Gene polymorphisms and serological markers of patients with active Crohn's disease in a clinical trial of antisense to ICAM-1.

abstract：:Interferon-gamma (IFN-gamma) has been recognized to possess diverse non-immunological effects on epithelial cells such as cellular growth and differentiation. We have previously demonstrated that IFN-gamma suppressed thyroid-stimulating hormone (TSH)-stimulated thyroglobulin (TG) synthesis in human thyrocytes through ...

journal_title：Clinical and experimental immunology

authors： Kung AW,Ma L,Lau KS

更新日期：1992-02-01 00:00:00

abstract：:Immunoblotting of platelets that have been subjected to SDS-PAGE has revealed that sera from normal individuals contain IgG which binds to many platelet components. This binding was seen with autologous and heterologous platelets using serum of males and of nulliparous females who had not received blood transfusions. ...

journal_title：Clinical and experimental immunology

authors： Pfueller SL,Logan D,Tran TT,Bilston RA

更新日期：1990-03-01 00:00:00

abstract：:The present report concerns the site of synthesis of alpha 1-anti-trypsin (alpha 1 AT). In this study circulating cells and tissue fragments were incubated with radioactive amino acids to be incorporated during protein synthesis. The de novo synthesis of proteins was demonstrated by autoradiography of the immunoelectr...

journal_title：Clinical and experimental immunology

authors： van Furth R,Kramps JA,Diesselhof-den Dulk MM

更新日期：1983-03-01 00:00:00

abstract：:The relationship between allergic airway inflammation and pneumococcal pneumonia is not well understood. We assessed susceptibility to experimental pneumococcal pneumonia in mice with and without allergic airway inflammation. Susceptibility to pneumococcal pneumonia was evaluated by challenging mice with a bioluminesc...

journal_title：Clinical and experimental immunology

authors： Kang CI,Rouse MS,Patel R,Kita H,Juhn YJ

更新日期：2009-06-01 00:00:00

abstract：:Chemotherapy has, besides the beneficial effects, several adverse effects. Suppression of the immune system is one of the most important problems. Infections caused by encapsulated bacteria like Streptococcus pneumoniae are responsible for a major part of infectious problems during and after treatment. The splenic mar...

journal_title：Clinical and experimental immunology

authors： Zandvoort A,Lodewijk ME,Klok PA,Breukels MA,Rijkers GT,Timens W

更新日期：2003-01-01 00:00:00

abstract：:Sarcoidosis is a multisystem disease of unknown etiology characterized by non-caseating granulomata, formed mainly from macrophages surrounded by lymphocytes and plasma cells. Using a novel method for the preparation of blood leucocytes for flow cytometry, we report increased expression of LeuCAMs (CD11/CD18) on perip...

journal_title：Clinical and experimental immunology

authors： Shakoor Z,Hamblin AS

更新日期：1992-10-01 00:00:00

abstract：:We have developed CD4+, tetanus antigen-specific T cell clones that proliferate in the presence of tetanus antigen and autologous irradiated peripheral blood leucocytes (PBL) as antigen-presenting cells (APC). There have been several reports that T cells can present antigen themselves. We have used tetanus antigen-spe...

journal_title：Clinical and experimental immunology

authors： Chirmule N,Kalyanaraman VS,Slade H,Oyaizu N,Pahwa S

更新日期：1990-05-01 00:00:00

abstract：:Here we describe the presence of IgG antibodies, in the sera of patients presenting with insulin-dependent diabetes mellitus (IDDM), that react in Western blots with a 60-kD protein (Mr 60K) from rat hepatic microsomal extracts. Sera from 60 IDDM patients were screened and 31.6% were positive for the Mr 60K band. This...

journal_title：Clinical and experimental immunology

authors： Pehuet-Figoni M,Alvarez F,Bach JF,Chatenoud L

更新日期：2000-11-01 00:00:00

abstract：:Type 1 diabetes (T1D) is an autoimmune disease caused by the T cell-mediated destruction of the pancreatic insulin-producing beta cells. Currently there are no widely accepted and standardized assays available to analyse the function of autoreactive T cells involved in T1D. The development of such an assay would great...

journal_title：Clinical and experimental immunology

authors： Mannering SI,Wong FS,Durinovic-Belló I,Brooks-Worrell B,Tree TI,Cilio CM,Schloot NC,Mallone R,Immunology of Diabetes Society T-Cell Workshop Committee.

更新日期：2010-11-01 00:00:00

abstract：:Leishmania parasites are the causative agents of leishmaniasis, a neglected tropical disease that causes substantial morbidity and considerable mortality in many developing areas of the world. Recent estimates suggest that roughly 10 million people suffer from cutaneous leishmaniasis (CL), and approximately 76,000 are...

journal_title：Clinical and experimental immunology

authors： Carlsen ED,Liang Y,Shelite TR,Walker DH,Melby PC,Soong L

更新日期：2015-11-01 00:00:00

abstract：:Serum factors activating the alternative pathway of complement in vitro, independent of classical pathway activation was demonstrated in six of eleven patients with systemic lupus erythematosus (SLE). These serum factors were detected by lysis of gluthathione-sensitized human erythrocytes and by C3 and factor B conver...

journal_title：Clinical and experimental immunology

authors： Wilson MR,Arroyave CM,Nakamura RM,Vaughan JH,Tan EM

更新日期：1976-10-01 00:00:00

abstract：:Human bronchoalveolar lavage (BAL) macrophages were obtained from normal human volunteers and infected with an AIDS-associated strain of Mycobacterium avium. Infected cells were exposed to purified envelope glycoprotein (gp120) from HIV-1 or to the recombinant non-glycosylated gp120 fragments PBI-RF and PBI-IIIB. Nati...

journal_title：Clinical and experimental immunology

authors： Denis M

更新日期：1994-10-01 00:00:00

abstract：:Listeriolysin O (LLO) has been proposed as a potential carrier or adjuvant molecule in the vaccination field. However, the cytotoxic and pro-apoptotic effects of LLO are the major limitations for this purpose. Here, we have performed a preclinical safety evaluation and characterized a new potential adjuvant applicatio...

journal_title：Clinical and experimental immunology

authors： Hernández-Flores KG,Calderón-Garcidueñas AL,Mellado-Sánchez G,Ruiz-Ramos R,Sánchez-Vargas LA,Thomas-Dupont P,Izaguirre-Hernández IY,Téllez-Sosa J,Martínez-Barnetche J,Wood L,Paterson Y,Cedillo-Barrón L,López-Franco O,Vivanco-Ci

更新日期：2017-04-01 00:00:00

abstract：:A technique is described which shows how to obtain a suspension of only progressively motile spermatozoa, from semen, by active penetration into an overlying buffer layer. About 60% of the number of motile spermatozoa in the original semen sample can be obtained as an output in the removed buffer layer. With this meth...

journal_title：Clinical and experimental immunology

authors： Hellema HW,Rümke P

更新日期：1978-01-01 00:00:00

abstract：:Cardiomyopathy is the most severe outcome of Chagas disease, causing more than 12 000 deaths/year. Immune cells participate in cardiomyopathy development either by direct tissue destruction, or by driving inflammation. We have shown that CD4- CD8- [double-negative (DN)] T cells are major sources of inflammatory and an...

journal_title：Clinical and experimental immunology

authors： Passos LSA,Magalhães LMD,Soares RP,Marques AF,Nunes MDCP,Gollob KJ,Dutra WO

更新日期：2017-10-01 00:00:00

abstract：:The present study reports a rare case of systemic M. scrofulaceum infection in an AIDS patient and analyses the inflammatory infiltrate in a lymph node by immunohistochemistry. Special emphasis is put on the histiocytes. The diffuse infiltrate consists mainly of large histiocytes that contain numerous bacilli. These c...

journal_title：Clinical and experimental immunology

authors： Delabie J,De Wolf-Peeters C,Bobbaers H,Bilbe G,Desmet VJ

更新日期：1991-08-01 00:00:00

abstract：:It has earlier been reported that the human monoclonal antibody (MoAb 33G2) and polyclonal antibodies reactive with Pf332 may interfere in vitro with the erythrocytic cycle of Plasmodium falciparum at two potential target sites for protective antibodies, indicating that the antigen may constitute an important target f...

journal_title：Clinical and experimental immunology

authors： Iqbal J,Perlmann P,Greenwood BM,Berzins K

更新日期：1993-10-01 00:00:00

abstract：:Dendritic cells were enriched from adenoids of children with otitis media with effusion (OME) by density gradient centrifugation and culture techniques. An enrichment of 40-140-fold was obtained for dendritic cells. These cells were identified using morphology, enzyme cytochemistry, immunocytochemistry and functional ...

journal_title：Clinical and experimental immunology

authors： van Nieuwkerk EB,van der Baan S,Richters CD,Kamperdijk EW

更新日期：1992-05-01 00:00:00

abstract：:It has been demonstrated immunohistologically using cryostat sections that the lectins PHA and Con A bind to human placentae. Both lectins stain trophoblastic basement membrane (TBM), perivascular tissue and stroma. No staining of trophoblasts was observed. It has been shown by blocking experiments that the lectin bin...

journal_title：Clinical and experimental immunology

authors： Johnson PM,Faulk WP

更新日期：1976-06-01 00:00:00

abstract：:Lymphocytes isolated from Graves' and Hashimoto thyroid tissue by enzymatic (dispase) digestion or mechanical disaggregation were markedly different in terms of their ability to synthesize thyroid autoantibodies in culture. Dispase digestion, followed by removal of thyroid follicular cells, gave a lymphocyte populatio...

journal_title：Clinical and experimental immunology

authors： McLachlan SM,Pegg CA,Atherton MC,Middleton SL,Dickinson A,Clark F,Proctor SJ,Proud G,Rees Smith B

更新日期：1986-08-01 00:00:00

abstract：:Ws/Ws rats have a small deletion of the c-kit gene, and are deficient in both mucosal and connective tissue-type mast cells. In this study, the role of mucosal type mast cells (MMC) in the development of intestinal ischaemia-reperfusion injury was investigated in Ws/Ws rats. Autoperfused segments of the jejunum were e...

journal_title：Clinical and experimental immunology

authors： Andoh A,Kimura T,Fukuda M,Araki Y,Fujiyama Y,Bamba T

更新日期：1999-04-01 00:00:00

abstract：:The aim of this study was to investigate the diagnostic value of using the copy number of propionibacterial rRNA as a biomarker for sarcoidosis. Ribosomal RNA of Propionibacterium acnes and P. granulosum was measured by real-time quantitative reverse transcription-polymerase chain reaction (RT-PCR) using formalin-fixe...

journal_title：Clinical and experimental immunology

authors： Zhou Y,Wei YR,Zhang Y,Du SS,Baughman RP,Li HP

更新日期：2015-09-01 00:00:00

abstract：:Toll-like receptor 4 (TLR4), which recognizes lipopolysaccharides, plays an important role in the innate immune response. In this study, we investigated the role of TLR4 in the development of experimental colitis with regard to the biological actions of macrophage migration inhibitory factor (MIF) using TLR4 null ((-/...

journal_title：Clinical and experimental immunology

authors： Ohkawara T,Takeda H,Nishihira J,Miyashita K,Nihiwaki M,Ishiguro Y,Takeda K,Akira S,Iwanaga T,Sugiyama T,Asaka M

更新日期：2005-09-01 00:00:00

abstract：:A major goal in organ transplantation has been to safely exploit the natural processes of immune tolerance in order to minimize the dose and duration of drug immunosuppression. In this commentary, I argue that we can learn from how tumours avoid rejection, to evolve a three-stage tolerance-inducing strategy for transp...

journal_title：Clinical and experimental immunology

authors： Waldmann H

更新日期：2017-08-01 00:00:00

abstract：:Four human B cell lines with a mature phenotype (immunoglobulin secretion and expression of membrane markers associated with maturation) were cultured in the presence of phorbol ester (PMA), dimethyl sulphoxide (DMSO) and two conditioned media. PMA and DMSO led to changes in phenotype which suggested the cells were be...

journal_title：Clinical and experimental immunology

authors： Zola H,Griffith V,Hunter I,Koh L,Bradley J

更新日期：1986-11-01 00:00:00

abstract：:Anti-endothelial cell antibodies (AECA) have been frequently detected in systemic vasculitis, which affects blood vessels of various sizes. To understand the pathogenic roles of AECA in systemic vasculitis, we attempted to identify target antigens for AECA comprehensively by a proteomic approach. Proteins extracted fr...

journal_title：Clinical and experimental immunology

authors： Karasawa R,Kurokawa MS,Yudoh K,Masuko K,Ozaki S,Kato T

更新日期：2010-09-01 00:00:00

abstract：:One of the major obstacles in dissecting the mechanism of pathology in human primary biliary cirrhosis (PBC) has been the absence of animal models. Our laboratory has focused on a model in which mice, following immunization with a xenobiotic chemical mimic of the immunodominant autoepitope of the E2 component of pyruv...

journal_title：Clinical and experimental immunology

authors： Shimoda S,Tsuneyama K,Kikuchi K,Harada K,Nakanuma Y,Nakamura M,Ishibashi H,Hisamoto S,Niiro H,Leung PS,Ansari AA,Gershwin ME,Akashi K

更新日期：2012-06-01 00:00:00

abstract：:The uptake of C-reactive protein (CRP)-pneumococcal C-polysaccharide (CPS) complexes by neutrophils was studied. A specific CRP dependent mechanism of uptake was demonstrated. This promoted CPS (complexed to CRP) clearance which was further enhanced by additional complement activation. Physiological concentrations of ...

journal_title：Clinical and experimental immunology

authors： Shephard EG,Anderson R,Strachan AF,Kühn SH,De Beer FC

更新日期：1986-03-01 00:00:00

abstract：:To clarify immunological differences among patients with Graves' disease (GD) and Hashimoto's disease (HD) at various levels of severity, we examined the expression of the CD154 molecules on peripheral T cells, which regulate B cell activation, B cell differentiation, and T-cell survival. We found decreases in the int...

journal_title：Clinical and experimental immunology

authors： Watanabe M,Yamamoto N,Matsuzuka F,Miyauchi A,Iwatani Y

更新日期：2004-06-01 00:00:00

abstract：:Intra-articular injection of highly purified or recombinant interleukin 1 (IL-1) into the rabbit knee induces a transient synovitis with leucocytic infiltration into the synovial lining and joint cavity and loss of proteoglycan from articular cartilage. Tumour necrosis factor alpha (TNF-alpha), which has many of the a...

journal_title：Clinical and experimental immunology

authors： Henderson B,Pettipher ER

更新日期：1989-02-01 00:00:00