Long-term effects of lanthanum intake on the neurobehavioral development of the rat.


:The effects of subchronic exposure to lanthanum on rats' physical and neurobehavioral development were investigated. Wistar rats were exposed to lanthanum through oral administration at 0, 0.1, 2, and 40 mg/kg concentrations from gestation day 0 through 5 months of age. Prior to weaning of the pups, physical parameters and neurobehaviors were assessed, including body weight gain, pinna detachment, eye opening, surface righting reflex and swimming endurance. At 30 days of age, DNA concentration and protein/DNA ratio of the whole brain were determined. At 150 days of age, the Morris water maze test was carried out to study the memory and learning abilities of the rats. Differences were found in the body weight gain, surface righting reflex and swimming endurance. Moreover, lanthanum exposure significantly altered the DNA concentration and Protein/DNA in brain. The Morris water maze test showed that lanthanum exposure at 40 mg/kg significantly impaired memory and learning abilities. These findings indicate that lanthanum is a potential behavior teratogen. The information provided by this work should be considered in future applications of lanthanides.


Neurotoxicol Teratol


Feng L,Xiao H,He X,Li Z,Li F,Liu N,Chai Z,Zhao Y,Zhang Z




Has Abstract


2006-01-01 00:00:00














  • Behavioral evaluations in developmental toxicity testing: MARTA survey results.

    abstract::During 1991, the Middle Atlantic Reproduction and Teratology Association (MARTA) conducted a survey of laboratories performing behavioral evaluations as part of GLP developmental toxicity studies. This survey was conducted to determine the extent to which an "industry standard" had evolved for behavioral test batterie...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Lochry EA,Johnson C,Wier PJ

    更新日期:1994-01-01 00:00:00

  • Evaluation of tremor in aluminum production workers.

    abstract::A cross-sectional study of 63 current and former aluminum potroom workers and 37 comparison workers was conducted to evaluate for evidence of neurological dysfunction, including tremor from long-term exposures to aluminum using sensitive quantitative measures of arm/hand and leg tremor. Signs of upper extremity tremor...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章


    authors: Dick RB,Krieg EF Jr,Sim MA,Bernard BP,Taylor BT

    更新日期:1997-11-01 00:00:00

  • Long-term cognitive sequelae of solvent intoxication.

    abstract::Memory problems lasting 8 months have previously been described for a small group of female solvent workers following an accidental workplace solvent intoxication. Three years after the intoxication the presence of longer-term residual impairment of cognitive functions was evaluated. The major residual difficulty unco...

    journal_title:Neurotoxicology and teratology

    pub_type: 临床试验,杂志文章


    authors: Stollery BT

    更新日期:1996-07-01 00:00:00

  • Recommendations for harmonization of data collection and analysis of developmental neurotoxicity endpoints in regulatory guideline studies: Proceedings of workshops presented at Society of Toxicology and joint Teratology Society and Neurobehavioral Terato

    abstract::The potential for developmental neurotoxicity (DNT) of environmental chemicals may be evaluated using specific test guidelines from the US Environmental Protection Agency or the Organisation for Economic Cooperation and Development (OECD). These guidelines generate neurobehavioral, neuropathological, and morphometric ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Li AA,Sheets LP,Raffaele K,Moser V,Hofstra A,Hoberman A,Makris SL,Garman R,Bolon B,Kaufmann W,Auer R,Lau E,Vidmar T,Bowers WJ

    更新日期:2017-09-01 00:00:00

  • Effect of a neurotoxic dose regimen of (+)-methamphetamine on behavior, plasma corticosterone, and brain monoamines in adult C57BL/6 mice.

    abstract:RATIONALE:In rats, neurotoxic doses of methamphetamine (MA) induce astrogliosis, long lasting monoamine reductions, reuptake transporter down-regulation, and learning impairments. OBJECTIVE:We tested whether comparable effects occur in C57BL/6 mice. METHOD:C57BL/6 mice were treated with 10mg/kgs.c.x4 MA on a single d...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Grace CE,Schaefer TL,Herring NR,Graham DL,Skelton MR,Gudelsky GA,Williams MT,Vorhees CV

    更新日期:2010-05-01 00:00:00

  • GABAA overactivation potentiates the effects of NMDA blockade during the brain growth spurt in eliciting locomotor hyperactivity in juvenile mice.

    abstract::Both NMDA receptor blockade and GABAA receptor overactivation during the brain growth spurt may contribute to the hyperactivity phenotype reminiscent of attention-deficit/hyperactivity disorder. Here, we evaluated the effects of exposure to MK801 (a NMDA antagonist) and/or to muscimol (a GABAA agonist) during the brai...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Oliveira-Pinto J,Paes-Branco D,Cristina-Rodrigues F,Krahe TE,Manhães AC,Abreu-Villaça Y,Filgueiras CC

    更新日期:2015-07-01 00:00:00

  • Developmental toxicity of the environmental pollutant 4-nonylphenol in zebrafish.

    abstract::4-Nonylphenol (4-NP), an estrogen mimicking compound is produced by biodegradation of alkylethoxylates. It is well established that 4-NP can affect the development of aquatic animals by disrupting the endocrine signals. Here we show for the first time in zebrafish that 4-NP does not only target the neuroendocrine syst...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Chandrasekar G,Arner A,Kitambi SS,Dahlman-Wright K,Lendahl MA

    更新日期:2011-11-01 00:00:00

  • Differential effects on cognitive functioning in 13- to 16-year-olds prenatally exposed to cigarettes and marihuana.

    abstract::Cognitive performance was examined in 145 thirteen- to sixteen-year-old adolescents for whom prenatal exposure to marihuana and cigarettes had been ascertained. The subjects were from a low-risk, predominantly middle-class sample participating in an ongoing, longitudinal study. The assessment battery included tests of...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Fried PA,Watkinson B,Gray R

    更新日期:2003-07-01 00:00:00

  • Silver exposure in developing zebrafish produces persistent synaptic and behavioral changes.

    abstract::Environmental silver exposures are increasing due to the use of silver nanoparticles, which exert antimicrobial actions by releasing Ag+, a suspected developmental neurotoxicant. We evaluated the long-term neurochemical and behavioral effects of embryonic Ag+ exposure in zebrafish at concentrations that had no overt e...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Powers CM,Levin ED,Seidler FJ,Slotkin TA

    更新日期:2011-03-01 00:00:00

  • Involvement of p53 in 1-beta-D-arabinofuranosylcytosine-induced rat fetal brain lesions.

    abstract::1-beta-D-Arabinofuranosylcytosine (Ara-C), a cytidine analogue cytotoxic to proliferating cells, has a teratogenic effect in the brain of experimental animals and causes neural cell apoptosis in vitro and in vivo. In the present study, pregnant rats were injected with Ara-C on Day 13 of gestation and the fetal brain w...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Yamauchi H,Katayama K,Ueno M,Uetsuka K,Nakayama H,Doi K

    更新日期:2004-07-01 00:00:00

  • Effects of sodium valproate on development and social behaviour in the Mongolian gerbil.

    abstract::Sodium valproate is an anticonvulsant widely prescribed because of its broad spectrum of activity. While acute toxicity from high doses is well recognized, there have been few animal studies of its chronic toxicity at therapeutic dose levels. Sodium valproate given continuously in drinking fluid (600 mg/l) throughout ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Chapman JB,Cutler MG

    更新日期:1989-03-01 00:00:00

  • Toxicological evaluation of the staircase test for assessing fine motor movements.

    abstract::A variety of tests have been developed to study neurotoxicant-related changes in motor function. However, despite recent advances, there remains a need for simple and specific tests of fine motor movements. Accordingly, we chose to evaluate whether a method developed for measuring changes in skilled movements followin...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Samsam TE,Gadrinab LG,Bushnell PJ

    更新日期:2004-01-01 00:00:00

  • Prenatal exposure to multiple toxic heavy metals and neonatal neurobehavioral development in Shanghai, China.

    abstract:BACKGROUND:Epidemiological studies examining the effects of prenatal toxic heavy metals exposure on neonatal development at the population-based level are limited. OBJECTIVE:To explore prenatal exposure levels to toxic heavy metals and examine whether exposure is associated with neonatal development. METHODS:A strati...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Yu XD,Yan CH,Shen XM,Tian Y,Cao LL,Yu XG,Zhao L,Liu JX

    更新日期:2011-07-01 00:00:00

  • Demonstration of physical dependence following chronic continuous methadone delivery via osmotic minipumps in pregnant rats.

    abstract::The effects of a 14-day (gestation days 7-20) chronic methadone (6.3-9.0 mg/kg/day) infusion via osmotic minipumps were studied on the induction of physical dependence in both pregnant and nonpregnant female rats. Following continued methadone exposure, an acute injection of naloxone (2.0 mg/kg, SC) produced the follo...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Darmani NA,Saady JJ,Schnoll SH,Martin BR

    更新日期:1991-11-01 00:00:00

  • The behavioral effects of pesticides in male mice.

    abstract::Male Swiss mice, 25-30 g, were utilized to define some of the behavioral effects of the herbicides Lasso [alachlor 43%; (A)], Basalin [fluchloralin 45%; (F)], Premerge 3 [dinoseb 51%; (D)], and the fungicide Maneb-80 [maneb 80%; (M)]. These compounds were tested for their effects on locomotor activity and for their ab...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Mitchell JA,Long SF,Wilson MC,Kallman MJ

    更新日期:1989-01-01 00:00:00

  • Prospects on behavioral studies of marine and freshwater toxins.

    abstract::While there is a long-standing tradition of using behavioral methods to study the effects of manufactured drugs and environmental chemicals, comparatively little attention has focused until recently on the behavioral effects of marine or freshwater toxins. A vast array of microorganisms, found in a variety of waters, ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: MacPhail RC,Jarema KA

    更新日期:2005-09-01 00:00:00

  • BDE99 (2,2',4,4',5-pentabromodiphenyl ether) suppresses differentiation into neurotransmitter phenotypes in PC12 cells.

    abstract::Early-life exposures to brominated diphenyl ethers (BDEs) lead to neurobehavioral abnormalities later in life. Although these agents are thyroid disruptors, it is not clear whether this mechanism alone accounts for the adverse effects. We evaluated the impact of 2,2',4,4',5-pentabromodiphenyl ether (BDE99) on PC12 cel...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Slotkin TA,Card J,Infante A,Seidler FJ

    更新日期:2013-05-01 00:00:00

  • Effect of early lead exposure on the maturation of children's postural balance: a longitudinal study.

    abstract::This prospective study investigated the impact of early exposure to lead on the maturation of children's postural balance. The effect of lead exposure on age-associated maturation of postural balance was investigated on 91 children from the Cincinnati Lead Study (CLS) with a 5-year geometric mean lead concentration in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Bhattacharya A,Shukla R,Dietrich KN,Bornschein RL

    更新日期:2006-05-01 00:00:00

  • Developmental neurotoxicity evaluation of the avermectin pesticide, emamectin benzoate, in Sprague-Dawley rats.

    abstract::The potential of emamectin benzoate (EB) to cause developmental neurotoxicity in Sprague-Dawley rats was assessed using a study design by the US EPA. Dosages of 0 (deionized water), 0.1, 0.6, or 3.6 mg/kg/day were administered at 5 ml/kg by oral gavage from gestational day (GD) 6 to lactational day (LD) 20 to groups o...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Wise LD,Allen HL,Hoe CM,Verbeke DR,Gerson RJ

    更新日期:1997-07-01 00:00:00

  • Optic nerve hypoplasia in an acute exposure model of the fetal alcohol syndrome.

    abstract::The effects of acute prenatal exposure to ethanol on the postnatal optic nerve have been examined in a C57B1/6J mouse model. Pregnant mice were exposed by intraperitoneal injection to ethanol (25% ethanol, each dose at 0.015 ml/g separated by 4 h), or to saline on the 8th gestational day and the optic nerve examined a...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Ashwell KW,Zhang LL

    更新日期:1994-03-01 00:00:00

  • Neurobehavioral deficits in neonatal rhesus monkeys exposed to cocaine in utero.

    abstract::In spite of significant efforts, the neurobehavioral deficits in infants born from cocaine-abusing mothers have not been clearly defined. In the present study, we examined the presence of these abnormalities in a rhesus monkey model of prenatal cocaine exposure using a nonhuman primate adaptation of the Neonatal Behav...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: He N,Bai J,Champoux M,Suomi SJ,Lidow MS

    更新日期:2004-01-01 00:00:00

  • Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening.

    abstract::Hazard information essential to guide developmental neurotoxicity risk assessments is limited for many chemicals. As developmental neurotoxicity testing using rodents is laborious and expensive, alternative species such as zebrafish are being adapted for rapid toxicity screening. Assessing the developmental neurotoxic...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Fan CY,Cowden J,Simmons SO,Padilla S,Ramabhadran R

    更新日期:2010-01-01 00:00:00

  • Subchronic neurotoxicity in rats of the structural fumigant, sulfuryl fluoride.

    abstract::Inhalation exposure of male and female Fischer 344 rats to sulfuryl fluoride [Vikane (Dow Chemical Company) gas fumigant] at 300 ppm for 6 hr/day, 5 days week, for 13 weeks caused diminished weight gain, dental fluorosis, a slight decrease in grooming, decreased flicker fusion threshold, slowing of flash, auditory and...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Mattsson JL,Albee RR,Eisenbrandt DL,Chang LW

    更新日期:1988-03-01 00:00:00

  • Prenatal ethanol exposure decreases hippocampal 3H-vinylidene kainic acid binding in 45-day-old rats.

    abstract::The effect of prenatal ethanol exposure on the kainate-sensitive subtype of glutamate receptor binding sites was studied using in vitro 3H-vinylidene kainic acid (VKA) autoradiography. Pregnant Sprague-Dawley rats were fed a liquid diet containing either 3.35% or 6.7% ethanol throughout gestation. Pair-fed dams receiv...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Farr KL,Montano CY,Paxton LL,Savage DD

    更新日期:1988-11-01 00:00:00

  • Developmental neurotoxic effects of chlorpyrifos on acetylcholine and serotonin pathways in an avian model.

    abstract::The developmental neurotoxicity of organophosphates such as chlorpyrifos (CPF) involves multiple mechanisms that ultimately compromise the function of specific neurotransmitter systems, notably acetylcholine (ACh) and serotonin (5-hydroxytryptamine, 5HT). Studies in mammalian models incorporate both direct effects on ...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Slotkin TA,Seidler FJ,Ryde IT,Yanai J

    更新日期:2008-09-01 00:00:00

  • Effects of exposure to PCBs and related compounds on growth and activity in children.

    abstract::Two hundred thirty-six children from two established cohorts at risk for exposure to polychlorinated biphenyls (PCBs) and related contaminants were evaluated at age 4 years. Prenatal exposure (assessed by cord serum PCB level) was associated with lower weight, an effect consistent with reports of growth retardation in...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Jacobson JL,Jacobson SW,Humphrey HE

    更新日期:1990-07-01 00:00:00

  • Low-level lead exposure triggers neuronal apoptosis in the developing mouse brain.

    abstract::While the toxic effects of lead have been recognized for millennia, it has remained a significant public health concern due to its continued use and toxicological potential. Of particular interest is the increased susceptibility of young children to the toxic effects of lead. Although the exact mechanism(s) for lead t...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Dribben WH,Creeley CE,Farber N

    更新日期:2011-07-01 00:00:00

  • Enhancement of developmental toxicity effects of chemicals by gestational stress. A review.

    abstract::Risk assessment of developmental toxicants is almost exclusively based on single chemicals studied in animals under controlled experimental conditions, as to reduce stress. Although humans may be exposed simultaneously to numerous hazards, little is known about the interaction of prenatal chemical exposures with other...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章,评审


    authors: Hougaard KS,Hansen AM

    更新日期:2007-07-01 00:00:00

  • Effects of acute ethanol intoxication during pregnancy on central dopaminergic system in male rats.

    abstract::Pregnant albino rats received 2 IP injections, spaced by 4 h, of either ethanol (2.9 g/kg in 24% v/v saline solution) or saline, on gestational day (GD) 8. During adulthood, male rats prenatally exposed to alcohol exhibited an increased stereotyped behavioral response to 12 mg/kg of amphetamine (AMPH) or 1 mg/kg of ap...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Fulginiti S,Minetti SA,Virgolini MB

    更新日期:1994-07-01 00:00:00

  • Effects of subdiaphragmatic vagotomy on the acquisition of a radiation-induced conditioned taste aversion.

    abstract::The effect of subdiaphragmatic vagotomy on the acquisition of a radiation-induced taste aversion was examined to assess the importance of the vagus nerve in transmitting information on the peripheral toxicity of radiation to the brain. Vagotomy had no effect on taste aversion learning, consistent with reports using ot...

    journal_title:Neurotoxicology and teratology

    pub_type: 杂志文章


    authors: Hunt WA,Rabin BM,Lee J

    更新日期:1987-01-01 00:00:00