Lymphocyte transformation test with rabbit liver specific lipoprotein (RLSP) in chronic active hepatitis.

abstract：:The close resemblance of MS to the animal model experimental autoimmune encephalomyelitis (EAE) has provided compelling data sustaining a pathogenic role of circulating T cells reactive against MBP. T cell antigen receptor (TCR) usage in EAE is commonly considered restricted; nevertheless, dynamic changes of TCR usage...

journal_title：Clinical and experimental immunology

authors： Uccelli A,Giunti D,Salvetti M,Ristori G,Fenoglio D,Abbruzzese,Mancardi G

更新日期：1998-01-01 00:00:00

abstract：:To gain insight into possible determinants of in vivo polyclonal B cell activation seen in rheumatoid arthritis (RA), we enumerated immunoglobulin secreting cells appearing in cultures of peripheral blood mononuclear cells that were stimulated with pokeweed mitogen (PWM) or a newly described polyclonal B cell activato...

journal_title：Clinical and experimental immunology

authors： Pardo I,Carafa C,Dziarski R,Levinson AI

更新日期：1984-05-01 00:00:00

abstract：:Mice were immunized with the cell wall of BCG suspended in an oil-in-saline emulsion, and examined against time for the emergence of T cell-mediated acquired immunity. Evidence is presented that shows that levels of acquired resistance expressed in these animals over the first month following inoculation, and which en...

journal_title：Clinical and experimental immunology

authors： Orme IM

更新日期：1988-03-01 00:00:00

abstract：:To gain some insight into the pathogenesis of proliferative lupus nephritis in MRL/lpr mice we investigated the kinetics of removal of immune complexes from the circulation, the carrier state of blood cells, the uptake of complexes by the mononuclear phagocyte system, and the localization of complexes in kidneys. In n...

journal_title：Clinical and experimental immunology

authors： Granholm NA,Cavallo T

更新日期：1990-11-01 00:00:00

abstract：:In both murine and human experimental systems, acute, low dose exposure of skin to ultraviolet B light (UVB) impairs the induction of allergic contact dermatitis (ACD) by haptens such as dinitrochlorobenzene (DNCB) in a significant proportion of individuals. By light microscopy, epidermal Langerhans cells (LC) have be...

journal_title：Clinical and experimental immunology

authors： Mommaas AM,Mulder AA,Vermeer M,Boom BW,Tseng C,Taylor JR,Streilein JW

更新日期：1993-06-01 00:00:00

abstract：:In order to evaluate the impact of induction and increase target antigen expression on immunotoxin potency, we measured the potentiating effect of recombinant immune interferon-gamma (rIFN-gamma) on the cytotoxicity of an anti HLA-DR ricin A-chain immunotoxin (2G5 RTA-IT) on the myeloid cell line ML-3. After 48 h of i...

journal_title：Clinical and experimental immunology

authors： Chiron M,Jaffrezou JP,Carayon P,Bordier C,Roubinet F,Xavier C,Brandely M,Laurent G

更新日期：1990-11-01 00:00:00

abstract：:Previous studies have shown that rabbit anti-mouse immunoglobulin sera (anti-Ig) which kill non-activated B lymphocytes in the presence of complement, are incapable of doing so when the cells are activated by antigen or mitogen into mitosis. Results reported here indicate that the resistance is not dependent on either...

journal_title：Clinical and experimental immunology

authors： Kerbel RS,Birbeck MS,Robertson D,Cartwright P

更新日期：1975-04-01 00:00:00

abstract：:Insulin autoantibodies (IAA) can appear in children within months of introducing solid foods to the diet and before clinical type 1 diabetes. The aim of this study was to determine whether infant dietary antigens could be immunizing agents of IAA. To this end, IAA binding to [(125) I]insulin was competed with food pre...

journal_title：Clinical and experimental immunology

authors： Adler K,Mueller DB,Achenbach P,Krause S,Heninger AK,Ziegler AG,Bonifacio E

更新日期：2011-04-01 00:00:00

abstract：:Bacille Calmette-Guérin (BCG), developed a century ago, is the only licensed tuberculosis (TB) vaccine in use to date. The protective efficacy of BCG against TB varies with no apparent protection in some population, and mechanisms of its immune protection is poorly known, and yet BCG is the most widely used vaccine, w...

journal_title：Clinical and experimental immunology

authors： Abebe F

更新日期：2012-09-01 00:00:00

abstract：:The effect of low-density lipoprotein (LDL) on the binding of DNA and DNA-anti-DNA immune complexes to cultured human skin fibroblasts was examined. Using radioisotope analysis, ELISA and indirect immunofluorescent staining, a correlation between plasma membrane-bound DNA or DNA-anti-DNA immune complexes and cell-asso...

journal_title：Clinical and experimental immunology

authors： Kabakov AE,Saenko VA,Poverenny AM

更新日期：1991-03-01 00:00:00

abstract：:The major subtypes of anti-neutrophil cytoplasmic antibodies (ANCA) detected by indirect immunofluorescence assay (IFA) are P-ANCA and C-ANCA. In patients with vasculitis, myeloperoxidase (MPO) is the major P-ANCA antigen and proteinase 3 (PR3) is the major C-ANCA antigen. BPI and azurocidin, which are also called 57-...

journal_title：Clinical and experimental immunology

authors： Yang JJ,Tuttle R,Falk RJ,Jennette JC

更新日期：1996-07-01 00:00:00

abstract：:Human polymorphonuclear cells (PMN) were found to adhere to a novel model of blood vessel wall-associated IgG. The internal surfaces of cellulose acetate hollow fibres, of comparable internal diameter to small blood vessels, were coated with normal serum human IgG, heat-aggregated IgG (HAIgG), laminin or fibrinogen. U...

journal_title：Clinical and experimental immunology

authors： D'Arrigo C,Candal-Couto JJ,Greer M,Veale DJ,Woof JM

更新日期：1995-04-01 00:00:00

abstract：:The number of NK T cells was measured in relation to the Th1/Th2 imbalance observed in RA. Peripheral blood samples of patients with RA (n = 60) and healthy controls (n = 36) were stained with anti-NK receptor 1A (anti-NKR-P1A), anti-CD56, and anti-CD3 MoAbs, and examined by three-colour flow cytometry. NK T (NKR-P1A+...

journal_title：Clinical and experimental immunology

authors： Yanagihara Y,Shiozawa K,Takai M,Kyogoku M,Shiozawa S

更新日期：1999-10-01 00:00:00

abstract：:Previous studies have indicated phenotypical differences in glutamic acid decarboxylase 65 autoantibodies (GADA) found in type 1 diabetes (T1D) patients, individuals at risk of developing T1D and stiff-person syndrome (SPS) patients. In a Phase II trial using aluminium-formulated GAD(65) (GAD-alum) as an immunomodula...

journal_title：Clinical and experimental immunology

authors： Chéramy M,Hampe CS,Ludvigsson J,Casas R

更新日期：2013-03-01 00:00:00

abstract：:The production in vitro of antibody to hepatitis B surface antigen by peripheral blood mononuclear cells of healthy volunteers was studied after each of the three doses of hepatitis B vaccine. An in vitro hepatitis B surface antigen antibody response was successfully induced in 12% of the specimens taken over a 7 mont...

journal_title：Clinical and experimental immunology

authors： Filion LG,Saginur R

更新日期：1988-12-01 00:00:00

abstract：:In this second review on chemokines, we focus on the polymorphisms and alternative splicings and on their consequences in disease. Because chemokines are key mediators in the pathogenesis of inflammatory, autoimmune, vascular and neoplastic disorders, a large number of studies attempting to relate particular polymorph...

journal_title：Clinical and experimental immunology

authors： Colobran R,Pujol-Borrell R,Armengol MP,Juan M

更新日期：2007-10-01 00:00:00

abstract：:Glutamic acid decarboxylase (GAD) is a major autoantigen in insulin-dependent diabetes mellitus (IDDM). This was initially identified as a 64-65 kD molecule according to migration in gels after immunoprecipitation from pancreatic islets. We studied the antigenicity of two different radiolabelled preparations of GAD, d...

journal_title：Clinical and experimental immunology

authors： Rowley MJ,Chen QY,Teoh KL,Zimmet PZ,Tuomi T,Knowles WJ,Mackay IR

更新日期：1996-11-01 00:00:00

abstract：:Ageing is a very complex process, the result of the dysregulation of multiple systems interacting in many ways. A prominent change occurring with ageing is related to the architecture and functioning of the immune system, viewed commonly as detrimental and termed 'immunosenescence'. However, age-associated changes may...

journal_title：Clinical and experimental immunology

authors： Fulop T,Witkowski JM,Le Page A,Fortin C,Pawelec G,Larbi A

更新日期：2017-01-01 00:00:00

abstract：:To elucidate the in vivo mechanisms involved in the impairment in pulmonary defence as the result of treatment with glucocorticoids, we established fatal pneumonia with bacteraemia in dexamethasone (DEX)-treated mice by means of an intratracheal challenge of Pseudomonas aeruginosa. An increased neutrophil influx was o...

journal_title：Clinical and experimental immunology

authors： Satoh S,Oishi K,Iwagaki A,Senba M,Akaike T,Akiyama M,Mukaida N,Atsushima KM,Nagatake T

更新日期：2001-11-01 00:00:00

abstract：:The diagnostic value of the determination of the relative distribution of B (SmIg-positive) and T (E rosetting) cells in the blood and in pleural or ascitic effusions was evaluated in 10 patients with tuberculosis and in six with malignant diseases. A higher percentage of T and a lower percentage of B lymphocytes in s...

journal_title：Clinical and experimental immunology

authors： Falcão RP,Bottura C

更新日期：1981-07-01 00:00:00

abstract：:While most of our understanding of immune dysfunction in dialysis patients involves alterations in CD28-CD80/86 signalling, nothing is known of CD46-mediated co-stimulation of T cells in these patients. Because C3b/C4b bind to CD46 and complement activation occurs during haemodialysis (HD), we addressed whether CD46-m...

journal_title：Clinical and experimental immunology

authors： Brinkkoetter PT,Marinaki S,Gottmann U,Fleckenstein S,Stump C,Van Der Woude FJ,Braun C,Yard BA

更新日期：2005-03-01 00:00:00

abstract：:The role of complement has been studied in the autologous phase of nephrotoxic nephritis (NTN) in rabbits. No reduction in glomerular fibrin deposition, crescent formation or protection from renal failure was observed in either the standard model of NTN when decomplementing doses of cobra venom factor (CVF) were given...

journal_title：Clinical and experimental immunology

authors： Thomson NM,Naish PF,Simpson IJ,Peters DK

更新日期：1976-06-01 00:00:00

abstract：:Peripheral large granular lymphocytes (LGL) were enumerated in normal subjects and patients with autoimmune thyroid diseases. In normal subjects, the percentage of LGL was significantly lower in women (mean +/- s.d., 17.0 +/- 3.6%; n = 35; P less than 0.05) than in men (19.5 +/- 5.3%; n = 20). In untreated patients wi...

journal_title：Clinical and experimental immunology

authors： Iwatani Y,Amino N,Kabutomori O,Mori H,Tamaki H,Motoi S,Izumiguchi Y,Miyai K

更新日期：1984-01-01 00:00:00

abstract：:Chronic bone infection is associated with bone resorption. From animal studies, CD3/CD28-activated T cells are known to enhance osteoclastogenesis and bone resorption. Because CD28 is expressed constitutively on T cells and its expression is down-regulated by chronic exposure to the inflammatory environment, we charac...

journal_title：Clinical and experimental immunology

authors： Kumar G,Roger PM,Ticchioni M,Trojani C,Bernard de Dompsur R,Bronsard N,Carles M,Bernard E

更新日期：2014-04-01 00:00:00

abstract：:Anti-citrullinated peptide antibodies (ACPA) are highly specific for rheumatoid arthritis (RA). However, the predominant B cell epitopes have not yet been defined. The aim of this study was to examine the reactivity of ACPA against different peptides derived from citrullinated proteins and to investigate whether or no...

journal_title：Clinical and experimental immunology

authors： Goules JD,Goules AV,Tzioufas AG

更新日期：2013-10-01 00:00:00

abstract：:In this review the authors discuss the evidence for T helper type 17 (Th17) cells as pathogenic T cells in autoimmunity. Studies with cytokine-deficient mice or blocking of interleukin (IL)-17, IL-21 and IL-22 have resulted in a conflicting data set. Although in the experimental autoimmune encephalomyelitis model the ...

journal_title：Clinical and experimental immunology

authors： Koenders MI,van den Berg WB

更新日期：2010-02-01 00:00:00

abstract：:Clinically, corticosteroids (CS) are among the first line drugs in the therapy of autoimmune and allergic diseases and potently inhibit the activation of immune cells. However, due to their pleiotropic mode of action, the prolonged use of CS is generally associated with a range of undesirable side-effects. In this stu...

journal_title：Clinical and experimental immunology

authors： Kalthoff FS,Chung J,Musser P,Stuetz A

更新日期：2003-09-01 00:00:00

abstract：:Using quantitative morphometric analysis of immunohistochemically stained tissue sections we compared hypertrophic obstructive adenoids (HOA, n = 10) from children without middle ear disease with chronically infected adenoids (CIA, n = 10) from children with middle ear disease. gamma delta T cell receptor (TCR)+ cells...

journal_title：Clinical and experimental immunology

authors： Olofsson K,Hellström S,Hammarström ML

更新日期：1996-11-01 00:00:00

abstract：:In vitro monoclonal immunoglobulin (mIg) production of cultured tumour cells--prepared from the bone marrow (BM) or from the peripheral blood (PB) of 40 multiple myeloma (MM) patients, 16 patients with monoclonal gammopathy of undetermined significance and two patients with M. Waldenström--was measured with an enzyme-...

journal_title：Clinical and experimental immunology

authors： Peest D,Gasch S,Thiele C,Bartels B,Brunkhorst U,Dallmann I,Hoffmann M,Schedel I,Deicher H

更新日期：1986-07-01 00:00:00

abstract：:To investigate the possible role of tryptophan metabolism in immune regulation of primary Sjögren's syndrome (pSS) the serum concentrations of tryptophan and its metabolite kynurenine were measured by reverse-phase high-performance liquid chromatography (HPLC) in 103 patients with pSS, 56 patients with sicca symptoms ...

journal_title：Clinical and experimental immunology

authors： Pertovaara M,Raitala A,Uusitalo H,Pukander J,Helin H,Oja SS,Hurme M

更新日期：2005-10-01 00:00:00