the vagus nerve in transmitting information on the peripheral toxicity of radiation to the brain. Vagotomy had no effect on taste aversion learning, consistent with reports using ot...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(87)90073-0
更新日期：1987-01-01 00:00:00
abstract：:A long-term prospective cohort study was conducted to examine the association between prenatal and postnatal exposure to environmental lead and childhood neuropsychological development. The possible interactive effects of blood lead and some covariates on early development were explored in this study. Our data suggest...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(92)90038-c
更新日期：1992-09-01 00:00:00
abstract：:Adolescence is a period of dramatic neural reorganization creating a period of vulnerability and the possibility for the development of psychopathology. The maturation of various neural circuits during adolescence depends, to a large degree, on one's experiences both physical and psychosocial. This occurs through a pr...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
doi：10.1016/j.ntt.2019.106834
更新日期：2019-01-01 00:00:00
abstract：:Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific per...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2009.08.008
更新日期：2010-03-01 00:00:00
abstract：:A multidisciplinary study to investigate 2,5-hexanedione (2,5-HD)-induced CNS-neurotoxicity and its proposed potentiation by acetone (AC) was conducted. Neurobehavioral testing, estimation of the brain-swelling reaction, neuropathological and morphometric measurements as well as synaptosomal 5-hydroxytryptamine (5-HT)...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90089-f
更新日期：1991-07-01 00:00:00
abstract：:Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and t...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(99)00012-4
更新日期：1999-07-01 00:00:00
abstract：:Maneb, an organomanganese fungicide, is largely used in agricultural regions for control of field crop pathologies. Despite its apparent low toxicity, there are reports showing that maneb has harmful effects on peripheral and central nervous systems. In this work the effects of acute administration of maneb were studi...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90018-4
更新日期：1989-09-01 00:00:00
abstract：:A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....
journal_title：Neurotoxicology and teratology
pub_type：
doi：10.1016/j.ntt.2012.01.008
更新日期：2012-03-01 00:00:00
abstract：:Methylphenidate (MPH) is a psychostimulant commonly used for the treatment of Attention-Deficit Hyperactivity Disorder (ADHD). Since the long-term effects of this drug on the central nervous system (CNS) are not well understood, we conducted microPET/CT scans on young adult male rhesus monkeys (n=4/group) to gather in...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2016.06.005
更新日期：2016-07-01 00:00:00
abstract：:Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2011.10.006
更新日期：2012-01-01 00:00:00
abstract：:Pregnant rats received saline once daily (Control QD) or twice daily (Control BID), cocaine 2 mg/kg IV daily (COC QD) or twice daily (COC BID) throughout gestation beginning on gestational day 4. The treatment was continued in nursing mothers until postnatal day 7. All studies were performed in their offsprings on pos...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(98)00026-9
更新日期：1998-11-01 00:00:00
abstract：:The effects of acute prenatal exposure to ethanol on the postnatal optic nerve have been examined in a C57B1/6J mouse model. Pregnant mice were exposed by intraperitoneal injection to ethanol (25% ethanol, each dose at 0.015 ml/g separated by 4 h), or to saline on the 8th gestational day and the optic nerve examined a...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90113-9
更新日期：1994-03-01 00:00:00
abstract：:Pregnant Sprague-Dawley CD rats were administered phenytoin by gavage on days 7-18 of gestation in doses of 0 or 200 mg/kg. Following completion of a series of behavioral tests (20), progeny (18 months of age) were examined for otoconia in the vestibular labyrinth of the inner ear. None of the controls (N = 22) had re...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90073-1
更新日期：1989-05-01 00:00:00
abstract：:We have utilized a mouse model of transplacental cocaine exposure to investigate the effects of cocaine dose and gestational timing in altering brain and body growth and postnatal behavior in exposed offspring. Pregnant dams were injected with cocaine HCl at 40 mg/kg/day (COC 40) or 20 mg/kg/day (COC 20), or 10 mg/kg/...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(97)00127-x
更新日期：1998-05-01 00:00:00
abstract：:Amitraz is a formamidine pesticide that has been reported to be a neurotoxic compound that induces convulsions among other effects. Excitatory and inhibitory neurotransmission is mediated mainly by glutamate and GABA, respectively, so their alteration could be responsible for induction of seizures. In this regard, ami...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2015.06.007
更新日期：2015-07-01 00:00:00
abstract：:The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex o...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)00076-p
更新日期：1995-05-01 00:00:00
