Mononuclear phagocytes from human bone marrow progenitor cells; morphology, surface phenotype, and functional properties of resting and activated cells.

abstract：:Sarcoidosis is a multisystem disease of unknown etiology characterized by non-caseating granulomata, formed mainly from macrophages surrounded by lymphocytes and plasma cells. Using a novel method for the preparation of blood leucocytes for flow cytometry, we report increased expression of LeuCAMs (CD11/CD18) on perip...

journal_title：Clinical and experimental immunology

authors： Shakoor Z,Hamblin AS

更新日期：1992-10-01 00:00:00

abstract：:Autoimmune diseases are either tissue-specific like multiple sclerosis (MS) or multisystemic like systemic lupus erythematosus (SLE), although clinically both exhibit common features. To gain insight into the properties of the genes involved in each disease we have investigated the gene expression signature of periphe...

journal_title：Clinical and experimental immunology

authors： Mandel M,Gurevich M,Pauzner R,Kaminski N,Achiron A

更新日期：2004-10-01 00:00:00

abstract：:Immunoenzymatic assays were developed for the measurement of antibodies against mycobacterial lipoarabinomannan (LAM), a cell-free proteic extract (CFX) of Mycobacterium leprae, and the 38-kD protein antigen of M. tuberculosis. Sera from 108 leprosy patients, belonging to all clinical-immunological forms of the spectr...

journal_title：Clinical and experimental immunology

authors： Sousa AO,Henry S,Marója FM,Lee FK,Brum L,Singh M,Lagrange PH,Aucouturier P

更新日期：1998-01-01 00:00:00

abstract：:Burkholderia pseudomallei is the causative agent of melioidosis. Historically believed to be a relatively rare human disease in tropical countries, a recent study estimated that, worldwide, there are approximately 165 000 human melioidosis cases per year, more than half of whom die. The bacterium is inherently resista...

journal_title：Clinical and experimental immunology

authors： Morici L,Torres AG,Titball RW

更新日期：2019-05-01 00:00:00

abstract：:Eight genetically different strains of mice were compared regarding the dissemination of Paracoccidioides brasiliensis to the lungs, liver and omentum/pancreas, DTH responses and specific antibody production at 16 weeks after intraperitoneal infection with Pb18, a virulent P. brasiliensis isolate. The degree of dissem...

journal_title：Clinical and experimental immunology

authors： Singer-Vermes LM,Sakamoto TN,Vaz CA,Calich VL

更新日期：1995-07-01 00:00:00

abstract：:An altered expression pattern of adhesion molecules (AM) on the surface of immune cells is a premise for their extravasation into the central nervous system (CNS) and the formation of acute brain lesions in multiple sclerosis (MS). We evaluated the impact of glatiramer acetate (GA) on cell-bound and soluble AM in the ...

journal_title：Clinical and experimental immunology

authors： Sellner J,Koczi W,Harrer A,Oppermann K,Obregon-Castrillo E,Pilz G,Wipfler P,Afazel S,Haschke-Becher E,Trinka E,Kraus J

更新日期：2013-09-01 00:00:00

abstract：:Ulcerative colitis (UC) and Crohn's disease (CD) are considered to be immunologically mediated disorders that share certain features with murine models of colitis. Whether any of these models are physiologically relevant to the human condition remains controversial. The hypothesis is that increased amounts of antibodi...

journal_title：Clinical and experimental immunology

authors： Ebert EC,Panja A,Das KM,Praveen R,Geng X,Rezac C,Bajpai M

更新日期：2009-01-01 00:00:00

abstract：:Ani s 7 is currently the most important excretory/secretory (ES) Anisakis simplex allergen, as it is the only one recognized by 100% of infected patients. The allergenicity of this molecule is due mainly to the presence of a novel CX(17-25)CX(9-22)CX(8)CX(6) tandem repeat motif not seen in any previously reported prot...

journal_title：Clinical and experimental immunology

authors： Anadón AM,Romarís F,Escalante M,Rodríguez E,Gárate T,Cuéllar C,Ubeira FM

更新日期：2009-06-01 00:00:00

abstract：:In order to determine whether or not IFN-gammaR is associated with regulatory mechanisms on human eosinophil function, we examined the expression of functional IFN-gammaR on human peripheral eosinophils. In this study, peripheral blood eosinophils were obtained from seven normal controls and 12 patients (bronchial ast...

journal_title：Clinical and experimental immunology

authors： Ishihara C,Ochiai K,Kagami M,Takashahi H,Matsuyama G,Yoshida S,Tomioka H,Koya N

更新日期：1997-12-01 00:00:00

abstract：:The respective roles of thymus-derived and bone marrow-derived lymphocytes in the immune response to DNA was investigated in mice reconstituted with various cell populations using cell transfers. A helper effect of thymus-derived cells in the immune response to DNA was suggested by experiments performed in athymic nud...

journal_title：Clinical and experimental immunology

authors： Fournié GJ,Lambert PH,Bankhurst AD,Miescher PA

更新日期：1976-10-01 00:00:00

abstract：:Modern era advancements in medical care, with improved treatment of infections, can result in delayed diagnosis of congenital immunodeficiencies. In this study we present a retrospective cohort of 16 patients diagnosed with Chronic Granulomatous Disease (CGD) at adulthood. Some of the patients had a milder clinical ph...

journal_title：Clinical and experimental immunology

authors： Barkai T,Somech R,Broides A,Gavrieli R,Wolach B,Marcus N,Hagin D,Stauber T

更新日期：2020-09-01 00:00:00

abstract：:The controlled induction of haemoxygenase-1 (HO-1), an enzyme that catabolizes haem, has been shown to reduce haem, preventing pathologies associated with haem toxicity. The hemoglobin genotype HbAS confers reduced susceptibility to severe complications of malaria by a mechanism that is not well understood. Using a lo...

journal_title：Clinical and experimental immunology

authors： Ademolue TW,Amodu OK,Awandare GA

更新日期：2017-05-01 00:00:00

abstract：:When MRL/lpr (H-2k) spleen cells were intraperitoneally injected into C.B-17-scid/scid (severe combined immunodeficient (SCID)) (H-2d) mice, the SCID (SCID-MRL/lpr) mice manifested a severe wasting syndrome with weight loss, splenic atrophy, and lymphoid cell infiltration in the liver and lung, as seen in lpr-GVHD. In...

journal_title：Clinical and experimental immunology

authors： Hosaka N,Nagata N,Miyashima S,Ikehara S

更新日期：1994-06-01 00:00:00

abstract：:Activin A is a cytokine whose multiple functions have yet to be fully determined. In this study, the role of proinflammatory cytokines in regulatory control of activin A production was shown in synoviocytes and chondrocytes. Additional facets of functional inflammation-related activities of activin A were also determi...

journal_title：Clinical and experimental immunology

authors： Yu EW,Dolter KE,Shao LE,Yu J

更新日期：1998-04-01 00:00:00

abstract：:Mice with SCID disease have previously been successfully engrafted with human peripheral blood mononuclear cells (PBMC) obtained from normal individuals and from patients with various diseases. To determine whether SCID mice engrafted with SLE PBMC produced autoantibodies with specificities similar to those in the SLE...

journal_title：Clinical and experimental immunology

authors： Ashany D,Hines J,Gharavi A,Mouradian J,Elkon KB

更新日期：1992-04-01 00:00:00

abstract：:There are estimated to be approximately 1500 people in the United Kingdom with C1 inhibitor (C1INH) deficiency. At BartsHealth National Health Service (NHS) Trust we manage 133 patients with this condition and we believe that this represents one of the largest cohorts in the United Kingdom. C1INH deficiency may be her...

journal_title：Clinical and experimental immunology

authors： Manson AL,Price A,Dempster J,Clinton-Tarestad P,Greening C,Enti R,Hill S,Grigoriadou S,Buckland MS,Longhurst HJ

更新日期：2013-07-01 00:00:00

abstract：:Previous reports have defined the capacity of ragweed pollen extract (RWA) to activate human complement (C) in fluid phase through the classical pathway and have ascertained a strong correlation between the extent of complement activation and the severity of symptoms of allergic rhinoconjunctivitis during the ragweed ...

journal_title：Clinical and experimental immunology

authors： Hidvégi T,Berrens L,Varga L,Marañon F,Schmidt B,Kirschfink M,Füst G

更新日期：1997-04-01 00:00:00

abstract：:Cell-mediated cytotoxicity (CTX) of meningioma patients was assessed postoperatively by a [3H]proline microcytotoxicity test. Autologous and allogeneic tumour cells were used for prelabelling with isotope and peripheral blood lymphocytes added in a ratio of 200:1. After 60 hg the plates were washed and residual CMP co...

journal_title：Clinical and experimental immunology

authors： Pees HW,Seidel B

更新日期：1976-05-01 00:00:00

abstract：:Circulating immune complexes (CIC) have been postulated to contribute to the development of secondary complications in diabetes mellitus. In this study, CIC were measured in control rats and both insulin deficient and insulin treated streptozotocin-induced diabetic rats. CIC were more prevalent in both groups of diabe...

journal_title：Clinical and experimental immunology

authors： Abrass CK

更新日期：1984-07-01 00:00:00

abstract：:In order to gain information about the nature of the defect in X-linked severe combined immunodeficiency (XSCID), we investigated gene expression in different lymphoid and haematopoietic cells of female carriers by looking for non-random X chromosome usage. We have shown non-random X chromosome usage in T lymphocyte e...

journal_title：Clinical and experimental immunology

authors： Goodship J,Malcolm S,Levinsky RJ

更新日期：1991-01-01 00:00:00

abstract：:In this second review on chemokines, we focus on the polymorphisms and alternative splicings and on their consequences in disease. Because chemokines are key mediators in the pathogenesis of inflammatory, autoimmune, vascular and neoplastic disorders, a large number of studies attempting to relate particular polymorph...

journal_title：Clinical and experimental immunology

authors： Colobran R,Pujol-Borrell R,Armengol MP,Juan M

更新日期：2007-10-01 00:00:00

abstract：:Mixed cryoglobulinaemia (MC) is a disorder characterized by the presence of large amounts of cryoprecipitating IgM-IgG complexes. An immune complex glomerulonephritis develops in one third of all patients, but its occurrence does not seem related to the amount of cryoglobulins in the sera, nor to their complement-fixi...

journal_title：Clinical and experimental immunology

authors： Dolcher MP,Marchini B,Sabbatini A,Longombardo G,Ferri C,Riente L,Bombardieri S,Migliorini P

更新日期：1994-05-01 00:00:00

abstract：:Immunization with thyrotropin receptor (TSHR)-adenovirus is an effective approach for inducing thyroid stimulating antibodies and Graves' hyperthyroidism in BALB/c mice. In contrast, mice of the same strain vaccinated with TSHR-DNA have low or absent TSHR antibodies and their T cells recognize restricted epitopes on t...

journal_title：Clinical and experimental immunology

authors： Pichurin PN,Chen CR,Nagayama Y,Pichurina O,Rapoport B,McLachlan SM

更新日期：2004-03-01 00:00:00

abstract：:Antibodies recognizing infliximab (IFX) may develop in a proportion of treated patients, leading to loss of response or hypersensitivity reactions (HRs). T cell response to IFX has been poorly investigated. This paper was addressed to detect IFX-specific T cells in treated patients with inflammatory diseases developin...

journal_title：Clinical and experimental immunology

authors： Vultaggio A,Petroni G,Pratesi S,Nencini F,Cammelli D,Milla M,Prignano F,Annese V,Romagnani S,Maggi E,Matucci A,ABIRISK Consortium.

更新日期：2016-12-01 00:00:00

abstract：:Elevated numbers of peripheral T cells expressing the activation associated antigen T9 are found in patients with active Crohn's disease. Expression of T9 is found to be correlated to the activity of the disease. However the presence of activated peripheral T cells is not restricted to Crohn's disease, but could also ...

journal_title：Clinical and experimental immunology

authors： Raedler A,Fraenkel S,Klose G,Thiele HG

更新日期：1985-06-01 00:00:00

abstract：:In this study we demonstrate that IgG present in the sera of patients with primary Sjögren's syndrome (PSS) could bind and activate muscarinic acetylcholine receptors (mAChRs) of rat parotid gland. These antibodies were able to inhibit in a non-competitive manner the binding of 3H-quinuclidinyl benzilate (QNB) to mACh...

journal_title：Clinical and experimental immunology

authors： Bacman S,Sterin-Borda L,Camusso JJ,Arana R,Hubscher O,Borda E

更新日期：1996-06-01 00:00:00

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00

abstract：:Type I diabetes (T1D) is a T cell-mediated autoimmune disease characterized by loss of tolerance to islet autoantigens, leading to the destruction of insulin-producing beta cells. Peripheral tolerance to self is maintained in health through several regulatory mechanisms, including a population of CD4+CD25hi naturally ...

journal_title：Clinical and experimental immunology

authors： Lawson JM,Tremble J,Dayan C,Beyan H,Leslie RD,Peakman M,Tree TI

更新日期：2008-12-01 00:00:00

abstract：:Lymphocyte transformation test has often been used as an in vitro test for nickel allergy. We have previously demonstrated the presence of nickel-reactive T cells in individuals with no history of allergic disease and with a negative patch test towards NiSO4. In this study, we show that this proliferative response was...

journal_title：Clinical and experimental immunology

authors： Lisby S,Hansen LH,Menn T,Baadsgaard O

更新日期：1999-08-01 00:00:00

abstract：:The monoclonal antibody HNK-1 identifies a subpopulation of lymphocytes containing almost all of the natural killer (NK) and antibody-dependent killer (K) cell activity. Using an immunoperoxidase technique on frozen tissue sections of human spleen, tonsil and lymph node we have demonstrated that cells identified by th...

journal_title：Clinical and experimental immunology

authors： Ritchie AW,James K,Micklem HS

更新日期：1983-03-01 00:00:00