Abstract:
:During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batteries. The most commonly used developmental parameters were eye opening, pinna unfolding, and sexual maturation (physical landmarks); surface righting, pupil constriction, and nonautomated acoustic startle (reflexive landmarks). Locomotor activity was used by 80% of the laboratories. The majority (76%) of laboratories conducted at least one learning and/or retention evaluation; nearly one-fourth of the laboratories routinely performed two. The most common learning tests were watermaze (primarily a simple two-choice discrimination task) and passive avoidance. Automated startle paradigms (habituation, prepulse modification, and/or startle elicitation) were evaluated by 28% of the laboratories. This survey showed a remarkable similarity in methodology across laboratories and a progressive increase in the number of GLP studies that included behavioral assessments. The results indicate that behavioral tests have become a common component of developmental toxicity assessments of pharmaceuticals.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Lochry EA,Johnson C,Wier PJdoi
10.1016/0892-0362(94)90009-4subject
Has Abstractpub_date
1994-01-01 00:00:00pages
55-63issue
1eissn
0892-0362issn
1872-9738journal_volume
16pub_type
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journal_title:Neurotoxicology and teratology
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abstract::This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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更新日期:2018-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(91)90046-y
更新日期:1991-11-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(95)00014-i
更新日期:1995-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
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更新日期:2006-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2011.07.005
更新日期:2011-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(00)00063-5
更新日期:2000-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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更新日期:2017-01-01 00:00:00
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更新日期:2004-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 临床试验,杂志文章
doi:10.1016/0892-0362(94)90048-5
更新日期:1994-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(88)90067-0
更新日期:1988-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2008.01.006
更新日期:2008-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
doi:10.1016/s0892-0362(99)00051-3
更新日期:2000-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2006.06.006
更新日期:2006-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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更新日期:2001-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(90)90005-w
更新日期:1990-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2010.11.001
更新日期:2011-03-01 00:00:00
abstract:BACKGROUND:We have previously reported the inverse associations between in utero levels of lead (Pb), arsenic (As) (i.e., toxic elements), and neurodevelopmental indicators (i.e., motor and state regulation cluster score) measured by the Brazelton Neonatal Behavioral Assessment Scale, third edition (NBAS III) in this c...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2013.12.006
更新日期:2014-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(01)00182-9
更新日期:2001-11-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2003.10.007
更新日期:2004-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(95)02050-0
更新日期:1996-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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更新日期:2001-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(87)90073-0
更新日期:1987-01-01 00:00:00
abstract::Lead (Pb) is a well-known poison interfering with calcium homeostasis and dopaminergic pathway. We hypothesized that environmental Pb exposure can interact with prolactin (PRL) secretion, regulated by calcium and dopamine, during pregnancy and in fetus. The objective of this longitudinal study was to determine the rel...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2005.03.009
更新日期:2005-05-01 00:00:00
abstract::Pyrethroids are pesticides with high insecticidal activity and relatively low potency in mammals. The influence of dosing volume on the neurobehavioral syndrome following oral acute exposure to the Type-I pyrethroid insecticide bifenthrin in corn oil was evaluated in adult male Long Evans rats. We tested bifenthrin ef...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2007.01.007
更新日期:2007-05-01 00:00:00