Matrix metalloproteinases inhibition promotes the polyfunctionality of human natural killer cells in therapeutic antibody-based anti-tumour immunotherapy.

abstract：:Immunization with thyrotropin receptor (TSHR)-adenovirus is an effective approach for inducing thyroid stimulating antibodies and Graves' hyperthyroidism in BALB/c mice. In contrast, mice of the same strain vaccinated with TSHR-DNA have low or absent TSHR antibodies and their T cells recognize restricted epitopes on t...

journal_title：Clinical and experimental immunology

authors： Pichurin PN,Chen CR,Nagayama Y,Pichurina O,Rapoport B,McLachlan SM

更新日期：2004-03-01 00:00:00

abstract：:In order to investigate the T cell cytokine profile during age-dependent maturation of the immune response, we evaluated the cytokine expression of CD4+ and CD8+ circulating cells by flow cytometric single-cell analysis after non-specific stimulation in vitro in different age groups of normal individuals, from cord bl...

journal_title：Clinical and experimental immunology

authors： Krampera M,Vinante F,Tavecchia L,Morosato L,Chilosi M,Romagnani S,Zanolin ME,Pizzolo G

更新日期：1999-08-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced...

journal_title：Clinical and experimental immunology

authors： Hansson AS,Lu S,Holmdahl R

更新日期：2002-01-01 00:00:00

abstract：:The sera of six patients infected with Trichinella spiralis were studied for the presence of circulating immune complexes (CIC). CIC were present in all six patients studied 1 month after infection. In two patients in whom serial serum samples were available, as clinical improvement occurred there was a decrease in th...

journal_title：Clinical and experimental immunology

authors： Géniteau M,Verroust PJ,Smith MD,Morel-Maroger L,Saimot G,Coulaud JP

更新日期：1977-10-01 00:00:00

abstract：:The recent development of salivary proteomics has led to the identification of potential biomarkers for diagnosing patients with primary Sjögren's syndrome (pSS). Here we sought to identify differentially produced salivary metabolites from pSS patients and healthy controls (HCs) that might be used to characterize this...

journal_title：Clinical and experimental immunology

authors： Kageyama G,Saegusa J,Irino Y,Tanaka S,Tsuda K,Takahashi S,Sendo S,Morinobu A

更新日期：2015-11-01 00:00:00

abstract：:Growth of a methylcholanthrene-induced fibrosarcoma in BALB/c mice was accompanied by an increase in the activation state of tumour-associated macrophages (TAM), as measured by their FcIgG receptor expression, phagocytic index and beta-glucuronidase levels. All of these parameters were markedly higher in TAM than in p...

journal_title：Clinical and experimental immunology

authors： Valdéz JC,Perdigón G

更新日期：1991-11-01 00:00:00

abstract：:In vitro inducible suppressor cell precursors were detected in the spleen of BALB/c but not in DBA/2 mice infected intraperitoneally with 10(8) Mycobacterium lepraemurium bacilli, thus suggesting that their development is genetically controlled. Two pairs of mouse strains congenic at the Ity/Lsh/Bcg locus (BALB/c-C.D2...

journal_title：Clinical and experimental immunology

authors： Gosselin D,Turcotte R,Lemieux S

更新日期：1994-05-01 00:00:00

abstract：:CD30 is a surface molecule which can be expressed by normal B and T lymphocytes. Our study focused on the CD30 expression and release compared with IL-4 expression as well as CD23-alpha/beta in peripheral blood mononuclear cells (PBMC) from atopic subjects and controls. Data showed a lack of CD30 mRNA expression in th...

journal_title：Clinical and experimental immunology

authors： Esnault S,Benbernou N,Lavaud F,Guenounou M

更新日期：1996-10-01 00:00:00

abstract：:The aim of this study was to investigate the role of IL-12 in patients with RA. IL-12 (p70) and its associated cytokines were measured in sera and synovial fluid (SF) using an enzyme-linked immunosorbent method. Seven American College of Rheumatology (ACR) core set measures as well as IL-12 levels were sequentially mo...

journal_title：Clinical and experimental immunology

authors： Kim W,Min S,Cho M,Youn J,Min J,Lee S,Park S,Cho C,Kim H

更新日期：2000-01-01 00:00:00

abstract：:A method enabling direct enumeration of mouse T and B cells from cytocentrifuged cell smears is described. The acid alpha-naphthyl acetate esterase (ANAE) staining was used as marker for T cells. The distribution of the ANAE marker-carrying lymphocytes closely followed the percentual distribution of T cells in spleen ...

journal_title：Clinical and experimental immunology

authors： Ranki A,Tötterman TH,Häyry P

更新日期：1976-12-01 00:00:00

abstract：:Monoclonal anti-dermatan sulphate antibodies were produced with hybridization after immunizing BALB/c mice with dermatan sulphate (DS). These antibodies were tested for cross-reactivity to double-stranded DNA (dsDNA) and heat-denatured DNA (ssDNA). Five clones had binding activity to DS, dsDNA and ssDNA in enzyme-link...

journal_title：Clinical and experimental immunology

authors： Ohnishi K,Sagawa A,Nakabayashi T,Ohmoto A,Megumi,Yoshikawa M,Watanabe I,Mukai M,Yasuda I,Nakagawa S

更新日期：1989-01-01 00:00:00

abstract：:Interleukin (IL)-22 is a cytokine involved in inflammatory and wound healing processes that is secreted primarily by T helper type 17 (Th17) cells. IL-22 receptor (IL-22R) expression is limited to epithelial cells of the digestive organs, respiratory tract and skin. Most tumours originating in these sites over-express...

journal_title：Clinical and experimental immunology

authors： Curd LM,Favors SE,Gregg RK

更新日期：2012-05-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease that develops as a result of the interaction between genetic and environmental risk factors. Although increasing evidence shows the importance of genes in determining the risk of RA, it is clear that environmental factors also have a vital role. Studies to da...

journal_title：Clinical and experimental immunology

authors： Colebatch AN,Edwards CJ

更新日期：2011-01-01 00:00:00

abstract：:Complement activation with formation of biologically potent mediators like C5a and the terminal C5b-9 complex (TCC) contributes essentially to development of inflammation and tissue damage in a number of autoimmune and inflammatory conditions. A particular role for complement in the ischaemia/reperfusion injury of the...

journal_title：Clinical and experimental immunology

authors： Harboe M,Ulvund G,Vien L,Fung M,Mollnes TE

更新日期：2004-12-01 00:00:00

abstract：:The NOD mouse is a model of human juvenile type I diabetes mellitus. As in humans and in the BB rat model, the development of diabetes in NOD mice is accompanied by evident manifestations of cell-mediated and humoral autoimmunity. Beside autoantibodies directed at putative islet cell antigens, NOD sera contain antibod...

journal_title：Clinical and experimental immunology

authors： Lehuen A,Altman J,Bach JF,Carnaud C

更新日期：1990-09-01 00:00:00

abstract：:During chronic inflammation, interleukin (IL)-22 expression is up-regulated in both CD4 and CD8 T cells, exerting a protective role in infections. However, in autoimmunity, IL-22 appears to have either a protective or a pathogenic role in a variety of murine models of autoimmunity and, by extrapolation, in humans. It ...

journal_title：Clinical and experimental immunology

authors： Yang GX,Sun Y,Tsuneyama K,Zhang W,Leung PS,He XS,Ansari AA,Bowlus C,Ridgway WM,Gershwin ME

更新日期：2016-08-01 00:00:00

abstract：:In humans and in laboratory animals, administration of a single does of glucocorticosteroids induces a rapid and transient decrease in the numbers of peripheral blood lymphocytes through a redistribution of circulating lymphocytes. This lymphocytopenic effect is an important factor in the immunosuppressive capacity of...

journal_title：Clinical and experimental immunology

authors： Bloemena E,Weinreich S,Schellekens PT

更新日期：1990-06-01 00:00:00

abstract：:After 3-4 weeks culture of human bone marrow cells in medium supplemented with IL-3, macrophage- (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), the firmly adherent cells exhibited the morphologic features of mononuclear phagocytes and were strongly esterase-positive. Flow cytometric analysis r...

journal_title：Clinical and experimental immunology

authors： Keller R,Keist R,Joller P,Groscurth P

更新日期：1993-01-01 00:00:00

abstract：:Previous studies show that endoplasmic reticulum-associated aminopeptidase (ERAP1/ERAP2) and runt-related transcription factor 3 (RUNX3) gene polymorphisms are associated with AS (ankylosing spondylitis) in European Caucasians. However, contradictory results were reported in different Asian populations. The purpose of...

journal_title：Clinical and experimental immunology

authors： Su W,Du L,Liu S,Deng J,Cao Q,Yuan G,Kijlstra A,Yang P

更新日期：2018-07-01 00:00:00

abstract：:There is increasing evidence that the functional state of the immune system at birth is predictive of the kinetics of immune maturation in early infancy. Moreover, this maturation process can have a major impact on early vaccine responses and can be a key determinant of risk for communicable and non-communicable disea...

journal_title：Clinical and experimental immunology

authors： van den Biggelaar AH,Holt PG

更新日期：2010-04-01 00:00:00

abstract：:Autoantibodies to the intermediate filament proteins vimentin and keratin were studied in sera of 50 Caribbean patients with Schistosoma mansoni infection and 50 control subjects. Autoantibodies were detected by indirect immunofluorescence on HEp-2 cells pretreated with colchicine. The incidence of anti-vimentin antib...

journal_title：Clinical and experimental immunology

authors： Boehme MW,Kataaha PK,Holborow EJ

更新日期：1989-08-01 00:00:00

abstract：:The possible role of cytokines in leprosy reactions was investigated by analysing the levels of tumour necrosis factor (TNF) and interleukin-1 (IL-1) in serum samples from 39 leprosy patients, 22 of them presenting either type I (upgrading) or type II (ENL) reactions. Fifty per cent of the patients showed elevated con...

journal_title：Clinical and experimental immunology

authors： Sarno EN,Grau GE,Vieira LM,Nery JA

更新日期：1991-04-01 00:00:00

abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

journal_title：Clinical and experimental immunology

authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

更新日期：2000-11-01 00:00:00

abstract：:T cells from systemic lupus erythematosus (SLE) patients display a wide array of anomalies in peripheral immune tolerance mechanisms. The role of ubiquitin ligases such as Cbl-b has been described recently in these phenomena. However, its role in resistance to suppression phenotype in SLE has not been characterized, w...

journal_title：Clinical and experimental immunology

authors： Romo-Tena J,Rajme-López S,Aparicio-Vera L,Alcocer-Varela J,Gómez-Martín D

更新日期：2018-01-01 00:00:00

abstract：:We have studied the skin and nerve fibrosis in toxic oil syndrome by in situ hybridization using specific cDNA probes for types I, III, and IV collagens. Fibroblasts with high levels of type I and III collagen mRNA were observed in biopsies from fibrotic skin areas. Similarly, type IV collagen mRNA was abundant in cel...

journal_title：Clinical and experimental immunology

authors： Gomez-Reino JJ,Sandberg M,Carreira PE,Vuorio E

更新日期：1993-07-01 00:00:00

abstract：:Fifty sera which gave ring-like nuclear staining in immunofluorescence on rat liver tissue sections were characterized. Using immunoprecipitation and Western blotting we showed that 10 of the sera contained antibodies to 200 kD polypeptide(s) of nuclear envelope. Clinical and biological data were available for nine of...

journal_title：Clinical and experimental immunology

authors： Lassoued K,Guilly MN,Andre C,Paintrand M,Dhumeaux D,Danon F,Brouet JC,Courvalin JC

更新日期：1988-11-01 00:00:00

abstract：:Neutrophils have the shortest half-life among circulating leucocytes and rapidly undergo apoptosis in vitro. The homologous Bcl-2 and Bax proteins have opposing effects, with Bcl-2 extending cellular survival and Bax promoting cell death following an apoptotic stimulus. We determined Bcl-2 to Bax expression ratios in ...

journal_title：Clinical and experimental immunology

authors： Van Der Vliet HJ,Wever PC,Van Diepen FN,Yong SL,Ten Berge IJ

更新日期：1997-11-01 00:00:00

abstract：:Ten out of 20 (50%) 17-week-old female NOD/WEHI mice developed an acute form of autoimmune diabetes when injected with two large doses of cyclophosphamide (CY), given at 14-day intervals. If these mice were treated under a prophylactic regimen with 2.5 mg/kg body weight per day of the novel immunosuppressant deoxysper...

journal_title：Clinical and experimental immunology

authors： Nicoletti F,Borghi MO,Meroni PL,Barcellini W,Fain C,Di Marco R,Menta R,Schorlemmer HU,Bruno G,Magro G

更新日期：1993-02-01 00:00:00

abstract：:In order to study T-cell function related to the production of autoimmune nephropathy, we immunized random-bred mice, homozygous athymic nude (nu/nu) mice and heterozygous hairy (nu/+) mice with human glomeruli contained in Freund's complete adjuvant. The random-bred and heterozygous hairy mice developed circulating a...

journal_title：Clinical and experimental immunology

authors： Bolton WK,Benton FR,Lobo PI

更新日期：1978-09-01 00:00:00

abstract：:Based on what is known about the biology of HIV-1 vertical transmission, the HIV burden of the mother, maternal immune factors and the integrity of the placental barrier are likely to play major roles. We therefore sought to determine whether the presence of antibodies in sera from 47 HIV-1-infected mothers, including...

journal_title：Clinical and experimental immunology

authors： Mabondzo A,Rouvier P,Raoul H,Le Naour R,Courpotin C,Hervé F,Parnet-Mathieu F,Lasfargues G,Dormont D

更新日期：1995-12-01 00:00:00