当前位置： SCI文献检索 > CLINICAL AND EXPERIMENTAL IMMUNOLOGY期刊下所有文献 > Adverse reactions to nitrofurantoin in relation to cellular and humoral immune responses.

Adverse reactions to nitrofurantoin in relation to cellular and humoral immune responses.

Abstract：

:Eighteen patients showing hypersensitivity to nitrofurantoin with symptoms like sudden fever, malaise, cough, pleuritis, leucocytosis and sometimes eosinophilia were analysed for immune reactions, i.e. lymphocyte transformation and specific antibodies. In addition, thirty-three individuals treated with the drug but with no clinical signs of the described reactions were included as controls. The lymphocyte transformation test (LTT) was found positive in ten out of the eighteen sensitive patients while one to three out of fourteen tested control patients were positive, depending on test conditions. An incubation period of 4 days in culture medium supplemented with autologous serum gave stimulation to a greater extent than did isologous serum and/or incubation for 6 days. The antibody determinations, with the enzyme-linked immunosorbent assay (ELISA), showed no IgE antibodies to nitrofurantoin in any of the patients. In contrast, most of the hypersensitive and even the control patients had specific IgG antibodies. The mean value of the antibodies of the sensitive group was higher than of the control group, but considerable overlapping between the groups was noted. In adverse reactions to nitrofurantoin a positive LTT and/or a high antibody titre to the drug favours an allergic mechanism and contributes to a more reliable diagnosis.

journal_name

Clin Exp Immunol

journal_title

Clinical and experimental immunology

authors

Bäck O,Lidén S,Ahlstedt S

subject

Has Abstract

pub_date

1977-06-01 00:00:00

pages

400-6

issue

3

eissn

0009-9104

issn

1365-2249

journal_volume

28

pub_type

杂志文章

相关文献

CLINICAL AND EXPERIMENTAL IMMUNOLOGY文献大全
  • Iron down-regulates macrophage anti-tumour activity by blocking nitric oxide production.

    abstract：:Although the inhibitory effect of iron on macrophage production of tumoricidal free radical nitric oxide (NO) has been reported, its possible influence on macrophage anti-tumour activity has not been established. In the present study, FeSO4 markedly reduced IFN-gamma + LPS-induced NO synthesis in mouse and rat macroph...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02515.x

    authors： Harhaji L,Vuckovic O,Miljkovic D,Stosic-Grujicic S,Trajkovic V

    更新日期：2004-07-01 00:00:00

  • Effect of thymosin on glucocorticoid receptor activity and glucocorticoid sensitivity of human thymocytes.

    abstract：:Incubation with thymosin fraction 5, (TMS F5 at 300 micrograms/ml) a partially purified thymic factor, reduced the steroid binding activity of human infant thymocytes from 9.6 +/- 2.1 fmole/ml to 5.0 +/- 2.0 fmole/ml. The glucocorticoid receptor activity in normal infant thymocytes was found to be 2,146 +/- 726 (s.d.)...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ma DD,Ho AH,Hoffbrand AV

    更新日期：1984-02-01 00:00:00

  • Increase of circulating gamma/delta T lymphocytes in the peripheral blood of patients affected by active inflammatory bowel disease.

    abstract：:In order to study the role of gamma/delta T cells in the pathogenesis of inflammatory bowel disease (IBD) in humans, we measured the percentage of these cells in the peripheral blood, assessed the ratio of the non-disulphide-linked (delta TCS1) type of T cell receptor (TCR) in the total gamma/delta T cells, studied th...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1994.tb06611.x

    authors： Giacomelli R,Parzanese I,Frieri G,Passacantando A,Pizzuto F,Pimpo T,Cipriani P,Viscido A,Caprilli R,Tonietti G

    更新日期：1994-10-01 00:00:00

  • Circulating immune complexes and severe sepsis: duration of infection as the main determinant.

    abstract：:The relation between the duration of bacterial infection and circulating immune complexes (CIC) level was evaluated using the C1q binding assay in a group of patients with well defined clinical sepsis. Fifty-four patients with endocarditis and 35 with post-open heart surgery mediastinitis were prospectively studied ov...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Pocidalo MA,Gibert C,Verroust P,Geniteau M,Adam C,Madec Y,Gaudebout C,Morel-Maroger L

    更新日期：1982-03-01 00:00:00

  • Strong prostaglandin associated suppression of the proliferation of human maternal lymphocytes by neonatal lymphocytes linked to T versus T cell interactions and differential PGE2 sensitivity.

    abstract：:Lymphocytes from human fetuses and newborns strongly, regularly, and non-specifically suppress the proliferation of PHA stimulated peripheral blood mononuclear leucocytes. The suppression is prostaglandin (PG)-dependent. Our present investigation clearly indicates that the suppression is associated with neonatal T ver...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Papadogiannakis N,Johnsen SA,Olding LB

    更新日期：1985-07-01 00:00:00

  • High dose interleukin-12 exacerbates Bordetella pertussis infection and is associated with suppression of cell-mediated immunity in a murine aerosol challenge model.

    abstract：:The in-vivo clearance of Bordetella pertussis infections in murine models in naive mice and animals vaccinated with whole-cell vaccine is considered to be via a Th-1-dependent mechanism in which interleukin-12 (IL)-12 may play a prominent role. It has also been demonstrated clearly that the treatment of animals with m...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2003.02352.x

    authors： Carter CR,Dagg BM,Whitmore KM,Keeble JR,Asokanathan C,Xing D,Walker KB

    更新日期：2004-02-01 00:00:00

  • Systemic inflammation alters the inflammatory response in experimental lipopolysaccharide-induced meningitis.

    abstract：:Experiments to evaluate the effect of the level and duration of endotoxaemia on the meningeal inflammatory response were performed in order to determine if systemic inflammation alters meningitis. Rabbits received either saline or Escherichia coli O111:B4 lipopolysacharide (LPS) intravenously at various doses (1, 3 or...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2006.03255.x

    authors： O'Reilly T,Ostergaard C,Vaxelaire J,Zak O

    更新日期：2007-01-01 00:00:00

  • Efficacy, safety, tolerability and pharmacokinetics of a novel human immune globulin subcutaneous, 20%: a Phase 2/3 study in Europe in patients with primary immunodeficiencies.

    abstract：:A highly concentrated (20%) immunoglobulin (Ig)G preparation for subcutaneous administration (IGSC 20%), would offer a new option for antibody replacement therapy in patients with primary immunodeficiency diseases (PIDD). The efficacy, safety, tolerability and pharmacokinetics of IGSC 20% were evaluated in a prospecti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,多中心研究

    doi：10.1111/cei.12866

    authors： Borte M,Kriván G,Derfalvi B,Maródi L,Harrer T,Jolles S,Bourgeois C,Engl W,Leibl H,McCoy B,Gelmont D,Yel L

    更新日期：2017-01-01 00:00:00

  • Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

    abstract：:Cellular sensitization to rabbit liver specific lipoprotein (RLSP) has been investigated using a lymphocyte transformation test in patients with chronic active hepatitis (CAH). A stimulation index greater than 2 was recorded in twenty out of twenty-five cases (eight of ten HBsAg positive and twelve of fiteen HBsAg neg...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ortona L,Laghi V,Cauda R,Nervo P

    更新日期：1979-11-01 00:00:00

  • Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1.

    abstract：:Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/ perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms in tumour necrosis factor (TNF)-alpha and intercellular adhesion molecule-1 (ICAM-1) are associated with occurrence and/or outcome in Crohn's disease. The aim of th...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章,多中心研究,随机对照试验

    doi：10.1111/j.1365-2249.2005.02830.x

    authors： Yacyshyn BR,Schievella A,Sewell KL,Tami JA

    更新日期：2005-07-01 00:00:00

  • Anti-cardiolipin antibodies and circulating immune complexes in type 1 diabetes mellitus: increased prevalence and relation to vascular complications.

    abstract：:Anti-cardiolipin antibodies, oxidatively modified low-density lipoproteins (oxLDL) and circulating immune complexes are humoral factors that have been linked to vascular damage. To analyse their possible role in the vascular complications in type 1 diabetes mellitus, we investigated patients with and without vascular ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1999.00788.x

    authors： Ahmed E,Nityanand S,Mustafa A,Brismar K,Lefvert AK

    更新日期：1999-02-01 00:00:00

  • The role of neutrophil activation in determining the outcome of pregnancy and modulation by hormones and/or cytokines.

    abstract：:Neutrophils are often exclusively considered as a first-line innate immune defence, able to rapidly kill or trap pathogens and causing in case of over-activation tissue damage. In the female reproductive tract, however, the presence and activity of neutrophils seems to be tightly regulated. Major players in orchestrat...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章,评审

    doi：10.1111/cei.13278

    authors： Hahn S,Hasler P,Vokalova L,van Breda SV,Lapaire O,Than NG,Hoesli I,Rossi SW

    更新日期：2019-10-01 00:00:00

  • Pharmacodynamics of recombinant human DNase I in serum.

    abstract：:Recombinant human deoxyribonuclease I (rhDNase) may be an effective therapeutic for the treatment of systemic lupus erythematosus (SLE). The pharmacodynamics of rhDNase in serum was investigated using two activity assays: one based on hydrolysis of a radiolabelled phage DNA and the other based on hydrolysis of human c...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1998.00647.x

    authors： Prince WS,Baker DL,Dodge AH,Ahmed AE,Chestnut RW,Sinicropi DV

    更新日期：1998-08-01 00:00:00

  • Fine specificity of anti-citrullinated peptide antibodies discloses a heterogeneous antibody population in rheumatoid arthritis.

    abstract：:Anti-citrullinated peptide antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). However, the predominant B cell epitopes have not yet been defined. The aim of this study was to examine the reactivity of ACPA against different peptides derived from citrullinated proteins and to investigate whether or no...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12145

    authors： Goules JD,Goules AV,Tzioufas AG

    更新日期：2013-10-01 00:00:00

  • Diverse antigen specificity of erythrocyte-reactive monoclonal autoantibodies from NZB mice.

    abstract：:The specificities of a panel of erythrocyte-reactive MoAbs derived from NZB mice with autoimmune haemolytic anaemia (AIHA) were determined by immunoprecipitation and immunoblotting. Of the eight antibodies, two (IgG1 MoAb 105-2H and IgG2a MoAb 34-3C) immunoprecipitated a 105-kD component identified as the erythrocyte ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.1996.d01-772.x

    authors： de Sá Oliveira GG,Izui S,Ravirajan CT,Mageed RA,Lydyard PM,Elson CJ,Barker RN

    更新日期：1996-08-01 00:00:00

  • The effect of cortisone acetate on pulmonary lesions in a rabbit model of hypersensitivity pneumonitis (cortisone and hypersensitivity pneumonitis).

    abstract：:Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Cashner FM,Schuyler MR,Salvaggio JE

    更新日期：1979-05-01 00:00:00

  • Circulating immune complexes in old people and in diabetics: correlation with autoantibodies.

    abstract：:Circulating immune complexes (CIC) were detected by a solid-phase radioassay in 34% of fifty-three insulin-dependent diabetics (IDD) as compared to 18% of forty-five non-insulin-dependent diabetics (NIDD) and 14% of 173 control subjects. In control subjects, the prevalence of CIC increased with age and was higher in m...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Delespesse G,Gausset P,Sarfati M,Dubi-Rucquoy M,Debisschop MJ,van Haelst L

    更新日期：1980-04-01 00:00:00

  • Identification of mouse T and B lymphocytes from cytocentrifuged cell smears.

    abstract：:A method enabling direct enumeration of mouse T and B cells from cytocentrifuged cell smears is described. The acid alpha-naphthyl acetate esterase (ANAE) staining was used as marker for T cells. The distribution of the ANAE marker-carrying lymphocytes closely followed the percentual distribution of T cells in spleen ...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Ranki A,Tötterman TH,Häyry P

    更新日期：1976-12-01 00:00:00

  • Treatment effect of CDKN1A on rheumatoid arthritis by mediating proliferation and invasion of fibroblast-like synoviocytes cells.

    abstract：:The objective of the present study was to evaluate the role of CDKN1A in rheumatoid arthritis (RA). Related gene expression data screened from Gene Expression Omnibus (GEO) were processed with network analysis. Protein-protein interaction was analysed through string database. Quantitative reverse transcription-polymer...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.13161

    authors： Gang X,Xu H,Si L,Zhu X,Yu T,Jiang Z,Wang Y

    更新日期：2018-11-01 00:00:00

  • Altered T cell development in human thymoma is related to impairment of MHC class II transactivator expression induced by interferon-gamma (IFN-gamma).

    abstract：:Thymoma is known to contain CD4+CD8+ T cells, indicating that neoplastic epithelial cells of thymoma have a function as thymic cortical epithelium. However, it has been shown that there is an impairment of CD4+ T cell development in thymoma and that IFN-gamma-induced HLA-DR expression on cultured thymic epithelial cel...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1046/j.1365-2249.2000.01256.x

    authors： Kadota Y,Okumura M,Miyoshi S,Kitagawa-Sakakida S,Inoue M,Shiono H,Maeda Y,Kinoshita T,Shirakura R,Matsuda H

    更新日期：2000-07-01 00:00:00

  • The effect of anti-neutrophil cytoplasm autoantibodies on the signal transduction in human neutrophils.

    abstract：:The effect of anti-neutrophil cytoplasm autoantibodies (ANCA) on neutrophil activation was studied by pre-incubating neutrophils with IgG and F(ab')2 prepared from ANCA patients with Wegener's granulomatosis or microscopic polyarteritis. We measured the generation of inositol triphosphate (IP3) (a product of hydrolysi...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1991.tb05738.x

    authors： Lai KN,Lockwood CM

    更新日期：1991-09-01 00:00:00

  • An approach to the routine estimation of circulating carcinoembryonic antigen immune complexes in patients with carcinomata of the gastrointestinal tract.

    abstract：:The carcinoembryonic antigen (CEA) distribution obtained after fractionation of thirty sera of patients with gastrointestinal tumours by gel filtration in Sephadex G200 was compared with that resulting from extraction of the sera with perchloric acid. In all cases gel filtration yielded a fraction of free CEA and in t...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Kapsopoulou-Dominos K,Anderer FA

    更新日期：1979-07-01 00:00:00

  • Ethyl pyruvate significantly inhibits tumour necrosis factor-α, interleukin-1β and high mobility group box 1 releasing and attenuates sodium taurocholate-induced severe acute pancreatitis associated with acute lung injury.

    abstract：:In this study, we examined the effect of ethyl pyruvate (EP) on pulmonary inflammation in rats with severe pancreatitis-associated acute lung injury (ALI). Severe acute pancreatitis (SAP) was induced in rats by the retrograde injection of 5% sodium taurocholate into the pancreatic duct. Rats were randomly divided into...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/cei.12062

    authors： Luan ZG,Zhang J,Yin XH,Ma XC,Guo RX

    更新日期：2013-06-01 00:00:00

  • Fine specificities of anti-nuclear antibodies in murine models of graft-versus-host disease.

    abstract：:Two models of murine graft-versus-host disease (GVHD) were studied with respect to autoantibody production and development of systemic lupus erythematosus (SLE) like disease. One model was induced by injection of (B10.A(4R) x B10.A(2R]F1 mice with parental (B10.A(4R] spleen and lymph node cells (groups I GVHD), the ot...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1990.tb05287.x

    authors： van Dam AP,Meilof JF,van den Brink HG,Smeenk RJ

    更新日期：1990-07-01 00:00:00

  • Circulating monocytes in patients with acute coronary syndromes lack sufficient interleukin-10 production after lipopolysaccharide stimulation.

    abstract：:Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes,...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.2004.02602.x

    authors： van Haelst PL,Tervaert JW,Bijzet J,Baljé-Volkers C,May JF,Langeveld B,Gans RO

    更新日期：2004-11-01 00:00:00

  • Synthesis and secretion of alpha 1-microglobulin by human lymphocytes.

    abstract：:alpha 1-Microglobulin (alpha 1-m) was purified by column chromatography from a supernatant fluid of cultured T and B lymphocytes stimulated with mitogens. This protein had a molecular weight of 33,000 as determined by sodium dodecyl sulphate (SDS) polyacrylamide gel electrophoresis, migrated in the alpha 1-region on i...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Itoh Y,Kin K,Kasahara T,Sakurabayashi I,Kawai T,Shiori-Nakano K,Takagi K

    更新日期：1979-07-01 00:00:00

  • Interferon production by cultured peripheral leucocytes of MS patients.

    abstract：:Peripheral blood leucocytes from multiple sclerosis (MS) patients and from normal individuals were tested for their interferon (IFN) producing capacity after stimulation in vitro with various lectins and viruses. The lectins, Con A, PHA and PWM, induced IFN-gamma. In a kinetic study, the response to Con A revealed its...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Vervliet G,Carton H,Meulepas E,Billiau A

    更新日期：1984-10-01 00:00:00

  • Anti-CD11b/CD18 antibodies reduce inflammation in acute colitis in rats.

    abstract：:The influx of monocytes and neutrophils into the inflamed tissue could be an important aspect in the pathogenesis of inflammatory bowel disease (IBD). A membrane protein involved in the monocyte/neutrophil adherence to endothelium is CD11b/CD18 or alpha M beta 2 (complement receptor type 3 = CR3). In the present study...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：10.1111/j.1365-2249.1995.tb08363.x

    authors： Palmen MJ,Dijkstra CD,van der Ende MB,Peña AS,van Rees EP

    更新日期：1995-08-01 00:00:00

  • Anticardiolipin antibodies in HIV infection: association with cerebral perfusion defects as detected by 99mTc-HMPAO SPECT.

    abstract：:Anticardiolipin antibodies (ACA) belong to a heterogeneous group of antibodies directed against negatively charged phospholipids. In patients with rheumatic disorders, their presence has been correlated to the occurrence of thromboembolic complications, thrombocytopenia, abortions and other disease manifestations. Sev...

    journal_title：Clinical and experimental immunology

    pub_type： 临床试验,杂志文章

    doi：10.1111/j.1365-2249.1994.tb05498.x

    authors： Rubbert A,Bock E,Schwab J,Marienhagen J,Nüsslein H,Wolf F,Kalden JR

    更新日期：1994-12-01 00:00:00

  • Immune complexes and antibodies to BCG in sera from patients with mycobacterial infections.

    abstract：:We have examined the prevalence of circulating immune complexes in sera from patients with mycobacterial infections. Sera from 68 percent of patients with active M. tuberculosis and 58 percent of patients with M. intracellulare infections had significantly elevated Clq binding activity (Clq-BA). In general there was a...

    journal_title：Clinical and experimental immunology

    pub_type： 杂志文章

    doi：

    authors： Carr RI,Chakraborty AK,Brunda MJ,Davidson PT,Damle PB,Hardtke MA,Gilbride KJ,Minden P

    更新日期：1980-03-01 00:00:00