Prenatal cocaine and/or nicotine exposure in rats: preliminary findings on long-term cognitive outcome and genital development at birth.

Abstract:

:Prenatal cocaine or nicotine exposure is associated with a variety of teratogenic effects. The current study was conducted to determine their effects alone and in combination on cognitive function and sexual differentiation. Pregnant Long-Evans rats (N = 19) were exposed to either cocaine (15 mg/kg/dose b.i.d. SC on GD 8-20); nicotine (4 mg/kg/day continuous SC infusion on GD 4-20); both nicotine + cocaine; or vehicle only. Birth weight and anogenital distance (AGD) were measured in all pups at birth. Learning and memory were tested in the Morris water maze (MWM) during prepubertal and pubertal ages in five daily consecutive sessions and a sixth session 1 week later and in the radial-arm maze (RAM) during adulthood. In the RAM, a drug challenge of the beta-noradrenergic antagonist propranolol (10-20 mg/kg) was given after acquisition training. Maternal weight gain was reduced 13-42% and offspring birth weight was reduced by 7-12% in all three exposure groups compared to controls. Cocaine decreased the AGD of males (2.68 mm) compared to 2.88 mm in noncocaine-exposed male pups (p < 0.025). A sex-selective cocaine effect was also seen after adjustment of AGD measurements for body weight. With this measure cocaine-treated females showed significantly (p < 0.05) greater AGD than those not exposed to cocaine. In the MWM, there were two types of trials: cued reference memory trials and uncued spatial working memory trials. On cued reference memory trials significant cocaine-induced latency deficits were seen on only the first session. On spatial working memory trials cocaine-induced latency deficits were seen throughout daily training on sessions 1-5, but not the retention session 6, 1 week later. During RAM acquisition, there were no significant differences in choice accuracy between exposure groups. Following propranolol challenge, deficits in choice accuracy were demonstrated in rats prenatally exposed to cocaine or nicotine. These rats did not show any response to propranolol, whereas the controls slightly improved their choice accuracy. The results of this study indicated that prenatal cocaine exposure altered long-term cognitive function under basal conditions in the MWM and drug challenge in the RAM, birth weight, and genital development. Cocaine-induced cognitive deficits were predominately in working memory rather than reference memory or long-term retention. Prenatal nicotine exposure was only observed to alter birth weight and cognitive function in response to propranolol challenge in the RAM.

journal_name

Neurotoxicol Teratol

authors

Cutler AR,Wilkerson AE,Gingras JL,Levin ED

doi

10.1016/s0892-0362(96)00125-0

subject

Has Abstract

pub_date

1996-11-01 00:00:00

pages

635-43

issue

6

eissn

0892-0362

issn

1872-9738

pii

S0892-0362(96)00125-0

journal_volume

18

pub_type

杂志文章
  • Neurotoxic effects from residential exposure to chemicals from an oil reprocessing facility and superfund site.

    abstract::Neurotoxicity has been described in workers exposed to solvents, PCBs, certain metals, and polyaromatic hydrocarbons but not often in residents near refineries or factories. We compared the neurobehavioral performance of residents near a plant that reprocessed used motor oil and chemical waste from 1966-1983 to refere...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1016/0892-0362(94)00057-k

    authors: Kilburn KH,Warshaw RH

    更新日期:1995-03-01 00:00:00

  • Gestational and lactational exposure to TCDD or coplanar PCBs alters adult expression of saccharin preference behavior in female rats.

    abstract::Previous studies have shown that maternal doses of 1 microg/kg or less of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in late gestation can demasculinize and feminize reproductive behavior in male rats. However, it was not known whether coplanar polychlorinated biphenyls (PCBs) had similar effects, or whether non-repro...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(00)00094-5

    authors: Amin S,Moore RW,Peterson RE,Schantz SL

    更新日期:2000-09-01 00:00:00

  • Exacerbation of iminodipropionitrile-induced behavioral toxicity, oxidative stress, and vestibular hair cell degeneration by gentamicin in rats.

    abstract::This study describes the effect of gentamicin, an aminoglycoside antibiotic on iminodipropionitrile (IDPN)-induced abnormal neurobehavioral syndrome in female Sprague-Dawley rats. The animals were exposed to IDPN in the dose of 100 mg/kg/day intraperitoneally for 7 days. Gentamicin (GM) was administered intraperitonea...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(99)00075-6

    authors: Al Deeb S,Al Moutaery K,Khan HA,Tariq M

    更新日期:2000-03-01 00:00:00

  • Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish.

    abstract::4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2011.09.009

    authors: Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

    更新日期:2011-11-01 00:00:00

  • The effects of perinatal AZT exposure on the acoustic startle response in adult rats.

    abstract::AZT (azidothymidine, zidovudine, ZDV) has become the standard medication to prevent the transmission of the human immunodeficiency virus from mother to fetus. The present study was designed to assess the acoustic startle response (ASR) in adult rats that had been perinatally exposed to AZT. Each litter was randomly as...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(02)00317-3

    authors: Melnick SM,Weedon J,Dow-Edwards DL

    更新日期:2002-11-01 00:00:00

  • Effects of 2,5-hexanedione alone and in combination with acetone on radial arm maze behavior, the "brain-swelling" reaction and synaptosomal functions.

    abstract::A multidisciplinary study to investigate 2,5-hexanedione (2,5-HD)-induced CNS-neurotoxicity and its proposed potentiation by acetone (AC) was conducted. Neurobehavioral testing, estimation of the brain-swelling reaction, neuropathological and morphometric measurements as well as synaptosomal 5-hydroxytryptamine (5-HT)...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(91)90089-f

    authors: Lam HR,Larsen JJ,Ladefoged O,Møller A,Strange P,Arlien-Søborg P

    更新日期:1991-07-01 00:00:00

  • Adverse effects of serotonin depletion in developing zebrafish.

    abstract::In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM pCPA for 24h and subsequently rescued...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2011.08.008

    authors: Airhart MJ,Lee DH,Wilson TD,Miller BE,Miller MN,Skalko RG,Monaco PJ

    更新日期:2012-01-01 00:00:00

  • Glucose and corticosterone changes in developing and adult rats following exposure to (+/-)-3,4-methylendioxymethamphetamine or 5-methoxydiisopropyltryptamine.

    abstract::The use of the club drugs 3,4-methylenedioxymethamphetamine (MDMA) and 5-methoxy-n,n-diisopropyltryptamine (Foxy) is of growing concern, especially as many of the effects, particularly during development, are unknown. The effects of these drugs upon homeostasis may be important since both are known to stimulate the hy...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2009.08.012

    authors: Graham DL,Herring NR,Schaefer TL,Vorhees CV,Williams MT

    更新日期:2010-03-01 00:00:00

  • BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells.

    abstract::Early-life exposures to brominated diphenyl ethers (BDEs) lead to neurobehavioral abnormalities later in life. Although these agents are thyroid disruptors, it is not clear whether this mechanism alone accounts for the adverse effects. We evaluated the impact of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) on PC12 cel...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2013.02.001

    authors: Slotkin TA,Card J,Infante A,Seidler FJ

    更新日期:2013-05-01 00:00:00

  • Changes in sleep-wake cycle after chronic exposure to uranium in rats.

    abstract::Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l(-1) in drinking water, for 90 days) on electroencephalographic ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2005.07.005

    authors: Lestaevel P,Bussy C,Paquet F,Dhieux B,Clarençon D,Houpert P,Gourmelon P

    更新日期:2005-11-01 00:00:00

  • A fostering/crossfostering analysis of the effects of prenatal ethanol exposure in a liquid diet on offspring development and behavior in rats.

    abstract::Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(89)90049-4

    authors: Vorhees CV

    更新日期:1989-03-01 00:00:00

  • Visuoperceptual functioning differs in 9- to 12-year olds prenatally exposed to cigarettes and marihuana.

    abstract::Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(99)00046-x

    authors: Fried PA,Watkinson B

    更新日期:2000-01-01 00:00:00

  • Factors influencing diisopropyl fluorophosphate-induced hypothermia and hyperthermia in the rat.

    abstract::Exposing rats to the anticholinesterase (anti-ChE) diisopropyl fluorophosphate (DFP) causes a transient period of hypothermia followed by a period of hyperthermia lasting approximately 48 h. Because a fever is a predominant thermoregulatory response in humans exposed to anti-ChE pesticides, the hyperthermic response i...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(95)02001-2

    authors: Gordon CJ

    更新日期:1995-11-01 00:00:00

  • Behavioral deficits due to prenatal exposure to cadmium chloride in CFY rat pups.

    abstract::The postnatal behavioral effects of 0.20, 0.62 and 2.0 mg/kg cadmium chloride administered to pregnant CFY rats on gestational days 7 through 15 were evaluated. Offspring were tested starting on postnatal day 23 on a rotorod for motor coordination, in an open field device for motor activity and emotionality, in a wate...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(90)90130-5

    authors: Lehotzky K,Ungváry G,Polinák D,Kiss A

    更新日期:1990-03-01 00:00:00

  • Prenatal ethanol exposure alters sensitivity to the effects of apomorphine given alone and in combination with ethanol on locomotor activity in adult male mouse offspring.

    abstract::Previous studies have indicated that prenatal ethanol (EtOH) exposure alters developing catecholamine (CA) systems and acute sensitivity to the locomotor stimulant effects of EtOH. The purpose of this study was to examine whether prenatal EtOH exposure influences the effects of the direct dopamine (DA) agonist apomorp...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(94)00055-i

    authors: Becker HC,Weathersby RT,Hale RL

    更新日期:1995-01-01 00:00:00

  • Characterization of performance on an automated visual recognition memory task in 7.5-month-old infants.

    abstract::Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to aut...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2020.106904

    authors: Dzwilewski KLC,Merced-Nieves FM,Aguiar A,Korrick SA,Schantz SL

    更新日期:2020-01-01 00:00:00

  • Evaluation of tremor in aluminum production workers.

    abstract::A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0892-0362(97)00061-5

    authors: Dick RB,Krieg EF Jr,Sim MA,Bernard BP,Taylor BT

    更新日期:1997-11-01 00:00:00

  • Chronic ambient hydrogen sulfide exposure and cognitive function.

    abstract:BACKGROUND:Exposures to hydrogen sulfide gas (H2S) have been inconclusively linked to a variety of negative cognitive outcomes. We investigated possible effects on cognitive function in an urban population with chronic, low-level exposure to H2S. METHODS:Participants were 1637 adults, aged 18-65 years from Rotorua cit...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2014.02.002

    authors: Reed BR,Crane J,Garrett N,Woods DL,Bates MN

    更新日期:2014-03-01 00:00:00

  • Effects of repeated administration of soman on schedule-controlled behavior and brain in the rat.

    abstract::The effects of repeated SC administration of soman on schedule-controlled performance and brain pathology were studied in the rat. Soman suppressed response rates in both components of a multiple fixed interval 50-sec fixed-ratio 25 (mult. FI 50-sec FR 25) schedule of reinforcement, although all animals revealed marke...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(90)90112-p

    authors: Hymowitz N,Ploshnick A,Laemle L,Brezenoff H

    更新日期:1990-01-01 00:00:00

  • Low-level lead exposure triggers neuronal apoptosis in the developing mouse brain.

    abstract::While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2011.05.006

    authors: Dribben WH,Creeley CE,Farber N

    更新日期:2011-07-01 00:00:00

  • The development of a neurobehavioral test battery for use in hazard evaluations in occupational settings.

    abstract::The interest in, and number of, neurobehavioral test batteries for use in occupational settings has increased markedly over the last decade. While this is a welcome development in furthering the cause for greater acceptance of these methods in hazard evaluation and toxicity testing, there are a number of issues that a...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(90)90015-5

    authors: Williamson AM

    更新日期:1990-09-01 00:00:00

  • Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates.

    abstract::Brain-derived neurotrophic factor (BDNF) is a neurotrophin critical for many developmental and physiological aspects of CNS function. Severe hypothyroidism in the early neonatal period results in developmental and cognitive impairments and reductions in mRNA and protein expression of BDNF in a number of brain regions....

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2011.04.001

    authors: Lasley SM,Gilbert ME

    更新日期:2011-07-01 00:00:00

  • Neurobehavioral changes in mice chronically exposed to methylmercury during fetal and early postnatal development.

    abstract::Pregnant C57BL/6 mice were chronically treated with 0, 4, 6, or 8 ppm of methylmercury chloride (MeHg) in drinking water during fetal and early postnatal development. Four behavioral functions were analyzed in female and male offspring between the age of 6 and 12 weeks: motor coordination learning on the rotarod; trai...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(03)00007-2

    authors: Goulet S,Doré FY,Mirault ME

    更新日期:2003-05-01 00:00:00

  • Decreased sensitivity in adolescent vs. adult rats to the locomotor activating effects of toluene.

    abstract::Volatile organic solvent (inhalant) abuse continues to be a major health concern throughout the world. Of particular concern is the abuse of inhalants by adolescents because of its toxicity and link to illicit drug use. Toluene, which is found in many products such as glues and household cleaners, is among the most co...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2007.08.001

    authors: Bowen SE,Charlesworth JD,Tokarz ME,Wright MJ Jr,Wiley JL

    更新日期:2007-11-01 00:00:00

  • Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model.

    abstract::The developmental neurotoxicity of organophosphates such as chlorpyrifos (CPF) involves multiple mechanisms that ultimately compromise the function of specific neurotransmitter systems, notably acetylcholine (ACh) and serotonin (5-hydroxytryptamine, 5HT). Studies in mammalian models incorporate both direct effects on ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2008.02.005

    authors: Slotkin TA,Seidler FJ,Ryde IT,Yanai J

    更新日期:2008-09-01 00:00:00

  • Influence of dosing volume on the neurotoxicity of bifenthrin.

    abstract::Pyrethroids are pesticides with high insecticidal activity and relatively low potency in mammals. The influence of dosing volume on the neurobehavioral syndrome following oral acute exposure to the Type-I pyrethroid insecticide bifenthrin in corn oil was evaluated in adult male Long Evans rats. We tested bifenthrin ef...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2007.01.007

    authors: Wolansky MJ,McDaniel KL,Moser VC,Crofton KM

    更新日期:2007-05-01 00:00:00

  • Effect of early lead exposure on the maturation of children's postural balance: a longitudinal study.

    abstract::This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2006.02.003

    authors: Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

    更新日期:2006-05-01 00:00:00

  • GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice.

    abstract::Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brai...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2015.05.011

    authors: Oliveira-Pinto J,Paes-Branco D,Cristina-Rodrigues F,Krahe TE,Manhães AC,Abreu-Villaça Y,Filgueiras CC

    更新日期:2015-07-01 00:00:00

  • Prenatal cocaine use and maternal depression: effects on infant neurobehavior.

    abstract:OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.ntt.2006.12.001

    authors: Salisbury AL,Lester BM,Seifer R,Lagasse L,Bauer CR,Shankaran S,Bada H,Wright L,Liu J,Poole K

    更新日期:2007-05-01 00:00:00

  • Effects of prenatal cocaine on behavioral adaptation to chronic stress in adult rats.

    abstract::Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(00)00104-5

    authors: Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

    更新日期:2000-11-01 00:00:00