Abstract:
:The precise factor responsible for the altered immunological reactivity and diminished inflammatory responses occurring in pregnancy is unknown. Recent observations implicate the pregnancy-associated alpha-2 glycoprotein (PAG). Using rosette assays for the detection of cells carrying Fc receptors and for the demonstration of surface HLA-DR antigens, we demonstrate that a serum protein fraction rich in PAG inhibits these surface markers on human monocytes. Brief exposure of normal peripheral blood monocytes to physiological concentrations of PAG led to almost total loss of Fc receptor expression, an effect that was concentration-related. Using a monoclonal anti-HLA-DR antibody linked to red cells, physiological concentrations of PAG also significantly inhibited the detection of HLA-DR on monocytes. As controls, we used a protein fraction isolated in identical fashion from male sera devoid of PAG, and an alpha-2 macroglobulin isolate. These findings suggest that PAG, by masking monocyte surface markers, could be responsible for the suppression of some cell functions during pregnancy.
journal_name
Clin Exp Immunoljournal_title
Clinical and experimental immunologyauthors
Persellin RH,Rhodes Jsubject
Has Abstractpub_date
1981-11-01 00:00:00pages
350-4issue
2eissn
0009-9104issn
1365-2249journal_volume
46pub_type
杂志文章abstract::An injection of human renal tubular fraction, Fx1A, with Freund's complete adjuvant in rats induces Heymann nephritis (HN) with clinical and morphological features similar to rat Fx1A-induced HN. The present study was undertaken to characterize antibody specificities and the corresponding antigen involved in human Fx1...
journal_title:Clinical and experimental immunology
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pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
pub_type: 杂志文章
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pub_type: 杂志文章
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journal_title:Clinical and experimental immunology
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journal_title:Clinical and experimental immunology
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