Polyclonal activation of murine B cells by a membrane proteoglycan of Klebsiella pneumoniae.

abstract：:The sera of seven out of eight patients with Herpes gestationis contained a factor which fixed C3 but not detectable amounts of immunoglobulin (Ig) on the basement membrane zone (BMZ) of normal human skin. Using C2-deficient human serum and C4-deficient guinea-pig serum, fixation was shown to be dependent upon activat...

journal_title：Clinical and experimental immunology

authors： Carruthers JA,Ewins AR

更新日期：1978-01-01 00:00:00

abstract：:Previous studies using isolated complement proteins have shown that more C4A than C4B binds to certain types of immune complexes. However, the in vivo binding of the C4 isoforms to an immune complex has not been investigated in detail and may differ from events when measured with the isolated proteins. We report here ...

journal_title：Clinical and experimental immunology

authors： Reilly BD

更新日期：1999-07-01 00:00:00

abstract：:Intravenous injection of t-butyl hydroperoxide rapidly killed Plasmodium vinckei in mice, and caused haemolysis. The same dose seemed harmless to unparasitized mice. Many parasites disintegrated inside circulating erythrocytes, so parasite death was not simply a passive consequence of haemolysis. Injection of desferri...

journal_title：Clinical and experimental immunology

authors： Clark IA,Hunt NH,Cowden WB,Maxwell LE,Mackie EJ

更新日期：1984-06-01 00:00:00

abstract：:Our aims were to identify the differential expression of microRNA (miR)-155, as well as to explore the possible regulatory effects of miR-155 on the differentiation and function of T helper type 17 (Th17) cells in atopic dermatitis (AD). The Th17 cell percentage and expression levels of miR-155, retinoic acid-related ...

journal_title：Clinical and experimental immunology

authors： Ma L,Xue HB,Wang F,Shu CM,Zhang JH

更新日期：2015-07-01 00:00:00

abstract：:A better understanding about the mechanisms involved in the pathogenesis of type 2 diabetes mellitus (T2D) showed that inflammatory cytokines such as tumour necrosis factor (TNF) and interleukin (IL)-1β play a pivotal role, mirroring data largely reported in rheumatoid arthritis (RA). IL-1β is produced mainly by monoc...

journal_title：Clinical and experimental immunology

authors： Ruscitti P,Cipriani P,Di Benedetto P,Liakouli V,Berardicurti O,Carubbi F,Ciccia F,Alvaro S,Triolo G,Giacomelli R

更新日期：2015-10-01 00:00:00

abstract：:Significant numbers of syncytial cells were observed in the bronchoalveolar lavage fluid (BALF) of a 42-year-old patient who had SLE with interstitial pneumonia. Electron microscopic study of the BALF cells and positive reverse transcriptase activity in the supernatant of the cultured cells revealed unknown retroviral...

journal_title：Clinical and experimental immunology

authors： Tamura N,Sekigawa I,Hashimoto H,Yamamoto N,Kira S

更新日期：1997-03-01 00:00:00

abstract：:Integral membrane proteins (IMP) represent a serologically distinct class of mycobacterial antigens which are potent stimulators of human T cells (Mehrotra et al., Clin Exp Immunol 1995; 102:626). The range of IMP from Mycobacterium fortuitum was resolved by continuous elution SDS-PAGE to recover 31 discrete fractions...

journal_title：Clinical and experimental immunology

authors： Mehrotra J,Mittal A,Dhindsa MS,Sinha S

更新日期：1997-09-01 00:00:00

abstract：:Many patients surviving vasculitis are prone to accelerated atherosclerosis and often have enhanced levels of antibodies to oxidized low-density lipoprotein (oxLDL). To measure anti-oxLDL antibodies, oxidation of LDL is achieved with copper (Cu) or malondialdehyde (MDA). Because, in vivo, LDL may be oxidized with myel...

journal_title：Clinical and experimental immunology

authors： Slot MC,Theunissen R,van Paassen P,Damoiseaux JG,Tervaert JW,Limburg Nephrology Working Group.

更新日期：2007-08-01 00:00:00

abstract：:Lymphocytes from normal individuals with the histocompatibility antigens HLA-B8 and DR3 have impaired proliferative responses when stimulated with suboptimal concentrations of mitogens. We have previously shown that an important factor in the impaired response is a failure to produce normal quantities of interleukin-2...

journal_title：Clinical and experimental immunology

authors： Hashimoto S,Michalski JP,Berman MA,McCombs C

更新日期：1990-02-01 00:00:00

abstract：:The diagnostic value of the determination of the relative distribution of B (SmIg-positive) and T (E rosetting) cells in the blood and in pleural or ascitic effusions was evaluated in 10 patients with tuberculosis and in six with malignant diseases. A higher percentage of T and a lower percentage of B lymphocytes in s...

journal_title：Clinical and experimental immunology

authors： Falcão RP,Bottura C

更新日期：1981-07-01 00:00:00

abstract：:Human red cells (RBC) coated with IgG anti-D are cleared from the circulation to the spleen by macrophages which express IgG receptors (Fcgamma R). Polymorphisms of Fcgamma RIIa and Fcgamma RIIIa affect IgG binding in vitro, and may alter the efficiency of clearance of immune complexes in vivo. In a RBC clearance stud...

journal_title：Clinical and experimental immunology

authors： Kumpel BM,De Haas M,Koene HR,Van De Winkel JG,Goodrick MJ

更新日期：2003-04-01 00:00:00

abstract：:Serological profiles for anti-Saccharomyces cerevisiae antibodies (ASCA)/ perinuclear antineutrophil cytoplasmic antibodies (pANCA) and gene polymorphisms in tumour necrosis factor (TNF)-alpha and intercellular adhesion molecule-1 (ICAM-1) are associated with occurrence and/or outcome in Crohn's disease. The aim of th...

journal_title：Clinical and experimental immunology

authors： Yacyshyn BR,Schievella A,Sewell KL,Tami JA

更新日期：2005-07-01 00:00:00

abstract：:The number of NK T cells was measured in relation to the Th1/Th2 imbalance observed in RA. Peripheral blood samples of patients with RA (n = 60) and healthy controls (n = 36) were stained with anti-NK receptor 1A (anti-NKR-P1A), anti-CD56, and anti-CD3 MoAbs, and examined by three-colour flow cytometry. NK T (NKR-P1A+...

journal_title：Clinical and experimental immunology

authors： Yanagihara Y,Shiozawa K,Takai M,Kyogoku M,Shiozawa S

更新日期：1999-10-01 00:00:00

abstract：:In sarcoidosis, a T helper 1 (Th1) response is an essential event and the up-regulation of interleukin-12 (IL-12) has been detected in affected disease sites. In order to investigate the clinical usefulness of circulating IL-12, we measured the serum concentrations of IL-12 by ELISA and performed immunohistochemistry ...

journal_title：Clinical and experimental immunology

authors： Shigehara K,Shijubo N,Ohmichi M,Kamiguchi K,Takahashi R,Morita-Ichimura S,Ohchi T,Tatsuno T,Hiraga Y,Abe S,Sato N

更新日期：2003-04-01 00:00:00

abstract：:Activation of human umbilical vein endothelial (HUVE) cells with the inflammatory mediators tumour necrosis factor-alpha (TNF), interleukin-1 (IL-1), lipopolysaccharide (LPS) and phorbol esters enhanced their adhesiveness for leucocytes. The appearance of an activation antigen ELAM-1, recognized by a monoclonal antibo...

journal_title：Clinical and experimental immunology

authors： Leeuwenberg JF,Jeunhomme GM,Buurman WA

更新日期：1990-09-01 00:00:00

abstract：:Compared to normal children, pre-natally infected infants had significantly elevated IgM concentrations throughout the first year of life and elevated IgA levels for the first 6 months. In contrast, IgG levels dropped significantly below normal at 3 months post-partum. Infants born without overt disease but with eleva...

journal_title：Clinical and experimental immunology

authors： McMurray DN,Rey H

更新日期：1981-05-01 00:00:00

abstract：:Histamine (10(-3)-10(-8) M) inhibits PHA-induced proliferation of human peripheral blood lymphocytes (HPBL). Inhibition is detected at low concentrations of PHA but is rarely observed at high PHA concentrations. The histamine type II (H2) receptor agonists dimaprit, impromidine and 4-methylhistamine (4MH) inhibit HPBL...

journal_title：Clinical and experimental immunology

authors： Badger AM,Young J,Poste G

更新日期：1983-01-01 00:00:00

abstract：:The distribution and regulatory function of immunoglobulin (Ig) synthesis by monocytes were assessed using several monoclonal antibodies and a cell sorter in samples from 13 patients with multiple myeloma (MM) and nine patients with benign monoclonal gammopathy (BMG). Since all of these cells were separated directly w...

journal_title：Clinical and experimental immunology

authors： Takeshita A

更新日期：1986-12-01 00:00:00

abstract：:The effector arm of the mucosal immune system comprises lymphocytes scattered at intraepithelial and lamina propria levels. Intraepithelial lymphocytes (IEL) are a large population of oligoclonal resting cells which exhibit phenotypic and functional characteristics of cytolytic T cells when activated. Several mechanis...

journal_title：Clinical and experimental immunology

authors： Ciccocioppo R,Di Sabatino A,Parroni R,D'alò S,Pistoia MA,Doglioni C,Cifone MG,Corazza GR

更新日期：2000-05-01 00:00:00

abstract：:Two colour fluorescent staining using anti-Leu-1 and anti-B1 monoclonal antibodies has been combined with continuous flow microfluorimetry to analyse and isolate the T and B cell populations in B cell chronic lymphocytic leukaemia (B-CLL) patients. In Rai stage 0 patients two distinct B1 positive populations were dete...

journal_title：Clinical and experimental immunology

authors： Murphy JJ,Tooze J,Millard RE,Hudson L

更新日期：1987-06-01 00:00:00

abstract：:Immunoglobulin M (IgM) levels and their relationship to isohaemagglutinins, febrile agglutinins, sheep cell agglutinins, and rheumatoid factor were measured in patients with acute hepatitis A, acute hepatitis B, chronic hepatitis B antigenaemia, and normal control populations. Significant IgM elevations were observed ...

journal_title：Clinical and experimental immunology

authors： Dietz WH Jr,Porcell O,Moon TE,Peters CJ,Purcell RH

更新日期：1976-01-01 00:00:00

abstract：:Sepsis is associated with depression of T cell-dependent immune reactivity with proinflammatory cytokines, such as tumour necrosis factor (TNF)-alpha, playing an important role. Recent investigations describe an association between these immunological alterations and disturbances of the endocrine system, related most ...

journal_title：Clinical and experimental immunology

authors： Hildebrand F,Pape HC,Harwood P,Wittwer T,Krettek C,van Griensven M

更新日期：2004-11-01 00:00:00

abstract：:Rabbits were sensitized with Micropolyspora faeni by intratracheal inoculations and later challenged with the same antigen either with or without parenteral administration of cortisone acetate prior to challenge. Animals developed anti-M. faeni serum precipitins, M. faeni-induced alveolar macrophage migration inhibiti...

journal_title：Clinical and experimental immunology

authors： Cashner FM,Schuyler MR,Salvaggio JE

更新日期：1979-05-01 00:00:00

abstract：:Gambian children with past or present Plasmodium falciparum malaria were investigated for the incidence of Coombs positivity using monospecific antisera. Approximately 50% were positive and the most frequent form of erythrocyte sensitization was with C3d. Other specificities, EIgG, EIgGC3d and EIgGC4bC3d were less com...

journal_title：Clinical and experimental immunology

authors： Facer CA,Bray RS,Brown J

更新日期：1979-01-01 00:00:00

abstract：:The membrane attack complex (MAC) of complement is activated by immune and non-immune mechanisms in the kidney. MAC has been found associated with glomerular immune deposits, but also to cell remnants, particularly along tubules and in vessel walls. Clusterin and S-protein (vitronectin) bind to MAC, rendering it cytol...

journal_title：Clinical and experimental immunology

authors： French LE,Tschopp J,Schifferli JA

更新日期：1992-06-01 00:00:00

abstract：:Recent experimental data indicate a pathogenic role of complement activation in congestive heart failure (CHF). The aim of this study was to evaluate contact and complement systems activation in patients hospitalized for an acute episode of CHF. Forty-two of 80 consecutive patients admitted at our hospital with confir...

journal_title：Clinical and experimental immunology

authors： Suffritti C,Tobaldini E,Schiavon R,Strada S,Maggioni L,Mehta S,Sandrone G,Toschi-Dias E,Cicardi M,Montano N

更新日期：2017-11-01 00:00:00

abstract：:Two kinds of brush border antigens were isolated from pronase-treated rat tubular material by gel filtration, DEAE-chromatography and disc-electrophoresis, successively. One, a 0.05 M antigen which was eluted from DEAE-column with 0.05 mol of NaCl solution, has no nephritogenic ability when inoculated into homologous ...

journal_title：Clinical and experimental immunology

authors： Kawai H,Yano S,Naruse T

更新日期：1986-11-01 00:00:00

abstract：:Perturbation of epithelial structure is a prominent but poorly understood feature of the immunopathological response to bacterial antigens which characterizes the destructive lesion of periodontitis. Western analysis of sera from 22 patients with periodontitis detected multiple antigens in extracts of epithelial cells...

journal_title：Clinical and experimental immunology

authors： Ye P,Harty DW,Chapple CC,Nadkarni MA,Carlo AA,Hunter N

更新日期：2003-03-01 00:00:00

abstract：:Patients with allergic rhinitis have traditionally been placed into 'seasonal' and 'perennial' categories, which do not account for the subclinical inflammatory state that exists in many patients. In subjects with seasonal and perennial allergic rhinitis, even subthreshold doses of allergen have been found to cause in...

journal_title：Clinical and experimental immunology

authors： Canonica GW,Compalati E

更新日期：2009-12-01 00:00:00

abstract：:There is increasing interest in the role of T cell exhaustion and it is well known that the natural history of chronic hepatitis C virus infection (HCV) is modulated by CD8(+) T cell immunobiology. There are many pathways that alter the presence of exhaustive T cells and, in particular, they are functionally impaired ...

journal_title：Clinical and experimental immunology

authors： Sumida K,Shimoda S,Iwasaka S,Hisamoto S,Kawanaka H,Akahoshi T,Ikegami T,Shirabe K,Shimono N,Maehara Y,Selmi C,Gershwin ME,Akashi K

更新日期：2013-10-01 00:00:00