Abstract:
:Visual thresholds for luminance increments were obtained behaviorally and electrophysiologically from rats exposed to a polychlorinated biphenyl (PCB) during development. Male Long-Evans rats exposed to 0, 0.25, or 1.0 microg/kg/day of 3,3',4,4', 5-pentachlorobiphenyl (PCB 126) through gestation and weaning were trained as adults to perform a signal detection task. Estimates of threshold were derived from psychometric functions for each animal relating the proportion of hits to signal intensity. Thresholds derived under three luminance conditions did not differ significantly among the PCB-treated groups. After behavioral testing was completed, flash-evoked potentials were recorded from dark-adapted awake animals. Peak amplitudes increased linearly over approximately 3 log units of intensity. Extrapolations to 0 amplitude along the linear portion of the amplitude-log intensity functions produced estimates of absolute threshold of -5.44 to -5.53 log cd/m(2)-s. Waveforms recorded from awake animals had a large late negative component that was absent in previously reported anesthetized preparations. Developmental exposure to PCB 126 had no significant effect on absolute threshold or peak amplitudes and latencies.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Geller AM,Bushnell PJ,Rice DCdoi
10.1016/s0892-0362(00)00067-2subject
Has Abstractpub_date
2000-07-01 00:00:00pages
521-31issue
4eissn
0892-0362issn
1872-9738pii
S0892-0362(00)00067-2journal_volume
22pub_type
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