Differential vulnerability of snake species to MPTP: a behavioral and biochemical comparison in ratsnakes (Elaphe) and watersnakes (Nerodia).

abstract：:Neurobehavioral studies often employ test batteries and confront issues of multiple testing and comparability between batteries. We have organized our battery of 12 tests into areas of neurobehavioral function to reduce the number of reported results, provide greater statistical power, and improve interpretability of ...

journal_title：Neurotoxicology and teratology

authors： Heyer NJ,Bittner AC Jr,Echeverria D

更新日期：1996-07-01 00:00:00

abstract：:The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...

journal_title：Neurotoxicology and teratology

authors： Minnema DJ,Hammond PB

更新日期：1994-11-01 00:00:00

abstract：:The effects of maternal urinary tract infection (UTI) or endotoxin exposure on fetal outcome in rats were investigated. Prior to conception, dams of the UTI group were water-deprived and anesthetized. The urinary tract was then catheterized and injected with 0.2 of 1 x 10(9) Escherichia coli. The endotoxin group was i...

journal_title：Neurotoxicology and teratology

authors： Cronise K,Kelly SJ

更新日期：2001-07-01 00:00:00

abstract：:To explore the effects of gestational cocaine exposure in a nonhuman primate model, pregnant rhesus monkeys were either treated (N = 10) with escalating doses of cocaine up to 7.5 mg/kg (IM), three times per day, 5 consecutive days per week, prior to conception and throughout gestation, or were not treated (N = 10) wi...

journal_title：Neurotoxicology and teratology

authors： Morris P,Binienda Z,Gillam MP,Klein J,McMartin K,Koren G,Duhart HM,Slikker W Jr,Paule MG

更新日期：1997-01-01 00:00:00

abstract：:The association of general anesthesia with developmental neurotoxicity, while nearly impossible to study in pediatric populations, is clearly demonstrable in a variety of animal models from rodents to nonhuman primates. Nearly all general anesthetics tested have been shown to cause abnormal brain cell death in animals...

journal_title：Neurotoxicology and teratology

authors： Zhang X,Liu F,Slikker W Jr,Wang C,Paule MG

更新日期：2017-01-01 00:00:00

abstract：:Environmental silver exposures are increasing due to the use of silver nanoparticles, which exert antimicrobial actions by releasing Ag+, a suspected developmental neurotoxicant. We evaluated the long-term neurochemical and behavioral effects of embryonic Ag+ exposure in zebrafish at concentrations that had no overt e...

journal_title：Neurotoxicology and teratology

authors： Powers CM,Levin ED,Seidler FJ,Slotkin TA

更新日期：2011-03-01 00:00:00

abstract：:This is the first in a series of studies investigating the developmental stage-specific neurobehavioral effects of all-trans retinoic acid (RA) exposure. Because high doses of this compound are known to be lethal to the developing organism, we first conducted a dose-response study to identify RA doses that produce low...

journal_title：Neurotoxicology and teratology

authors： Holson RR,Gazzara RA,Ferguson SA,Ali SF,Laborde JB,Adams J

更新日期：1997-09-01 00:00:00

abstract：:Visual thresholds for luminance increments were obtained behaviorally and electrophysiologically from rats exposed to a polychlorinated biphenyl (PCB) during development. Male Long-Evans rats exposed to 0, 0.25, or 1.0 microg/kg/day of 3,3',4,4', 5-pentachlorobiphenyl (PCB 126) through gestation and weaning were train...

journal_title：Neurotoxicology and teratology

authors： Geller AM,Bushnell PJ,Rice DC

更新日期：2000-07-01 00:00:00

abstract：:During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...

journal_title：Neurotoxicology and teratology

authors： Lochry EA,Johnson C,Wier PJ

更新日期：1994-01-01 00:00:00

abstract：:Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

journal_title：Neurotoxicology and teratology

authors： Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

更新日期：2000-11-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Neurotoxicology and teratology

authors： Cross NC,Chelonis JJ,Finch MN,Edwards MC,Baldwin RL

更新日期：2009-02-05 00:00:00

abstract：:We hypothesized that prenatal cocaine exposure results in less optimal infant behavior and more impaired maternal-infant interaction in healthy term infants. Infants were evaluated with the Neonatal Behavioral Assessment Scale (NBAS) at days 1-3 and 11-30 of age, and mother-infant pairs with the Nursing Child Assessme...

journal_title：Neurotoxicology and teratology

authors： Neuspiel DR,Hamel SC,Hochberg E,Greene J,Campbell D

更新日期：1991-03-01 00:00:00

abstract：:1-beta-D-Arabinofuranosylcytosine (Ara-C), a cytidine analogue cytotoxic to proliferating cells, has a teratogenic effect in the brain of experimental animals and causes neural cell apoptosis in vitro and in vivo. In the present study, pregnant rats were injected with Ara-C on Day 13 of gestation and the fetal brain w...

journal_title：Neurotoxicology and teratology

authors： Yamauchi H,Katayama K,Ueno M,Uetsuka K,Nakayama H,Doi K

更新日期：2004-07-01 00:00:00

abstract：:Using a timed-breeding protocol, one group of female rhesus monkeys was implanted subcutaneously with osmotic minipumps containing 0.3 mg/kg/h cocaine (N=18) or saline (N=18) from day 24 postconception through gestation. Another group received cocaine (N=12) or saline (N=8) from conception through day 42 of gestation....

journal_title：Neurotoxicology and teratology

authors： Howell LL,Schama KF,Ellis JE,Grimley PJ,Kitchens AJ,Byrd LD

更新日期：2001-03-01 00:00:00

abstract：:Sensory-evoked potentials (EPs) were studied in male Long-Evans and Fischer-344 rats in order to characterize the electrophysiological consequences of chronic inhalation exposure to trichloroethylene (TCE). Groups of ten Long-Evans rats were exposed to air or 1600 ppm or 3200 ppm TCE for twelve weeks and evaluated per...

journal_title：Neurotoxicology and teratology

authors： Rebert CS,Day VL,Matteucci MJ,Pryor GT

更新日期：1991-01-01 00:00:00

abstract：:The use of the club drugs 3,4-methylenedioxymethamphetamine (MDMA) and 5-methoxy-n,n-diisopropyltryptamine (Foxy) is of growing concern, especially as many of the effects, particularly during development, are unknown. The effects of these drugs upon homeostasis may be important since both are known to stimulate the hy...

journal_title：Neurotoxicology and teratology

authors： Graham DL,Herring NR,Schaefer TL,Vorhees CV,Williams MT

更新日期：2010-03-01 00:00:00

abstract：:The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...

journal_title：Neurotoxicology and teratology

authors： Méndez-Armenta M,Barroso-Moguel R,Villeda-Hernández J,Romero-Díaz V,Ríos C

更新日期：1997-05-01 00:00:00

abstract：:In this study, p-chlorophenylalanine (pCPA), an inhibitor of tryptophan hydroxylase (the rate limiting enzyme of serotonin synthesis), was used to reduce serotonin (5HT) levels during early development in zebrafish embryos. One day old dechorionated embryos were treated with 25 μM pCPA for 24h and subsequently rescued...

journal_title：Neurotoxicology and teratology

authors： Airhart MJ,Lee DH,Wilson TD,Miller BE,Miller MN,Skalko RG,Monaco PJ

更新日期：2012-01-01 00:00:00

abstract：:Previous work showed that rats develop tolerance to the acute behavioral effects of trichloroethylene (TCE) on signal detection if they inhale TCE while performing the task and that this tolerance depends more upon learning than upon changes in metabolism of TCE. The present study sought to characterize this tolerance...

journal_title：Neurotoxicology and teratology

authors： Oshiro WM,Krantz QT,Bushnell PJ

更新日期：2001-11-01 00:00:00

abstract：:This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

journal_title：Neurotoxicology and teratology

authors： Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

更新日期：2006-05-01 00:00:00

abstract：:Chemical warfare nerve agents (CWNAs) are known to cause behavioral abnormalities in cases of human exposures and in animal models. The behavioral consequences of single exposures to CWNAs that cause observable toxic signs are particularly well characterized in animals; however, less is known regarding repeated smalle...

journal_title：Neurotoxicology and teratology

authors： Smith CD,Lee RB,Moran AV,Sipos ML

更新日期：2016-03-01 00:00:00

abstract：:This study examined the effects of chronic postweaning lead (Pb) exposure in Long-Evans rats on a series of spatial alternation tasks. All tasks were administered in automated testing chambers, with a nosepoke as the critical response. While neither Pb-exposed group (median blood lead levels: 19 and 39 micrograms/dl, ...

journal_title：Neurotoxicology and teratology

authors： Alber SA,Strupp BJ

更新日期：1996-01-01 00:00:00

abstract：:Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to aut...

journal_title：Neurotoxicology and teratology

authors： Dzwilewski KLC,Merced-Nieves FM,Aguiar A,Korrick SA,Schantz SL

更新日期：2020-01-01 00:00:00

abstract：:Cocaine-induced conditioned place preference (CPP) was tested in adult offspring of Sprague-Dawley dams that had been injected subcutaneously with 40 mg/kg/3cc cocaine HCl (C40) daily from gestational days 8-20, pair-fed (PF) dams injected with saline, and nontreated control (LC) dams. C40 and PF dams gained significa...

journal_title：Neurotoxicology and teratology

authors： Heyser CJ,Miller JS,Spear NE,Spear LP

更新日期：1992-01-01 00:00:00

abstract：:Methylmercury (MeHg), an environmental contaminant primarily found in fish and seafood, may pose long-term health risks to pregnant women and their developing children. The objective of this study was to determine whether co-consumption of nutritional supplements would alter the effects of MeHg on reproductive and dev...

journal_title：Neurotoxicology and teratology

authors： Beyrouty P,Chan HM

更新日期：2006-01-01 00:00:00

abstract：:In the United States, the regulation and testing of chemicals that may impact on human health is mandated by a number of different laws and regulated by several government agencies. Toxicologic screening in laboratory animals has created a major database for predicting adverse health effects of drugs, food and cosmeti...

journal_title：Neurotoxicology and teratology

authors： Steinberg M

更新日期：1987-11-01 00:00:00

abstract：:Most behavioral teratology studies have focused on pharmaceutical agents. Investigations of developmental toxicity are lacking for the majority of the nearly 100,000 industrial chemicals currently in use. Only some three dozen chemicals have been examined for behavioral/neurochemical deviations in offspring following ...

journal_title：Neurotoxicology and teratology

authors： Nelson BK

更新日期：1990-07-01 00:00:00

abstract：:Sodium valproate is an anticonvulsant widely prescribed because of its broad spectrum of activity. While acute toxicity from high doses is well recognized, there have been few animal studies of its chronic toxicity at therapeutic dose levels. Sodium valproate given continuously in drinking fluid (600 mg/l) throughout ...

journal_title：Neurotoxicology and teratology

authors： Chapman JB,Cutler MG

更新日期：1989-03-01 00:00:00

abstract：:The study aim was to determine whether low level exposure to organophosphate pesticides (OPs) causes neuropsychological or psychiatric impairment. Methodological weaknesses of earlier studies were addressed by: recruiting participants who had retired on ill health grounds; excluding participants with a history of acut...

journal_title：Neurotoxicology and teratology

authors： Mackenzie Ross SJ,Brewin CR,Curran HV,Furlong CE,Abraham-Smith KM,Harrison V

更新日期：2010-07-01 00:00:00

abstract：:Research suggests that use and abuse of marijuana can be especially harmful if it occurs during adolescence, a period of vast developmental changes throughout the brain. We examined the effects of 2mg/kg (9)-tetrahydrocannabinol (THC) administered daily via intra-peritoneal injections during juvenile/early adolescence...

journal_title：Neurotoxicology and teratology

authors： Harte LC,Dow-Edwards D

更新日期：2010-09-01 00:00:00