Differential vulnerability of snake species to MPTP: a behavioral and biochemical comparison in ratsnakes (Elaphe) and watersnakes (Nerodia).


:The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behavioral and biochemical effects of MPTP were assessed in the black ratsnake Elaphe o. obsoleta and the banded watersnake Nerodia f. fasciata--species that display contrasting behavioral sensitivities to dopaminergic antagonists and to amphibian toxins. We report that MPTP induces depletion of norepinephrine and serotonin in fore, mid and hindbrain regions and depletion of dopamine in fore and midbrain regions in E.o. obsoleta. MPTP also induced a marked reduction in righting ability in E.o. obsoleta. In N.f. fasciata, norepinephrine and dopamine were depleted by MPTP in all three brain regions and serotonin was only significantly reduced in the forebrain. In contrast to E.o. obsoleta, N.f. fasciata demonstrated no behavioral disorders. This study demonstrates a behavioral and biochemical sensitivity to MPTP in E.o. obsoleta that differs from that in N.f. fasciata. The differential sensitivities to monoaminergic modulation may be related to the contrasting diets of these species.


Neurotoxicol Teratol


Temple JG,Miller DB,Barthalmus GT




Has Abstract


2002-03-01 00:00:00














  • Failure of acute cocaine administration to differentially affect acoustic startle and activity in rats prenatally exposed to cocaine.

    abstract::Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Foss JA,Riley EP

    更新日期:1991-09-01 00:00:00

  • Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure.

    abstract::The present study was designed to investigate the possible involvement of TLR4 pathway in the mouse hippocampus following toluene exposure. Male C3H/HeN and C3H/HeJ (TLR4 defective) mice were exposed to 0, 5, 50 or 500 ppm of toluene for 6 weeks. The expressions of TLR4-related signal transduction pathway mRNAs in the...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Win-Shwe TT,Kunugita N,Yoshida Y,Fujimaki H

    更新日期:2011-09-01 00:00:00

  • Effects of exposure to PCBs and related compounds on growth and activity in children.

    abstract::Two hundred thirty-six children from two established cohorts at risk for exposure to polychlorinated biphenyls (PCBs) and related contaminants were evaluated at age 4 years. Prenatal exposure (assessed by cord serum PCB level) was associated with lower weight, an effect consistent with reports of growth retardation in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Jacobson JL,Jacobson SW,Humphrey HE

    更新日期:1990-07-01 00:00:00

  • Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish.

    abstract::4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

    更新日期:2011-11-01 00:00:00

  • d-Methionine protects against cisplatin-induced neurotoxicity in cortical networks.

    abstract::Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of various types of cancer. Patients undergoing cisplatin treatment often suffer from a condition known as "chemobrain", ototoxicity, peripheral neuropathy, weight loss, nausea, vomiting, nephrotoxicity, seizures, hearing loss and tinni...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Gopal KV,Wu C,Shrestha B,Campbell KC,Moore EJ,Gross GW

    更新日期:2012-09-01 00:00:00

  • Zebrafish as potential model for developmental neurotoxicity testing: a mini review.

    abstract::The zebrafish is a powerful toxicity model; biochemical assays can be combined with observations at a structural and functional level within one individual. This mini review summarises the potency of zebrafish as a model for developmental neurotoxicity screening, and its possibilities to investigate working mechanisms...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: de Esch C,Slieker R,Wolterbeek A,Woutersen R,de Groot D

    更新日期:2012-11-01 00:00:00

  • Lead and conditioned fear to contextual and discrete cues.

    abstract::Male Fischer 344 rats received either tap water or water containing 250 ppm lead for 90 days prior to training in either Pavlovian fear conditioning or consummatory contrast, an aversive reward reduction paradigm. In Experiment 1, lead-exposed and -unexposed rats were trained in operant chambers over a 6-min session. ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Salinas JA,Huff NC

    更新日期:2002-07-01 00:00:00

  • Breast-feeding and gender as moderators of teratogenic effects on cognitive development.

    abstract::Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Jacobson JL,Jacobson SW

    更新日期:2002-05-01 00:00:00

  • Central auditory processing in school-age children prenatally exposed to cigarette smoke.

    abstract::One hundred and ten, 6- to 11-year-old children from a low-risk, predominantly middle class sample who are participants in an ongoing longitudinal drug study were assessed using a central auditory processing task (SCAN) that made perceptual rather than linguistic demands. Maternal smoking during pregnancy was linearly...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章


    authors: McCartney JS,Fried PA,Watkinson B

    更新日期:1994-05-01 00:00:00

  • Neurobehavioral evaluation of rhesus monkey infants fed cow's milk formula, soy formula, or soy formula with added manganese.

    abstract::The possible neurobehavioral effects of excess manganese in soy formula were studied. Male rhesus monkeys (n=8/group) were fed a commercial cow's milk based formula (Control), a commercial soy protein based formula (Soy), or the soy formula with added manganese (Soy+Mn) from birth to 4 months of age. Soy formulas natu...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Golub MS,Hogrefe CE,Germann SL,Tran TT,Beard JL,Crinella FM,Lonnerdal B

    更新日期:2005-07-01 00:00:00

  • Retinal lesions in rat fetuses prenatally exposed to cocaine.

    abstract::The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Méndez-Armenta M,Barroso-Moguel R,Villeda-Hernández J,Romero-Díaz V,Ríos C

    更新日期:1997-05-01 00:00:00

  • Behavioral toxicology of cognition: extrapolation from experimental animal models to humans: behavioral toxicology symposium overview.

    abstract::A variety of behavioral instruments are available for assessing important aspects of cognition in both animals and humans and, in many cases, the same instruments can be used in both. While nonhuman primates are phylogenetically closest to humans, rodents, pigeons and other animals also offer behaviors worthy of note....

    journal_title:Neurotoxicology and teratology



    authors: Paule MG,Green L,Myerson J,Alvarado M,Bachevalier J,Schneider JS,Schantz SL

    更新日期:2012-03-01 00:00:00

  • Maternal cocaine use and infant behavior.

    abstract::We hypothesized that prenatal cocaine exposure results in less optimal infant behavior and more impaired maternal-infant interaction in healthy term infants. Infants were evaluated with the Neonatal Behavioral Assessment Scale (NBAS) at days 1-3 and 11-30 of age, and mother-infant pairs with the Nursing Child Assessme...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Neuspiel DR,Hamel SC,Hochberg E,Greene J,Campbell D

    更新日期:1991-03-01 00:00:00

  • Behavioral and electrophysiological estimates of visual thresholds in awake rats treated with 3,3',4,4',5-pentachlorobiphenyl (PCB 126).

    abstract::Visual thresholds for luminance increments were obtained behaviorally and electrophysiologically from rats exposed to a polychlorinated biphenyl (PCB) during development. Male Long-Evans rats exposed to 0, 0.25, or 1.0 microg/kg/day of 3,3',4,4', 5-pentachlorobiphenyl (PCB 126) through gestation and weaning were train...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Geller AM,Bushnell PJ,Rice DC

    更新日期:2000-07-01 00:00:00

  • Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride.

    abstract::Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Mattsson JL,Albee RR,Eisenbrandt DL,Chang LW

    更新日期:1988-03-01 00:00:00

  • Long-term effects of lanthanum intake on the neurobehavioral development of the rat.

    abstract::The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameter...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Feng L,Xiao H,He X,Li Z,Li F,Liu N,Chai Z,Zhao Y,Zhang Z

    更新日期:2006-01-01 00:00:00

  • Reduced neuronal proliferation by proconvulsant drugs in the developing zebrafish brain.

    abstract::Seizures have been reported to modify neural development in the immature brain. In this study, we attempted to determine whether pentylenetetrazol (a GABAergic receptor antagonist, PTZ)-induced seizures influence cell proliferation in zebrafish larvae (5 and 15 days of post-fertilization), using bromodeoxyuridine (Brd...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Kim YH,Lee Y,Lee K,Lee T,Kim YJ,Lee CJ

    更新日期:2010-09-01 00:00:00

  • Effects of prenatal cocaine on behavioral adaptation to chronic stress in adult rats.

    abstract::Prenatal exposure to cocaine in rats has previously been shown to alter the behavioral and hormonal responses to acute stressors, although no work has yet examined stress adaptation in these animals in adulthood, a possibility examined in this experiment. Male and female offspring of Sprague-Dawley rat dams given 40 m...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Campbell JO,Bliven TD,Silveri MM,Snyder KJ,Spear LP

    更新日期:2000-11-01 00:00:00

  • Comparative neurotoxicity study of mercury-based inorganic compounds including Ayurvedic medicines Rasasindura and Kajjali in zebrafish model.

    abstract::Zebrafish behavioral model is a powerful tool for neuroscience research. Behavioral changes in the zebrafish are studied by administering drugs. With the aid of automated and open-source MATLAB program, high-accuracy tracking of zebrafish can be achieved, and the important behavioral parameters can be calculated. Alth...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Biswas S,Balodia N,Bellare J

    更新日期:2018-01-01 00:00:00

  • Low-level prenatal exposure to nicotine and infant neurobehavior.

    abstract:OBJECTIVE:To examine the association between prenatal exposure to nicotine from tobacco smoke and infant neurobehavior using tobacco biomarkers and a sensitive and comprehensive measure of infant neurobehavior. STUDY DESIGN:Participants were 318 infants (206 White, 95 Black, 17 Other) and their mothers. Prenatal tobac...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Yolton K,Khoury J,Xu Y,Succop P,Lanphear B,Bernert JT,Lester B

    更新日期:2009-11-01 00:00:00

  • This is your teen brain on drugs: In search of biological factors unique to dependence toxicity in adolescence.

    abstract::Response variability across the lifespan is an important consideration in toxicology and risk assessment, and the toxic effects of drugs and chemicals during adolescence need more research. This paper summarizes a workshop presented in March 2019, at the Society of Toxicology Annual Meeting in Baltimore, Maryland, tha...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Kwan LY,Eaton DL,Andersen SL,Dow-Edwards D,Levin ED,Talpos J,Vorhees CV,Li AA

    更新日期:2020-01-01 00:00:00

  • Effect of early lead exposure on the maturation of children's postural balance: a longitudinal study.

    abstract::This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

    更新日期:2006-05-01 00:00:00

  • Anxiety in adult female mice following perinatal exposure to chlorpyrifos.

    abstract::Epidemiologic studies suggested a possible link between prenatal exposure to organophosphate insecticides (OP) and long-term mental delay and some behavioral troubles. Experimental studies in rats and mice have confirmed that a relatively short exposure to low doses of OP such as chlorpyrifos (CPF) during specific per...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Braquenier JB,Quertemont E,Tirelli E,Plumier JC

    更新日期:2010-03-01 00:00:00

  • Effect of sulfite on cognitive function in normal and sulfite oxidase deficient rats.

    abstract::Sulfites, which are commonly used as preservatives, are continuously formed in the body during metabolism of sulfur-containing amino acids. Sulfite is oxidized to sulfate ion by sulfite oxidase (SOX, EC. The aim of this study was to investigate the possible toxic effects of sulfite on neurons by measuring ac...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Küçükatay V,Savcioğlu F,Hacioğlu G,Yargiçoğlu P,Ağar A

    更新日期:2005-01-01 00:00:00

  • Permanent motor activity and learning disorders induced by exposure to phenytoin during gestation and early infancy in the rat.

    abstract::Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Wolansky MJ,Azcurra JM

    更新日期:2005-03-01 00:00:00

  • Ethanol-induced cell death in cultured rat astroglia.

    abstract::Because of the important role of glial cells in brain maturation and reports on their delayed proliferation following ethanol exposure, it was considered of interest to investigate the mechanism of ethanol action on these cells. Biochemical parameters related to the apoptotic and necrotic processes in astroglial cells...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Holownia A,Ledig M,Ménez JF

    更新日期:1997-03-01 00:00:00

  • Chronic ambient hydrogen sulfide exposure and cognitive function.

    abstract:BACKGROUND:Exposures to hydrogen sulfide gas (H2S) have been inconclusively linked to a variety of negative cognitive outcomes. We investigated possible effects on cognitive function in an urban population with chronic, low-level exposure to H2S. METHODS:Participants were 1637 adults, aged 18-65 years from Rotorua cit...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Reed BR,Crane J,Garrett N,Woods DL,Bates MN

    更新日期:2014-03-01 00:00:00

  • Enhancement of developmental toxicity effects of chemicals by gestational stress. A review.

    abstract::Risk assessment of developmental toxicants is almost exclusively based on single chemicals studied in animals under controlled experimental conditions, as to reduce stress. Although humans may be exposed simultaneously to numerous hazards, little is known about the interaction of prenatal chemical exposures with other...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Hougaard KS,Hansen AM

    更新日期:2007-07-01 00:00:00

  • A fostering/crossfostering analysis of the effects of prenatal ethanol exposure in a liquid diet on offspring development and behavior in rats.

    abstract::Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Vorhees CV

    更新日期:1989-03-01 00:00:00

  • Effect of late fetal irradiation on adult behavior of mouse: Dose-response relationship.

    abstract::Pregnant Swiss mice were exposed to 0.3-1.5 Gy of gamma radiation on day 17 of gestation and allowed to deliver the offspring. When the F1 mice were 6 months old, they were subjected to a number of behavioral tests. Open-field and dark-bright arena tests were conducted to study locomotor and exploratory activities. Le...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Devi PU,Hossain M,Bisht KS

    更新日期:1999-03-01 00:00:00