Abstract：
:Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3 days posttreatment for the determination of dopamine (DA), serotonin (5-HT), and metabolites. MA induced significant monoamine reductions but the magnitude of these reductions was not significantly different between males and females. In the MA 5 mg/kg groups, neostriatal DA content was reduced by 51.2% and 44.8%, whereas 5-HT content was reduced by 30.6% and 23.9% of controls for males and females, respectively. In the MA 10 mg/kg groups, neostriatal DA content was reduced by 72.9% and 65.8%, whereas striatal 5-HT content was reduced by 77.4% and 73.6% of controls for males and females, respectively. No significant differences in thermal responses to MA were observed between genders. Unlike reports in mice, gender does not play a role in MA-induced monoamine reductions in rat neostriatum when MA-induced hyperthermia is comparable across sexes. The data also showed a threshold effect in which dopamine depletions were not correlated with hyperthermia at core body temperatures above approximately 41 degrees C.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Fukumura M,Cappon GD,Broening HW,Vorhees CVdoi
10.1016/s0892-0362(97)00094-9subject
Has Abstractpub_date
1998-07-01 00:00:00pages
441-8issue
4eissn
0892-0362issn
1872-9738pii
S0892-0362(97)00094-9journal_volume
20pub_type
杂志文章abstract：:Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...
journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2005.11.002
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90027-2
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2010.01.006
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journal_title：Neurotoxicology and teratology
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pub_type： 杂志文章
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pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2012.07.003
更新日期：2013-03-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(92)90015-3
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
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更新日期：2012-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2017.11.001
更新日期：2018-01-01 00:00:00
