Abstract：
:Ochratoxin A (a mycotoxin) is known to cause cell death in the developing brain of embryos 1-2 days after treatment. Microcephaly was observed with high frequency in mice by prenatal treatment with ochratoxin A. Using a stereological method, the numerical densities of neurons and synapses were investigated in the somatosensory cortex of 6-week-old microcephalic mice. The numerical density of neurons in ochratoxin A-treated mice represented a 39% increase compared to the control mice, but there was no difference in the numerical density of synapses. The somatosensory cortices of control mice had about 13,000 synapses per neuron, whereas ochratoxin A-treated mice had about 9,400 synapses per neuron. The deficits in synapse-to-neuron ratios seen in ochratoxin A-induced microcephalic brain seemed to result from a reduced dendritic growth.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Fukui Y,Hayasaka S,Itoh M,Takeuchi Ydoi
10.1016/0892-0362(92)90015-3subject
Has Abstractpub_date
1992-05-01 00:00:00pages
191-6issue
3eissn
0892-0362issn
1872-9738pii
0892-0362(92)90015-3journal_volume
14pub_type
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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更新日期：1988-07-01 00:00:00
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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abstract：:The effect of subdiaphragmatic vagotomy on the acquisition of a radiation-induced taste aversion was examined to assess the importance of the vagus nerve in transmitting information on the peripheral toxicity of radiation to the brain. Vagotomy had no effect on taste aversion learning, consistent with reports using ot...
journal_title：Neurotoxicology and teratology
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