Effects of the dietary amount and source of protein, resistance training and anabolic-androgenic steroids on body weight and lipid profile of rats.

Abstract:

INTRODUCTION:Dietary protein amount and source, hypertrophy resistance training (RT) and anabolicandrogenic steroids (AAS) may affect body weight and plasma and hepatic lipid profile. MATERIAL AND METHODS:157 adult male Wistar rats were randomly distributed in 16 experimental groups resulting in: normal-protein (NP) or high-protein (HP) diets, whey or soy-protein diets, with or without RT and with or without AAS, for 3 months. RESULTS AND DISCUSSION:Final body weight was lower in the RT and AAS groups compared to sedentary and non- AAS groups, respectively (all, p<0.001). Plasma total cholesterol (TC) was lower for the HP compared to the NP diets, for the whey compared to the soy-protein diets and for the AAS compared to the non-AAS groups (all, p<0.001). Plasma HDL-cholesterol was higher in the RT groups (p<0.05) but lower for the AAS groups (p<0.001), the HP and the soy-protein diets (p<0.05). Plasma triglycerides (TAG) were lower for the HP diet (p<0.001), for the RT (p=0.002) and the non-AAS groups (p=0.001). Liver TC was lower for the NP (p<0.01), for the soyprotein (p<0.05) and for the AAS groups (p<0.001). Liver TAG were lower for the whey-protein diet (p<0.001), RT and non-AAS groups (both, p<0.05). Some interactions were found, such as the greater effect of AAS on reducing body weight of rats that performed RT or ingested a HP diet (all, p<0.05). HDL-cholesterol was higher when RT was combined with HP diets (p=0.010) or non-AAS and when HP diets were combined with non-AAS (both,p<0.001). Groups that combined RT with non-AAS administration obtained the lowest hepatic TAG (p<0.05). CONCLUSION:Among all the interventions tested, AAS was the factor that most negatively affected plasma and hepatic lipid profile, whereas HP diets and RT could benefit lipid profile, especially when combined. :Introducción: La cantidad y la fuente de proteína, el entrenamiento de fuerza hipertrofia (EF) y los esteroides anabolizantes androgénicos (EAA) pueden alterar el peso corporal y el perfil lipídico plasmático y hepático. Material y métodos: 157 ratas Wistar adultas macho se distribuyeron al azar en 16 grupos experimentales del siguiente modo: dietas normoproteica (NP) o hiperproteicas (HP), proteínas de lactosuero o de soja, con y sin EF y con o sin EAA, durante un periodo experimental de 3 meses. Resultados y discusión: El peso corporal final fue menor en los grupos con EF y EAA en comparación con los grupo sedentario y sin EAA, respectivamente (todos, p<0,001). El colesterol plasmático total (CT) fue menor en el grupo con dieta HP en comparación con las dieta NP, para las dietas de proteínas de lactosuero en comparación con las proteínas de soja, y para el grupo con EAA en comparación con el grupo sin EAA (todos, p<0,001). Las concentraciones plasmáticas de colesterol HDL fueron superiores en los grupos de EF (p<0,05) y menores en los grupos con EAA (p<0,001), y de dieta HP o con proteína de soja (p<0,05). Los triglicéridos (TAG) plasmáticos fueron menores con la dieta HP (p<0,001), el EF (p=0,002) y la no administración de EAA (p=0,001). El CT hepático fue menor en los grupos de dieta NP (p<0,01), dieta con proteínas de soja (p<0,05) y grupo de EAA (p<0,001). Los TAG hepáticos fueron menores en los grupos de dieta de proteínas de lactosuero (p<0,001), EF y sin EAA (ambos, p<0,05). Se hallaron algunas interacciones como un mayor efecto de los EAA en la reducción del peso corporal de las ratas que realizaron EF o ingirieron una dieta HP (todos, p<0,05). Las concentraciones plasmáticas de colesterol HDL fueron superiores cuando se combinó el EF con las dietas HP (p=0,010) o sin EAA y cuando las dietas HP se combinaron con el no uso de EAA (ambos, p<0,001). Finalmente, los grupos que combinaron el EF sin EAA obtuvieron los valores más bajos de TAG hepáticos (p<0,05). Conclusión: De entre todas las intervenciones testadas, los EAA fueron el factor que más negativamente afectó al perfil lipídico plasmático y hepático, mientras que las dietas HP y el EF podrían beneficiar, en general, el perfil lipídico, especialmente cuando se combinan.

journal_name

Nutr Hosp

journal_title

Nutricion hospitalaria

authors

Aparicio VA,Sánchez C,Ortega FB,Nebot E,Kapravelou G,Porres JM,Aranda P

doi

10.3305/nh.2013.28.1.6055

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

127-36

issue

1

eissn

0212-1611

issn

1699-5198

journal_volume

28

pub_type

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