Is interferon-gamma the right marker for bacille Calmette-Guérin-induced immune protection? The missing link in our understanding of tuberculosis immunology.

abstract：:In a family with partial or total adenine phosphoribosyl transferase (APRT) deficiency, T and B cell function was evaluated by counting rosette-forming cells, by investigating lymphocyte transformation to phytohaemagglutinin (PHA), concanavalin A (Con A) and pokeweed mitogen (PWM), by assaying serum immunoglobulins an...

journal_title：Clinical and experimental immunology

authors： Stevens WJ,Peetermans ME,Van Acker KJ

更新日期：1979-06-01 00:00:00

abstract：:Factor H and the FHL-1/reconectin protein are two human plasma proteins that act as important regulators of the alternative complement pathway. Each protein is encoded by a unique transcript, but both mRNAs are derived from the factor H gene by means of alternative processing. In order to address potential functional ...

journal_title：Clinical and experimental immunology

authors： Friese MA,Hellwage J,Jokiranta TS,Meri S,Müller-Quernheim HJ,Peter HH,Eibel H,Zipfel PF

更新日期：2000-08-01 00:00:00

abstract：:Clinically, corticosteroids (CS) are among the first line drugs in the therapy of autoimmune and allergic diseases and potently inhibit the activation of immune cells. However, due to their pleiotropic mode of action, the prolonged use of CS is generally associated with a range of undesirable side-effects. In this stu...

journal_title：Clinical and experimental immunology

authors： Kalthoff FS,Chung J,Musser P,Stuetz A

更新日期：2003-09-01 00:00:00

abstract：:The prolonged generalized lymphadenopathy syndrome (PGL) has been considered a prodromal condition to the Acquired immunodeficiency syndrome (AIDS), but the clinical, virological and immunological characteristics of patients who will develop AIDS are not known. We report on the immunological profile of intravenous dru...

journal_title：Clinical and experimental immunology

authors： De Paoli P,Reitano M,Battistin S,Martelli P,Villalata D,Bergamo F,Tirelli U,Carbone A,Diodato S,Bosio R

更新日期：1986-06-01 00:00:00

abstract：:C4BP has a central role in regulating the classical complement (C') pathway, but it is still uncertain whether or not it is consumed during in vivo complement activation. Attempts to demonstrate changes in C4BP plasma levels in systemic lupus erythematosus and essential mixed cryoglobulinaemia have failed, probably du...

journal_title：Clinical and experimental immunology

authors： Bergamaschini L,Miedico A,Cicardi M,Coppola R,Faioni EN,Agostoni A

更新日期：1999-05-01 00:00:00

abstract：:The present standard of care for B cell non-Hodgkin's lymphoma includes the anti-CD20 monoclonal antibody rituximab. Although combination treatments with chemotherapy and rituximab improved the duration of remissions and overall survival in indolent B cell lymphoma, the disease is essentially incurable. Thus, new ther...

journal_title：Clinical and experimental immunology

authors： Manzur S,Cohen S,Haimovich J,Hollander N

更新日期：2012-12-01 00:00:00

abstract：:Sjögren's syndrome (SS) is an autoimmune disease characterized by clonal B cell attack of the exocrine glands and dysregulated expression of B cell-activating factor (BAFF). Based upon the current data of increased rates of lymphoid malignancy, as non-Hodgkin's lymphoma (NHL) is associated with SS, we propose the dete...

journal_title：Clinical and experimental immunology

authors： Guzmán LM,Castillo D,Aguilera SO

更新日期：2010-07-01 00:00:00

abstract：:Myasthenia gravis (MG) is a debilitating and potentially fatal neuromuscular disease characterized by the generation of autoantibodies reactive with nicotinic acetylcholine receptors (AChR) that cause loss of AChR from the neuromuscular endplate with resultant failure of neuromuscular transmission. A role for compleme...

journal_title：Clinical and experimental immunology

authors： Chamberlain-Banoub J,Neal JW,Mizuno M,Harris CL,Morgan BP

更新日期：2006-11-01 00:00:00

abstract：:Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

journal_title：Clinical and experimental immunology

authors： Cashner FM,Schuyler MR,Salvaggio JE

更新日期：1979-05-01 00:00:00

abstract：:Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

journal_title：Clinical and experimental immunology

authors： Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

更新日期：1988-12-01 00:00:00

abstract：:Suppression of the lymphocyte response to concanavalin A (Con A), phytohaemagglutinin (PHA) and protein A from Staphylococcus aureus (SpA) by Con A-induced suppressor cells was measured in twenty-four patients with recently active-recovering multiple sclerosis (MS), twelve with inactive MS and twenty-three healthy con...

journal_title：Clinical and experimental immunology

authors： Gonzalez RL,Dau PC,Spitler LE

更新日期：1979-04-01 00:00:00

abstract：:Antigenic diversity in field populations of Plasmodium falciparum parasites may delay the acquisition of protective immunity to malaria, the development of which may thus require repeated exposure to infection over a prolonged period of time. In this study we show that P. falciparum parasites may vary in their sensiti...

journal_title：Clinical and experimental immunology

authors： Flyg BW,Perlmann H,Perlmann P,Esposito F,Berzins K

更新日期：1997-02-01 00:00:00

abstract：:In stimulated cultures, a proportion of human T lymphocytes form multilayer rosettes with sheep red blood cells (SRBC) and they can be easily separated from common E rosettes by velocity sedimentation. We have developed a simplified method for harvesting multilayer rosettes and quantifying them. Practical applications...

journal_title：Clinical and experimental immunology

authors： Abuaf N,Leynadier F,Luce H,Dry J

更新日期：1981-04-01 00:00:00

abstract：:The effect of anti-neutrophil cytoplasm autoantibodies (ANCA) on neutrophil activation was studied by pre-incubating neutrophils with IgG and F(ab')2 prepared from ANCA patients with Wegener's granulomatosis or microscopic polyarteritis. We measured the generation of inositol triphosphate (IP3) (a product of hydrolysi...

journal_title：Clinical and experimental immunology

authors： Lai KN,Lockwood CM

更新日期：1991-09-01 00:00:00

abstract：:Parasite antigens released from Trypanosoma cruzi-infected cells were adsorbed to infected and uninfected mammalian cells thus rendering them susceptible to immune lysis by antibody and cell-mediated immunity directed against the parasite. BALB/c mice infected with T. cruzi for 15 days developed cytotoxic T lymphocyte...

journal_title：Clinical and experimental immunology

authors： Ribeiro Dos Santos R,Hudson L

更新日期：1980-04-01 00:00:00

abstract：:Mixed leucocyte culture blocking factor activity (MLC-BFA) in the plasma of haemodialysis patients appears as a result of recent blood transfusions and is concentrated in IgG fractions of the blocking serum. Four patients neither developed lymphocytotoxins nor MLC-BFA in spite of having received multiple blood transfu...

journal_title：Clinical and experimental immunology

authors： Sengar DP,Rashid A,Perelmutter L,Harris JE

更新日期：1975-05-01 00:00:00

abstract：:Cell-mediated cytotoxicity was examined in thirty-seven patients with systemic sclerosis using both whole blood and purified peripheral blood mononuclear cells (PBM) to measure antibody-dependent (ADCC) and phytohaemagglutinin (PHA) induced lymphocyte cytotoxicity to 51Cr-labelled Chang liver cells. In twenty-three mi...

journal_title：Clinical and experimental immunology

authors： Wright JK,Hughes P,Rowell NR,Sneddon IB

更新日期：1979-04-01 00:00:00

abstract：:PHA activated human peripheral blood mononuclear cells (MNC) were incubated with human interleukin 2 (IL-2) in the absence or in the presence of 10(-6)-10(-9) M hydrocortisone (HC). HC suppressed the proliferative response of the activated MNC to highly purified human leucocyte IL-2 in a dose dependent manner. This su...

journal_title：Clinical and experimental immunology

authors： Horst HJ,Flad HD

更新日期：1987-04-01 00:00:00

abstract：:T helper type 1 (Th1)-type polarization plays a critical role in the pathophysiology of acute graft-versus-host disease (aGVHD). The differentiation of T cells into this subtype is dictated by the nature of the donor naive CD4(+) T cell-host antigen presenting cell (APC) interaction. Suppressors of cytokine signalling...

journal_title：Clinical and experimental immunology

authors： Zhao J,Zhang T,He H,Xie Y

更新日期：2010-06-01 00:00:00

abstract：:The search for novel chemical classes of anti-malarial compounds to cope with the current state of chemoresistance of malaria parasites has led to the identification of Plasmodium falciparum aminopeptidase 1 (PfA-M1) as a new therapeutic target. PfA-M1, known to be involved in the hemoglobin digestion cascade which he...

journal_title：Clinical and experimental immunology

authors： Oyegue-Liabagui SL,Imboumy-Limoukou RK,Kouna CL,Bangueboussa F,Schmitt M,Florent I,Lekana-Douki JB

更新日期：2020-06-01 00:00:00

abstract：:F-42, an autoantibody found in the sera of some patients with systemic lupus erythematosus, was isolated from sera of seven different patients. By binding of the autoantibodies to cell bound C42, the autoantibodies were purified to homogeneity and radiolabelled with 125I. Purified preparations of 125I-F-42 were bound ...

journal_title：Clinical and experimental immunology

authors： Daha MR,Hazevoet HM,van Es LA

更新日期：1984-06-01 00:00:00

abstract：:Complement receptor 1-related gene/protein y (Crry) is a potent murine complement regulator that inhibits C3 convertases. Transgenic mice that overexpress soluble Crry (sCrry), directed systemically by the metallothionein-I promoter, have been used as an animal model for chronic blockade of complement activation. Rece...

journal_title：Clinical and experimental immunology

authors： Kang HJ,Bao L,Xu Y,Quigg RJ,Giclas PC,Holers VM

更新日期：2004-05-01 00:00:00

abstract：:In Helicobacter pylori gastritis gastric epithelium plays a central role in the innate immunity to H. pylori. However, epithelial receptors interacting with H. pylori have been poorly characterized so far. Recently a new triggering receptor expressed on myeloid cells-1 (TREM-1) has been identified on human neutrophils...

journal_title：Clinical and experimental immunology

authors： Schmausser B,Endrich S,Beier D,Moran AP,Burek CJ,Rosenwald A,Rieckmann P,Müller-Hermelink HK,Eck M

更新日期：2008-04-01 00:00:00

abstract：:Identification of autoimmune processes and introduction of new autoantigens involved in the pathogenesis of multiple sclerosis (MS) can be helpful in the design of new drugs to prevent unresponsiveness and side effects in patients. To find significant changes, we evaluated the autoantibody repertoires in newly diagnos...

journal_title：Clinical and experimental immunology

authors： Pazhouhandeh M,Sahraian MA,Siadat SD,Fateh A,Vaziri F,Tabrizi F,Ajorloo F,Arshadi AK,Fatemi E,Piri Gavgani S,Mahboudi F,Rahimi Jamnani F

更新日期：2018-04-01 00:00:00

abstract：:During pathogenesis of diabetes, pancreatic islets are exposed to high levels of cytokines and other inflammatory mediators that induce deterioration of insulin-producing beta cells. Macrophage migration inhibitory factor (MIF) plays a key role in the onset and development of several immunoinflammatory diseases and al...

journal_title：Clinical and experimental immunology

authors： Stojanovic I,Saksida T,Nikolic I,Nicoletti F,Stosic-Grujicic S

更新日期：2012-08-01 00:00:00

abstract：:Allele variants in the L-carnitine (LCAR) transporters OCTN1 (SLC22A4, 1672 C --> T) and OCTN2 (SLC22A5, -207 G --> C) have been implicated in susceptibility to Crohn's disease (CD). LCAR is consumed in the diet and transported actively from the intestinal lumen via the organic cation transporter OCTN2. While recogniz...

journal_title：Clinical and experimental immunology

authors： Fortin G,Yurchenko K,Collette C,Rubio M,Villani AC,Bitton A,Sarfati M,Franchimont D

更新日期：2009-04-01 00:00:00

abstract：:Dendritic cells (DC) are the most professional antigen-presenting cells of the immune system and are capable of initiating immune responses in vitro and in vivo. One of the great challenges in immunotherapy protocols is to introduce relevant antigens into DC for stimulation of major histocompatibility complex (MHC) cl...

journal_title：Clinical and experimental immunology

authors： Ponsaerts P,Van Tendeloo VF,Berneman ZN

更新日期：2003-12-01 00:00:00

abstract：:Immune complexes (IC) were detected and isolated from the serum of Brown Norway (BN), (Lewis x BN)F1, and Lewis rats bearing a Moloney sarcoma (MST). IC were isolated from the serum of individual rats employing a system of G-200 chromatography and passage through a heavy chain specific anti-rat IgG Immunoadsorbent. Ig...

journal_title：Clinical and experimental immunology

authors： Balint JR

更新日期：1982-04-01 00:00:00

abstract：:Eosinophils contribute to the pathogenesis of bullous pemphigoid (BP) by secretion of proinflammatory cytokines and proteases. Trafficking of eosinophils into tissue in animal models and asthma depends on interleukin-5 and a family of chemokines named eotaxins, comprising CCL11, CCL24 and CCL26. Up-regulation of CCL11...

journal_title：Clinical and experimental immunology

authors： Günther C,Wozel G,Meurer M,Pfeiffer C

更新日期：2011-11-01 00:00:00

abstract：:Previous studies have shown that male mice of strains with high target organ responsiveness to androgen, the C57L/J and RF/J, have lower plasma immunoglobulin levels and weaker antibody responses to protein and polysaccharide antigens than mice of low androgen responder (LAR) strains, the A/J and 129/J. In the current...

journal_title：Clinical and experimental immunology

authors： Cohn DA

更新日期：1986-01-01 00:00:00