Abstract:
:Pregnant C57BL/6 mice were chronically treated with 0, 4, 6, or 8 ppm of methylmercury chloride (MeHg) in drinking water during fetal and early postnatal development. Four behavioral functions were analyzed in female and male offspring between the age of 6 and 12 weeks: motor coordination learning on the rotarod; training to spatial alternation in the standard T maze followed by a working memory test with delays; spontaneous locomotion and rearings in the open field; reference and working memory assessment in the modified T maze [Behav. Neurosci. 102 (1988) 635]. Chronic perinatal treatment with MeHg resulted in moderate brain levels of mercury near birth which rapidly decreased during nursing. MeHg exerted an effect on the performance of females, but not of males, on two of the four measurements. All treated females exhibited less locomotion than control mice when the open field was new, but not in the following four sessions when the environment was becoming increasingly familiar. Working memory was impaired in females treated with 6 and 8 ppm of MeHg in the modified T maze, but not on the test with delays in the standard T maze. Taken together, these results show that chronic exposure to MeHg during fetal and postnatal development had sex-dependent effects on horizontal exploration and on working memory in the modified T maze, and no effects on motor coordination learning and reference memory.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Goulet S,Doré FY,Mirault MEdoi
10.1016/s0892-0362(03)00007-2subject
Has Abstractpub_date
2003-05-01 00:00:00pages
335-47issue
3eissn
0892-0362issn
1872-9738pii
S0892036203000072journal_volume
25pub_type
杂志文章abstract::The effects of maternal urinary tract infection (UTI) or endotoxin exposure on fetal outcome in rats were investigated. Prior to conception, dams of the UTI group were water-deprived and anesthetized. The urinary tract was then catheterized and injected with 0.2 of 1 x 10(9) Escherichia coli. The endotoxin group was i...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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doi:10.1016/0892-0362(94)90126-0
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abstract::Pyrethroid insecticides have been divided into Types I and II based on behavioral profiles of toxicity produced by life-threatening dosages. In order to assess potential alterations in acquired (operant) behavior, acute dosage-effect and time-course determinations for permethrin (Type I) and cypermethrin (Type II) wer...
journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2003.12.007
更新日期:2004-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
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更新日期:2006-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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更新日期:2010-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2010.08.003
更新日期:2011-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1995-03-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 临床试验,杂志文章
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更新日期:1997-11-01 00:00:00
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2008.02.005
更新日期:2008-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
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更新日期:2020-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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doi:10.1016/j.ntt.2018.10.003
更新日期:2018-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
doi:10.1016/j.ntt.2005.01.009
更新日期:2005-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
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doi:10.1016/0892-0362(89)90084-6
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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更新日期:1987-11-01 00:00:00
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journal_title:Neurotoxicology and teratology
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更新日期:2010-09-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
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更新日期:2006-05-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章,评审
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更新日期:2019-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2016.11.010
更新日期:2017-01-01 00:00:00
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journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2003.08.003
更新日期:2004-01-01 00:00:00
abstract::Roles of age and withdrawal were explored in mechanisms underlying the action of amphetamine (Amph), by monitoring the serotonergic and GABAergic expression in key brain regions of the rat. Postnatal 21 and 60 day-old male rats were intraperitoneally injected with D-Amph, 5 mg/kg, or saline, three times daily for 14 d...
journal_title:Neurotoxicology and teratology
pub_type: 杂志文章
doi:10.1016/j.ntt.2006.10.001
更新日期:2007-03-01 00:00:00