Abstract：
:Ethanol exposure on gestational day (GD) 7 in the mouse has previously been shown to result in ventromedian forebrain deficits along with facial anomalies characteristic of fetal alcohol syndrome (FAS). To further explore ethanol's teratogenic effect on the ventromedian forebrain in this mouse model, scanning electron microscopic and histological analyses were conducted. For this, time mated C57Bl/6J mice were injected with 2.9g/kg ethanol or saline twice, at a 4h interval, on their 7th day of pregnancy. On GD 12.5, 13 and 17, control and ethanol-exposed specimens were collected and processed for light and scanning electron microscopic analyses. Gross morphological changes present in the forebrains of ethanol-exposed embryos included cerebral hemispheres that were too close in proximity or rostrally united, enlarged foramina of Monro, enlarged or united lateral ventricles, and varying degrees of hippocampal and ventromedian forebrain deficiency. In GD 12.5 control and ethanol-exposed embryos, in situ hybridization employing probes for Nkx2.1 or Fzd8 to distinguish the preoptic area and medial ganglionic eminences (MGEs) from the lateral ganglionic eminences, respectively, confirmed the selective loss of ventromedian tissues. Immunohistochemical labeling of oligodendrocyte progenitors with Olig2, a transcription factor necessary for their specification, and of GABA, an inhibitory neurotransmitter, showed ethanol-induced reductions in both. To investigate later consequences of ventromedian forebrain loss, MGE-derived somatostatin-expressing interneurons in the subpallial region of GD 17 fetal mice were examined, with results showing that the somatostatin-expressing interneurons that were present were dysmorphic in the ethanol-exposed fetuses. The potential functional consequences of this insult are discussed.
journal_name
Neurotoxicol Teratoljournal_title
Neurotoxicology and teratologyauthors
Godin EA,Dehart DB,Parnell SE,O'Leary-Moore SK,Sulik KKdoi
10.1016/j.ntt.2010.11.001subject
Has Abstractpub_date
2011-03-01 00:00:00pages
231-9issue
2eissn
0892-0362issn
1872-9738pii
S0892-0362(10)00195-9journal_volume
33pub_type
杂志文章abstract：:Memory problems lasting 8 months have previously been described for a small group of female solvent workers following an accidental workplace solvent intoxication. Three years after the intoxication the presence of longer-term residual impairment of cognitive functions was evaluated. The major residual difficulty unco...
journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
doi：10.1016/0892-0362(96)00024-4
更新日期：1996-07-01 00:00:00
abstract：:In a methadone maintenance program for pregnant, drug dependent women, an investigation was undertaken (1) to study the occurrence of violence experienced by the women as children and as adults and (2) to lean whether those who report past violence/abuse are more likely to neglect and/or abandon their children to the ...
journal_title：Neurotoxicology and teratology
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doi：10.1016/0892-0362(87)90022-5
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abstract：:Early-life exposures to brominated diphenyl ethers (BDEs) lead to neurobehavioral abnormalities later in life. Although these agents are thyroid disruptors, it is not clear whether this mechanism alone accounts for the adverse effects. We evaluated the impact of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) on PC12 cel...
journal_title：Neurotoxicology and teratology
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doi：10.1016/j.ntt.2013.02.001
更新日期：2013-05-01 00:00:00
abstract：:A study of possible undue neurobehavioral effects of low-level lead exposure was performed in Danish school children who entered first grade in 1982. Lead absorption was found to relate to impaired psychological test performance and difficulties at school. However, this relationship was confounded by medical risk fact...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(88)90089-x
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abstract：:The increased use of cocaine in the United States and worldwide has created great concern about its effects on fetuses and neonates of pregnant cocaine abusers. The effects on neonates are varied: fetal growth delay, microcephaly, abnormal neurological functions, microphthalmia, and maternal obstetric complications. I...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(96)00227-9
更新日期：1997-05-01 00:00:00
abstract：:Cisplatin is a platinum-based chemotherapeutic agent widely used for the treatment of various types of cancer. Patients undergoing cisplatin treatment often suffer from a condition known as "chemobrain", ototoxicity, peripheral neuropathy, weight loss, nausea, vomiting, nephrotoxicity, seizures, hearing loss and tinni...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2012.06.002
更新日期：2012-09-01 00:00:00
abstract：:One hundred and ten, 6- to 11-year-old children from a low-risk, predominantly middle class sample who are participants in an ongoing longitudinal drug study were assessed using a central auditory processing task (SCAN) that made perceptual rather than linguistic demands. Maternal smoking during pregnancy was linearly...
journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
doi：10.1016/0892-0362(94)90048-5
更新日期：1994-05-01 00:00:00
abstract：:A multidisciplinary study to investigate 2,5-hexanedione (2,5-HD)-induced CNS-neurotoxicity and its proposed potentiation by acetone (AC) was conducted. Neurobehavioral testing, estimation of the brain-swelling reaction, neuropathological and morphometric measurements as well as synaptosomal 5-hydroxytryptamine (5-HT)...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90089-f
更新日期：1991-07-01 00:00:00
abstract：:A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...
journal_title：Neurotoxicology and teratology
pub_type： 临床试验,杂志文章
doi：10.1016/s0892-0362(97)00061-5
更新日期：1997-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2014.05.001
更新日期：2014-07-01 00:00:00
abstract：:The ability of a neurobehavioral screening battery to differentiate the effects of two pyrethroids, permethrin and cypermethrin, was assessed in this experiment. Although the structures of these pesticides differ only in the alpha-cyano group, the behavioral syndromes associated with the Type I and II pyrethroids are ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(93)90065-v
更新日期：1993-03-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(02)00265-9
更新日期：2002-07-01 00:00:00
abstract：:Experimental models and clinical data indicate that the incidence of motor and learning disorders may be increased in children of epileptic mothers taking phenytoin (PHT) during pregnancy. There is little data on the vulnerability of infants to PHT-induced long-term behavioral toxicity after gestational or early life ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2004.12.006
更新日期：2005-03-01 00:00:00
abstract：:Sensory-evoked potentials (EPs) were studied in male Long-Evans and Fischer-344 rats in order to characterize the electrophysiological consequences of chronic inhalation exposure to trichloroethylene (TCE). Groups of ten Long-Evans rats were exposed to air or 1600 ppm or 3200 ppm TCE for twelve weeks and evaluated per...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(91)90031-q
更新日期：1991-01-01 00:00:00
abstract：:Lead is a persistent metal and commonly present in our living environment. The present study was aimed to investigate lead-induced embryonic toxicity, behavioral responses, and adult learning/memory deficit in zebrafish. Lead acetate (PbAc) induced malformations such as uninflated swim bladder, bent spine and yolk-sac...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2012.09.001
更新日期：2012-11-01 00:00:00
abstract：:Pregnant Long-Evans rats were fed a liquid diet containing either 35% ethanol-derived calories (group E) or were pair-fed to group E dams using the same diet with an equivalent amount of sucrose-derived calories (group PFC) on days 7-18 of gestation. At birth half the litters were fostered to other dams of the same tr...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90049-4
更新日期：1989-03-01 00:00:00
abstract：:Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ab...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90084-6
更新日期：1989-01-01 00:00:00
abstract：:Evidence is presented showing that serial choice reaction performance is disrupted at low blood lead levels (PbB), and that parametric variation of task characteristics modulates the degree of disruption. This evidence is based on two independent studies in 6- to 9-year-old children living in two lead smelter areas in...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90043-3
更新日期：1989-11-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2005.03.009
更新日期：2005-05-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2013.03.060
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(00)00094-5
更新日期：2000-09-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,评审
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更新日期：1993-05-01 00:00:00
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journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(97)00093-7
更新日期：1998-05-01 00:00:00
abstract：:Using a timed-breeding protocol, one group of female rhesus monkeys was implanted subcutaneously with osmotic minipumps containing 0.3 mg/kg/h cocaine (N=18) or saline (N=18) from day 24 postconception through gestation. Another group received cocaine (N=12) or saline (N=8) from conception through day 42 of gestation....
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/s0892-0362(01)00121-0
更新日期：2001-03-01 00:00:00
abstract：:Ionizing radiation is a precise tool for altering formation of the developing cerebral cortex of the fetal rat. Whole body exposure of the pregnant rat on gestational day 13, 15 or 17 to 1.0 Gy of gamma radiation resulted in maximum thinning of the cortex on days 15 and 17. In the preweaning period, functional tests (...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(88)90040-2
更新日期：1988-07-01 00:00:00
abstract：:Research suggests that not only is marijuana use prevalent among women of reproductive age, but a significant number of women continue to use marijuana and its derivatives throughout pregnancy. Many studies have shown, in both humans and animals, that marijuana exposure during adolescence and adulthood is detrimental ...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/j.ntt.2011.10.006
更新日期：2012-01-01 00:00:00
abstract：:The reduction in growth resulting from lead (PB) exposure in weanling rats is consistent with a lowering of the biological set-point for food intake. In this study the effects of lead on the patterns of food intake were examined. For 10 days (from ages 26 to 36 days), female rats were provided with drinking water cont...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(94)90040-x
更新日期：1994-11-01 00:00:00
abstract：OBJECTIVE:The present study examined the impact of both perinatal maternal depression and cocaine use on infant neurobehavior at 1 month of age in a large, multi-site study. METHODS:Infant neurobehavior was examined in 1053 infants at 1 month of age using the NICU Network Neurobehavioral Scale (NNNS). Mothers were int...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章,多中心研究
doi：10.1016/j.ntt.2006.12.001
更新日期：2007-05-01 00:00:00
abstract：:Two hundred thirty-six children from two established cohorts at risk for exposure to polychlorinated biphenyls (PCBs) and related contaminants were evaluated at age 4 years. Prenatal exposure (assessed by cord serum PCB level) was associated with lower weight, an effect consistent with reports of growth retardation in...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(90)90050-m
更新日期：1990-07-01 00:00:00
abstract：:Caffeine, added to the drinking water of males used for impregnation and gestant BALB/c mice such that their daily caffeine intake was 60 mg/kg, modified the passive avoidance behavior of the offspring when tested as adults. Caffeine-treated and control mice of the F1 generation were then cross-mated. The F2 generatio...
journal_title：Neurotoxicology and teratology
pub_type： 杂志文章
doi：10.1016/0892-0362(89)90007-x
更新日期：1989-07-01 00:00:00
