Abstract:
:We examined the relationship between acquired color vision loss and exposure to toluene and total hydrocarbons among 125 male workers. Seventy-two toluene-exposed printers were compared with 34 workers from the same photogravure plant with ambient background exposure, and with 19 workers from a bookbinding plant located in the same town (nonexposed). Environmental mean toluene exposure level at workstation was estimated from individual 8-h sampling. Historic exposure data from the last 30 years were used to construct two cumulative exposure indices, one for toluene and one for total hydrocarbons. Airborne toluene levels were overall lower than the current Threshold Limit Value (TLV) of 50 ppm. Color vision was assessed by the Lanthony D-15 desaturated panel. Color vision loss was quantitatively established by the Color Confusion Index (CCI) and classified by type of acquired dyschromatopsia according to Verriest's classification. CCI was positively related to current airborne toluene levels, and cumulative exposure indices for toluene and total hydrocarbons (.18< or =r< or =.35). Odds ratios of acquired dyschromatopsia were significant for current airborne toluene, toluene, and total hydrocarbon past exposure (1.27 [1.02-1.58], 1.21 [1.04-1.39], 1.15 [1.02-1.31], respectively). In conclusion, this study suggests that the Lanthony D-15 desaturated panel detects early neurotoxic effects among workers exposed to toluene.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Campagna D,Stengel B,Mergler D,Limasset JC,Diebold F,Michard D,Huel Gdoi
10.1016/s0892-0362(01)00163-5subject
Has Abstractpub_date
2001-09-01 00:00:00pages
473-80issue
5eissn
0892-0362issn
1872-9738pii
S0892-0362(01)00163-5journal_volume
23pub_type
杂志文章abstract::4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2006.07.004
更新日期:2006-11-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/0892-0362(89)90037-8
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/s0892-0362(99)00046-x
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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