Abstract：
:A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements following motor pathway lesions in rodents would provide a sensitive, specific, and economical approach to assessing fine motor control in the toxicology laboratory. We measured skilled paw reaching using the "staircase test" developed by Montoya et al. [Prog. Brain Res. 82 (1990) 459], in which a rat retrieves food pellets by reaching down from a central platform to a series of descending steps on either side, grasping the pellets in its forepaw, and lifting them to its mouth. Staircase boxes were scaled for the body weights of young adult male (350 g) and female (250 g) Long-Evans rats. Studies were conducted using harmaline, a tremorigen; scopolamine; methyl scopolamine; and 2,4-dithiobiuret (DTB), a compound that causes muscle weakness by interfering with cholinergic transmission at the neuromuscular junction. Harmaline (0, 1.0, 3.0, and 10.0 mg/kg) reduced pellet retrieval only at a dose that also caused visible tremor. Both scopolamine (0, 0.1, 0.3, and 1.0 mg/kg) and methyl scopolamine (0, 0.104, 0.312, and 1.04 mg/kg) impaired pellet retrieval; scopolamine was more effective than methyl scopolamine. DTB (5 daily doses of 0, 0.1, 0.2, and 0.5 mg/kg) had no effect on retrieval, even when causing visible signs of weakness. These data cast doubt on the utility of this method for detecting and quantifying subtle chemical-induced changes in motor function in rats.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Samsam TE,Gadrinab LG,Bushnell PJdoi
10.1016/S0892-0362(03)00093-Xsubject
Has Abstractpub_date
2004-01-01 00:00:00pages
113-20issue
1eissn
0892-0362issn
1872-9738pii
S089203620300093Xjournal_volume
26pub_type
杂志文章abstract：:Pregnant Sprague-Dawley rats were fed a liquid diet containing either 0% (group C), 18% (group L), or 36% (group H) ethanol-derived calories (EDC) from gestational day 1 to 20. Male offspring were assessed under a conditioned taste aversion paradigm (PND 35-45), in a complex maze (PND 68-80), and for operant behavior ...
journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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pub_type： 杂志文章,评审
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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doi：10.1016/j.ntt.2006.02.003
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doi：10.1016/j.ntt.2010.10.006
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
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journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
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journal_title：Neurotoxicology and teratology
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更新日期：2018-01-01 00:00:00
