Incidence of arthritis and autoreactivity of anti-collagen antibodies after immunization of DBA/1 mice with heterologous and autologous collagen II.

abstract：:The prevalence of atopic diseases in children has increased during the last decades. Atopic symptoms usually appear early in life. This implies an early priming for atopic disease, possibly even at the fetal level. We therefore compared the presence and production of IgE in the local in utero environment during pregna...

journal_title：Clinical and experimental immunology

authors： Sverremark Ekstrom E,Nilsson C,Holmlund U,van der Ploeg I,Sandstedt B,Lilja G,Scheynius A

更新日期：2002-02-01 00:00:00

abstract：:Interleukin-6 (IL-6) is a key cytokine featuring redundancy and pleiotropic activity. It plays a central role in host defence against environmental stress such as infection and injury. Dysregulated, persistent interleukin (IL)-6 production has been implicated in the development of various autoimmune, chronic inflammat...

journal_title：Clinical and experimental immunology

authors： Mesquida M,Leszczynska A,Llorenç V,Adán A

更新日期：2014-06-01 00:00:00

abstract：:Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after expos...

journal_title：Clinical and experimental immunology

authors： De Moerloose PA,Frazer IH,Sewell WA,Collins EJ,Mackay IR

更新日期：1986-05-01 00:00:00

abstract：:Nerve growth factor (NGF) regulates B cell activation and differentiation and is an autocrine survival factor for memory B lymphocytes. We have reported recently that the number of memory B cells is reduced during HIV-1 infection. In this study we evaluated whether alteration in the NGF supply was involved in memory B...

journal_title：Clinical and experimental immunology

authors： Titanji K,Nilsson A,Mörch C,Samuelsson A,Sönnerborg A,Grutzmeier S,Zazzi M,De Milito A

更新日期：2003-05-01 00:00:00

abstract：:Treatment of systemic infection with Candida albicans with a combination of an antifungal agent (i.e. fluconazole) and a thymus-derived immunostimulant (i.e. thymosin alpha 1 (T alpha 1)) in mice immunosuppressed by morphine treatments was investigated. In normal mice, fluconazole given after infection with 10(6) C. a...

journal_title：Clinical and experimental immunology

authors： di Francesco P,Gaziano R,Casalinuovo IA,Belogi L,Palamara AT,Favalli C,Garaci E

更新日期：1994-09-01 00:00:00

abstract：:Dendritic cells (DCs) are powerful antigen-presenting cells capable of maintaining peripheral tolerance. The possibility to generate tolerogenic DCs opens new therapeutic approaches in the prevention or remission of autoimmunity. There is currently no treatment inducing long-term tolerance and remission in type 1 diab...

journal_title：Clinical and experimental immunology

authors： Marin-Gallen S,Clemente-Casares X,Planas R,Pujol-Autonell I,Carrascal J,Carrillo J,Ampudia R,Verdaguer J,Pujol-Borrell R,Borràs FE,Vives-Pi M

更新日期：2010-05-01 00:00:00

abstract：:The proliferative responses to stimulation with phytohaemagglutinin (PHA) in cultures of lymphocytes from newly calved and non-pregnant cattle were compared. Lymphocyte cultures from newly calved cows were seen to respond less to PHA than cultures from the non-pregnant cows. It is suggested that this depression in res...

journal_title：Clinical and experimental immunology

authors： Wells PW,Burrells C,Martin WB

更新日期：1977-07-01 00:00:00

abstract：:To elucidate the mechanisms of anti-DNA production, we assessed the binding of sera of normal human subjects (NHS) and patients with SLE to a panel of bacterial and mammalian DNA. Using single-stranded DNA as antigens in an ELISA, NHS showed significant binding to some but not all bacterial DNA, while lacking reactivi...

journal_title：Clinical and experimental immunology

authors： Wu ZQ,Drayton D,Pisetsky DS

更新日期：1997-07-01 00:00:00

abstract：:The open reading frame of human proteinase 3 (PR3) without the prepro-peptide was cloned and expressed in Escherichia coli (rcPR3) and in Pichia pastoris (rpPR3). The 6-histidine tagged rpPR3 was efficiently secreted into culture supernatant from which it could be purified by immobilized metal chelate chromatography. ...

journal_title：Clinical and experimental immunology

authors： Harmsen MC,Heeringa P,van der Geld YM,Huitema MG,Klimp A,Tiran A,Kallenberg CG

更新日期：1997-11-01 00:00:00

abstract：:Malignant rabbit fibroma virus (MV) directly suppresses generation of antibody responses and mitogen induced T and B lymphocyte proliferation. We investigated whether this phenomenon required expression of the complete viral genome. Phosphonoacetic acid (PAA) inhibits poxvirus specific DNA polymerases. Adding PAA to c...

journal_title：Clinical and experimental immunology

authors： Strayer DS,Skaletsky E,Leibowitz JL

更新日期：1986-10-01 00:00:00

abstract：:Both MRL-lpr/lpr (lpr) and BXSB mice fall victim to autoimmune disease as a function of age. To combine their properties, brother-sister mating of (female lpr x male BXSB)F1 mice was done. Mice for mating were selected according to indicators of early onset of glomerulonephritis and subsequent early death (i.e., EOD)....

journal_title：Clinical and experimental immunology

authors： Honda S,Nemoto K,Mae T,Kinjoh K,Kyogoku M,Kawamura H,Miyazawa S,Weerashinghe A,Watanabe H,Narita J,Koya T,Arakawa M,Abo T

更新日期：1999-04-01 00:00:00

abstract：:Hybridization of peripheral blood lymphocytes from patients with rheumatoid arthritis has yielded 14 monoclonal antibodies which react with cultured human epithelial cells. Immunofluorescence staining identifies at last five different types of antibody. Solid phase immunosorbent assays show a variety of cross-reaction...

journal_title：Clinical and experimental immunology

authors： Haskard DO,Gul V,Morgan A,Kataaha P,Staines NA,Archer JR

更新日期：1985-09-01 00:00:00

abstract：:Tuberculosis (TB) enhances human immunodeficiency virus-1 (HIV-1) activity in patients with dual HIV-1/TB infection. Therapies that control augmentations of HIV-1 activity at sites of Mycobacterium tuberculosis (MTB) infection may be useful in inhibition of viral expansion. Regulated upon activation, normal T-cell exp...

journal_title：Clinical and experimental immunology

authors： Toossi Z,Mayanja-Kizza H,Baseke J,Peters P,Wu M,Abraha A,Aung H,Okwera A,Hirsch C,Arts E

更新日期：2005-11-01 00:00:00

abstract：:The kinetics and effects of in vivo spontaneous apoptosis and activation-induced cell death (AICD) upon CD4+ and CD8+ lymphocyte subsets and CD4 naive cell numbers were studied in HIV+ subjects with CD4 pretreatment values > 200/mm3, who were subsequently treated for 48 weeks with HAART alone or in combination with si...

journal_title：Clinical and experimental immunology

authors： Caggiari L,Zanussi S,Bortolin MT,D'andrea M,Nasti G,Simonelli C,Tirelli U,De Paoli P

更新日期：2000-04-01 00:00:00

abstract：:Eighteen patients showing hypersensitivity to nitrofurantoin with symptoms like sudden fever, malaise, cough, pleuritis, leucocytosis and sometimes eosinophilia were analysed for immune reactions, i.e. lymphocyte transformation and specific antibodies. In addition, thirty-three individuals treated with the drug but wi...

journal_title：Clinical and experimental immunology

authors： Bäck O,Lidén S,Ahlstedt S

更新日期：1977-06-01 00:00:00

abstract：:Interferons play an important, but incompletely understood role in HIV-related disease. We investigated the effect of HAART on plasma levels of IFN-alpha, IFN-gamma, neopterin and interferon-inducible protein 10 (IP-10) in 41 HIV-infected patients during 78 weeks of therapy. At baseline HIV-infected patients had raise...

journal_title：Clinical and experimental immunology

authors： Stylianou E,Aukrust P,Bendtzen K,Müller F,Frøland SS

更新日期：2000-03-01 00:00:00

abstract：:Lidocaine, bupivacaine or ropivacaine are used routinely to manage perioperative pain. Sparse data exist evaluating the effects of local anaesthetics (LA) on fibroblasts, which are involved actively in wound healing. Therefore, we investigated the effects of the three LA to assess the survival, viability and prolifera...

journal_title：Clinical and experimental immunology

authors： Fedder C,Beck-Schimmer B,Aguirre J,Hasler M,Roth-Z'graggen B,Urner M,Kalberer S,Schlicker A,Votta-Velis G,Bonvini JM,Graetz K,Borgeat A

更新日期：2010-11-01 00:00:00

abstract：:The skin is a major target organ in human graft-versus-host disease (GVHD) after bone-marrow transplantation. GVHD can be induced in mice by i.v. injection of T cells into unirradiated semi-allogeneic or lethally irradiated allogeneic recipients. However, in the murine systemic GVHD model, cutaneous lesions occur only...

journal_title：Clinical and experimental immunology

authors： Kawai K,Matsumoto Y,Watanabe H,Ito M,Fujiwara M

更新日期：1991-05-01 00:00:00

abstract：:The relation of clinical and laboratory findings at the time clinical presentation to subsequent survival was investigated in 204 patients with macroglobulinaemia. It was found that the ten following clinical and laboratory parameters were of prognostic significance and a further twelve were not. The best prognoses we...

journal_title：Clinical and experimental immunology

authors： Carter P,Koval JJ,Hobbs JR

更新日期：1977-05-01 00:00:00

abstract：:To characterize the antigenic parts of the 16K protein of Mycobacterium tuberculosis, overlapping peptides according to the amino acid sequence of the 16K protein were synthesized. In total, 14 peptides of 20 amino acids in length with an overlap of 10 amino acids and two additional decapeptides (amino acids 31-40 and...

journal_title：Clinical and experimental immunology

authors： Verbon A,Hartskeerl RA,Moreno C,Kolk AH

更新日期：1992-09-01 00:00:00

abstract：:A syngeneic, monoclonal, anti-idiotype antibody, G6D9, was raised against the mouse monoclonal IgM HNK-1. G6D9, characterized as an IgG1-kappa, inhibits the binding of HNK-1 to the myelin-associated glycoprotein (MAG). G6D9 does not interfere with the binding of various human monoclonal anti-MAG IgM to their specific ...

journal_title：Clinical and experimental immunology

authors： Schluep M,Page N,Burger D,Steck AJ

更新日期：1989-02-01 00:00:00

abstract：:Soluble histocompatibility antigens of the class II region have been detected in synovial fluids obtained from patients with rheumatoid arthritis. A capture immunoassay involving two monoclonal antibodies was used; interference by rheumatoid factor, which is a feature of such assays, was overcome by mild pretreatment ...

journal_title：Clinical and experimental immunology

authors： Stevenson FK,Douglass WA,Spellerberg MB,Walters MT,Cawley MI

更新日期：1990-04-01 00:00:00

abstract：:Podocytes, the main target of immune complex, participate actively in the development of glomerular injury as immune cells. Dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin (DC-SIGN) is an innate immune molecular that has an immune recognition function, and is involved in mediation of ce...

journal_title：Clinical and experimental immunology

authors： Cai M,Zhou T,Wang X,Shang M,Zhang Y,Luo M,Xu C,Yuan W

更新日期：2016-03-01 00:00:00

abstract：:Fractalkine (FKN/CX3CL1) has been detected in synovial fluids from osteoarthritis (OA) patients. Additionally, low-level expression of the FKN receptor, CX3CR1, has been demonstrated in OA synovial lining. This study aimed to determine a biological function for this ligand/receptor pair in OA and to assess a potential...

journal_title：Clinical and experimental immunology

authors： Klosowska K,Volin MV,Huynh N,Chong KK,Halloran MM,Woods JM

更新日期：2009-05-01 00:00:00

abstract：:Blood monocytes of patients with thyroid autoimmune disease (TAID) display defects in rearranging their cortical actomyosin cytoskeleton ('polarize') in response to chemoattractants. Such rearrangements also take place after the adherence of monocytes to the extracellular matrix (ECM). It is therefore not surprising t...

journal_title：Clinical and experimental immunology

authors： Canning MO,Grotenhuis K,De Haan-Meulman M,De Wit HJ,Berghout A,Drexhage HA

更新日期：2001-07-01 00:00:00

abstract：:We have previously demonstrated that HIV envelope gp41 binding to specific antibodies decreases after preincubation of fluid-phase gp41 in normal human serum. This inhibition is proven to be mediated by the classical complement pathway. In this study recombinant gp41 (rgp41) and/or synthetic peptides were preadsorbed ...

journal_title：Clinical and experimental immunology

authors： Hidvégi T,Prohászka Z,Ujhelyi E,Thielens NM,Dierich MP,Hampl H,Arlaud G,Nagy K,Füst G

更新日期：1993-12-01 00:00:00

abstract：:Most patients with late-onset bypogammaglobulinaemia have normal numbers of B cells. In addition, some of these patients have been shown to have circulating T cells which suppress immunolobulin production in vitro. From our present studies on a large series of patients it appears that these two findings distinguish tw...

journal_title：Clinical and experimental immunology

authors： Platts-Mills TA,De Gast GC,Webster AD,Asherson GL,Wilkins SR

更新日期：1981-05-01 00:00:00

abstract：:In Helicobacter pylori gastritis gastric epithelium plays a central role in the innate immunity to H. pylori. However, epithelial receptors interacting with H. pylori have been poorly characterized so far. Recently a new triggering receptor expressed on myeloid cells-1 (TREM-1) has been identified on human neutrophils...

journal_title：Clinical and experimental immunology

authors： Schmausser B,Endrich S,Beier D,Moran AP,Burek CJ,Rosenwald A,Rieckmann P,Müller-Hermelink HK,Eck M

更新日期：2008-04-01 00:00:00

abstract：:Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

journal_title：Clinical and experimental immunology

authors： Cashner FM,Schuyler MR,Salvaggio JE

更新日期：1979-05-01 00:00:00

abstract：:Expression of the inducible form of nitric oxide synthase (iNOS) has been found to be up-regulated in cytokine-stimulated mesangial cells (MC) and in experimental glomerulonephritis. Since direct toxicity of nitric oxide (NO) has been implicated in damage of bacteria, neoplastic and intact pancreatic cells, we investi...

journal_title：Clinical and experimental immunology

authors： Hruby Z,Beck KF

更新日期：1997-01-01 00:00:00