Abstract:
INTRODUCTION:Evidences suggest that fat intake, visceral obesity and intracellular lipids are related to insulin impairment. OBJECTIVE:The objective of the present paper was correlate visceral obesity and metabolic alterations in control (CTR) and hyperlipidic cafeteria diet (CFT) fed animals. METHODS:After 6 months of diet treatment, liver and muscle of the male rats were utilized to determined glucose uptake and glycogen metabolism after administration of 0.4I U/kg insulin in vivo, and correlate the visceral adiposity to these two parameters. RESULTS:Ample range of physiologic answers to body composition in metabolic profile of the both diets was found. No differences were found in glycemia and triacylglycerol after insulin action in both groups, however CFT group accumulated higher adiposity, mostly visceral fat, and showed lower glycogen content in the liver. We also found an inverse correlation between visceral adiposity and glucose uptake and a decrease of the glycogen synthase active form in the liver. CTR animals demonstrated an inverse correlation between glucose uptake and visceral adiposity in the muscle. DISCUSSION AND CONCLUSION:It was observed a variability of metabolic alterations in animals which can be related to degree of accumulation of abdominal adiposity and ingestion of diet fats. Further studies will be required to clarify the reasons for the observed liver alterations in CFT and muscle alterations in CTR animals. :Introducción: Las evidencias sugieren que la ingesta de grasas, obesidad visceral y lípidos intracelulares están relacionados con resistencia a la acción de la insulina. Objetivo: El objetivo del presente trabajo fue correlacionar la obesidad visceral con alteraciones metabólicas en los animales controles (CTR) y alimentados con la dieta de cafeteria hiperlipidica (CFT). Metodos: Después de 6 meses de tratamiento con dieta, el hígado y lo musculo esqueletico de los ratones se utilizaron para determinar la captación de glucosa y el metabolismo del glucógeno después de la administración de la insulina 0.4 UI/kg in vivo y correlacionar la adiposidad visceral a estos dos parámetros. Resultados: Una amplia gama de respuestas fisiológicas a la composición corporal era encontrado. No se encontraron diferencias en la glucemia y triglicéridos después de la acción de la insulina en ambos grupos, sin embargo CFT grupo acumuló mayor adiposidad, principalmente adiposidad visceral, y mostraron menor contenido de glucógeno en el hígado. También se encontró una correlación inversa entre la adiposidad visceral y la captación de glucosa y una disminución de la forma activa de la enzima glucógeno sintasa en el hígado. Animales CTR demostrado una correlación inversa entre la captación de glucosa y la adiposidad visceral en el músculo. Discusión y conclusiones: Se observó una gran variabilidad de alteraciones metabólicas en los animales que se pueden relacionados con las tasas de acumulación de la adiposidad visceral y la ingestión de grasas dietéticas. Más estudios serán necesarios para aclarar las razones de las alteraciones observadas en el hígado de los animales CFT y las alteraciones musculares en animales CTR.
journal_name
Nutr Hospjournal_title
Nutricion hospitalariaauthors
Kaiser de Souza D,de Souza FA,de Fraga LS,Peres Konrad S,Belló-Klein A,Martins da Silva RS,Kucharski LCdoi
10.3305/nh.2013.28.2.6181subject
Has Abstractpub_date
2013-03-01 00:00:00pages
545-52issue
2eissn
0212-1611issn
1699-5198journal_volume
28pub_type
杂志文章abstract:INTRODUCTION:The Food Neophobia Scale (FNS), originally developed in English, has been widely used in different studies to assess the individual's willingness to try new foods. However, a process of translation and cultural adaptation is required to enable the use of FNS in other countries. OBJECTIVE:to translate and ...
journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,meta分析,评审
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章,评审
doi:
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journal_title:Nutricion hospitalaria
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doi:
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:1993-01-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2010-11-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2009-11-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
doi:
更新日期:2004-03-01 00:00:00
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journal_title:Nutricion hospitalaria
pub_type: 杂志文章
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