Stimulation of antibody synthesis induced by surgical trauma in rats.

abstract：:Monocyte-depleted mononuclear cells (MNC) from healthy subjects synthesized IgM-class antibody to single-stranded DNA (anti-ssDNA) at significantly higher levels than unfractionated MNC. The increased production of IgM anti-ssDNA by monocyte-depleted normal MNC was inhibited to a greater degree than total IgM by addit...

journal_title：Clinical and experimental immunology

authors： Okawa-Takatsuji M,Aotsuka S,Uwatoko S,Kinoshita M,Yokohari R

更新日期：1989-09-01 00:00:00

abstract：:Serum and salivary responses of 95 infants to either a standard (4 x 10(4) plaque-forming units (PFU), 47 neonates) or a high dose (4 x 10(5) PFU, 48 neonates) of tetravalent reassortant rhesus rotavirus vaccine (administered at 2 days and at 6 weeks of age) were evaluated in a double-blind clinical trial. Serum and s...

journal_title：Clinical and experimental immunology

authors： Friedman MG,Segal B,Zedaka R,Sarov B,Margalith M,Bishop R,Dagan R

更新日期：1993-05-01 00:00:00

abstract：:Several studies in murine systems have suggested a role of apoptosis in the pathogenesis of leishmaniasis. However, the role of apoptosis in visceral leishmaniasis in man has not been explored. In this study, we show that patients with visceral leishmaniasis demonstrate significant dysregulation of Fas and Fas ligand....

journal_title：Clinical and experimental immunology

authors： Eidsmo L,Wolday D,Berhe N,Sabri F,Satti I,El Hassan AM,Sundar S,Chiodi F,Akuffo H

更新日期：2002-11-01 00:00:00

abstract：:Eight genetically different strains of mice were compared regarding the dissemination of Paracoccidioides brasiliensis to the lungs, liver and omentum/pancreas, DTH responses and specific antibody production at 16 weeks after intraperitoneal infection with Pb18, a virulent P. brasiliensis isolate. The degree of dissem...

journal_title：Clinical and experimental immunology

authors： Singer-Vermes LM,Sakamoto TN,Vaz CA,Calich VL

更新日期：1995-07-01 00:00:00

abstract：:Disseminated infection with virulent Mycobacterium avium in C57Bl/6 (B6) mice leads to severe lymphocyte depletion in secondary lymphoid organs. In this study, we found an up-regulation of caspase-8 activity in spleen cell extracts from M. avium 25291-infected B6 mice compared to non-infected mice. The activation of t...

journal_title：Clinical and experimental immunology

authors： Borges M,Rosa GT,Appelberg R

更新日期：2011-06-01 00:00:00

abstract：:The sera of seven out of eight patients with Herpes gestationis contained a factor which fixed C3 but not detectable amounts of immunoglobulin (Ig) on the basement membrane zone (BMZ) of normal human skin. Using C2-deficient human serum and C4-deficient guinea-pig serum, fixation was shown to be dependent upon activat...

journal_title：Clinical and experimental immunology

authors： Carruthers JA,Ewins AR

更新日期：1978-01-01 00:00:00

abstract：:Immune responses towards malignant plasma cells have clearly been demonstrated in the course of monoclonal B cell dyscrasias and shown to be mostly specific for idiotypic determinants of the monoclonal immunoglobulin (Ig). These responses are specifically efficient against lymphoma cells expressing a membrane form of ...

journal_title：Clinical and experimental immunology

authors： Galea HR,Cogné M

更新日期：2002-08-01 00:00:00

abstract：:In this paper we describe the clinical and molecular features of a new case (GOR) of homozygous human TAP2 deficiency, analysing the phenotype and function of NK cells. The patient presented from infancy with recurrent sinopulmonary infections; a selective IgG2 deficiency, negative antibody response to polysaccharide ...

journal_title：Clinical and experimental immunology

authors： Matamoros N,Milà J,Llano M,Balas A,Vicario JL,Pons J,Crespí C,Martinez N,Iglesias-Alzueta J,López-Botet M

更新日期：2001-08-01 00:00:00

abstract：:There is a link between increased allergy and a reduction of some infections in western countries. Epidemiological data also show that respiratory allergy is less frequent in people exposed to orofaecal and foodborne microbes such as Toxoplasma gondii. Infection with T. gondii induces a strong cell-mediated immunity w...

journal_title：Clinical and experimental immunology

authors： Fenoy I,Giovannoni M,Batalla E,Martin V,Frank FM,Piazzon I,Goldman A

更新日期：2009-02-01 00:00:00

abstract：:Allergic disorders are viewed generally as organ diseases and thus referred to organ specialists, such as the ear, nose and throat specialist for rhinitis, the pulmonologist for asthma, the dermatologist for dermatitis, and so on. Indeed, the systemic nature of allergy is made evident by the fact that the same individ...

journal_title：Clinical and experimental immunology

authors： Pucci S,Incorvaia C

更新日期：2008-09-01 00:00:00

abstract：:Native type II collagens of rat, chick, bovine, human and murine origin have been used for immunization of male and female DBA/1 mice of different ages. The four heterologous collagens were able to induce arthritis in both male and female mice although the incidence of arthritis was higher in males. The onset of arthr...

journal_title：Clinical and experimental immunology

authors： Holmdahl R,Jansson L,Gullberg D,Rubin K,Forsberg PO,Klareskog L

更新日期：1985-12-01 00:00:00

abstract：:Inducible co-stimulator-positive (ICOS) and programmed cell death 1-positive (PD-1) are important markers for follicular helper T cells (Tfh); however, their roles and clinical values in ulcerative colitis (UC) remain unknown. In this study, we recruited 68 UC patients and 34 healthy controls. Circulating ICOS+ , PD-1...

journal_title：Clinical and experimental immunology

authors： Long Y,Zhao X,Liu C,Xia C,Liu C

更新日期：2020-10-01 00:00:00

abstract：:It has always been known that anti-tissue transglutaminase 2 (anti-TG2) antibodies are produced in the small intestine. Their serum titres correlate with mucosal damage degree and decrease on a gluten-free diet (GFD). We aimed to correlate intestinal anti-TG2 antibodies levels with degree of mucosal damage and GFD dur...

journal_title：Clinical and experimental immunology

authors： Tosco A,Auricchio R,Aitoro R,Ponticelli D,Primario M,Miele E,Rotondi Aufiero V,Discepolo V,Greco L,Troncone R,Maglio M

更新日期：2014-09-01 00:00:00

abstract：:A retrospective chart review was conducted at a single centre, capturing data on 173 primary immunodeficiency disease (PIDD) patients, including 40 obese patients, using subcutaneous administration of immunoglobulin (Ig) (SCIG) (16 or 20%) delivered by infusion pump or subcutaneous (s.c.) rapid push. Patients previous...

journal_title：Clinical and experimental immunology

authors： Shapiro R

更新日期：2013-08-01 00:00:00

abstract：:Integral membrane proteins (IMP) represent a serologically distinct class of mycobacterial antigens which are potent stimulators of human T cells (Mehrotra et al., Clin Exp Immunol 1995; 102:626). The range of IMP from Mycobacterium fortuitum was resolved by continuous elution SDS-PAGE to recover 31 discrete fractions...

journal_title：Clinical and experimental immunology

authors： Mehrotra J,Mittal A,Dhindsa MS,Sinha S

更新日期：1997-09-01 00:00:00

abstract：:This study was performed to determine whether or not IL-18, formerly called IFN-gamma-inducing factor, is involved in the pathogeneses of allergic disorders. Peripheral blood mononuclear cells (PBMC) were obtained from patients with allergic bronchial asthma (BA), patients with atopic dermatitis (AD) and controls who ...

journal_title：Clinical and experimental immunology

authors： El-Mezzein RE,Matsumoto T,Nomiyama H,Miike T

更新日期：2001-11-01 00:00:00

abstract：:The role of T cells in the pathophysiology of chronic obstructive pulmonary disease (COPD) is not yet certain, although varying reports have shown increases in T helper 1 (Th1) and/or Th2 cytokines in peripheral blood and bronchoalveolar lavage (BAL). No studies have examined cytokine production by intraepithelial T c...

journal_title：Clinical and experimental immunology

authors： Hodge G,Nairn J,Holmes M,Reynolds PN,Hodge S

更新日期：2007-10-01 00:00:00

abstract：:Polyspecific IgG given intravenously at high doses (IVIG) is used for immunomodulatory therapy in autoimmune diseases such as idiopathic thrombocytopenic purpura and myasthenia gravis. It is assumed that the clinical effect is brought about in part by a modulation of mononuclear phagocyte function, in particular by an...

journal_title：Clinical and experimental immunology

authors： Jungi TW,Brcic M,Kuhnert P,Spycher MO,Li F,Nydegger UE

更新日期：1990-10-01 00:00:00

abstract：:Parechymal cells (PC) were prepared by digestion of perfused, lavaged rat lung in a mixture of collagenase and DNase, and harvested on a discontinuous percoll gradient. The process yielded on average 1.0 X 10(8) viable cells/gram tissue. PC were pulsed with soluble antigen, and tested for their capacity to trigger ant...

journal_title：Clinical and experimental immunology

authors： Holt PG,Degebrodt A,O'Leary C,Krska K,Plozza T

更新日期：1985-12-01 00:00:00

abstract：:Evidence is emerging that exposure to mercury (Hg) may elicit many pathological manifestations, including immunomodulation. We tested whether changing cellular activation pathways may affect the immunomodulation by Hg. Human cell cultures were set up where isolated peripheral blood mononuclear cells, activated by mono...

journal_title：Clinical and experimental immunology

authors： Hemdan NY,Lehmann I,Wichmann G,Lehmann J,Emmrich F,Sack U

更新日期：2007-05-01 00:00:00

abstract：:The non-specific acute phase response in mice is associated with increased resistance to bacterial infection, which is critically mediated by granulocyte colony stimulating factor (G-CSF), but the behaviour of G-CSF in the human acute phase response is not known. Cardiothoracic surgery is a powerful acute phase stimul...

journal_title：Clinical and experimental immunology

authors： Noursadeghi M,Pepys MB,Gallimore R,Cohen J

更新日期：2005-04-01 00:00:00

abstract：:The aim of this study was to determine the contribution of neutrophils to adjuvant arthritis (AA) by in vivo depletion of peripheral blood neutrophils. Specific anti-neutrophil MoAb, RP3 (10 mg), or a control antibody was given twice daily on days 8-11 after injection of Mycobacterium tuberculosis in inbred male Sprag...

journal_title：Clinical and experimental immunology

authors： Santos LL,Morand EF,Hutchinson P,Boyce NW,Holdsworth SR

更新日期：1997-02-01 00:00:00

abstract：:The production of anti-tetanus toxoid (TT) antibody and anti-anti-TT (auto-anti-Id) antibody has been measured in three young and three old persons. Both antibodies were measured using ELISA. We found that: (i) the anti-TT response of old subjects was lower than that of young subjects, (ii) serum auto-anti-Id antibody...

journal_title：Clinical and experimental immunology

authors： Arreaza EE,Gibbons JJ Jr,Siskind GW,Weksler ME

更新日期：1993-04-01 00:00:00

abstract：:It has previously been shown that murine sarcoma cells express high-affinity IL-4 receptors (IL-4R) which are internalized after binding to the ligand (Puri et al., Cancer Res 1991; 51:3011-7). We have also reported that human renal cell carcinoma cells express high-affinity IL-4R, and IL-4 inhibits tumour growth in v...

journal_title：Clinical and experimental immunology

authors： Obiri NI,Siegel JP,Varricchio F,Puri RK

更新日期：1994-01-01 00:00:00

abstract：:Glomerulonephritis with organized microtubular monoclonal immunoglobulin deposits (GOMMID) and glomerulonephritis related to type I cryoglobulin are well-known but rare complications of B cell derived chronic lymphocytic leukaemia. In these disorders, monoclonal Ig have never been studied at the molecular level. We co...

journal_title：Clinical and experimental immunology

authors： Galea HR,Bridoux F,Aldigier JC,Paraf F,Bordessoule D,Touchard G,Cogné M

更新日期：2002-07-01 00:00:00

abstract：:Turner syndrome (TS) is associated with an increased frequency of autoimmunity. Frequently observed autoimmune diseases in TS are also seen in the autoimmune polyendocrine syndrome type I (APS I), of which Addison disease is a key component. An overlapping antibody profile between TS and APS I could be considered. The...

journal_title：Clinical and experimental immunology

authors： Berglund A,Cleemann L,Oftedal BE,Holm K,Husebye ES,Gravholt CH

更新日期：2019-03-01 00:00:00

abstract：:This study aimed to examine whether acute intermittent porphyria (AIP) is associated with systemic inflammation and whether the inflammation correlates with disease activity. A case-control study with 50 AIP cases and age-, sex- and place of residence-matched controls was performed. Plasma cytokines, insulin and C-pep...

journal_title：Clinical and experimental immunology

authors： Storjord E,Dahl JA,Landsem A,Fure H,Ludviksen JK,Goldbeck-Wood S,Karlsen BO,Berg KS,Mollnes TE,W Nielsen E,Brekke OL

更新日期：2017-03-01 00:00:00

abstract：:Two colour fluorescent staining using anti-Leu-1 and anti-B1 monoclonal antibodies has been combined with continuous flow microfluorimetry to analyse and isolate the T and B cell populations in B cell chronic lymphocytic leukaemia (B-CLL) patients. In Rai stage 0 patients two distinct B1 positive populations were dete...

journal_title：Clinical and experimental immunology

authors： Murphy JJ,Tooze J,Millard RE,Hudson L

更新日期：1987-06-01 00:00:00

abstract：:The carcinoembryonic antigen (CEA) distribution obtained after fractionation of thirty sera of patients with gastrointestinal tumours by gel filtration in Sephadex G200 was compared with that resulting from extraction of the sera with perchloric acid. In all cases gel filtration yielded a fraction of free CEA and in t...

journal_title：Clinical and experimental immunology

authors： Kapsopoulou-Dominos K,Anderer FA

更新日期：1979-07-01 00:00:00

abstract：:Since thyroid follicular epithelial cells (thyrocytes) have been shown to express a number of functions similar to monocytes, they were further examined for their potency in secreting thymocyte-stimulating activity (TSA). Although spontaneous production of TSA could not be detected when thyrocytes were cultured in the...

journal_title：Clinical and experimental immunology

authors： Hirose W,Kawagoe M,Hara M,Kitani A,Hirose T,Norioka K,Harigai M,Nakamura H

更新日期：1987-10-01 00:00:00