Prenatal ethanol exposure in rats: long-lasting effects on learning.

abstract：:In the United States, the regulation and testing of chemicals that may impact on human health is mandated by a number of different laws and regulated by several government agencies. Toxicologic screening in laboratory animals has created a major database for predicting adverse health effects of drugs, food and cosmeti...

journal_title：Neurotoxicology and teratology

authors： Steinberg M

更新日期：1987-11-01 00:00:00

abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

journal_title：Neurotoxicology and teratology

authors： Vorhees CV

更新日期：1989-03-01 00:00:00

abstract：:Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. 1.8.3.1). The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...

journal_title：Neurotoxicology and teratology

authors： Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar A

更新日期：2005-01-01 00:00:00

abstract：:We examined the relationship between acquired color vision loss and exposure to toluene and total hydrocarbons among 125 male workers. Seventy-two toluene-exposed printers were compared with 34 workers from the same photogravure plant with ambient background exposure, and with 19 workers from a bookbinding plant locat...

journal_title：Neurotoxicology and teratology

authors： Campagna D,Stengel B,Mergler D,Limasset JC,Diebold F,Michard D,Huel G

更新日期：2001-09-01 00:00:00

abstract：:Mitochondrial DNA (mtDNA) mutations are hypothesized to play a pathogenic role in aging and age-related neurodegenerative diseases such as Parkinson's disease (PD). In support of this, high levels of somatic mtDNA mutations in “POLG mutator” mice carrying a proofreading-deficient form of mtDNA polymerase ã (Polg(D257A...

journal_title：Neurotoxicology and teratology

authors： Dai Y,Clark J,Zheng K,Kujoth GC,Prolla TA,Simon DK

更新日期：2014-11-01 00:00:00

abstract：:Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3...

journal_title：Neurotoxicology and teratology

authors： Fukumura M,Cappon GD,Broening HW,Vorhees CV

更新日期：1998-07-01 00:00:00

abstract：OBJECTIVE:The concurrence of prenatal alcohol exposure with other drug exposure, low socioeconomic status and environmental risk factors may obscure associations, if any, between prenatal cocaine exposure and child outcomes. This study evaluates the effects of prenatal cocaine exposure on child behavior in analyses str...

journal_title：Neurotoxicology and teratology

authors： Sood BG,Nordstrom Bailey B,Covington C,Sokol RJ,Ager J,Janisse J,Hannigan JH,Delaney-Black V

更新日期：2005-03-01 00:00:00

abstract：:We examined the distribution of cocaine and its metabolites benzoylecgonine (BE) and norcocaine (NOR) in pregnant Sprague-Dawley rats and fetuses following twice-daily subcutaneous (s.c.) injections of 20 mg/kg cocaine HCl from gestational day (GD) 8 through GD 20. On GD 21, the animals received a single injection and...

journal_title：Neurotoxicology and teratology

authors： Collins LM,Pahl JA,Meyer JS

更新日期：1999-11-01 00:00:00

abstract：:High exposure to toluene may cause optic neuropathy and retinopathy, both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue-yellow dyschromatopsia. This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined befor...

journal_title：Neurotoxicology and teratology

authors： Muttray A,Wolters V,Jung D,Konietzko J

更新日期：1999-01-01 00:00:00

abstract：:Sensory-evoked potentials (EPs) were studied in male Long-Evans and Fischer-344 rats in order to characterize the electrophysiological consequences of chronic inhalation exposure to trichloroethylene (TCE). Groups of ten Long-Evans rats were exposed to air or 1600 ppm or 3200 ppm TCE for twelve weeks and evaluated per...

journal_title：Neurotoxicology and teratology

authors： Rebert CS,Day VL,Matteucci MJ,Pryor GT

更新日期：1991-01-01 00:00:00

abstract：:The identification of mechanisms and outcomes for neurobehavioral teratogenesis is critical to our ability to develop therapies to ameliorate or reverse the deleterious effects of exposure to developmental neurotoxicants. We established mechanistically-based complementary models for the study of cholinergic systems in...

journal_title：Neurotoxicology and teratology

authors： Yanai J,Brick-Turin Y,Dotan S,Langford R,Pinkas A,Slotkin TA

更新日期：2010-01-01 00:00:00

abstract：:Reversible protein phosphorylation is a central mechanism regulating many biological functions, and abnormal protein phosphorylation can have a devastating impact on cellular control mechanisms, including a contributing role in neurodegenerative processes. Hence, many promising novel drug development strategies involv...

journal_title：Neurotoxicology and teratology

authors： Amador FC,Henriques AG,da Cruz E Silva OA,da Cruz E Silva EF

更新日期：2004-05-01 00:00:00

abstract：:Cocaine-induced conditioned place preference (CPP) was tested in adult offspring of Sprague-Dawley dams that had been injected subcutaneously with 40 mg/kg/3cc cocaine HCl (C40) daily from gestational days 8-20, pair-fed (PF) dams injected with saline, and nontreated control (LC) dams. C40 and PF dams gained significa...

journal_title：Neurotoxicology and teratology

authors： Heyser CJ,Miller JS,Spear NE,Spear LP

更新日期：1992-01-01 00:00:00

abstract：:The effect of subdiaphragmatic vagotomy on the acquisition of a radiation-induced taste aversion was examined to assess the importance of the vagus nerve in transmitting information on the peripheral toxicity of radiation to the brain. Vagotomy had no effect on taste aversion learning, consistent with reports using ot...

journal_title：Neurotoxicology and teratology

authors： Hunt WA,Rabin BM,Lee J

更新日期：1987-01-01 00:00:00

abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

journal_title：Neurotoxicology and teratology

authors： Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

更新日期：2000-11-01 00:00:00

abstract：:A study of possible undue neurobehavioral effects of low-level lead exposure was performed in Danish school children who entered first grade in 1982. Lead absorption was found to relate to impaired psychological test performance and difficulties at school. However, this relationship was confounded by medical risk fact...

journal_title：Neurotoxicology and teratology

authors： Lyngbye T,Hansen ON,Grandjean P

更新日期：1988-11-01 00:00:00

abstract：:The prevalence and magnitude of effect of individual risk markers for specific developmental disorders vary widely across diagnostic category. The four study cohorts for this project were patients from four diagnostic registries in North Dakota for fetal alcohol syndrome (FAS), autism, sudden infant death syndrome (SI...

journal_title：Neurotoxicology and teratology

authors： Klug MG,Burd L,Kerbeshian J,Benz B,Martsolf JT

更新日期：2003-11-01 00:00:00

abstract：:The potential of emamectin benzoate (EB) to cause developmental neurotoxicity in Sprague-Dawley rats was assessed using a study design by the US EPA. Dosages of 0 (deionized water), 0.1, 0.6, or 3.6 mg/kg/day were administered at 5 ml/kg by oral gavage from gestational day (GD) 6 to lactational day (LD) 20 to groups o...

journal_title：Neurotoxicology and teratology

authors： Wise LD,Allen HL,Hoe CM,Verbeke DR,Gerson RJ

更新日期：1997-07-01 00:00:00

abstract：:Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

journal_title：Neurotoxicology and teratology

authors： Oshiro WM,Krantz QT,Bushnell PJ

更新日期：2001-11-01 00:00:00

abstract：:A pharmacological challenge of nonhuman primate open field behavior, similar to that which previously assessed the cholinergic system (10), was used here to measure potential lead-induced alterations in the dopaminergic system. Monkeys that had been treated with lead during the first year postpartum were assessed at 7...

journal_title：Neurotoxicology and teratology

authors： Ferguson SA,Felipa HN,Bowman RE

更新日期：1996-03-01 00:00:00

abstract：:Behavioral and neurochemical analyses were conducted on preweanling CD rats prenatally exposed to either 0, 0.375 or 0.750 mg/kg/day reserpine SC on gestation days 12-15. Offspring body weights were taken on test days, and pups were tested for negative geotaxis responding on postnatal day 8, developmental activity on ...

journal_title：Neurotoxicology and teratology

authors： Buelke-Sam J,Ali SF,Kimmel GL,Slikker W Jr,Newport GD,Harmon JR

更新日期：1989-09-01 00:00:00

abstract：:A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...

journal_title：Neurotoxicology and teratology

authors： Dick RB,Krieg EF Jr,Sim MA,Bernard BP,Taylor BT

更新日期：1997-11-01 00:00:00

abstract：:We have utilized a mouse model of transplacental cocaine exposure to investigate the effects of cocaine dose and gestational timing in altering brain and body growth and postnatal behavior in exposed offspring. Pregnant dams were injected with cocaine HCl at 40 mg/kg/day (COC 40) or 20 mg/kg/day (COC 20), or 10 mg/kg/...

journal_title：Neurotoxicology and teratology

authors： Wilkins AS,Jones K,Kosofsky BE

更新日期：1998-05-01 00:00:00

abstract：:Preclinical studies suggest that propofol may cause damage to immature neurons. However, the effect of maternal propofol exposure on the neuronal development of the offspring is largely unknown. In this study, pregnant rats were assigned to receive continuous infusion of saline (control) or propofol for 1 h (1HP) or 2...

journal_title：Neurotoxicology and teratology

authors： Li J,Xiong M,Alhashem HM,Zhang Y,Tilak V,Patel A,Siegel A,Ye JH,Bekker A

更新日期：2014-05-01 00:00:00

abstract：:We hypothesized that prenatal cocaine exposure results in less optimal infant behavior and more impaired maternal-infant interaction in healthy term infants. Infants were evaluated with the Neonatal Behavioral Assessment Scale (NBAS) at days 1-3 and 11-30 of age, and mother-infant pairs with the Nursing Child Assessme...

journal_title：Neurotoxicology and teratology

authors： Neuspiel DR,Hamel SC,Hochberg E,Greene J,Campbell D

更新日期：1991-03-01 00:00:00

abstract：:Neurobehavioral studies often employ test batteries and confront issues of multiple testing and comparability between batteries. We have organized our battery of 12 tests into areas of neurobehavioral function to reduce the number of reported results, provide greater statistical power, and improve interpretability of ...

journal_title：Neurotoxicology and teratology

authors： Heyer NJ,Bittner AC Jr,Echeverria D

更新日期：1996-07-01 00:00:00

abstract：:In spite of significant efforts, the neurobehavioral deficits in infants born from cocaine-abusing mothers have not been clearly defined. In the present study, we examined the presence of these abnormalities in a rhesus monkey model of prenatal cocaine exposure using a nonhuman primate adaptation of the Neonatal Behav...

journal_title：Neurotoxicology and teratology

authors： He N,Bai J,Champoux M,Suomi SJ,Lidow MS

更新日期：2004-01-01 00:00:00

abstract：:Long-Evans rats with micrencephaly induced by prenatal exposure to methylazoxymethanol acetate and normal controls were trained in a two-choice box to discriminate between stimuli of different brightness (black vs. white) or pattern (horizontal vs. vertical alternating black-and-white stripes). Mild footshock was used...

journal_title：Neurotoxicology and teratology

authors： Rabe A,Lee MH

更新日期：1990-07-01 00:00:00

abstract：:This longitudinal study evaluated whether the level of intrauterine cocaine exposure (IUCE) or the interaction between IUCE and contextual variables was related during middle childhood to executive functioning, as assessed with the Stroop Color-Word and Rey Osterrieth Complex Figure tests. The Stroop Interference scor...

journal_title：Neurotoxicology and teratology

authors： Rose-Jacobs R,Waber D,Beeghly M,Cabral H,Appugleise D,Heeren T,Marani J,Frank DA

更新日期：2009-05-01 00:00:00

abstract：:This paper discusses issues pertaining to the validity, precision, and interpretation of epidemiologic studies of neurotoxicity. With regard to validity, the critical issues pertain to the appropriate strategy for confounder adjustment, particularly when confounders are complex, multi-faceted constructs, and to the ne...

journal_title：Neurotoxicology and teratology

authors： Bellinger DC

更新日期：2009-09-01 00:00:00