Synthesis of alpha 1-anti-trypsin by human monocytes.

abstract：:Autoimmune Addison's disease (AAD), or primary adrenocortical insufficiency, is a classical organ-specific autoimmune disease with 160 years of history. AAD is remarkably homogeneous with one major dominant self-antigen, the cytochrome P450 21-hydroxylase enzyme, which is targeted by both autoantibodies and autoreacti...

journal_title：Clinical and experimental immunology

authors： Hellesen A,Bratland E

更新日期：2019-01-01 00:00:00

abstract：:An original representative of histamine-containing peptidomimetics L-glutamyl-histamine (L-Glu-Hist) was synthesized and characterized as a cytokine mimic leading to cellular responses of improved specificity. The energy-minimized 3-D conformations of L-Glu-Hist derived from its chemical structure resulted in stabiliz...

journal_title：Clinical and experimental immunology

authors： Babizhayev MA,Semiletov YA,Lul'kin YA,Sakina NL,Savel'yeva EL,Alimbarova LM,Barinskii IP

更新日期：2005-03-01 00:00:00

abstract：:Insufficient stimulatory capacities of autologous dendritic cells (DC) may contribute in part to impaired T cell stimulation and therefore viral persistence in patients with chronic hepatitis B virus (HBV) infection. In order to characterize the antigen presenting functions of DC from chronic HBV carriers and controls...

journal_title：Clinical and experimental immunology

authors： Löhr HF,Pingel S,Böcher WO,Bernhard H,Herzog-Hauff S,Rose-John S,Galle PR

更新日期：2002-10-01 00:00:00

abstract：:Both MRL-lpr/lpr (lpr) and BXSB mice fall victim to autoimmune disease as a function of age. To combine their properties, brother-sister mating of (female lpr x male BXSB)F1 mice was done. Mice for mating were selected according to indicators of early onset of glomerulonephritis and subsequent early death (i.e., EOD)....

journal_title：Clinical and experimental immunology

authors： Honda S,Nemoto K,Mae T,Kinjoh K,Kyogoku M,Kawamura H,Miyazawa S,Weerashinghe A,Watanabe H,Narita J,Koya T,Arakawa M,Abo T

更新日期：1999-04-01 00:00:00

abstract：:Plasmacytoid dendritic cells (pDCs) are of crucial importance in immune regulation and response to microbial factors. In multiple sclerosis (MS), pDCs from peripheral blood showed an immature phenotype, but its role in susceptibility to MS is not determined. Because infectious diseases are established triggers of exac...

journal_title：Clinical and experimental immunology

authors： Bayas A,Stasiolek M,Kruse N,Toyka KV,Selmaj K,Gold R

更新日期：2009-09-01 00:00:00

abstract：:Cell mediated immunity (CMI) to hepatitis B viral antigens was studied in BALB/mice after immunization with purified hepatitis B surface antigen (HBsAg), or core antigen (HBcAg), with adjuvants. The two in vitro assays for cell-mediated immunity (CMI), utilizing lymph node cells, were release of interferon after expos...

journal_title：Clinical and experimental immunology

authors： De Moerloose PA,Frazer IH,Sewell WA,Collins EJ,Mackay IR

更新日期：1986-05-01 00:00:00

abstract：:Autoantibodies directed against the Sm proteins of the spliceosome complex are found in approximately 25% of systemic lupus erythematosus (SLE) patients sera. To determine which regions of the Sm D polypeptide are involved in the lupus autoimmune response, binding to overlapping octapeptides of Sm D has been evaluated...

journal_title：Clinical and experimental immunology

authors： James JA,Mamula MJ,Harley JB

更新日期：1994-12-01 00:00:00

abstract：:Four human B cell lines with a mature phenotype (immunoglobulin secretion and expression of membrane markers associated with maturation) were cultured in the presence of phorbol ester (PMA), dimethyl sulphoxide (DMSO) and two conditioned media. PMA and DMSO led to changes in phenotype which suggested the cells were be...

journal_title：Clinical and experimental immunology

authors： Zola H,Griffith V,Hunter I,Koh L,Bradley J

更新日期：1986-11-01 00:00:00

abstract：:In normal subjects, factor B and C3b inactivator (KAF) levels were linearly related (r = 0-71); factor B levels in subjects with low normal levels of KAF were significantly lower than in those with high normal levels of KAF. This relationship is postulated to be the result of modulation by the level of KAF of the avai...

journal_title：Clinical and experimental immunology

authors： Forristal J,Iitaka K,Vallota EH,West CD

更新日期：1977-04-01 00:00:00

abstract：:Antibody levels specific for capsular polysaccharides of Streptococcus pneumoniae and Haemophilus influenzae type b (Hib) and to tetanus toxoid (TT), were measured in serum samples of 750 age-stratified subjects from the UK. The study subjects comprised healthy adult volunteers and hospitalized children undergoing ele...

journal_title：Clinical and experimental immunology

authors： Hazlewood M,Nusrat R,Kumararatne DS,Goodall M,Raykundalia C,Wang DG,Joyce HJ,Milford-Ward A,Forte M,Pahor A

更新日期：1993-08-01 00:00:00

abstract：:The C77G polymorphism in exon A of the human CD45 gene occurs with low frequency in healthy individuals. An enhanced frequency of C77G individuals has been reported in cohorts of patients suffering from multiple sclerosis, systemic sclerosis, autoimmune hepatitis, hepatitis C and human immunodeficiency virus (HIV)-1. ...

journal_title：Clinical and experimental immunology

authors： Windhagen A,Sönmez D,Hornig-Do HT,Kalinowsky A,Schwinzer R

更新日期：2007-12-01 00:00:00

abstract：:Recent experimental data indicate a pathogenic role of complement activation in congestive heart failure (CHF). The aim of this study was to evaluate contact and complement systems activation in patients hospitalized for an acute episode of CHF. Forty-two of 80 consecutive patients admitted at our hospital with confir...

journal_title：Clinical and experimental immunology

authors： Suffritti C,Tobaldini E,Schiavon R,Strada S,Maggioni L,Mehta S,Sandrone G,Toschi-Dias E,Cicardi M,Montano N

更新日期：2017-11-01 00:00:00

abstract：:Ten out of 14 rhesus monkeys developed arthritis after a single immunization with bovine type II collagen (B-CII). In contrast to primary resistant monkeys, arthritic animals showed a B-CII specific T cell proliferation during the induction phase of the disease. All surviving animals showed a full remission of the dis...

journal_title：Clinical and experimental immunology

authors： Bakker NP,van Erck MG,'t Hart LA,Jonker M

更新日期：1991-11-01 00:00:00

abstract：:Analysis of the VH gene repertoire of the J558 family was done in lipopolysaccharide (LPS)-stimulated resting cells and in vivo activated cells derived from C57Bl/6-lpr mice (IghCb). Using a restriction fragment length polymorphism (RFLP) based on digestion with the restriction enzyme Pstl, the expression of the subfa...

journal_title：Clinical and experimental immunology

authors： Alarcón-Riquelme ME,Fernández C

更新日期：1995-02-01 00:00:00

abstract：:The reproducibility of a simplified, sensitive and rapid agarose-cell droplet assay for leucocyte migration inhibition factor (LIF) activity was studied. Removal of T cells with anti-T-cell serum eliminated LIF activity, indicating that in humans it is probably the T cell that produces LIF. Cord blood lymphocytes prod...

journal_title：Clinical and experimental immunology

authors： Hahn T,Levin S,Handzel ZT

更新日期：1976-06-01 00:00:00

abstract：:Reduced microbial exposure in early life may contribute to the increase of atopic diseases in 'westernized' societies but the underlying mechanisms remain elusive. The objective of this study was to examine how exposure to bacterial lipopolysaccharide (LPS) during early antigen encounter might influence the maturation...

journal_title：Clinical and experimental immunology

authors： Haddeland U,Sletten GB,Brandtzaeg P,Nakstad B

更新日期：2005-02-01 00:00:00

abstract：:Anti-cardiolipin antibodies, oxidatively modified low-density lipoproteins (oxLDL) and circulating immune complexes are humoral factors that have been linked to vascular damage. To analyse their possible role in the vascular complications in type 1 diabetes mellitus, we investigated patients with and without vascular ...

journal_title：Clinical and experimental immunology

authors： Ahmed E,Nityanand S,Mustafa A,Brismar K,Lefvert AK

更新日期：1999-02-01 00:00:00

abstract：:Recent studies have suggested that a high percentage of Epstein-Barr virus (EBV)-infected lymphocytes in peripheral blood of patients with chronic, active EBV infection (CAEBV) is of T cell origin. Although T cells are expanded oligoclonally in CAEBV, it is not clear whether the restricted diversity of T cells arise f...

journal_title：Clinical and experimental immunology

authors： Toyabe S,Harada W,Uchiyama M

更新日期：2003-10-01 00:00:00

abstract：:Dipeptidyl peptidase IV (DPIV), a T cell enzyme, has been implicated in the regulation of lymphocyte proliferation in response to lectins and allogeneic cells. A sensitive fluorimetric assay has been established for the enzyme and used to investigate DPIV activity, kinetics and the subcellular localization in lymphocy...

journal_title：Clinical and experimental immunology

authors： Harland C,Shah T,Webster AD,Peters TJ

更新日期：1988-11-01 00:00:00

abstract：:Bacille Calmette-Guérin (BCG), developed a century ago, is the only licensed tuberculosis (TB) vaccine in use to date. The protective efficacy of BCG against TB varies with no apparent protection in some population, and mechanisms of its immune protection is poorly known, and yet BCG is the most widely used vaccine, w...

journal_title：Clinical and experimental immunology

authors： Abebe F

更新日期：2012-09-01 00:00:00

abstract：:The value of the MLR in predicting graft outcome was evaluated in forty cadaveric grafts. The MLR was assessed by the one and two way stimulation index (SI), the relative response (RR), and the stabilized relative response (SRR). Graft function was assessed by function at 3 and 6 months after transplantation, and a re...

journal_title：Clinical and experimental immunology

authors： Cullen PR,Lester S,Rouch J,Morris PJ

更新日期：1977-05-01 00:00:00

abstract：:We report here the characterization and fine specificity of a human monoclonal IgM lambda reacting with double stranded DNA. The purified IgM and its Fab fragment bind to DNA in the Farr or Crithidia lucilae assays as well as in an immunoenzymatic test. In the latter case, binding was inhibited by native DNA, by DNA a...

journal_title：Clinical and experimental immunology

authors： Fermand JP,Danon F,Brouet JC

更新日期：1985-02-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:Acute coronary syndromes (ACS) are associated with inflammation resulting from monocyte activation. We sought for differences in the production of pro- and anti-inflammatory cytokines by monocytes from patients with ACS. C-reactive protein (CRP) and neopterin were measured in 22 patients with acute coronary syndromes,...

journal_title：Clinical and experimental immunology

authors： van Haelst PL,Tervaert JW,Bijzet J,Baljé-Volkers C,May JF,Langeveld B,Gans RO

更新日期：2004-11-01 00:00:00

abstract：:Mice with SCID disease have previously been successfully engrafted with human peripheral blood mononuclear cells (PBMC) obtained from normal individuals and from patients with various diseases. To determine whether SCID mice engrafted with SLE PBMC produced autoantibodies with specificities similar to those in the SLE...

journal_title：Clinical and experimental immunology

authors： Ashany D,Hines J,Gharavi A,Mouradian J,Elkon KB

更新日期：1992-04-01 00:00:00

abstract：:We have previously reported the finding of circulating antibodies recognizing two proteins of 100 and 120 kD (PO100 and PO120) from Pityrosporum ovale in patients with psoriasis. These antibodies were specific, since they were not detected in normal sera nor in other diseases linked to P. ovale such as seborrhoeic der...

journal_title：Clinical and experimental immunology

authors： Mathov I,Plotkin L,Abatangelo C,Galimberti R,Squiquera L,Leoni J

更新日期：1996-07-01 00:00:00

abstract：:In general, exogenous proteins are processed by antigen-presenting cells in the endosomes for major histocompatibility complex (MHC) class II presentation to CD4+ T cells, while proteins synthesized endogenously are processed in the cytoplasm for MHC class I presentation to CD8+ T cells. However, it is recognized that...

journal_title：Clinical and experimental immunology

authors： Voeten JT,Rimmelzwaan GF,Nieuwkoop NJ,Fouchier RA,Osterhaus AD

更新日期：2001-09-01 00:00:00

abstract：:Fourteen cadaver kidney donors were pretreated with a rapid infusion of 5 g of cyclophosphamide and 5 g of methylprednisolone in an attempt to reduce graft immunogenicity by altering immunogenic "passenger" leucocytes. The effects of this drug infusion on peripheral lymphocytes were monitored by measuring the ability ...

journal_title：Clinical and experimental immunology

authors： Jeffery JR,Guttmann RD,Charpentier B

更新日期：1976-09-01 00:00:00

abstract：:Dysregulation of apoptosis, particularly in the Fas/Fas ligand (FasL) pathway, is considered to be involved in the pathogenesis of autoimmune diseases such as systemic lupus erythematosus (SLE). Recently, a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds FasL and inhibits FasL-induced apoptosis, has...

journal_title：Clinical and experimental immunology

authors： Otsuki T,Tomokuni A,Sakaguchi H,Aikoh T,Matsuki T,Isozaki Y,Hyodoh F,Ueki H,Kusaka M,Kita S,Ueki A

更新日期：2000-02-01 00:00:00

abstract：:The close resemblance of MS to the animal model experimental autoimmune encephalomyelitis (EAE) has provided compelling data sustaining a pathogenic role of circulating T cells reactive against MBP. T cell antigen receptor (TCR) usage in EAE is commonly considered restricted; nevertheless, dynamic changes of TCR usage...

journal_title：Clinical and experimental immunology

authors： Uccelli A,Giunti D,Salvetti M,Ristori G,Fenoglio D,Abbruzzese,Mancardi G

更新日期：1998-01-01 00:00:00