Dynamics of M1 macrophages in oral mucosal lesions during the development of acute graft-versus-host disease in rats.

abstract：:Circulating immune complexes were repeatedly searched for using the C1q-binding assay and the Raji cell test in Lewis and BN rats immunized with the Fx1A fraction from convoluted proximal tubule or with kidney homogenate, mixed with various adjuvants. An autoimmune glomerulonephritis was easily induced in Lewis rats. ...

journal_title：Clinical and experimental immunology

authors： Zanetti M,Bellon B,Verroust P,Druet P

更新日期：1980-10-01 00:00:00

abstract：:Small molecule metabolites that are produced or altered by host-associated microbial communities are emerging as significant immune response modifiers. However, there is a key gap in our knowledge of how oral microbial metabolites affect the immune response. Here, we examined the effects of metabolites from five bacte...

journal_title：Clinical and experimental immunology

authors： Whiteson K,Agrawal S,Agrawal A

更新日期：2017-06-01 00:00:00

abstract：:Nitric oxide (NO) is a mediator of inflammatory injury which is inhibited by glucocorticoids and is implicated in rheumatoid (RA) and adjuvant arthritis (AA). The glucocorticoid-induced anti-inflammatory molecule lipocortin 1 is expressed in RA synovium, but the effects of lipocortin 1 on synovial inflammation have be...

journal_title：Clinical and experimental immunology

authors： Yang YH,Hutchinson P,Santos LL,Morand EF

更新日期：1998-01-01 00:00:00

abstract：:Human alveolar macrophages (AM) were obtained by bronchoalveolar lavage from 18 patients with a variety of conditions. For each patient the percentages of AM showing the following properties were determined: (1) staining for the enzymes non-specific esterase (NSE) and acid phosphatase (ACP); (2) in vitro phagocytosis ...

journal_title：Clinical and experimental immunology

authors： Gant VA,Hamblin AS

更新日期：1985-06-01 00:00:00

abstract：:In a previous work we have demonstrated that in patients exhibiting a late allergic reaction (LAR), alveolar macrophages (AM) collected 18 h after bronchial allergen challenge produced high levels of IL-6 and tumour necrosis factor-alpha (TNF) which is known to up-regulate the endothelial cell expression of adhesion m...

journal_title：Clinical and experimental immunology

authors： Lassalle P,Gosset P,Delneste Y,Tsicopoulos A,Capron A,Joseph M,Tonnel AB

更新日期：1993-10-01 00:00:00

abstract：:We have shown previously that IgG2a anti-Thy-1 MoAb (ER4G) induces apoptosis of rat mesangial cells (GMC) in vitro. Since the classical complement pathway plays an essential role in Thy-1 nephritis, we analysed whether C1q, a subunit of the first component of complement, enhances the ER4G-mediated apoptosis of rat GMC...

journal_title：Clinical and experimental immunology

authors： Sato T,van Dixhoorn MG,Heemskerk E,van Es LA,Daha MR

更新日期：1997-09-01 00:00:00

abstract：:Anti-CD2 MoAbs have previously been shown to induce tolerance and to block B cell differentiation, T cell and monocyte activation. Since these immune functions are important in joint inflammation, we asked whether administration of the anti-CD2 MoAb OX34 has a beneficial effect on established rat adjuvant arthritis, a...

journal_title：Clinical and experimental immunology

authors： Hoffmann JC,Herklotz C,Zeidler H,Bayer B,Westermann J

更新日期：1997-10-01 00:00:00

abstract：:To clarify the association between factors regulating DNA methylation and the prognosis of autoimmune thyroid diseases (AITDs), we genotyped single nucleotide polymorphisms in genes encoding DNA methyltransferase 1 (DNMT1), DNMT3A, DNMT3B, methylenetetrahydrofolate reductase (MTHFR) and methionine synthase reductase (...

journal_title：Clinical and experimental immunology

authors： Arakawa Y,Watanabe M,Inoue N,Sarumaru M,Hidaka Y,Iwatani Y

更新日期：2012-11-01 00:00:00

abstract：:The influence of cyclosporin A (CsA) on type II collagen-induced arthritis (CIA) in the rhesus monkey has been investigated. CsA was administered subcutaneously in a dose of 25 mg/kg per day during 9-18 days and additionally 12.5 mg/kg per day for 7 days. At this dosing regime no significant alterations of haematologi...

journal_title：Clinical and experimental immunology

authors： Bakker NP,Van Besouw N,Groenestein R,Jonker M,Hart LA

更新日期：1993-09-01 00:00:00

abstract：UNLABELLED:OTHER THEMES PUBLISHED IN THIS IMMUNOLOGY IN THE CLINIC REVIEW SERIES Allergy, Host Responses, Cancer, Type 1 diabetes and viruses, Metabolic diseases. SUMMARY:Initiation of a successful immune response requires a working set of sensors that detect any noxious agent within the cellular microenvironment and ...

journal_title：Clinical and experimental immunology

authors： Mankan AK,Kubarenko A,Hornung V

更新日期：2012-03-01 00:00:00

abstract：:We found that IgA is predominant among the immune deposits in the renal glomeruli of mice infected with Schistosoma mansoni, and thus conducted an analysis of the deposition of different immunoglobulin isotypes in the glomeruli throughout the course of infection in mice. Both immunofluorescent and immunoperoxidase met...

journal_title：Clinical and experimental immunology

authors： el-Sherif AK,Befus D

更新日期：1988-01-01 00:00:00

abstract：:Thyroid autoantigens require internalization and processing by antigen-presenting cells to induce immune responses. Besides pinocytosis, antigen uptake can be receptor-mediated. The mannose receptor (ManR) has a cysteine rich domain (CR) and eight carbohydrate recognition domains (CRD) that bind glycosylated proteins....

journal_title：Clinical and experimental immunology

authors： Chazenbalk GD,Pichurin PN,Guo J,Rapoport B,McLachlan SM

更新日期：2005-02-01 00:00:00

abstract：:Dysregulation of IL-6 synthesis is thought to play a role in the development of a number of age-related conditions, such as rheumatoid arthritis, osteoporosis, atherosclerosis, Alzheimer's disease and B cell malignancies. Recently it has been suggested that the production of IL-6 is influenced by the adrenal hormone d...

journal_title：Clinical and experimental immunology

authors： Young DG,Skibinski G,Mason JI,James K

更新日期：1999-09-01 00:00:00

abstract：:An eosinophil stimulating material (ESM) is described in the blister fluids (BF) of six patients with bullous pemphigoid (BP). This ESM is similar in function to a subspecies of human colony stimulating factor (CSF), CSF-alpha, since (i) it stimulated the production from bone marrow cells of day 14 colonies (31 +/- 15...

journal_title：Clinical and experimental immunology

authors： Varigos GA,Morstyn G,Vadas MA

更新日期：1982-12-01 00:00:00

abstract：:The distribution and regulatory function of immunoglobulin (Ig) synthesis by monocytes were assessed using several monoclonal antibodies and a cell sorter in samples from 13 patients with multiple myeloma (MM) and nine patients with benign monoclonal gammopathy (BMG). Since all of these cells were separated directly w...

journal_title：Clinical and experimental immunology

authors： Takeshita A

更新日期：1986-12-01 00:00:00

abstract：:Circulating immune complexes have been investigated in jirds (Meriones unguiculatus) infected with the filarial nematode Brugia pahangi. Two-month-old male jirds were inoculated with seventy-five B. pahangi infective larvae into the left groin. At 8 months post-infection, sera of individual animals from a group of sev...

journal_title：Clinical and experimental immunology

authors： Karavodin LM,Ash LR

更新日期：1980-05-01 00:00:00

abstract：:Vitamin D has been shown to modulate innate immune responses in vitro and ex vivo; however, human in-vivo data are lacking. At high latitudes, seasonal vitamin D deficiency is common due to alternating ultraviolet (UV)-B radiation exposure. In the present study, we investigated whether levels of 25 hydroxyvitamin D(3)...

journal_title：Clinical and experimental immunology

authors： Kox M,van den Berg MJ,van der Hoeven JG,Wielders JP,van der Ven AJ,Pickkers P

更新日期：2013-02-01 00:00:00

abstract：:In sarcoidosis, a T helper 1 (Th1) response is an essential event and the up-regulation of interleukin-12 (IL-12) has been detected in affected disease sites. In order to investigate the clinical usefulness of circulating IL-12, we measured the serum concentrations of IL-12 by ELISA and performed immunohistochemistry ...

journal_title：Clinical and experimental immunology

authors： Shigehara K,Shijubo N,Ohmichi M,Kamiguchi K,Takahashi R,Morita-Ichimura S,Ohchi T,Tatsuno T,Hiraga Y,Abe S,Sato N

更新日期：2003-04-01 00:00:00

abstract：:Peripheral T lymphocytes from asymptomatic HBsAg carriers and hepatitis B (HB) immune (naturally acquired or vaccine induced) donors were induced into interleukin-2 (IL-2) secretion by plasma-derived HBsAg and the translational products of the S- and pre-S2+S gene of HB virus (HBV) in vitro. Biphasic time courses of I...

journal_title：Clinical and experimental immunology

authors： Sylvan SP,Hekkström UB

更新日期：1989-11-01 00:00:00

abstract：:Oestradiol and the selective oestrogen receptor modulator (SERM) raloxifene have been shown to ameliorate collagen-induced arthritis (CIA) in rats and in mice. One aim was to investigate if raloxifene exerts its anti-arthritic and anti-osteoporotic effects during the induction or effector phase of arthritis. A second ...

journal_title：Clinical and experimental immunology

authors： Jochems C,Islander U,Erlandsson M,Engdahl C,Lagerquist M,Ohlsson C,Nandakumar KS,Holmdahl R,Carlsten H

更新日期：2011-07-01 00:00:00

abstract：:Chronic bone infection is associated with bone resorption. From animal studies, CD3/CD28-activated T cells are known to enhance osteoclastogenesis and bone resorption. Because CD28 is expressed constitutively on T cells and its expression is down-regulated by chronic exposure to the inflammatory environment, we charac...

journal_title：Clinical and experimental immunology

authors： Kumar G,Roger PM,Ticchioni M,Trojani C,Bernard de Dompsur R,Bronsard N,Carles M,Bernard E

更新日期：2014-04-01 00:00:00

abstract：:Both MRL-lpr/lpr (lpr) and BXSB mice fall victim to autoimmune disease as a function of age. To combine their properties, brother-sister mating of (female lpr x male BXSB)F1 mice was done. Mice for mating were selected according to indicators of early onset of glomerulonephritis and subsequent early death (i.e., EOD)....

journal_title：Clinical and experimental immunology

authors： Honda S,Nemoto K,Mae T,Kinjoh K,Kyogoku M,Kawamura H,Miyazawa S,Weerashinghe A,Watanabe H,Narita J,Koya T,Arakawa M,Abo T

更新日期：1999-04-01 00:00:00

abstract：:Even though the existence of phosphodiesterase (PDE) 7 in T cells has been proved, the lack of a selective PDE7 inhibitor has confounded an accurate assessment of PDE7 function in such cells. In order to elucidate the role of PDE7 in human T cell function, the effects of two PDE inhibitors on PDE7A activity, cytokine ...

journal_title：Clinical and experimental immunology

authors： Nakata A,Ogawa K,Sasaki T,Koyama N,Wada K,Kotera J,Kikkawa H,Omori K,Kaminuma O

更新日期：2002-06-01 00:00:00

abstract：:Although increasing evidence demonstrates the association between intestinal dysbiosis and pancreatic diseases such as chronic pancreatitis and pancreatic cancer, it remains largely unknown whether intestinal dysbiosis is involved in the immunopathogenesis of autoimmune pancreatitis (AIP). Recently, we found that inte...

journal_title：Clinical and experimental immunology

authors： Kamata K,Watanabe T,Minaga K,Hara A,Sekai I,Otsuka Y,Yoshikawa T,Park AM,Kudo M

更新日期：2020-12-01 00:00:00

abstract：:The effect of various exogenous cells on the in-vitro PWM stimulation of immunoglobulin synthesis by normal human peripheral blood mononuclear cells was investigated. The accessory cells tested were bovine and human endothelial cells, bovine and human fibroblasts, normal human monocytes, and a monocyte cell line U937....

journal_title：Clinical and experimental immunology

authors： King MA,Roche WR,Nelson DS

更新日期：1986-09-01 00:00:00

abstract：:Saimiri sciureus monkeys have been successfully immunized against a human malaria parasite, Plasmodium falciparum, using soluble antigens purified from schizont and merozoite extracts. High levels of antibodies reacting with schizont and merozoite specific polypeptides of 140 and 200 kdaltons were detected in the sera...

journal_title：Clinical and experimental immunology

authors： Perrin LH,Loche M,Dedet JP,Roussilhon C,Fandeur T

更新日期：1984-04-01 00:00:00

abstract：:B-lymphocytes from healthy children and young adults who were seronegative for autoantibodies and B lymphocytes from umbilical cord blood of newborns were induced to secrete a variety of autoantibodies upon infection with Epstein-Barr virus. Such autoantibody-secreting clones were obtained from different lymphoid tiss...

journal_title：Clinical and experimental immunology

authors： Uhlig H,Rutter G,Dernick R

更新日期：1985-10-01 00:00:00

abstract：:A preparation of the putative antibody in HN (Heymann's nephritis) lacking preformed immune complexes, obtained from the acid eluates of kidneys with HN, purified through ion exchange and gel-filtration chromatography, characterized by immunoelectrophoresis, sucrose density-gradient ultracentrifugation, 125I-Clq assay...

journal_title：Clinical and experimental immunology

authors： Makker SP,Kirson IJ,Moorthy B

更新日期：1982-02-01 00:00:00

abstract：:Neurotrophins nerve growth factor (NGF), brain-derived growth factor (BDNF), neurotrophin-3 (NT-3) and neurotrophin-4 (NT-4) and their high-affinity tyrosine protein kinase receptor (Trk) family, TrkA, TrkB, TrkC, and low-affinity p75(NTR) receptor, are key molecules implicated in the development of the central nervou...

journal_title：Clinical and experimental immunology

authors： Samah B,Porcheray F,Gras G

更新日期：2008-03-01 00:00:00

abstract：:Mycoplasma pneumoniae is an obligate pathogen that causes pneumonia, tracheobronchitis, pharyngitis and asthma in humans. It is well recognized that membrane lipoproteins are immunostimulants exerting as lipopolysaccharides (LPS) and play a crucial role in the pathogenesis of inflammatory responses upon M. pneumoniae ...

journal_title：Clinical and experimental immunology

authors： Luo H,He J,Qin L,Chen Y,Chen L,Li R,Zeng Y,Zhu C,You X,Wu Y

更新日期：2021-01-01 00:00:00