Endothelial cell enhancement of PWM induced immunoglobulin synthesis by peripheral blood mononuclear cells.

abstract：:In this study we demonstrate that IgG present in the sera of patients with primary Sjögren's syndrome (PSS) could bind and activate muscarinic acetylcholine receptors (mAChRs) of rat parotid gland. These antibodies were able to inhibit in a non-competitive manner the binding of 3H-quinuclidinyl benzilate (QNB) to mACh...

journal_title：Clinical and experimental immunology

authors： Bacman S,Sterin-Borda L,Camusso JJ,Arana R,Hubscher O,Borda E

更新日期：1996-06-01 00:00:00

abstract：:Evidence is emerging that exposure to mercury (Hg) may elicit many pathological manifestations, including immunomodulation. We tested whether changing cellular activation pathways may affect the immunomodulation by Hg. Human cell cultures were set up where isolated peripheral blood mononuclear cells, activated by mono...

journal_title：Clinical and experimental immunology

authors： Hemdan NY,Lehmann I,Wichmann G,Lehmann J,Emmrich F,Sack U

更新日期：2007-05-01 00:00:00

abstract：:Studies of patients with active tuberculosis (TB) and infected healthy individuals have shown that interferon (IFN)-gamma is present in sites of Mycobacterium tuberculosis infection in comparable levels. This suggests that there is a deficiency in the macrophage response to IFN-gamma in TB patients. We used recombinan...

journal_title：Clinical and experimental immunology

authors： Esquivel-Solís H,Quiñones-Falconi F,Zarain-Herzberg A,Amieva-Fernández RI,López-Vidal Y

更新日期：2009-10-01 00:00:00

abstract：:A randomized controlled trial of treatment with thymic humoral factor (THF) in 20 children with severe complicated acute measles infection, resulted in objective benefit as evidenced by improvement in the ESR and a fall in C-reactive protein, fewer complications and a reduced incidence of secondary herpes infection. A...

journal_title：Clinical and experimental immunology

authors： Beatty DW,Handzel ZT,Pecht M,Ryder CR,Hughes J,McCabe K,Trainin N

更新日期：1984-06-01 00:00:00

abstract：:The levels of soluble IL-2Ralpha (sIL-2Ralpha) in serum were measured in HTLV-1 carriers and ATL patients in order to evaluate their possible correlation with clinical status. Mean sIL-2R levels in ATL patients were found to be 9704 U/ml for the acute/lymphoma type, 1961 U/ml for the chronic type and 788 U/ml for the ...

journal_title：Clinical and experimental immunology

authors： Araki K,Harada K,Nakamoto K,Shiroma M,Miyakuni T

更新日期：2000-02-01 00:00:00

abstract：:Severe thrombocytopenia and increased vascular permeability are two major characteristics of dengue haemorrhagic fever (DHF). To develop a better understanding of the roles of platelet-associated IgG (PAIgG) and IgM (PAIgM) in inducing thrombocytopenia and its severity of disease in patients with secondary dengue viru...

journal_title：Clinical and experimental immunology

authors： Saito M,Oishi K,Inoue S,Dimaano EM,Alera MT,Robles AM,Estrella BD Jr,Kumatori A,Moji K,Alonzo MT,Buerano CC,Matias RR,Morita K,Natividad FF,Nagatake T

更新日期：2004-11-01 00:00:00

abstract：:We studied the relationship between the HLA specificities associated with multiple sclerosis (MS) susceptibility in southern Italy and the reactivity of the human myelin basic protein (hMBP) immunogenic peptides 84-98 and 143-168, using short-term T-cell lines established from 9 MS patients and from 8 healthy individu...

journal_title：Clinical and experimental immunology

authors： Montanaro D,Sanna V,Matarese G,Larby BB,Racioppi L,Carrieri PB,Bruno R,Davey NJ,Zappacosta S,Fontana S

更新日期：2001-02-01 00:00:00

abstract：:To determine the effect of prolonged administration of exogenous interferon on the autoimmune disease of NZB/W female mice, forty-four NZB/W mice received three injections per week of 6.4 x 10(4) interferon units from birth to 33 weeks, forty mice were injected with mock interferon and forty-eight mice were left untre...

journal_title：Clinical and experimental immunology

authors： Adam C,Thoua Y,Ronco P,Verroust P,Tovey M,Morel-Maroger L

更新日期：1980-05-01 00:00:00

abstract：:Anti-endothelial cell antibodies (AECA) have been frequently detected in systemic vasculitis, which affects blood vessels of various sizes. To understand the pathogenic roles of AECA in systemic vasculitis, we attempted to identify target antigens for AECA comprehensively by a proteomic approach. Proteins extracted fr...

journal_title：Clinical and experimental immunology

authors： Karasawa R,Kurokawa MS,Yudoh K,Masuko K,Ozaki S,Kato T

更新日期：2010-09-01 00:00:00

abstract：:Positive skin reactions to PPD in guinea-pigs immunized with Freund's complete adjuvant (FCA) were reversed after treatment with 10 mg/kg/day nifurtimox for 12 days. The in vitro migration of peripheral blood leucocytes from FCA-immunized guinea-pigs was inhibited with PPD, but it returned to normal values after nifur...

journal_title：Clinical and experimental immunology

authors： Lelchuk R,Cardoni RL,Levis S

更新日期：1977-12-01 00:00:00

abstract：:We explored the effects of local anaesthetics, which are proposed to affect the plasma membrane, on human natural killer (NK) cells. Human NK cell activity was inhibited by lidocaine and procaine in a dose-dependent manner. Procaine inhibited not only NK cytolysis but also the binding of NK cells to target cells when ...

journal_title：Clinical and experimental immunology

authors： Takagi S,Kitagawa S,Oshimi K,Takaku F,Miura Y

更新日期：1983-08-01 00:00:00

abstract：:Individuals with a negative intradermal reaction to tuberculin PPD have long been described in the Mycobacterium tuberculosis exposed, immune-competent population. Here, we studied PPD-specific blood T lymphocytes from these subjects for phenotypic markers relevant to skin migration, including the expression of the sk...

journal_title：Clinical and experimental immunology

authors： Magnani ZI,Confetti C,Besozzi G,Codecasa LR,Panina-Bordignon P,Lang R,Rossi GA,Pardi R,Burastero SE

更新日期：2000-01-01 00:00:00

abstract：:Saimiri sciureus monkeys have been successfully immunized against a human malaria parasite, Plasmodium falciparum, using soluble antigens purified from schizont and merozoite extracts. High levels of antibodies reacting with schizont and merozoite specific polypeptides of 140 and 200 kdaltons were detected in the sera...

journal_title：Clinical and experimental immunology

authors： Perrin LH,Loche M,Dedet JP,Roussilhon C,Fandeur T

更新日期：1984-04-01 00:00:00

abstract：:This study analyses the expression by rat lymphocytes of six renal brush border (BB) antigens defined by a set of monoclonal antibodies and demonstrates that a 90 kD protein (gp 90), synthesized by BB and glomeruli is found on the surface of T and B cells. The other antigens, including the 330 kD protein involved in H...

journal_title：Clinical and experimental immunology

authors： Van Leer EH,Moullier P,Ronco P,Verroust P

更新日期：1987-03-01 00:00:00

abstract：:Membranous nephropathy (MN), the leading cause of nephrotic syndrome in adults, is characterized by the deposition of subepithelial immune deposits that consist mainly of immunoglobulin (Ig)G and complement. Most of the cases are primary or idiopathic (iMN), while only approximately 25% of the cases are secondary to s...

journal_title：Clinical and experimental immunology

authors： Sinico RA,Mezzina N,Trezzi B,Ghiggeri GM,Radice A

更新日期：2016-02-01 00:00:00

abstract：:Functional impairments of polymorphonuclear granulocytes (PMN) are believed to contribute to hampered inflammation and host defence in alcoholics. We studied effects of i.v. ethanol administration on PMN responses in rabbits during induction of a knee-joint synovitis. The synovitis conferred systemic effects, since ch...

journal_title：Clinical and experimental immunology

authors： Nilsson E,Thomsen P,Ericson L,Palmblad J

更新日期：1995-10-01 00:00:00

abstract：:We have studied the role of three mouse distinct non-H-2 genes (Bcg, Tbc-1, xid) in several phenomena of antituberculosis immunity and resistance. On the basis of median survival time (MST) of mice following infection with virulent Mycobacterium tuberculosis H37Rv, Bcg gene did not control resistance to the lethal dos...

journal_title：Clinical and experimental immunology

authors： Nikonenko BV,Apt AS,Mezhlumova MB,Avdienko VG,Yeremeev VV,Moroz AM

更新日期：1996-04-01 00:00:00

abstract：:A positive Mitsuda skin test for delayed type hypersensitivity to Mycobacterium leprae is associated with a high level of protection against lepromatous leprosy, while the value of tuberculin sensitivity in leprosy is less pronounced. Cutaneous lymphocytes, isolated from the Mitsuda reaction of a PPD-positive individu...

journal_title：Clinical and experimental immunology

authors： Roberts PP,Dockrell HM,McAdam KP

更新日期：1988-06-01 00:00:00

abstract：:Anticardiolipin antibodies (ACA) belong to a heterogeneous group of antibodies directed against negatively charged phospholipids. In patients with rheumatic disorders, their presence has been correlated to the occurrence of thromboembolic complications, thrombocytopenia, abortions and other disease manifestations. Sev...

journal_title：Clinical and experimental immunology

authors： Rubbert A,Bock E,Schwab J,Marienhagen J,Nüsslein H,Wolf F,Kalden JR

更新日期：1994-12-01 00:00:00

abstract：:Bullous pemphigoid is a blistering skin disease characterized by autoantibodies against the NC16a domain of bullous pemphigoid 180. This study was performed to characterize and map the fine specificity of T cell responses to NC16a. Peripheral blood mononuclear cells (PBMC) from a total of 28 bullous pemphigoid patient...

journal_title：Clinical and experimental immunology

authors： Pickford WJ,Gudi V,Haggart AM,Lewis BJ,Herriot R,Barker RN,Ormerod AD

更新日期：2015-05-01 00:00:00

abstract：:IgE was isolated from a patient with the hyper IgE, recurrent infection syndrome by immunoadsorption on sepharose bound goat anti-human IgE. Addition of this IgE to a monolayer culture of human monocytes resulted in a dose-dependent increase in PGE2 secretion. The addition of F(ab')2 fraction of goat anti-human IgE in...

journal_title：Clinical and experimental immunology

authors： Passwell JH,Geiger B,Levanon M,Davidsohn J,Cohen BE,Ramot B

更新日期：1984-12-01 00:00:00

abstract：:After 3-4 weeks culture of human bone marrow cells in medium supplemented with IL-3, macrophage- (M-CSF), and granulocyte-macrophage colony-stimulating factor (GM-CSF), the firmly adherent cells exhibited the morphologic features of mononuclear phagocytes and were strongly esterase-positive. Flow cytometric analysis r...

journal_title：Clinical and experimental immunology

authors： Keller R,Keist R,Joller P,Groscurth P

更新日期：1993-01-01 00:00:00

abstract：:To identify and measure the spontaneous cell-mediated cytotoxicity of natural killer cells, we used the lysis of an established lymphoblastoid cell line as target in a 4-hr 51Cr-release assay. Mononuclear cell suspensions of the peripheral blood of thirty-four patients with Crohn's disease (group CD), eleven patients ...

journal_title：Clinical and experimental immunology

authors： Auer IO,Ziemer E,Sommer H

更新日期：1980-10-01 00:00:00

abstract：:Lung cancer is strongly associated with cigarette smoking. More than 20 lung carcinogens have been identified in cigarette smoke and one of the most abundant is 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK). We hypothesized that NNK modulates alveolar macrophage (AM) mediator production, thus contributing to ca...

journal_title：Clinical and experimental immunology

authors： Therriault MJ,Proulx LI,Castonguay A,Bissonnette EY

更新日期：2003-05-01 00:00:00

abstract：:Supernatants of both CD4+ and CD8+ alloreactive T cell clones induced IgM, IgG and IgA synthesis by peripheral blood lymphocytes (PBL) of healthy donors in vitro. These supernatants were also tested on their capacity to induce immunoglobulin production by PBL of four patients with CVI and one patient with CVI and thym...

journal_title：Clinical and experimental immunology

authors： Pastorelli G,Roncarolo MG,Touraine JL,Rousset F,Pene J,de Vries JE

更新日期：1989-12-01 00:00:00

abstract：:We previously demonstrated that high levels of IL-6/sIL-6R complexes are present in sera of patients with systemic juvenile idiopathic arthritis (s-JIA) and that the amount of IL-6 estimated in the IL-6/sIL-6R complexes is markedly higher than that measured by the B9 assay. Here, we show that two additional bioassays,...

journal_title：Clinical and experimental immunology

authors： Pignatti P,Ciapponi L,Galle P,Hansen MB,Massa M,Meazza C,Paonessa G,Novick D,Ciliberto G,Martini A,De Benedetti F

更新日期：2003-02-01 00:00:00

abstract：:An expanded T cell subpopulation (CD8+ Leu-7+) has previously been reported in the peripheral blood of patients with Crohn's disease. This subpopulation of T cells was associated with a 'covert suppressor' function, particularly in patients with mild/early Crohn's disease, suppressing immunoglobulin production in vitr...

journal_title：Clinical and experimental immunology

authors： Deem RL,Targan SR,Niederlehner A,Shanahan F

更新日期：1990-06-01 00:00:00

abstract：:Extracorporeal photopheresis (ECP) has been used as a prophylactic and therapeutic option to avoid and treat rejection after heart transplantation (HTx). Tolerance-inducing effects of ECP such as up-regulation of regulatory T cells (T(regs)) are known, but specific effects of ECP on regulatory T cell (T(reg)) subsets ...

journal_title：Clinical and experimental immunology

authors： Dieterlen MT,Bittner HB,Pierzchalski A,Dhein S,Mohr FW,Barten MJ

更新日期：2014-04-01 00:00:00

abstract：:Oxazolone-induced colitis in mice has become a recognized model to study the efficacy of therapeutics targeting the immunological response underlying the development of inflammatory bowel disease. However, this model cannot be used when therapeutics designed to address human targets do not interact with the respective...

journal_title：Clinical and experimental immunology

authors： Nolte T,Zadeh-Khorasani M,Safarov O,Rueff F,Gülberg V,Herbach N,Wollenberg A,Mueller T,Siebeck M,Wolf E,Gropp R

更新日期：2013-05-01 00:00:00

abstract：:Bronchoalveolar washings (BAW) were obtained from rats primarily infected with N. brasiliensis during the early infection stage that coincides with the lung passage of the parasite and the recruitment of inflammatory cells. BAW were tested for IL-1, IL-6 and tumour necrosis factor (TNF) activities. We found that IL-1 ...

journal_title：Clinical and experimental immunology

authors： Benbernou N,Matsiota-Bernard P,Jolivet C,Ougen P,Guenounou M

更新日期：1992-05-01 00:00:00