Effects of amphetamine on serotoninergic and GABAergic expression of developing brain.


:Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 days and then withdrawn from Amph for 0 or 14 days; these animals received single injections on day 15 (W0d) or day 29 (W14d). Following Amph injections, though both age groups exhibited hyperlocomotion, stereotypy and behavioral sensitization, the juvenile showed 100-300% longer latencies to reach and 30%-42% shorter duration of maximal behavioral scores than the adult from day 2-29. Immunocytochemical analysis revealed down-regulation of 42-76% in 5-hydroxytryptamine (HT) immunoreactive processes in motor and somatosensory cortices, and hippocampus of both ages after Amph exposure at W0d. At W14d, the 5-HT resembled saline-control in the Amph-treated juvenile, whereas remained weakened in the adult. By contrast, densities of GAD67 (glutamic acid decarboxylase)-boutons were up-regulated by 35-545% in the neocortical areas, nucleus accumbens, caudate-putamen and hippocampus of all Amph-administered rats. After 14 days withdrawal, the juvenile recovered the decreased 5-HT fibers, but not the increased GABAergic, indicating unique roles of the two systems in response to Amph.


Neurotoxicol Teratol


Yin HS,Tan HW




Has Abstract


2007-03-01 00:00:00














  • Exposure to mephedrone during gestation increases the risk of stillbirth and induces hippocampal neurotoxicity in mice offspring.

    abstract::In recent years, abuse of synthetic cathinones, in particular, mephedrone, has increased among young adults worldwide. The study aim is to investigate the effects of mephedrone exposure during the gestational period on mice offspring outcomes, focusing on hippocampal neurotoxicity. The pregnant mice received mephedron...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Naseri G,Fazel A,Golalipour MJ,Haghir H,Sadeghian H,Mojarrad M,Hosseini M,Shahrokhi Sabzevar S,Beheshti F,Ghorbani A

    更新日期:2018-01-01 00:00:00

  • Effect of early lead exposure on the maturation of children's postural balance: a longitudinal study.

    abstract::This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

    更新日期:2006-05-01 00:00:00

  • Zebrafish as potential model for developmental neurotoxicity testing: a mini review.

    abstract::The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: de Esch C,Slieker R,Wolterbeek A,Woutersen R,de Groot D

    更新日期:2012-11-01 00:00:00

  • Gestational toluene exposure effects on spontaneous and amphetamine-induced locomotor behavior in rats.

    abstract::Gestational Toluene Exposure Effects on Spontaneous and Amphetamine-Induced Locomotor Behavior in Rats. Bowen, S.E., Mohammadi, M.H., Batis, J.C., and Hannigan, J.H. Neurotoxicology and Teratology, XX, 2006. The abuse of volatile organic solvents (inhalants) continues to be a major health concern throughout the world....

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Bowen SE,Mohammadi MH,Batis JC,Hannigan JH

    更新日期:2007-03-01 00:00:00

  • Reduced expression of α5GABAA receptors elicits autism-like alterations in EEG patterns and sleep-wake behavior.

    abstract::A reduction in the activity of GABAA receptors, particularly α5 subunit-containing GABAA receptors (α5GABAARs), has been implicated in the etiology of Autism Spectrum Disorders (ASD). Genetically modified mice that lack α5GABAARs (Gabra5-/-) exhibit autism-like behaviors and both enhanced and impaired learning and mem...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Mesbah-Oskui L,Penna A,Orser BA,Horner RL

    更新日期:2017-05-01 00:00:00

  • WITHDRAWN: Use of Interval Schedules to Examine Motivation and Sustained Attention.

    abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Cross NC,Chelonis JJ,Finch MN,Edwards MC,Baldwin RL

    更新日期:2009-02-05 00:00:00

  • Effects of cocaine/polydrug exposure and maternal psychological distress on infant birth outcomes.

    abstract::To assess teratogenic effects of cocaine exposure and maternal psychological distress on birth outcomes, we conducted a longitudinal prospective study of 415 infants (218 cocaine-exposed--CE, 197 nonexposed--NE). Drug exposure was determined through a combination of maternal self-report, urine, and meconium screens. M...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Singer LT,Salvator A,Arendt R,Minnes S,Farkas K,Kliegman R

    更新日期:2002-03-01 00:00:00

  • Neuroglial responses to the dopaminergic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mouse striatum.

    abstract::We have studied the reactive responses of both astrocytes and microglia to dopaminergic denervation of the striatum by MPTP. Following MPTP treatment, increased GFAP immunoreactivity reached a peak at 2 days and persisted for at least 6 weeks. Immunoreactivity to vimentin was also markedly increased in astrocytes 48 h...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Francis JW,Von Visger J,Markelonis GJ,Oh TH

    更新日期:1995-01-01 00:00:00

  • Very low level environmental exposure to lead and prolactin levels during pregnancy.

    abstract::Lead (Pb) is a well-known poison interfering with calcium homeostasis and dopaminergic pathway. We hypothesized that environmental Pb exposure can interact with prolactin (PRL) secretion, regulated by calcium and dopamine, during pregnancy and in fetus. The objective of this longitudinal study was to determine the rel...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Takser L,Mergler D,Lafond J

    更新日期:2005-05-01 00:00:00

  • Low-level lead exposure triggers neuronal apoptosis in the developing mouse brain.

    abstract::While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Dribben WH,Creeley CE,Farber N

    更新日期:2011-07-01 00:00:00

  • Cognitive and biochemical effects of monosodium glutamate and aspartame, administered individually and in combination in male albino mice.

    abstract::The present study was designed to investigate the in vivo effects of monosodium glutamate (MSG) and aspartame (ASM) individually and in combination on the cognitive behavior and biochemical parameters like neurotransmitters and oxidative stress indices in the brain tissue of mice. Forty male Swiss albino mice were ran...

    journal_title:Neurotoxicology and teratology

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    authors: Abu-Taweel GM,A ZM,Ajarem JS,Ahmad M

    更新日期:2014-03-01 00:00:00

  • Impaired glutamatergic and GABAergic transmission by amitraz in primary hippocampal cells.

    abstract::Amitraz is a formamidine pesticide that has been reported to be a neurotoxic compound that induces convulsions among other effects. Excitatory and inhibitory neurotransmission is mediated mainly by glutamate and GABA, respectively, so their alteration could be responsible for induction of seizures. In this regard, ami...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Del Pino J,Frejo MT,Baselga MJ,Moyano P,Díaz MJ

    更新日期:2015-07-01 00:00:00

  • Prenatal cocaine exposure and postnatal hypoxia independently decrease carotid body dopamine in neonatal rats.

    abstract::The effects of prenatal cocaine exposure on the levels of carotid body dopamine (DA) and its metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) were investigated in 5-day-old rat pups exposed to normoxic and hypoxic conditions. Timed-pregnant Sprague-Dawley rats were injected b.i.d. with ei...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Lipton JW,Yuengsrigul A,Ling ZD,Weese-Mayer DE,Carvey PM

    更新日期:1996-05-01 00:00:00

  • Behavioral evaluations in developmental toxicity testing: MARTA survey results.

    abstract::During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Lochry EA,Johnson C,Wier PJ

    更新日期:1994-01-01 00:00:00

  • Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates.

    abstract::Brain-derived neurotrophic factor (BDNF) is a neurotrophin critical for many developmental and physiological aspects of CNS function. Severe hypothyroidism in the early neonatal period results in developmental and cognitive impairments and reductions in mRNA and protein expression of BDNF in a number of brain regions....

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Lasley SM,Gilbert ME

    更新日期:2011-07-01 00:00:00

  • Permanent motor activity and learning disorders induced by exposure to phenytoin during gestation and early infancy in the rat.

    abstract::Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Wolansky MJ,Azcurra JM

    更新日期:2005-03-01 00:00:00

  • An update on incidence of FAS: FAS is not an equal opportunity birth defect.

    abstract::The incidence of Fetal Alcohol Syndrome is now estimated at 0.97 cases per 1,000 live births in the general obstetric population and 4.3% among "heavy" drinkers. The general incidence is more than 20 times higher in the United States (1.95 per 1,000) compared to Europe and other countries (0.08 per 1,000). Within the ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Abel EL

    更新日期:1995-07-01 00:00:00

  • Characterizing tolerance to trichloroethylene (TCE): effects of repeated inhalation of TCE on performance of a signal detection task in rats.

    abstract::Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Oshiro WM,Krantz QT,Bushnell PJ

    更新日期:2001-11-01 00:00:00

  • Effects of repeated administration of soman on schedule-controlled behavior and brain in the rat.

    abstract::The effects of repeated SC administration of soman on schedule-controlled performance and brain pathology were studied in the rat. Soman suppressed response rates in both components of a multiple fixed interval 50-sec fixed-ratio 25 (mult. FI 50-sec FR 25) schedule of reinforcement, although all animals revealed marke...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Hymowitz N,Ploshnick A,Laemle L,Brezenoff H

    更新日期:1990-01-01 00:00:00

  • Prenatal exposure to anti-HIV drugs. long-term neurobehavioral effects of lamivudine (3TC) in CD-1 mice.

    abstract::The present study was aimed at investigating the long-term effects of prenatal exposure to lamivudine (3TC), an antiretroviral drug used in clinical practice alone or in combination with zidovudine (AZT) to prevent mother-to-child transmission of the HIV virus. Pregnant CD-1 mice were given per os twice daily either 3...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Calamandrei G,Venerosi A,Branchi I,Valanzano A,Alleva E

    更新日期:2000-05-01 00:00:00

  • Neuropsychological and psychiatric functioning in sheep farmers exposed to low levels of organophosphate pesticides.

    abstract::The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acut...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Mackenzie Ross SJ,Brewin CR,Curran HV,Furlong CE,Abraham-Smith KM,Harrison V

    更新日期:2010-07-01 00:00:00

  • Does chronic prenatal methadone exposure affect beta-receptor subtypes in placental, fetal and maternal brain homogenates?

    abstract::Computer competition analysis of 3H-DHA (3H-dihydroalprenolol, a nonselective beta-adrenergic radioligand) binding in the presence of unlabeled metoprolol (a beta 1-selective antagonist) indicates the existence of both beta 1- and beta 2-adrenergic receptor subtypes in the rat placenta and confirms previous reports th...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Darmani NA,Schnoll SH,Fuchs B,Martin BR

    更新日期:1991-01-01 00:00:00

  • Behavioral deficits due to prenatal exposure to cadmium chloride in CFY rat pups.

    abstract::The postnatal behavioral effects of 0.20, 0.62 and 2.0 mg/kg cadmium chloride administered to pregnant CFY rats on gestational days 7 through 15 were evaluated. Offspring were tested starting on postnatal day 23 on a rotorod for motor coordination, in an open field device for motor activity and emotionality, in a wate...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Lehotzky K,Ungváry G,Polinák D,Kiss A

    更新日期:1990-03-01 00:00:00

  • Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish.

    abstract::4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

    更新日期:2011-11-01 00:00:00

  • Nerve conduction, visual evoked responses and electroretinography in tunnel workers previously exposed to acrylamide and N-methylolacrylamide containing grouting agents.

    abstract::The study examines possible persisting effects on the peripheral nervous system and visual system in tunnel workers previously exposed to acrylamide and N-methylolacrylamide during grouting work. We compared neurophysiological function in 44 tunnel workers previously exposed during grouting operations (2-10 years post...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Goffeng LO,Heier MS,Kjuus H,Sjöholm H,Sørensen KA,Skaug V

    更新日期:2008-05-01 00:00:00

  • Cognitive flexibility deficits in male mice exposed to neonatal hyperoxia followed by concentrated ambient ultrafine particles.

    abstract::Epidemiological evidence indicates an association between early-life exposure to air pollution and preterm birth. Thus, it is essential to address the subsequent vulnerability of preterm infants, who are exposed to unique factors at birth including hyperoxia, and subsequently to air pollution. Health effects of air po...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Morris-Schaffer K,Sobolewski M,Welle K,Conrad K,Yee M,O'Reilly MA,Cory-Slechta DA

    更新日期:2018-01-01 00:00:00

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    abstract::The effect of inhalation exposure to toluene (3700 mg/m3, 1000 ppm, 21 h/day, 5 days/week, during 4 weeks) on male Sprague-Dawley rats was tested. A wide range of test situations was used, including an operant test with baseline performance and extinction, motor coordination, and exploratory activity. All tests were m...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Forkman BA,Ljungberg T,Johnson AC,Nylén P,Ståhle L,Höglund G,Ungerstedt U

    更新日期:1991-09-01 00:00:00

  • Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C.

    abstract::Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Slotkin TA,Seidler FJ,Spindel ER

    更新日期:2011-05-01 00:00:00

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    abstract::The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behav...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Temple JG,Miller DB,Barthalmus GT

    更新日期:2002-03-01 00:00:00

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    abstract::The central nervous system is the principal target of 1,1,1-trichloroethane (TRI), and several studies of this volatile solvent have demonstrated effects on learned animal behaviors. There have been few attempts, however, to quantitatively relate such effects to blood or target organ (brain) solvent concentrations. Th...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Warren DA,Reigle TG,Muralidhara S,Dallas CE

    更新日期:1998-03-01 00:00:00