Altered regulation of mitogen responsiveness by suppressor cells in multiple sclerosis.

abstract：:By using a flow cytometric technique which allows direct identification of proliferating cells within mixed cell populations, we have previously described that soluble extracts obtained from Mycobacterium tuberculosis or M. avium represent strong stimuli for human gammadelta+ T cells. In the present study, we demonstr...

journal_title：Clinical and experimental immunology

authors： Batoni G,Esin S,Harris RA,Källenius G,Svenson SB,Andersson R,Campa M,Wigzell H

更新日期：1998-04-01 00:00:00

abstract：:Autoreactivity to heat shock protein 60 (Hsp60) has been implicated in the pathogenesis and regulation of chronic inflammation, especially in autoimmune diseases. In transplantation, there is a lack of information regarding the cytokine profile and specificity of cells that recognize self-Hsp60 as well as the kinetics...

journal_title：Clinical and experimental immunology

authors： Caldas C,Luna E,Spadafora-Ferreira M,Porto G,Iwai LK,Oshiro SE,Monteiro SM,Fonseca JA,Lemos F,Hammer J,Ho PL,Kalil J,Coelho V

更新日期：2006-10-01 00:00:00

abstract：:Leucocyte adhesion deficiency type 1 (LAD-1) is characterized by the incapacity of leucocytes to carry out their adhesion functions via their CD11/CD18 antigens, which are also referred to as the leucocyte integrins. The patients generally suffer from poor wound healing and recurrent bacterial and fungal infections. I...

journal_title：Clinical and experimental immunology

authors： Mathew EC,Shaw JM,Bonilla FA,Law SK,Wright DA

更新日期：2000-07-01 00:00:00

abstract：:This study was undertaken to determine if Brazilian Pemphigus foliaceus (BPF) autoantibodies will fix complement as do P. vulgaris (PV) autoantibodies. When sections of human skin were examined following indirect immunofluorescence (IF) staining, BPF autoantibodies reacted with the upper layers of epidermis, while PV ...

journal_title：Clinical and experimental immunology

authors： Kawana S,Diaz LA,Rivitti EA,Geoghegan WD,Jordon RE

更新日期：1988-03-01 00:00:00

abstract：:An attempt was made to correlate lymphocyte subset abnormalities with the development of experimental autoimmune thyroiditis (EAIT) in thymectomized and irradiated rats of five inbred strains. The peripheral blood subpopulations were analysed using the fluorescence-activated cell sorter (FACS-IV). A significant lympho...

journal_title：Clinical and experimental immunology

authors： Smith E,Behan WM,Menzies CB,Behan PO

更新日期：1987-02-01 00:00:00

abstract：:Human peripheral blood lymphocytes were examined for rosette formation with autologous erythrocytes. When normal human lymphocytes were stimulated with phorbol myristate acetate (PMA) in the presence of autologous serum, the levels of autorosette forming cells (ARFC) were strongly enhanced. Pre-culture was necessary f...

journal_title：Clinical and experimental immunology

authors： Sakano T,Hyodo S,Kittaka E,Tanaka Y,Usui T

更新日期：1982-09-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It is not known why ANCA develop, but it has been shown that they participate in pathogenesis by activating polymorphonuclear n...

journal_title：Clinical and experimental immunology

authors： Ohlsson SM,Pettersson Å,Ohlsson S,Selga D,Bengtsson AA,Segelmark M,Hellmark T

更新日期：2012-10-01 00:00:00

abstract：:In a previous work we have demonstrated that in patients exhibiting a late allergic reaction (LAR), alveolar macrophages (AM) collected 18 h after bronchial allergen challenge produced high levels of IL-6 and tumour necrosis factor-alpha (TNF) which is known to up-regulate the endothelial cell expression of adhesion m...

journal_title：Clinical and experimental immunology

authors： Lassalle P,Gosset P,Delneste Y,Tsicopoulos A,Capron A,Joseph M,Tonnel AB

更新日期：1993-10-01 00:00:00

abstract：:In this study we demonstrate that IgG present in the sera of patients with primary Sjögren's syndrome (PSS) could bind and activate muscarinic acetylcholine receptors (mAChRs) of rat parotid gland. These antibodies were able to inhibit in a non-competitive manner the binding of 3H-quinuclidinyl benzilate (QNB) to mACh...

journal_title：Clinical and experimental immunology

authors： Bacman S,Sterin-Borda L,Camusso JJ,Arana R,Hubscher O,Borda E

更新日期：1996-06-01 00:00:00

abstract：:Mucous membrane pemphigoid (MMP) (also known as cicatricial pemphigoid) is a rare autoimmune mucocutaneous blistering disease that affects mucous membranes derived from stratified squamous epithelium and the skin. A subset of MMP affects only the oral cavity and is referred to as the oral pemphigoid (OP). MMP and OP a...

journal_title：Clinical and experimental immunology

authors： Mignogna M,Lanza A,Rossiello L,Ruocco V,Ahmed AR

更新日期：2006-07-01 00:00:00

abstract：:In vitro IgG synthesis by peripheral blood mononuclear cells (PBM) from patients with chronic liver disease (CLD) was studied. In addition, the effect of pokeweed mitogen (PWM), polyadenylic-polyuridylic acid complexes (poly A:U) and thymosin fraction 5 on IgG synthesis was determined. Unstimulated cultures of PBM fro...

journal_title：Clinical and experimental immunology

authors： Mutchnick MG,Lederman HM,Missirian A,Johnson AG

更新日期：1981-02-01 00:00:00

abstract：:Although the role of the T cell-mediated autoimmune reaction in type 1 diabetes (T1D) is conclusive, studies including data from human circulating CD4(+) and CD8(+) lymphocytes subsets during the disease onset and posterior development are scarce. Further, chemokines and chemokine receptors are key players in the migr...

journal_title：Clinical and experimental immunology

authors： Hedman M,Faresjö M,Axelsson S,Ludvigsson J,Casas R

更新日期：2008-09-01 00:00:00

abstract：:To gain some insight into the pathogenesis of proliferative lupus nephritis in MRL/lpr mice we investigated the kinetics of removal of immune complexes from the circulation, the carrier state of blood cells, the uptake of complexes by the mononuclear phagocyte system, and the localization of complexes in kidneys. In n...

journal_title：Clinical and experimental immunology

authors： Granholm NA,Cavallo T

更新日期：1990-11-01 00:00:00

abstract：:Rheumatoid arthritis (RA) is a chronic inflammatory disease primarily affecting cartilaginous joints but also extra-articular tissues such as the nose and upper respiratory tract. We have investigated extra-articular cartilage involvement in two commonly used animal models for RA, collagen-induced and pristane-induced...

journal_title：Clinical and experimental immunology

authors： Hansson AS,Lu S,Holmdahl R

更新日期：2002-01-01 00:00:00

abstract：:The lymphocyte activating properties of a membrane proteoglycan (MPG) extracted from a mutant non-encapsulated strain of Klebsiella pneumoniae (Kp) (biotype a I-145) were investigated. Kp MPG induced a strong proliferative response of BALB/c spleen cells and Peyer's patches cells. Thymidine incorporation was dose-rela...

journal_title：Clinical and experimental immunology

authors： Millet I,Lafont S,de Fraissinette A,Jeannin M,Revillard JP,Normier G,Dussourd d'Hinterland L

更新日期：1987-10-01 00:00:00

abstract：:Depression of one or more parameters of cellular and/or humoral immune responses was found in 60% of general hospital patients treated with phenytoin and 47% of patients treated with carbamazepine. Phenytoin-treated patients failed to manifest delayed hypersensitivity (DHS) reactions to common antigens, and to make an...

journal_title：Clinical and experimental immunology

authors： Sorrell TC,Forbes IJ

更新日期：1975-05-01 00:00:00

abstract：:Normal T cells bearing receptors for the Fc portion of IgG that were incubated in anti-RNP or anti-DNA at the time of activation with phytohaemagglutinin showed different effects on this activation as determined by flow cytometric analysis of acridine orange stained cells. Incubation in anti-RNP caused an arrest in th...

journal_title：Clinical and experimental immunology

authors： Alarcón-Segovia D,Llorente L

更新日期：1983-05-01 00:00:00

abstract：:Antibody responses in immunoglobulin G1, G2, G3, G4, A (IgA1) and M isotypes were studied in 10 patients with an acute influenza A and in another 10 patients with a parainfluenza type 1 virus infection using radioimmunoassay with standardized monoclonal anti-immunoglobulins. A four-fold or greater increase of antibody...

journal_title：Clinical and experimental immunology

authors： Julkunen I,Hovi T,Seppälä I,Mäkelä O

更新日期：1985-04-01 00:00:00

abstract：:The presence of autoantibodies detected by immunofluorescence to single endocrine cells, of human duodenum is described in three groups of patients and two control groups. Of 173 coeliac cases, four had GIP cell antibodies, one had secretin cell antibodies and twenty-one reacted with both cell types. Of twelve tropica...

journal_title：Clinical and experimental immunology

authors： Mirakian R,Bottazzo GF,Doniach D

更新日期：1980-07-01 00:00:00

abstract：:Erythrocyte autoantibodies in NZB mice react by hemagglutination methods with exposed and hidden red cell antigens. The hidden antigens can be exposed by treatment with proteolytic enzymes. By indirect immunofluorescence one antibody population can be shown to react with modified red cells. In the present study the lo...

journal_title：Clinical and experimental immunology

authors： Linder E

更新日期：1977-03-01 00:00:00

abstract：:The presence of antibodies reactive to a recently cloned host-derived antigen GOR is highly correlated with the presence of antibodies to the hepatitis C virus (HCV). We explored the molecular basis for this observation, and address the following question: are antibodies reactive with GOR19-27 (QKAKSNPNR) a result of ...

journal_title：Clinical and experimental immunology

authors： Zhang ZX,Chen M,Wallhagen K,Trojnar J,Magnius LO,Wahren B,Sällberg M

更新日期：1994-06-01 00:00:00

abstract：:The lymphocyte stimulation test has been standardized in a normal human population using four virus cell-associated antigens (VCAA): human embryonic lung cells infected with the LEC and Norrby strains of measles virus, mumps virus, and vaccinia virus. Following 1 week of treatment with the immunopotentiating drug leva...

journal_title：Clinical and experimental immunology

authors： Dau PC,Johnson KP,Spitler LE

更新日期：1976-11-01 00:00:00

abstract：:Vulnerability to Streptococcus pneumoniae is most pronounced in children. The microbial virulence factors and the features of the host immune response contributing to this phenomenon are not completely understood. In the current study, the humoral immune response to separated Strep. pneumoniae surface proteins and the...

journal_title：Clinical and experimental immunology

authors： Lifshitz S,Dagan R,Shani-Sekler M,Grossman N,Fleminger G,Friger M,Nebenzahl YM

更新日期：2002-02-01 00:00:00

abstract：:Lymphocytes isolated from Graves' and Hashimoto thyroid tissue by enzymatic (dispase) digestion or mechanical disaggregation were markedly different in terms of their ability to synthesize thyroid autoantibodies in culture. Dispase digestion, followed by removal of thyroid follicular cells, gave a lymphocyte populatio...

journal_title：Clinical and experimental immunology

authors： McLachlan SM,Pegg CA,Atherton MC,Middleton SL,Dickinson A,Clark F,Proctor SJ,Proud G,Rees Smith B

更新日期：1986-08-01 00:00:00

abstract：:Complement C6 has a common charge polymorphism designated A and B with gene frequencies of 0.65 and 0.35. The probable molecular basis for this is a Glu (C6A) for Ala (C6B) substitution at amino acid position 98, and is detected by digestion with the restriction enzyme Dde I of a polymerase chain reaction (PCR)-amplif...

journal_title：Clinical and experimental immunology

authors： Fernie BA,Hobart MJ,Delbridge G,Potter PC,Orren A,Lachmann PJ

更新日期：1994-02-01 00:00:00

abstract：:Anaemia of chronic disease (ACD) is frequently found in rheumatoid arthritis (RA). In the pathogenesis of ACD both cytokines, such as tumour necrosis factor-alpha (TNF-alpha), IL-1 and IL-6 as well as a relative deficiency of erythropoietin (EPO), are thought to play a key role. In the present study the role of IL-6 i...

journal_title：Clinical and experimental immunology

authors： Jongen-Lavrencic M,Peeters HR,Rozemuller H,Rombouts WJ,Martens AC,Vreugdenhil G,Pillay M,Cox PH,Bijser M,Brutel G,Breedveld FC,Swaak AJ

更新日期：1996-02-01 00:00:00

abstract：:To determine the effect of prolonged administration of exogenous interferon on the autoimmune disease of NZB/W female mice, forty-four NZB/W mice received three injections per week of 6.4 x 10(4) interferon units from birth to 33 weeks, forty mice were injected with mock interferon and forty-eight mice were left untre...

journal_title：Clinical and experimental immunology

authors： Adam C,Thoua Y,Ronco P,Verroust P,Tovey M,Morel-Maroger L

更新日期：1980-05-01 00:00:00

abstract：:The 20-kD homologous restriction factor (HRF20), which is identical to CD59, is a membrane-associated protein which inhibits the reaction of C9 to form membrane attack complex (MAC) of homologous complements. In various human glomerular diseases deposition of complement components is frequently seen and MAC is reporte...

journal_title：Clinical and experimental immunology

authors： Tamai H,Matsuo S,Fukatsu A,Nishikawa K,Sakamoto N,Yoshioka K,Okada N,Okada H

更新日期：1991-05-01 00:00:00

abstract：:Goodpasture (GP) antigens, protein components reactive with human autoantibodies against glomerular basement membrane (GBM), were identified in human alveolar basement membrane (ABM) using an enzyme-linked immunoassay (ELISA), Western blotting and immunoprecipitation. All six anti-GBM antisera studied, three obtained ...

journal_title：Clinical and experimental immunology

authors： Yoshioka K,Iseki T,Okada M,Morimoto Y,Eryu N,Maki S

更新日期：1988-12-01 00:00:00

abstract：:Circulating immunoglobulin (Ig)G antibodies against M(2) muscarinic acetylcholine receptors (M(2) mAChR) have been implicated in Chagas' disease (ChD) pathophysiology. These antibodies bind to and activate their target receptor, displaying agonist-like activity through an unclear mechanism. This study tested the abili...

journal_title：Clinical and experimental immunology

authors： Beltrame SP,Auger SR,Bilder CR,Waldner CI,Goin JC

更新日期：2011-05-01 00:00:00