Toluene-induced hearing loss in acivicin-treated rats.

Abstract:

:Toluene can be considered an ototoxic chemical compound in the rat. Outer hair cells are particularly sensitive to this aromatic organic solvent or to one of its metabolites. The objective of the present study was to evaluate the possible role played by cysteine S-conjugates in the ototoxic process in Long-Evans rats. To this end, renal and hepatic metabolism of toluene was modified by treatment with acivicin, an inhibitor of gamma-glutamyl transferase (gamma-GT). First, the efficacy of the acivicin treatment was established from a dose-response investigation in which urinary gamma-GT was measured daily in rats exposed to 1750 ppm toluene, 6 h per day for five days. A twice weekly 5 mg/kg dose was reduced urinary gamma-GT by 70-78%. In a subacute experiment, rats were exposed to 1750 ppm toluene for four consecutive weeks, in which the efficacy of the acivicin treatment was monitored by quantifying the urinary end product of the conjugate pathway: benzyl mercapturic acid (BMA). A 38.5% decrease in BMA was measured at the end of the exposure period. Hearing impairment was evaluated using auditory (inferior colliculus) evoked potentials and completed with conventional histological approaches. The toluene-exposed and the acivicin-treated rats exposed to toluene both had a 7-dB permanent auditory threshold shift at 16-20 kHz. Hair cell loss was not dependent on acivicin treatment. Therefore, the partial inhibition of gamma-GT did not modify the toluene ototoxicity, suggesting that toluene-induced hearing loss is not strongly mediated by the production of cysteine S-conjugates. However, the data do not rule out the possibility that these metabolites may play a minor role.

journal_name

Neurotoxicol Teratol

authors

Waniusiow D,Campo P,Cossec B,Cosnier F,Grossman S,Ferrari L

doi

10.1016/j.ntt.2008.02.006

subject

Has Abstract

pub_date

2008-05-01 00:00:00

pages

154-60

issue

3

eissn

0892-0362

issn

1872-9738

pii

S0892-0362(08)00041-X

journal_volume

30

pub_type

杂志文章
  • Characterization of performance on an automated visual recognition memory task in 7.5-month-old infants.

    abstract::Infant looking behaviors measured during visual assessment paradigms may be more reliable predictors of long-term cognitive outcomes than standard measures such as the Bayley Scales of Infant Development typically used in environmental epidemiology. Infrared eye tracking technology offers an innovative approach to aut...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2020.106904

    authors: Dzwilewski KLC,Merced-Nieves FM,Aguiar A,Korrick SA,Schantz SL

    更新日期:2020-01-01 00:00:00

  • Repeated forced swim stress has additive effects in anxiety behavior and in cathecolamine levels of adult rats exposed to deltamethrin.

    abstract::Deltamethrin (DTM) is a type II pyrethroid insecticide that elicits autonomic and neuroendocrine responses that indicate high levels of stress, presumably caused by the neurotoxic effect of the insecticide. This study investigated the effect of DTM exposure (10 mg/kg, p.o.) and an additional stress induced in the forc...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2014.10.001

    authors: Habr SF,Macrini DJ,Florio JC,Bernardi MM

    更新日期:2014-11-01 00:00:00

  • Pyrethroid effects on schedule-controlled behavior: time and dosage relationships.

    abstract::Pyrethroid insecticides have been divided into Types I and II based on behavioral profiles of toxicity produced by life-threatening dosages. In order to assess potential alterations in acquired (operant) behavior, acute dosage-effect and time-course determinations for permethrin (Type I) and cypermethrin (Type II) wer...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(87)90035-3

    authors: Peele DB,Crofton KM

    更新日期:1987-09-01 00:00:00

  • Reduced auditory acuity in rat pups from excess and deficient omega-3 fatty acid consumption by the mother.

    abstract::Consumption of the nutrients omega-3 fatty acids (omega-3 FA) during pregnancy and lactation is considered beneficial to fetal and infant development. It may also reduce the incidence and severity of preterm births by prolonging gestational length. However several recent human and animal studies have reported that ove...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2006.10.009

    authors: Church MW,Jen KL,Stafferton T,Hotra JW,Adams BR

    更新日期:2007-03-01 00:00:00

  • Neurological deficits in children: medical risk factors and lead exposure.

    abstract::A study of possible undue neurobehavioral effects of low-level lead exposure was performed in Danish school children who entered first grade in 1982. Lead absorption was found to relate to impaired psychological test performance and difficulties at school. However, this relationship was confounded by medical risk fact...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(88)90089-x

    authors: Lyngbye T,Hansen ON,Grandjean P

    更新日期:1988-11-01 00:00:00

  • d-Methionine protects against cisplatin-induced neurotoxicity in cortical networks.

    abstract::Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of various types of cancer. Patients undergoing cisplatin treatment often suffer from a condition known as "chemobrain", ototoxicity, peripheral neuropathy, weight loss, nausea, vomiting, nephrotoxicity, seizures, hearing loss and tinni...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2012.06.002

    authors: Gopal KV,Wu C,Shrestha B,Campbell KC,Moore EJ,Gross GW

    更新日期:2012-09-01 00:00:00

  • Changes in sleep-wake cycle after chronic exposure to uranium in rats.

    abstract::Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l(-1) in drinking water, for 90 days) on electroencephalographic ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2005.07.005

    authors: Lestaevel P,Bussy C,Paquet F,Dhieux B,Clarençon D,Houpert P,Gourmelon P

    更新日期:2005-11-01 00:00:00

  • Effects of high doses of toluene on color vision.

    abstract::High exposure to toluene may cause optic neuropathy and retinopathy, both associated with dyschromatopsia. Another solvent, ethanol, is known to induce acute blue-yellow dyschromatopsia. This study investigated the acute effects of high doses of toluene on color vision. Eight male printshop workers were examined befor...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0892-0362(98)00027-0

    authors: Muttray A,Wolters V,Jung D,Konietzko J

    更新日期:1999-01-01 00:00:00

  • Differential vulnerability of snake species to MPTP: a behavioral and biochemical comparison in ratsnakes (Elaphe) and watersnakes (Nerodia).

    abstract::The synthetic neurotoxicant 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induces a Parkinsonian-like syndrome in humans and nonhuman primates, and also causes movement disorders in rodents, fish, amphibians and lizards. To date, the effects of MPTP have not been characterized in snakes. In this study, the behav...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(02)00204-0

    authors: Temple JG,Miller DB,Barthalmus GT

    更新日期:2002-03-01 00:00:00

  • Reduced neuronal proliferation by proconvulsant drugs in the developing zebrafish brain.

    abstract::Seizures have been reported to modify neural development in the immature brain. In this study, we attempted to determine whether pentylenetetrazol (a GABAergic receptor antagonist, PTZ)-induced seizures influence cell proliferation in zebrafish larvae (5 and 15 days of post-fertilization), using bromodeoxyuridine (Brd...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2010.04.054

    authors: Kim YH,Lee Y,Lee K,Lee T,Kim YJ,Lee CJ

    更新日期:2010-09-01 00:00:00

  • Thermoregulatory effects of chlorpyrifos in the rat: long-term changes in cholinergic and noradrenergic sensitivity.

    abstract::Subcutaneous injection of a sublethal dose of chlorpyrifos (CHLP), an organophosphate (OP) pesticide, causes long-term inhibition in cholinesterase activity (ChE) of brain, blood, and other tissues. Such prolonged inhibition in ChE should lead to marked behavioral and autonomic thermoregulatory patterns, especially in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(94)90002-7

    authors: Gordon CJ

    更新日期:1994-01-01 00:00:00

  • Breast-feeding and gender as moderators of teratogenic effects on cognitive development.

    abstract::Researchers in the Netherlands have reported that the associations of prenatal polychlorinated biphenyl (PCB) exposure with poorer cognitive performance in childhood are generally stronger and statistically significant only among non-breast-fed children. This paper reports a similar pattern of greater vulnerability am...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(02)00197-6

    authors: Jacobson JL,Jacobson SW

    更新日期:2002-05-01 00:00:00

  • Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced rat fetal brain lesions.

    abstract::1-beta-D-Arabinofuranosylcytosine (Ara-C), a cytidine analogue cytotoxic to proliferating cells, has a teratogenic effect in the brain of experimental animals and causes neural cell apoptosis in vitro and in vivo. In the present study, pregnant rats were injected with Ara-C on Day 13 of gestation and the fetal brain w...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2004.03.010

    authors: Yamauchi H,Katayama K,Ueno M,Uetsuka K,Nakayama H,Doi K

    更新日期:2004-07-01 00:00:00

  • Influence of 5-azacytidine on differentiation and growth in rat nervous system tumor cell lines.

    abstract::In vitro studies with permanent cell lines derived from ENU-induced rat CNS and PNS tumors have shown that substances acting on second messenger systems as well as glucocorticoids have a cytostatic effect at high cell densities, but enhance proliferation at low densities. The nontoxic cytostatic effects are partially ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(89)90037-8

    authors: Stark M,Bilzer T,Inoue N,Wechsler W

    更新日期:1989-11-01 00:00:00

  • Dysmorphic and anthropometric outcomes in 6-year-old prenatally cocaine-exposed children.

    abstract::Dysmorphologic and anthropometric assessments were performed on 154 6-year-old children prenatally exposed to cocaine (PCE) and 131 high-risk controls (NCE) of similar race and social class. Adjusted mean height z scores demonstrated a dose-response with metahydroxybenzoylecgonine above a threshold of 100 ng/g of meco...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2005.09.003

    authors: Minnes S,Robin NH,Alt AA,Kirchner HL,Satayathum S,Salbert BA,Ellison L,Singer LT

    更新日期:2006-01-01 00:00:00

  • Effects of monensin feeding during development on female rats and their offspring.

    abstract::Monensin, a growth-promoting agent and coccidiostat used in veterinary medicine, was studied in terms of its effects on the development of female rats and their offspring when added to the diet. Young female rats received 100 or 300 ppm monensin mixed with powdered chow diet until adulthood, when they were mated and t...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(99)00012-4

    authors: de Souza Spinosa H,Nicolau A,Maruo VM,Bernardi MM

    更新日期:1999-07-01 00:00:00

  • Effects of subdiaphragmatic vagotomy on the acquisition of a radiation-induced conditioned taste aversion.

    abstract::The effect of subdiaphragmatic vagotomy on the acquisition of a radiation-induced taste aversion was examined to assess the importance of the vagus nerve in transmitting information on the peripheral toxicity of radiation to the brain. Vagotomy had no effect on taste aversion learning, consistent with reports using ot...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(87)90073-0

    authors: Hunt WA,Rabin BM,Lee J

    更新日期:1987-01-01 00:00:00

  • Prenatal cocaine and/or nicotine exposure in rats: preliminary findings on long-term cognitive outcome and genital development at birth.

    abstract::Prenatal cocaine or nicotine exposure is associated with a variety of teratogenic effects. The current study was conducted to determine their effects alone and in combination on cognitive function and sexual differentiation. Pregnant Long-Evans rats (N = 19) were exposed to either cocaine (15 mg/kg/dose b.i.d. SC on G...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(96)00125-0

    authors: Cutler AR,Wilkerson AE,Gingras JL,Levin ED

    更新日期:1996-11-01 00:00:00

  • 3-Nitropropionic acid produces indirect excitotoxic damage to rat striatum.

    abstract::The mechanism of striatal damage induced by 3-nitropropionic acid (3-NPA) was studied in rats by neuropathological and neurochemical methods. Neuronal shrinkage with astrogliosis was observed in striatum after local injection of 0.5-5 mumol 3-NPA. Decortications involving dorsal and lateral aspects of frontal cortex o...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(94)00076-p

    authors: Fu Y,He F,Zhang S,Huang J,Zhang J,Jiao X

    更新日期:1995-05-01 00:00:00

  • Prenatal exposure to multiple toxic heavy metals and neonatal neurobehavioral development in Shanghai, China.

    abstract:BACKGROUND:Epidemiological studies examining the effects of prenatal toxic heavy metals exposure on neonatal development at the population-based level are limited. OBJECTIVE:To explore prenatal exposure levels to toxic heavy metals and examine whether exposure is associated with neonatal development. METHODS:A strati...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2011.05.010

    authors: Yu XD,Yan CH,Shen XM,Tian Y,Cao LL,Yu XG,Zhao L,Liu JX

    更新日期:2011-07-01 00:00:00

  • Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening.

    abstract::Hazard information essential to guide developmental neurotoxicity risk assessments is limited for many chemicals. As developmental neurotoxicity testing using rodents is laborious and expensive, alternative species such as zebrafish are being adapted for rapid toxicity screening. Assessing the developmental neurotoxic...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2009.04.065

    authors: Fan CY,Cowden J,Simmons SO,Padilla S,Ramabhadran R

    更新日期:2010-01-01 00:00:00

  • GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice.

    abstract::Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brai...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2015.05.011

    authors: Oliveira-Pinto J,Paes-Branco D,Cristina-Rodrigues F,Krahe TE,Manhães AC,Abreu-Villaça Y,Filgueiras CC

    更新日期:2015-07-01 00:00:00

  • Development of neurons and synapses in ochratoxin A-induced microcephalic mice: a quantitative assessment of somatosensory cortex.

    abstract::Ochratoxin A (a mycotoxin) is known to cause cell death in the developing brain of embryos 1-2 days after treatment. Microcephaly was observed with high frequency in mice by prenatal treatment with ochratoxin A. Using a stereological method, the numerical densities of neurons and synapses were investigated in the soma...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(92)90015-3

    authors: Fukui Y,Hayasaka S,Itoh M,Takeuchi Y

    更新日期:1992-05-01 00:00:00

  • Toluene ototoxicity in rats: assessment of the frequency of hearing deficit by electrocochleography.

    abstract::To identify the frequency range most sensitive to toluene-induced auditory damage, the auditory function of adult Long-Evans rats exposed to 1750 ppm of toluene (6 h/day, 5 days/week, 4 weeks), was tested by recording auditory-evoked potentials directly from the round window of the cochlea. The present electrocochleog...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(98)00057-9

    authors: Lataye R,Campo P,Loquet G

    更新日期:1999-05-01 00:00:00

  • Effects of repeated administration of soman on schedule-controlled behavior and brain in the rat.

    abstract::The effects of repeated SC administration of soman on schedule-controlled performance and brain pathology were studied in the rat. Soman suppressed response rates in both components of a multiple fixed interval 50-sec fixed-ratio 25 (mult. FI 50-sec FR 25) schedule of reinforcement, although all animals revealed marke...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/0892-0362(90)90112-p

    authors: Hymowitz N,Ploshnick A,Laemle L,Brezenoff H

    更新日期:1990-01-01 00:00:00

  • Prenatal nicotine exposure in rhesus monkeys compromises development of brainstem and cardiac monoamine pathways involved in perinatal adaptation and sudden infant death syndrome: amelioration by vitamin C.

    abstract::Maternal smoking during pregnancy greatly enhances perinatal morbidity/mortality and is the major risk factor for Sudden Infant Death Syndrome (SIDS). Studies in developing rodents indicate that nicotine is a neuroteratogen that targets monoamine pathways involved in the responses to hypoxia that are in turn, hypothes...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2011.02.001

    authors: Slotkin TA,Seidler FJ,Spindel ER

    更新日期:2011-05-01 00:00:00

  • Neurobehavioral deficits in neonatal rhesus monkeys exposed to cocaine in utero.

    abstract::In spite of significant efforts, the neurobehavioral deficits in infants born from cocaine-abusing mothers have not been clearly defined. In the present study, we examined the presence of these abnormalities in a rhesus monkey model of prenatal cocaine exposure using a nonhuman primate adaptation of the Neonatal Behav...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2003.08.003

    authors: He N,Bai J,Champoux M,Suomi SJ,Lidow MS

    更新日期:2004-01-01 00:00:00

  • Methamphetamine-induced dopamine and serotonin reductions in neostriatum are not gender specific in rats with comparable hyperthermic responses.

    abstract::Methamphetamine (MA)-induced monoamine depletions in male and female Sprague-Dawley CD rats were studied under conditions in which the magnitude of MA-induced hyperthermia was comparable between the sexes. MA (5 or 10 mg/kg) or saline (3 ml/kg) was administered SC four times at 2-h intervals. Animals were sacrificed 3...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(97)00094-9

    authors: Fukumura M,Cappon GD,Broening HW,Vorhees CV

    更新日期:1998-07-01 00:00:00

  • Visuoperceptual functioning differs in 9- to 12-year olds prenatally exposed to cigarettes and marihuana.

    abstract::Visuoperceptual performance was examined in 146 9- to 12-year old children for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects, participants in an ongoing longitudinal study, were from a low-risk, predominantly middle class sample. The tasks ranged in complexity from those that re...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/s0892-0362(99)00046-x

    authors: Fried PA,Watkinson B

    更新日期:2000-01-01 00:00:00

  • Neuropsychological sequelae from acute poisoning and long-term exposure to carbamate and organophosphate pesticides.

    abstract:UNLABELLED:This research examines the effects of different degrees of pesticide exposure on neuropsychological performance. Exposures varied from acute poisoning coupled with chronic exposure to low or high levels of chronic exposure (defined by years of exposure). A cross-sectional neuropsychological and biochemical s...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章

    doi:10.1016/j.ntt.2006.07.004

    authors: Roldan-Tapia L,Nieto-Escamez FA,del Aguila EM,Laynez F,Parron T,Sanchez-Santed F

    更新日期:2006-11-01 00:00:00