Anesthetics disrupt growth cone guidance cue sensing through actions on the GABAA α2 receptor mediated by the immature chloride gradient.

abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

journal_title：Neurotoxicology and teratology

authors： Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

更新日期：2000-11-01 00:00:00

abstract：:Because of the important role of glial cells in brain maturation and reports on their delayed proliferation following ethanol exposure, it was considered of interest to investigate the mechanism of ethanol action on these cells. Biochemical parameters related to the apoptotic and necrotic processes in astroglial cells...

journal_title：Neurotoxicology and teratology

authors： Holownia A,Ledig M,Ménez JF

更新日期：1997-03-01 00:00:00

abstract：:We examined the relationship between acquired color vision loss and exposure to toluene and total hydrocarbons among 125 male workers. Seventy-two toluene-exposed printers were compared with 34 workers from the same photogravure plant with ambient background exposure, and with 19 workers from a bookbinding plant locat...

journal_title：Neurotoxicology and teratology

authors： Campagna D,Stengel B,Mergler D,Limasset JC,Diebold F,Michard D,Huel G

更新日期：2001-09-01 00:00:00

abstract：:Fifty nondrug-exposed infants and 74 cocaine/polydrug-exposed infants were evaluated on the Movement Assessment of Infants (MAI). The test provides an assessment of risk for motor dysfunction at age 4 months. There was a significant difference in total risk scores between the two groups of infants with cocaine-exposed...

journal_title：Neurotoxicology and teratology

authors： Schneider JW,Chasnoff IJ

更新日期：1992-03-01 00:00:00

abstract：:The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the...

journal_title：Neurotoxicology and teratology

authors： Win-Shwe TT,Kunugita N,Yoshida Y,Fujimaki H

更新日期：2011-09-01 00:00:00

abstract：:This paper discusses issues pertaining to the validity, precision, and interpretation of epidemiologic studies of neurotoxicity. With regard to validity, the critical issues pertain to the appropriate strategy for confounder adjustment, particularly when confounders are complex, multi-faceted constructs, and to the ne...

journal_title：Neurotoxicology and teratology

authors： Bellinger DC

更新日期：2009-09-01 00:00:00

abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

journal_title：Neurotoxicology and teratology

authors： Vorhees CV

更新日期：1989-03-01 00:00:00

abstract：:Toluene can be considered an ototoxic chemical compound in the rat. Outer hair cells are particularly sensitive to this aromatic organic solvent or to one of its metabolites. The objective of the present study was to evaluate the possible role played by cysteine S-conjugates in the ototoxic process in Long-Evans rats....

journal_title：Neurotoxicology and teratology

authors： Waniusiow D,Campo P,Cossec B,Cosnier F,Grossman S,Ferrari L

更新日期：2008-05-01 00:00:00

abstract：:Perfluorinated alkyls are widely-used agents that accumulate in ecosystems and organisms because of their slow rate of degradation. There is increasing concern that these agents may be developmental neurotoxicants and the present study was designed to develop an avian model for the neurobehavioral teratogenicity of pe...

journal_title：Neurotoxicology and teratology

authors： Pinkas A,Slotkin TA,Brick-Turin Y,Van der Zee EA,Yanai J

更新日期：2010-03-01 00:00:00

abstract：:This population-based retrospective cohort study examined Structural Magnetic Resonance Imaging (MRI) of the brain in relation to prenatal and early postnatal exposure to tetrachloroethylene (PCE)-contaminated drinking water on Cape Cod, Massachusetts. Subjects were identified through birth records from 1969 through 1...

journal_title：Neurotoxicology and teratology

authors： Janulewicz PA,Killiany RJ,White RF,Martin BM,Winter MR,Weinberg JM,Aschengrau A

更新日期：2013-07-01 00:00:00

abstract：:The present study provides a characterization of the behavioral changes induced in preweaning mice by prenatal exposure to lamivudine (3TC), an antiviral drug recently entered in the clinical practice to treat HIV patients. Pregnant CD1 mice were given per os bidaily either 3TC at different doses (125, 250, or 500 mg/...

journal_title：Neurotoxicology and teratology

authors： Calamandrei G,Venerosi A,Branchi I,Valanzano A,Puopolo M,Alleva E

更新日期：1999-07-01 00:00:00

abstract：:Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...

journal_title：Neurotoxicology and teratology

authors： Kilburn KH,Warshaw RH

更新日期：1995-03-01 00:00:00

abstract：:Terbutaline, a β2-adrenoceptor agonist, is used off-label for long-term management of preterm labor; such use is associated with increased risk of neurodevelopmental disorders, including autism spectrum disorders. We explored the mechanisms underlying terbutaline's effects on development of peripheral sympathetic proj...

journal_title：Neurotoxicology and teratology

authors： Slotkin TA,Seidler FJ

更新日期：2013-03-01 00:00:00

abstract：:While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, ...

journal_title：Neurotoxicology and teratology

authors： MacPhail RC,Jarema KA

更新日期：2005-09-01 00:00:00

abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...

journal_title：Neurotoxicology and teratology

authors： Morris P,Binienda Z,Gillam MP,Klein J,McMartin K,Koren G,Duhart HM,Slikker W Jr,Paule MG

更新日期：1997-01-01 00:00:00

abstract：:Brain-derived neurotrophic factor (BDNF) is a neurotrophin critical for many developmental and physiological aspects of CNS function. Severe hypothyroidism in the early neonatal period results in developmental and cognitive impairments and reductions in mRNA and protein expression of BDNF in a number of brain regions....

journal_title：Neurotoxicology and teratology

authors： Lasley SM,Gilbert ME

更新日期：2011-07-01 00:00:00

abstract：:Animals exposed prenatally to alcohol (4 g/kg/day) via maternal peroral intubation or control offspring were reared after weaning either alone in standard steel/wire cages or in groups of eight, for 6 weeks. Rats exposed prenatally to alcohol and reared in isolation had a dysmetric stride length indicative of an ataxi...

journal_title：Neurotoxicology and teratology

authors： Hannigan JH,Berman RF,Zajac CS

更新日期：1993-07-01 00:00:00

abstract：:The prevalence and magnitude of effect of individual risk markers for specific developmental disorders vary widely across diagnostic category. The four study cohorts for this project were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SI...

journal_title：Neurotoxicology and teratology

authors： Klug MG,Burd L,Kerbeshian J,Benz B,Martsolf JT

更新日期：2003-11-01 00:00:00

abstract：:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...

journal_title：Neurotoxicology and teratology

authors： Yin HS,Tan HW

更新日期：2007-03-01 00:00:00

abstract：:Pregnant C57BL/6 mice were chronically treated with 0, 4, 6, or 8 ppm of methylmercury chloride (MeHg) in drinking water during fetal and early postnatal development. Four behavioral functions were analyzed in female and male offspring between the age of 6 and 12 weeks: motor coordination learning on the rotarod; trai...

journal_title：Neurotoxicology and teratology

authors： Goulet S,Doré FY,Mirault ME

更新日期：2003-05-01 00:00:00

abstract：:This paper discusses the application of repeated measures methods in the statistical analysis of an experiment in behavioral toxicology. The chronic marijuana smoke exposure study conducted at the National Center for Toxicological Research is used for an example of the types of problems that one encounters in analyzin...

journal_title：Neurotoxicology and teratology

authors： Allen RR,Slikker W Jr,Paule MG

更新日期：1990-09-01 00:00:00

abstract：:The discovery of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) leads to the hypothesis that Parkinson's disease (PD) is maybe initiated or precipitated by environmental or endogenous toxins by the mechanism similar to that of MPTP in genetically-predisposed individuals. Endogenous analogs of MPTP, such as beta-c...

journal_title：Neurotoxicology and teratology

authors： Matsubara K,Aoyama K,Suno M,Awaya T

更新日期：2002-09-01 00:00:00

abstract：:Prenatal cocaine or nicotine exposure is associated with a variety of teratogenic effects. The current study was conducted to determine their effects alone and in combination on cognitive function and sexual differentiation. Pregnant Long-Evans rats (N = 19) were exposed to either cocaine (15 mg/kg/dose b.i.d. SC on G...

journal_title：Neurotoxicology and teratology

authors： Cutler AR,Wilkerson AE,Gingras JL,Levin ED

更新日期：1996-11-01 00:00:00

abstract：OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...

journal_title：Neurotoxicology and teratology

authors： Salisbury AL,Lester BM,Seifer R,Lagasse L,Bauer CR,Shankaran S,Bada H,Wright L,Liu J,Poole K

更新日期：2007-05-01 00:00:00

abstract：:Three experimental groups and one control group of Long-Evans rats were used to study the combined effects of toluene and ethanol on auditory function. The first experimental group was exposed to toluene vapors (1750 ppm, 6 h/day, 5 days/week, 4 weeks), the second one was daily gavaged with a saline solution of ethano...

journal_title：Neurotoxicology and teratology

authors： Campo P,Lataye R,Cossec B,Villette V,Roure M,Barthelemy C

更新日期：1998-05-01 00:00:00

abstract：:This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

journal_title：Neurotoxicology and teratology

authors： Al Deeb S,Al Moutaery K,Khan HA,Tariq M

更新日期：2000-03-01 00:00:00

abstract：:The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post...

journal_title：Neurotoxicology and teratology

authors： Goffeng LO,Heier MS,Kjuus H,Sjöholm H,Sørensen KA,Skaug V

更新日期：2008-05-01 00:00:00

abstract：:Previous studies have shown that maternal doses of 1 microg/kg or less of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in late gestation can demasculinize and feminize reproductive behavior in male rats. However, it was not known whether coplanar polychlorinated biphenyls (PCBs) had similar effects, or whether non-repro...

journal_title：Neurotoxicology and teratology

authors： Amin S,Moore RW,Peterson RE,Schantz SL

更新日期：2000-09-01 00:00:00

abstract：:The effects of maternal urinary tract infection (UTI) or endotoxin exposure on fetal outcome in rats were investigated. Prior to conception, dams of the UTI group were water-deprived and anesthetized. The urinary tract was then catheterized and injected with 0.2 of 1 x 10(9) Escherichia coli. The endotoxin group was i...

journal_title：Neurotoxicology and teratology

authors： Cronise K,Kelly SJ

更新日期：2001-07-01 00:00:00

abstract：:Exposing rats to the anticholinesterase (anti-ChE) diisopropyl fluorophosphate (DFP) causes a transient period of hypothermia followed by a period of hyperthermia lasting approximately 48 h. Because a fever is a predominant thermoregulatory response in humans exposed to anti-ChE pesticides, the hyperthermic response i...

journal_title：Neurotoxicology and teratology

authors： Gordon CJ

更新日期：1995-11-01 00:00:00