Peroxiredoxin 2 is a novel autoantigen for anti-endothelial cell antibodies in systemic vasculitis.

abstract：:Common variable immunodeficiency (CVID) is the name given to a clinically heterogeneous group of hypogammaglobulinaemic immunodeficiency states. Bronchiectasis is a feature of this disease and is believed to be the result of recurrent bacterial infection affecting the respiratory tract. Bronchiectasis is also a featur...

journal_title：Clinical and experimental immunology

authors： Sansom ME,Ferry BL,Sherrell ZP,Chapel HM

更新日期：2002-12-01 00:00:00

abstract：:Chronic bone infection is associated with bone resorption. From animal studies, CD3/CD28-activated T cells are known to enhance osteoclastogenesis and bone resorption. Because CD28 is expressed constitutively on T cells and its expression is down-regulated by chronic exposure to the inflammatory environment, we charac...

journal_title：Clinical and experimental immunology

authors： Kumar G,Roger PM,Ticchioni M,Trojani C,Bernard de Dompsur R,Bronsard N,Carles M,Bernard E

更新日期：2014-04-01 00:00:00

abstract：:We have reported previously that Lactobacillus casei ssp. casei, together with specific substrate dextran, exhibited an adjuvant effect of stimulating humoral immune responses against bovine serum albumin (BSA) as a model antigen in BALB/c mice. In the present study, among the Lactobacillus species tested, L. casei ss...

journal_title：Clinical and experimental immunology

authors： Ogawa T,Asai Y,Tamai R,Makimura Y,Sakamoto H,Hashikawa S,Yasuda K

更新日期：2006-01-01 00:00:00

abstract：:Transmembrane activator and calcium modulator and cyclophilin ligand interactor-immunoglobulin (TACI-Ig) is a human fusion protein that binds and neutralizes both B lymphocyte stimulator (BLyS), a cytokine shown to be a key regulator of B cell maturation, proliferation and survival, and a proliferation-inducing ligand...

journal_title：Clinical and experimental immunology

authors： Wang D,Chang Y,Wu Y,Zhang L,Yan S,Xie G,Qin Q,Jin J,Wang W,Fang J,Wei W

更新日期：2011-02-01 00:00:00

abstract：:Human cartilage gp-39 (HC gp-39) is a well-known autoantigen in rheumatoid arthritis (RA). However, the exact localization, fluctuation and function of HC gp-39 in RA are unknown. Therefore, using a glucose-6-phosphate isomerase (GPI)-induced model of arthritis, we investigated these aspects of HC gp-39 in arthritis. ...

journal_title：Clinical and experimental immunology

authors： Tanaka Y,Matsumoto I,Inoue A,Umeda N,Takai C,Sumida T

更新日期：2014-08-01 00:00:00

abstract：:Since thyroid follicular epithelial cells (thyrocytes) have been shown to express a number of functions similar to monocytes, they were further examined for their potency in secreting thymocyte-stimulating activity (TSA). Although spontaneous production of TSA could not be detected when thyrocytes were cultured in the...

journal_title：Clinical and experimental immunology

authors： Hirose W,Kawagoe M,Hara M,Kitani A,Hirose T,Norioka K,Harigai M,Nakamura H

更新日期：1987-10-01 00:00:00

abstract：:GVHD is a major complication in allogeneic bone marrow transplantation (BMT). MHC class I mismatching increases GVHD, but in MHC-matched BMT minor histocompatibility antigens (mH) presented by MHC class I result in significant GVHD. To examine the modification of GVHD in the absence of cell surface MHC class I molecul...

journal_title：Clinical and experimental immunology

authors： Shenoy S,Desch K,Duffy B,Thorson P,Mohanakumar T

更新日期：1998-05-01 00:00:00

abstract：:An experimental model of immunological deficiency obtained by treating mice for 6 months with serum of human blood drawn from different healthy individuals has been studied. The results show that an alteration of a circulating lymphocyte population with alterations of the ratio CD4+/CD8+ appeared in mice stimulated fo...

journal_title：Clinical and experimental immunology

authors： Galdiero F,Galdiero M,Nuzzo I,Vitiello M,Bentivoglio C,Romano-Carratelli C

更新日期：1997-11-01 00:00:00

abstract：:Interleukin 15 (IL-15) is critical for the development of human and murine natural killer (NK) cells and hepatic-derived NK T cells (NKT) in mice, and for the homeostatic maintenance of NK/NKT and CD8(+) memory T cells. The lymphocyte repertoire of an adult human liver includes significant populations of NK and NKT-li...

journal_title：Clinical and experimental immunology

authors： Golden-Mason L,Kelly AM,Doherty DG,Traynor O,McEntee G,Kelly J,Hegarty JE,O'Farrelly C

更新日期：2004-10-01 00:00:00

abstract：:Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a group of autoimmune diseases, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). It is not known why ANCA develop, but it has been shown that they participate in pathogenesis by activating polymorphonuclear n...

journal_title：Clinical and experimental immunology

authors： Ohlsson SM,Pettersson Å,Ohlsson S,Selga D,Bengtsson AA,Segelmark M,Hellmark T

更新日期：2012-10-01 00:00:00

abstract：:The objective of this study was to evaluate prospectively the relationship between Yersinia enterocolitica (YE) infection and the development of overt autoimmune hypo- or hyperthyroidism (study A) and the de novo occurrence of thyroid antibodies (study B). This was a prospective cohort study of 790 euthyroid women who...

journal_title：Clinical and experimental immunology

authors： Effraimidis G,Tijssen JG,Strieder TG,Wiersinga WM

更新日期：2011-07-01 00:00:00

abstract：:Small molecule metabolites that are produced or altered by host-associated microbial communities are emerging as significant immune response modifiers. However, there is a key gap in our knowledge of how oral microbial metabolites affect the immune response. Here, we examined the effects of metabolites from five bacte...

journal_title：Clinical and experimental immunology

authors： Whiteson K,Agrawal S,Agrawal A

更新日期：2017-06-01 00:00:00

abstract：:The secondary antibody response to 5.0 microgram flagellin was studied by haemagglutination in 132 healthy or convalescent subjects given a primary challenge with 5.0 microgram flagellin from 1 to 44 months previously. The peak titre, expressed as total antibody, occurred at 2 weeks and was mainly immunoglobulin (Ig)G...

journal_title：Clinical and experimental immunology

authors： Whittingham S,Buckley JD,Mackay IR

更新日期：1978-11-01 00:00:00

abstract：:In susceptible mice, the heavy metal ion mercury is able to induce a strong immune activation, which resembles a T helper 2 (Th2) type of immune response and is characterized by a polyclonal B cell activation, formation of high levels of IgG1 and IgE antibodies, production of autoantibodies of different specificities ...

journal_title：Clinical and experimental immunology

authors： Brenden N,Rabbani H,Abedi-Valugerdi M

更新日期：2001-08-01 00:00:00

abstract：:The effect of various exogenous cells on the in-vitro PWM stimulation of immunoglobulin synthesis by normal human peripheral blood mononuclear cells was investigated. The accessory cells tested were bovine and human endothelial cells, bovine and human fibroblasts, normal human monocytes, and a monocyte cell line U937....

journal_title：Clinical and experimental immunology

authors： King MA,Roche WR,Nelson DS

更新日期：1986-09-01 00:00:00

abstract：:A 3.5 year old boy with X-linked severe combined immunodeficiency disease (SCID), who had been in laminar flow isolation throughout his life, developed a B cell tumour producing up to 3008 mg/dl of an IgM kappa paraprotein 1 month after infusion of both liver and thymus cells from a fetal donor and 6 months after the ...

journal_title：Clinical and experimental immunology

authors： Shirley LR,Buckley RH,Borowitz MJ,Welt SI,Kostyu DD

更新日期：1982-06-01 00:00:00

abstract：:A purified preparation of Epstein-Barr virus (EBV) has been shown to activate the classical complement pathway by direct interaction with the first component of complement, C1, without the intervention of antibody. No evidence was found for activation of the alternative pathway. Following classical pathway activation ...

journal_title：Clinical and experimental immunology

authors： Martin H,McConnell I,Gorick B,Hughes-Jones NC

更新日期：1987-03-01 00:00:00

abstract：:In vitro delayed hypersensitivity was studied in patients with either the chronic or the indeterminate phase of Chagas' disease. Normal healthy individuals were used as controls. The leucocyte migration inhibition test was applied using an antigen an extract of culture forms of T. cruzi or an extract of normal rat hea...

journal_title：Clinical and experimental immunology

authors： Toledo Barros MA,Amato Neto V,Mendes E,Mota I

更新日期：1979-11-01 00:00:00

abstract：:We have studied both the humoral and cell mediated immune systems of 23 children with beta-thalassaemia major. In children who had not been splenectomized, a 3-fold expansion in the number of circulating B cells and a modest polyclonal gammopathy was present. Of these patients 70% had decreased numbers of circulating ...

journal_title：Clinical and experimental immunology

authors： Dwyer J,Wood C,McNamara J,Williams A,Andiman W,Rink L,O'Connor T,Pearson H

更新日期：1987-06-01 00:00:00

abstract：:In order to gain information about the nature of the defect in X-linked severe combined immunodeficiency (XSCID), we investigated gene expression in different lymphoid and haematopoietic cells of female carriers by looking for non-random X chromosome usage. We have shown non-random X chromosome usage in T lymphocyte e...

journal_title：Clinical and experimental immunology

authors： Goodship J,Malcolm S,Levinsky RJ

更新日期：1991-01-01 00:00:00

abstract：:The capacity of B cells from patients with chronic lymphocytic leukaemia (CLL) to produce and secrete immunoglobulin following mitogen stimulation was investigated using sensitive radioimmunoassays for mu, gamma, alpha, kappa, and lambda immunoglobulin chains. Lymphocytes from seven of the 11 patients studied secreted...

journal_title：Clinical and experimental immunology

authors： Johnstone AP,Jensenius JC,Millard RE,Hudson L

更新日期：1982-03-01 00:00:00

abstract：:The effect of cyclosporin A (CyA) immunosuppression on the murine thymic microenvironment and T lymphocyte development has been analysed using monoclonal antibodies to epithelial and lymphocyte subpopulations, macrophages and major histocompatibility complex (MHC) class II antigens in immunohistochemistry and flow cyt...

journal_title：Clinical and experimental immunology

authors： Kanariou M,Huby R,Ladyman H,Colic M,Sivolapenko G,Lampert I,Ritter M

更新日期：1989-11-01 00:00:00

abstract：:Enormous progress has been made during the last 25 years in our understanding of the aetiopathogenesis of the anti-neutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides (AAV). This has led to improvements in early diagnosis, treatment and secondary prevention of these diseases. Nevertheless, there are sti...

journal_title：Clinical and experimental immunology

authors： Kallenberg CG

更新日期：2011-05-01 00:00:00

abstract：:The cytotoxic functions of highly purified blood lymphocytes from patients with breast cancer were studied before and after radiotherapy. Addition of PHA or of rabbit antibodies to target cells (chicken erythrocytes) were chosen as two means of inducing lymphocyte cytotoxicity in vitro. The proportion of T and non-T-l...

journal_title：Clinical and experimental immunology

authors： Wasserman J,Melén B,Blomgren H,Glas U,Perlmann P

更新日期：1975-11-01 00:00:00

abstract：:Serum IgG-antilipoprotein-autoantibody activity (at 4 degrees C) of a plane xanthoma patient was shown by double-immunodiffusion method. Cryoglobulins in the serum were dissociated to polyclonal IgG and alpha- and beta-lipoproteins by acidification and were reconstructed by neutralization. IgG fraction of the cryoglob...

journal_title：Clinical and experimental immunology

authors： Kodama H

更新日期：1977-06-01 00:00:00

abstract：:The role of macrophage infiltrates in oral mucosal acute graft-versus-host disease (AGVHD) remains unclear, although clinical studies suggest that macrophage infiltration correlates directly with the severity of AGVHD. In this study, we investigated the role of M1 macrophage infiltration in the oral mucosa of rats wit...

journal_title：Clinical and experimental immunology

authors： Seno K,Yasunaga M,Kajiya H,Izaki-Hagio K,Morita H,Yoneda M,Hirofuji T,Ohno J

更新日期：2017-12-01 00:00:00

abstract：:The modulatory effect of human milk proteins from colostrum and late milk on the proliferative response of human T lymphocytes activated by mitogens (OKT3 and leucoagglutinin from Phaseolus vulgaris) and alloantigens was studied. High concentrations (10-100 micrograms/ml) of crude colostral milk proteins had an inhibi...

journal_title：Clinical and experimental immunology

authors： Mincheva-Nilsson L,Hammarström ML,Juto P,Hammarström S

更新日期：1990-03-01 00:00:00

abstract：:Secretion of IgM and IgG in vitro by B cells from patients with common variable immunodeficiency (CVI) has been used to classify the disease into three groups. On stimulation with anti-IgM and IL-2, group A patients' cells fail to secrete IgM or IgG, group B patients' cells secrete no IgG and significantly lower level...

journal_title：Clinical and experimental immunology

authors： Franz A,Bryant A,Webster AD,Farrant J

更新日期：1992-03-01 00:00:00

abstract：:Lyme borreliosis is a complex infection, where some individuals develop so-called 'chronic borreliosis'. The pathogenetic mechanisms are unknown, but the type of immune response is probably important for healing. A strong T helper cell type 1 (Th1)-like response has been suggested as crucial for eradication of Borreli...

journal_title：Clinical and experimental immunology

authors： Ekerfelt C,Andersson M,Olausson A,Bergström S,Hultman P

更新日期：2007-10-01 00:00:00

abstract：:Both antigen specific and non-specific immunoregulation by cells have been described in jirds infected with Brugia pahangi, but the contribution of serum factors to immunoregulatory phenomena in this infection has not been examined. The present study determined the effect of serum from normal or B. pahangi infected ji...

journal_title：Clinical and experimental immunology

authors： Lammie PJ,Katz SP,Anderson WH

更新日期：1984-03-01 00:00:00