Abstract:
:While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead toxicity is currently not well understood, research has established that it can be a potent NMDA antagonist. Previous research has established that exposure to NMDA antagonists during the brain growth spurt period (first 2 weeks of life in mice) can produce apoptotic neurodegeneration throughout the brain. Based on this information, the ability of lead exposure (two injections of 350 mg/kg lead 4h apart) to produce apoptosis in the neonatal mouse brain was assessed histologically 8-24h after treatment using activated caspase-3 immunohistochemistry, De Olmos silver technique, Nissl staining, and electron microscopy. Lead exposure produced significant neurodegeneration in the caudate/putamen, hippocampus, subiculum, and superficial and deep cortical layers of the frontal cortical regions. Further ultrastructural examination revealed cellular profiles consistent with apoptotic cell death. Statistical results showed that lead exposure significantly increased apoptotic neurodegeneration above that seen in normal controls in animals treated at postnatal day 7, but not on day 14. The results of this study may provide a basis for further elucidation of mechanisms through which the immature nervous system may be particularly susceptible to lead exposure.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Dribben WH,Creeley CE,Farber Ndoi
10.1016/j.ntt.2011.05.006subject
Has Abstractpub_date
2011-07-01 00:00:00pages
473-80issue
4eissn
0892-0362issn
1872-9738pii
S0892-0362(11)00064-Xjournal_volume
33pub_type
杂志文章abstract::Pregnant C57BL/6 mice were chronically treated with 0, 4, 6, or 8 ppm of methylmercury chloride (MeHg) in drinking water during fetal and early postnatal development. Four behavioral functions were analyzed in female and male offspring between the age of 6 and 12 weeks: motor coordination learning on the rotarod; trai...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 临床试验,杂志文章
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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更新日期:2006-11-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type:
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更新日期:2012-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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更新日期:1995-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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更新日期:1994-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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更新日期:2020-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2016.06.005
更新日期:2016-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2017.07.001
更新日期:2017-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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更新日期:1990-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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更新日期:2008-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2003.12.007
更新日期:2004-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(90)90050-m
更新日期:1990-07-01 00:00:00
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journal_title:Neurotoxicology and teratology
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更新日期:1992-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2011.07.005
更新日期:2011-09-01 00:00:00
abstract::Behavioral and neurochemical analyses were conducted on preweanling CD rats prenatally exposed to either 0, 0.375 or 0.750 mg/kg/day reserpine SC on gestation days 12-15. Offspring body weights were taken on test days, and pups were tested for negative geotaxis responding on postnatal day 8, developmental activity on ...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(89)90028-7
更新日期:1989-09-01 00:00:00
abstract::Understanding the potentially harmful long term consequences of prenatal marijuana exposure is important given the increase in number of pregnant women smoking marijuana to relieve morning sickness. Altered executive functioning is one area of research that has suggested negative consequences of prenatal marijuana exp...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
doi:10.1016/j.ntt.2016.05.010
更新日期:2016-01-01 00:00:00
abstract::Pregnant rats were administered 40 mg/kg of cocaine hydrochloride subcutaneously on gestation days 14 through 21. Rats in one control group were pair-fed to the cocaine group and injected with the saline vehicle during the dosing period, while an untreated control group was simply weighed throughout pregnancy. Materna...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(91)90064-4
更新日期:1991-09-01 00:00:00