Abstract：
:Previous reports have defined the capacity of ragweed pollen extract (RWA) to activate human complement (C) in fluid phase through the classical pathway and have ascertained a strong correlation between the extent of complement activation and the severity of symptoms of allergic rhinoconjunctivitis during the ragweed blooming season. In the present study the complement-activating and specific IgE-binding capacities of various ragweed allergen preparations were compared. Elimination of physically adsorbed (flavonoid) pigments from the allergenic proteins had no significant effect on their complement-consuming capacity, although the process strongly diminished specific IgE binding. Removal of an IgE-binding trypsin inhibitor from RWA significantly enhanced RWA-induced complement activation, whereas it did not change IgE binding. These findings indicate that neither the physically adsorbed pigments nor the trypsin inhibitor are involved in complement activation by ragweed pollen allergens, and suggest that complement activation and specific IgE binding are distinct molecular properties of ragweed pollen allergen.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Hidvégi T,Berrens L,Varga L,Marañon F,Schmidt B,Kirschfink M,Füst Gdoi
10.1046/j.1365-2249.1997.d01-974.xsubject
Has Abstractpub_date
1997-04-01 00:00:00pages
122-7issue
1eissn
0009-9104issn
1365-2249journal_volume
108pub_type
杂志文章abstract：:Loss of pancreatic beta-cells in type I diabetes is associated with an increase in T helper 1 (Th1) proinflammatory cytokines in the islet milieu, with a concomitant reduction in Th2 anti-inflammatory cytokines. In animal models, manoeuvres designed to polarize Th1 responses towards Th2, particularly involving interle...
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pub_type： 杂志文章
doi：10.1046/j.1365-2249.1997.4511469.x
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journal_title：Clinical and experimental immunology
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doi：10.1111/j.1365-2249.1995.tb03658.x
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doi：
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doi：
更新日期：1983-01-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1977-03-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1985-04-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：10.1046/j.1365-2249.1996.d01-607.x
更新日期：1996-02-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：10.1111/cei.13474
更新日期：2020-09-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1978-05-01 00:00:00
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doi：10.1046/j.1365-2249.2001.01474.x
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1981-11-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1976-09-01 00:00:00
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journal_title：Clinical and experimental immunology
pub_type： 杂志文章
doi：
更新日期：1986-04-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1984-03-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
更新日期：1981-11-01 00:00:00
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journal_title：Clinical and experimental immunology
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doi：
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journal_title：Clinical and experimental immunology
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